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    Medicine drink food and feed having an action of strengthening bone
    1.
    发明授权
    Medicine drink food and feed having an action of strengthening bone 失效
    药物饮食食物和饲料具有加强骨骼的作用

    公开(公告)号：US06344437B1

    公开(公告)日：2002-02-05

    申请号：US08819110

    申请日：1997-03-17

    申请人： Yukihiro Takada ,  Seiichiro Aoe ,  Ken Kato ,  Yasuhiro Toba ,  Junichi Yamamura

    发明人： Yukihiro Takada ,  Seiichiro Aoe ,  Ken Kato ,  Yasuhiro Toba ,  Junichi Yamamura

    IPC分类号： A61K31593

    CPC分类号： A61K38/39 ,  A21D2/261 ,  A23C9/1315 ,  A23C19/082 ,  A23J1/10 ,  A23K20/147 ,  A23K50/42 ,  A23L2/66 ,  A23L29/256 ,  A23L29/284 ,  A23L33/17 ,  Y10S514/801

    摘要： The present invention is to provide a novel medicine, drink, food or feed having an action of strengthening bone. More specifically, the present invention is to provide a medicine, drink, food or feed combined with collagen, fraction containing collagen or degradation product thereof. Fraction containing collagen was prepared by mincing skin corium layer into pieces, defatting it and lyophylization or by pulverizing bone, decalcifying it and lyophylization. Oral administration of these can stimulate proliferation of osteoblast, inhibit bone resorption and strengthen bone. They can be useful for improvement of osteoporosis, bone fracture, bone pain, etc.

    摘要翻译： 本发明提供一种具有加强骨的作用的新型药物，饮料，食品或饲料。 更具体地说，本发明提供与胶原蛋白，含有胶原蛋白或其降解产物的组分组合的药物，饮料，食品或饲料。 通过将皮肤层切成块，脱脂和冻干或通过粉碎骨，脱钙和冻干来制备含胶原蛋白。 口服这些可以刺激成骨细胞的增殖，抑制骨吸收和加强骨骼。 它们可用于改善骨质疏松症，骨折，骨痛等。

    Skin collagen production promoter
    9.
    发明申请
    Skin collagen production promoter 审中-公开
    皮肤胶原蛋白生产促进剂

    公开(公告)号：US20060247162A1

    公开(公告)日：2006-11-02

    申请号：US10553830

    申请日：2003-05-07

    申请人： Yoshikazu Morita ,  Yukihiro Takada ,  Yasuhiro Toba ,  Wataru Ooi ,  Hiroshi Kawakami

    发明人： Yoshikazu Morita ,  Yukihiro Takada ,  Yasuhiro Toba ,  Wataru Ooi ,  Hiroshi Kawakami

    IPC分类号： A61K38/17 ,  A61K35/20

    CPC分类号： A61K35/20 ,  A23L33/18 ,  A23L33/19 ,  A61K8/64 ,  A61K38/018 ,  A61Q19/00 ,  A61Q19/007 ,  A61Q19/08

    摘要： It is intended to provide a skin collagen production promoter, foods and drinks for promoting skin collagen production and cosmetics for promoting skin collagen production which are useful in preventing skin chapping, wrinkles, worsening in skin fitness, etc. Namely, a skin collagen production promoter, foods and drinks for promoting skin collagen production and cosmetics for promoting skin collagen production which contain as the active ingredient(s) a milk-origin basic protein fraction and/or a basic peptide fraction obtained by digesting the above-described basic protein fraction with a protein digesting enzyme such as pepsin or pancreatin. The above basic protein fraction and basic peptide fraction have an effect of increasing skin collagen level.

    摘要翻译： 旨在提供用于促进皮肤胶原蛋白生产的皮肤胶原蛋白生产促进剂，用于促进皮肤胶原蛋白生产的化妆品的食品和饮料，其可用于防止皮肤瘙痒，皱纹，皮肤适应性恶化等。也就是说，皮肤胶原产生促进剂 ，用于促进皮肤胶原蛋白产生的食品和饮料以及用于促进皮肤胶原蛋白生产的化妆品，其含有作为活性成分的乳源性碱性蛋白质级分和/或通过将上述碱性蛋白质级分消化而获得的碱性肽级分， 蛋白质消化酶如胃蛋白酶或胰酶。 上述碱性蛋白质级分和碱性肽级分具有增加皮肤胶原蛋白水平的作用。

    Method of producing fractions containing a high concentration of milk basic cystatin and decomposition products thereof
    10.
    发明授权
    Method of producing fractions containing a high concentration of milk basic cystatin and decomposition products thereof 有权
    制备含有高浓度的乳碱性半胱氨酸蛋白酶抑制剂及其分解产物的级分的方法

    公开(公告)号：US06649590B2

    公开(公告)日：2003-11-18

    申请号：US09876267

    申请日：2001-06-06

    申请人： Yukihiro Takada ,  Atsushi Serizawa ,  Yasuhiro Matsuoka ,  Yasuhiro Toba ,  Hiroshi Kawakami

    发明人： Yukihiro Takada ,  Atsushi Serizawa ,  Yasuhiro Matsuoka ,  Yasuhiro Toba ,  Hiroshi Kawakami

    IPC分类号： A61K3800

    CPC分类号： A61K35/20 ,  A21D2/263 ,  A21D13/80 ,  A23C9/1307 ,  A23C19/082 ,  A23J1/20 ,  A23J3/08 ,  A23J3/343 ,  A23K20/147 ,  A23K20/174 ,  A23K20/22 ,  A23L33/19

    摘要： A milk basic protein fraction is heated if necessary, the resulting precipitate is removed to recover the resulting supernatant, alcohol is added to this supernatant, a fraction containing a high concentration of milk basic cystatin is recovered by removing the resulting precipitate and brought into contact with a carrier containing a sulfuric acid group, such as heparin, to recover a fraction which is not adsorbed onto the carrier, and this fraction is then treated with an ultrafiltration membrane having an cut-off molecular weight of 10-50 kDa to recover the permeate to produce a fraction containing a high concentration of milk basic cystatin. Alternatively, a milk-derived basic protein composition is brought into contact with an anion exchange resin to recover a fraction which is not adsorbed onto the resin, after which this fraction is brought into contact with a cation exchange resin to recover the target fraction by eluting a fraction which is adsorbed onto the resin with an eluent to produce a fraction containing a high concentration of milk basic cystatin. Further, a decomposition product of the fraction containing a high concentration of milk basic cystatin is produced by decomposing this fraction containing a high concentration of milk basic cystatin with protease.

    摘要翻译： 如果需要，加热牛奶碱性蛋白质级分，除去所得沉淀物以回收所得上清液，向该上清液中加入醇，通过除去所得沉淀物并与之接触，回收含有高浓度的乳碱性半胱氨酸蛋白酶的级分 含有硫酸基的载体如肝素，以回收未吸附到载体上的级分，然后用截留分子量为10-50kDa的超滤膜处理该级分以回收渗透物 以产生含有高浓度的牛奶碱性半胱氨酸蛋白酶的部分。 或者，将乳衍生的碱性蛋白质组合物与阴离子交换树脂接触以回收未吸附到树脂上的级分，之后使该级分与阳离子交换树脂接触，以通过洗脱来回收目标级分 用洗脱液吸附到树脂上的一部分，以产生含有高浓度的乳碱性半胱氨酸蛋白酶的部分。 此外，含有高浓度的乳碱性半胱氨酸蛋白酶抑制剂的级分的分解产物是通过将含有高浓度的乳碱性半胱氨酸蛋白酶的部分用蛋白酶分解而产生的。