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    High throughput screening of ion channels
    1.
    发明授权
    High throughput screening of ion channels 有权
    离子通道的高通量筛选

    公开(公告)号：US08329009B2

    公开(公告)日：2012-12-11

    申请号：US12757499

    申请日：2010-04-09

    申请人： Yuri Vladimirovich Osipchuk ,  James Richard Wasson ,  Edward D. Verdonk

    发明人： Yuri Vladimirovich Osipchuk ,  James Richard Wasson ,  Edward D. Verdonk

    IPC分类号： C12M1/00 ,  C12M3/00 ,  C25B9/00 ,  C40B30/06 ,  C12Q1/00

    CPC分类号： G01N27/327 ,  B01L3/0275 ,  B01L3/5085 ,  B01L2300/0609 ,  B01L2300/0645 ,  B01L2300/0829 ,  C40B60/12 ,  G01N33/48728 ,  G01N33/6872

    摘要： Multi-well plates having contoured well designs allow multi-stage high throughput parallel assaying of ion channels or ion transporters. A well of a multi-well plate has a bottom region that is sized and shaped to simultaneous accommodate a sensing electrode and a pipette for delivering, e.g., test compounds, wash fluid, and optionally ligands. Such multi-well plates may be coupled with an instrument having a pipette head and an electrode plate. Such arrangement facilitates fluidic contact between cells and fluids provided via a pipette. It also facilitates washing of wells with buffers or other wash solutions to allow serial exposure of test cells to various reagents or other stimuli. Generally, the design allows control and test experiments to be performed on the same cell (or cells) in a single well.

    摘要翻译： 具有轮廓井设计的多孔板允许离子通道或离子转运体的多级高通量平行测定。 多孔板的孔具有底部区域，其尺寸和形状可同时容纳感测电极和用于输送例如测试化合物，洗涤液体和任选的配体的移液管。 这样的多孔板可以与具有移液管头和电极板的仪器联接。 这种布置有利于通过移液管提供的细胞和流体之间的流体接触。 它还促进用缓冲液或其它洗涤溶液洗涤孔，以允许将测试细胞连续暴露于各种试剂或其它刺激物。 通常，该设计允许在单个孔中的相同细胞（或细胞）上进行控制和测试实验。

    HIGH THROUGHPUT SCREENING OF ION CHANNELS
    2.
    发明申请
    HIGH THROUGHPUT SCREENING OF ION CHANNELS 有权
    离子通道的高通量筛选

    公开(公告)号：US20110251102A1

    公开(公告)日：2011-10-13

    申请号：US12757499

    申请日：2010-04-09

    申请人： Yuri Vladimirovich Osipchuk ,  James Richard Wasson ,  Edward D. Verdonk

    发明人： Yuri Vladimirovich Osipchuk ,  James Richard Wasson ,  Edward D. Verdonk

    IPC分类号： C40B30/06 ,  C40B30/00 ,  C40B60/12

    CPC分类号： G01N27/327 ,  B01L3/0275 ,  B01L3/5085 ,  B01L2300/0609 ,  B01L2300/0645 ,  B01L2300/0829 ,  C40B60/12 ,  G01N33/48728 ,  G01N33/6872

    摘要： Multi-well plates having contoured well designs allow multi-stage high throughput parallel assaying of ion channels or ion transporters. A well of a multi-well plate has a bottom region that is sized and shaped to simultaneous accommodate a sensing electrode and a pipette for delivering, e.g., test compounds, wash fluid, and optionally ligands. Such multi-well plates may be coupled with an instrument having a pipette head and an electrode plate. Such arrangement facilitates fluidic contact between cells and fluids provided via a pipette. It also facilitates washing of wells with buffers or other wash solutions to allow serial exposure of test cells to various reagents or other stimuli. Generally, the design allows control and test experiments to be performed on the same cell (or cells) in a single well.

    摘要翻译： 具有轮廓井设计的多孔板允许离子通道或离子转运体的多级高通量平行测定。 多孔板的孔具有底部区域，其尺寸和形状可同时容纳感测电极和用于输送例如测试化合物，洗涤液体和任选的配体的移液管。 这样的多孔板可以与具有移液管头和电极板的仪器联接。 这种布置有利于通过移液管提供的细胞和流体之间的流体接触。 它还促进用缓冲液或其它洗涤溶液洗涤孔，以允许将测试细胞连续暴露于各种试剂或其它刺激物。 通常，该设计允许在单个孔中的相同细胞（或细胞）上进行控制和测试实验。

    Biochemical assay device using frustrated total internal reflection modulator with an imaging optical waveguide
    3.
    发明授权
    Biochemical assay device using frustrated total internal reflection modulator with an imaging optical waveguide 有权
    使用具有成像光波导的沮丧的全内反射调制器的生化测定装置

    公开(公告)号：US06707958B2

    公开(公告)日：2004-03-16

    申请号：US09988468

    申请日：2001-11-20

    申请人： Richard D. Pering ,  David A. King ,  Richard J. Pittaro ,  Shahida Rana ,  Frederick A. Stawitcke ,  Edward D. Verdonk

    发明人： Richard D. Pering ,  David A. King ,  Richard J. Pittaro ,  Shahida Rana ,  Frederick A. Stawitcke ,  Edward D. Verdonk

    IPC分类号： G02B600

    CPC分类号： G01N21/552 ,  B01L3/5085 ,  G01N35/028

    摘要： A biochemical assay device optically scans individual biological sample containing wells in an assay plate. The device includes an imaging system overlaying the assay plate wherein a scanning light propagates by total internal reflection within an optical waveguide. The waveguide includes a plurality of pixel locations, each aligned with a well in the assay plate, at which total internal reflection is selectively frustrated to output an incident beam of light. That light illuminates the well and causes generation of an emission beam of light that is detected by a photoreceptor. The device further includes a driver circuit that controls the selective frustration of total internal reflection at each pixel location in order to scan each well in the assay plate. A processor is also included in the device to process the detected emission beams of light generated by the scanned wells for purposes of assaying the biological sample contained in each scanned well.

    摘要翻译： 生物化学测定装置在测定板中光学扫描含有孔的各种生物样品。 该装置包括覆盖测定板的成像系统，其中扫描光通过光波导内的全内反射传播。 波导包括多个像素位置，每个像素位置与测定板中的阱对准，在该位置处，全内反射被选择性地挫败以输出入射光束。 该光照射井，并产生由感光体检测到的发射光束。 该装置还包括驱动器电路，其控制每个像素位置处的全内反射的选择性挫败，以扫描测定板中的每个孔。 为了分析每个扫描井中包含的生物样品的目的，处理器还包括在该装置中以处理由扫描井产生的检测到的发射光束。

    HIGH THROUGHPUT SCREENING OF ION CHANNELS
    6.
    发明申请
    HIGH THROUGHPUT SCREENING OF ION CHANNELS 有权
    离子通道的高通量筛选

    公开(公告)号：US20130048511A1

    公开(公告)日：2013-02-28

    申请号：US13654936

    申请日：2012-10-18

    申请人： Edward D. Verdonk

    发明人： Edward D. Verdonk

    IPC分类号： G01N27/26

    CPC分类号： B01L3/5085 ,  B01J2219/00317 ,  B01J2219/00369 ,  B01J2219/00653 ,  B01J2219/0074 ,  B01L3/0275 ,  B01L2300/0609 ,  B01L2300/0645 ,  B01L2300/0829 ,  C40B60/12 ,  G01N33/48728

    摘要： Multi-well plates having contoured well designs allow multi-stage high throughput parallel assaying of ion channels or ion transporters. A well of a multi-well plate has a bottom region that is sized and shaped to simultaneously accommodate a sensing electrode and a pipette for delivering test compounds, wash fluid, and optionally ligands. The multi-well plates when coupled with an instrument having a pipette head and an electrode plate facilitates fluidic contact between cells and fluids delivered via a pipette for washing of wells with buffers or other wash solutions for serial exposure of test cells to various reagents or other stimuli. The control and test experiments are performed on the same cell (or cells) in a single well.

    摘要翻译： 具有轮廓井设计的多孔板允许离子通道或离子转运体的多级高通量平行测定。 多孔板的孔具有底部区域，其尺寸和形状可同时容纳用于传送测试化合物，洗涤液体和任选配体的感测电极和移液管。 当与具有移液管头和电极板的仪器结合时，多孔板有助于通过移液管递送的细胞和流体之间的流体接触，以用于用于将测试细胞连续暴露于各种试剂或其它的缓冲液或其它洗涤溶液 刺激。 对照和测试实验在单个孔中的相同细胞（或细胞）上进行。

    Extraction and transportation of blood for analysis
    9.
    发明授权
    Extraction and transportation of blood for analysis 有权
    提取和运输血液进行分析

    公开(公告)号：US06364890B1

    公开(公告)日：2002-04-02

    申请号：US09614318

    申请日：2000-07-12

    申请人： Paul Lum ,  Leslie A. Leonard ,  Edward D. Verdonk ,  Dominique M. Freeman ,  Michael Greenstein ,  Catherine Keely-Templin

    发明人： Paul Lum ,  Leslie A. Leonard ,  Edward D. Verdonk ,  Dominique M. Freeman ,  Michael Greenstein ,  Catherine Keely-Templin

    IPC分类号： A61B1732

    CPC分类号： A61B5/15144 ,  A61B5/14532 ,  A61B5/150022 ,  A61B5/150099 ,  A61B5/150106 ,  A61B5/150427 ,  A61B5/150969 ,  A61B5/150984 ,  A61B5/15113

    摘要： A device for sampling blood from the skin of a patient by puncture. The device includes one or more lancets for lancing the skin and a fluid-conducting plate unit for transporting blood from the lancing wound. The plate unit has one or more channels for conducting fluid to one or more target locations. Preferably there is a first channel for conducting away a first portion of fluid that contains more of a fluid that is emitted initially (initial fluid) from the puncture wound and a second channel for conducting a second portion of fluid that contains less of the initial fluid from the puncture wound. Blood is drawn into the channels by capillary force. The device can be used to lance the skin and obtain a representative sample of blood with relatively simple procedures.

    摘要翻译： 一种用于通过穿刺从患者皮肤取样血液的装置。 该装置包括用于切割皮肤的一个或多个刺血针和用于从穿刺伤口输送血液的导流板单元。 板单元具有用于将流体传导到一个或多个目标位置的一个或多个通道。 优选地，存在用于传导第一部分流体的第一通道，所述第一部分流体包含更多的来自穿刺伤口的最初发射的流体（初始流体）和用于传导含有较少初始流体的第二部分流体的第二通道 从穿刺伤口。 通过毛细血管力将血液吸入通道。 该装置可用于以相对简单的程序来刺激皮肤并获得代表性的血液样品。

    Lancet device with skin movement control and ballistic preload
    10.
    发明授权
    Lancet device with skin movement control and ballistic preload 有权
    刺血针装置具有皮肤运动控制和弹道预载

    公开(公告)号：US06306152B1

    公开(公告)日：2001-10-23

    申请号：US09264598

    申请日：1999-03-08

    申请人： Edward D. Verdonk ,  Paul Lum

    发明人： Edward D. Verdonk ,  Paul Lum

    IPC分类号： A61B1734

    CPC分类号： A61B5/150977 ,  A61B5/150022 ,  A61B5/150114 ,  A61B5/150152 ,  A61B5/150282 ,  A61B5/150435 ,  A61B5/15117 ,  A61B5/1519

    摘要： A device for puncturing the skin of a patient. The device includes a lancet for puncturing the skin and a skin stabilizer associated with the lancet for stabilizing the skin to reduce its freedom of movement when the lancet strikes it. The skin stabilizer has an opening through which the lancet can pass to puncture the skin. The skin stabilizer applies pressure on the skin around the opening. The application of pressure, in additional to reducing the freedom of movement of the skin directly held by the skin stabilizer, also increases the tautness of the skin in the opening prior to the lancet penetrating the skin. The opening is not substantially larger than the size of the lancet.

    摘要翻译： 一种用于刺穿患者皮肤的装置。 该装置包括用于刺穿皮肤的刺血针和与柳叶刀相关联的皮肤稳定器，用于稳定皮肤以减少当柳叶刀撞击皮肤时的运动自由度。 皮肤稳定器具有刺血针穿过的开口以刺穿皮肤。 皮肤稳定剂对开口周围的皮肤施加压力。 施加压力，除了降低由皮肤稳定剂直接保持的皮肤的运动自由之外，还增加了刺血针穿透皮肤之前的开口中的皮肤的紧张度。 开口面积不大于柳叶刀的尺寸。