专利检索 ap:("Yves LeBlanc" OR "Patrick Roy" OR "Serge Leger" OR "Erich Grimm" OR "Zhaoyin Wang") AND inv:"Zhaoyin Wang" 第 1 页

1.

发明授权
(methylsulfonyl)phenyl-2-(5H)-furanones with oxygen link as COX-2 inhibitors 失效
标题翻译：（甲基磺酰基）苯基-2-（5H） - 呋喃酮与氧连接作为COX-2抑制剂

公开(公告)号：US6071954A

公开(公告)日：2000-06-06

申请号：US42168

申请日：1998-03-13

申请人： Yves LeBlanc , Patrick Roy , Serge Leger , Erich Grimm , Zhaoyin Wang

发明人： Yves LeBlanc , Patrick Roy , Serge Leger , Erich Grimm , Zhaoyin Wang

IPC分类号： C07D307/60 , C07D407/12 , A61K31/365

CPC分类号： C07D407/12 , C07D307/60

摘要： The invention encompasses the novel compound of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases. ##STR1## The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula I.

摘要翻译： 本发明包括可用于治疗环氧合酶-2介导的疾病的新颖的式I化合物。本发明还包括用于治疗包含式I化合物的环氧合酶-2介导的疾病的某些药物组合物。

2.

发明授权
Diaryl-5-oxygenated-2-(5H) -furanones as COX-2 inhibitors 失效
标题翻译：二芳基-5-氧化-2-（5H） - 呋喃酮作为COX-2抑制剂

公开(公告)号：US5691374A

公开(公告)日：1997-11-25

申请号：US443620

申请日：1995-05-18

申请人： Cameron Black , Erich Grimm , Zhaoyin Wang , Serge Leger

发明人： Cameron Black , Erich Grimm , Zhaoyin Wang , Serge Leger

IPC分类号： C07D333/02 , A61K31/19 , A61K31/365 , A61K31/38 , A61K31/381 , A61P1/00 , A61P7/02 , A61P13/02 , A61P15/00 , A61P25/04 , A61P29/00 , A61P35/02 , A61P43/00 , C07C317/44 , C07C317/46 , C07D307/60 , C07D307/64 , C07D333/52 , C07D405/04 , C07D407/04 , C07D409/04 , C07D417/04

CPC分类号： C07D405/04 , C07C317/44 , C07D307/60 , C07D307/64 , C07D407/04 , C07D409/04 , C07D417/04

摘要： The invention encompasses the novel compound of Formula I as well as a method of treating cyclooxygenase-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula I. ##STR1## The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula I.

摘要翻译： 本发明包括式I的新型化合物以及治疗环氧合酶-2介导的疾病的方法，其包括向需要这种治疗无需治疗有效量的式I化合物的患者给药。本发明还包括用于治疗包含式I化合物的环氧合酶-2介导的疾病的某些药物组合物。

3.

发明授权
Phenyl heterocycles as cox-2 inhibitors 失效

公开(公告)号：US5767291A

公开(公告)日：1998-06-16

申请号：US738144

申请日：1996-10-25

申请人： Yves Ducharme , Jacques Yves Gauthier , Petpiboon Prasit , Yves Leblanc , Zhaoyin Wang , Serge Leger , Michel Therien

发明人： Yves Ducharme , Jacques Yves Gauthier , Petpiboon Prasit , Yves Leblanc , Zhaoyin Wang , Serge Leger , Michel Therien

摘要： The invention encompasses the novel compound of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases. ##STR1## The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula I.

4.

发明授权
Phenyl heterocycles as cox-2 inhibitors 失效
标题翻译：苯基杂环作为cox-2抑制剂

公开(公告)号：US5550142A

公开(公告)日：1996-08-27

申请号：US438130

申请日：1995-05-08

申请人： Yves Ducharme , Jacques Y. Gauthier , Petpiboon Prasit , Yves Leblanc , Zhaoyin Wang , Serge Leger , Michel Therien

发明人： Yves Ducharme , Jacques Y. Gauthier , Petpiboon Prasit , Yves Leblanc , Zhaoyin Wang , Serge Leger , Michel Therien

IPC分类号： C07D333/06 , A61K31/00 , A61K31/10 , A61K31/12 , A61K31/122 , A61K31/18 , A61K31/19 , A61K31/255 , A61K31/34 , A61K31/341 , A61K31/35 , A61K31/351 , A61K31/365 , A61K31/38 , A61K31/381 , A61K31/395 , A61K31/40 , A61K31/4015 , A61K31/425 , A61K31/426 , A61K31/66 , A61P1/00 , A61P1/02 , A61P1/04 , A61P7/04 , A61P11/06 , A61P15/00 , A61P17/02 , A61P19/00 , A61P19/02 , A61P21/00 , A61P25/28 , A61P29/00 , A61P31/12 , A61P31/16 , A61P35/00 , A61P43/00 , C07C20060101 , C07C13/08 , C07C13/10 , C07C305/18 , C07C307/02 , C07C311/15 , C07C311/16 , C07C311/29 , C07C311/37 , C07C311/46 , C07C311/49 , C07C311/51 , C07C317/10 , C07C317/24 , C07C323/29 , C07D207/26 , C07D207/333 , C07D207/38 , C07D207/444 , C07D207/448 , C07D275/02 , C07D277/02 , C07D277/22 , C07D277/24 , C07D277/26 , C07D307/33 , C07D307/38 , C07D307/58 , C07D309/32 , C07D333/04 , C07D333/12 , C07D333/16 , C07D333/18 , C07D333/24 , C07D333/38 , C07D333/40 , C07D405/04 , C07D407/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D503/04 , C07F9/40 , C07F9/547 , C07F9/572 , C07F9/6506 , C07F9/653 , C07F9/6539 , C07F9/655

CPC分类号： C07D275/02 , C07C311/29 , C07C311/46 , C07C311/49 , C07C317/24 , C07D277/26 , C07D307/38 , C07D307/58 , C07D333/18 , C07D333/38 , C07D405/04 , C07C2101/08

摘要： The invention encompasses the novel compound of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases. ##STR1## The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula I.

摘要翻译： 本发明包括可用于治疗环氧合酶-2介导的疾病的新颖的式I化合物。本发明还包括用于治疗环氧合酶-2介导的疾病的某些药物组合物，其包含式I化合物。

5.

发明授权
Alkylated styrenes as prodrugs to COX-2 inhibitors 失效
标题翻译：烷基化苯乙烯作为前药转化为COX-2抑制剂

公开(公告)号：US5789413A

公开(公告)日：1998-08-04

申请号：US786517

申请日：1997-01-21

申请人： Cameron Black , Erich Grimm , Serge Leger , Greg Hughes , Petpiboon Prasit , Zhaoyin Wang

发明人： Cameron Black , Erich Grimm , Serge Leger , Greg Hughes , Petpiboon Prasit , Zhaoyin Wang

IPC分类号： C07C311/29 , C07C317/22 , C07C317/24 , C07C317/44 , C07C317/46 , C07D307/58 , C07D307/60 , C07D307/64 , C07D307/66 , C07D307/94 , C07D405/12 , A61K31/10 , A61K31/165 , C07C59/42 , C07C317/14

CPC分类号： C07D405/12 , C07C311/29 , C07C317/22 , C07C317/24 , C07C317/44 , C07C317/46 , C07D307/58 , C07D307/60 , C07D307/64 , C07D307/66 , C07D307/94

摘要： The invention encompasses the novel compound of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases. ##STR1## The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula I.

摘要翻译： 本发明包括可用于治疗环氧合酶-2介导的疾病的新颖的式I化合物。本发明还包括用于治疗包含式I化合物的环氧合酶-2介导的疾病的某些药物组合物。

6.

发明授权
Diaryl-2-(5H)-furanones as Cox-2 inhibitors 失效
标题翻译：二芳基-2-（5H） - 呋喃酮作为Cox-2抑制剂

公开(公告)号：US06222048B1

公开(公告)日：2001-04-24

申请号：US09011674

申请日：1997-06-12

申请人： Cameron Black , Erich Grimm , Serge Leger , Petpiboon Prasit , Zhaoyin Wang

发明人： Cameron Black , Erich Grimm , Serge Leger , Petpiboon Prasit , Zhaoyin Wang

IPC分类号： C07D30758

CPC分类号： C07D405/04 , C07D307/58 , C07D307/83 , C07D307/94 , C07D333/32 , C07D407/04 , C07D417/04 , C07D417/14 , C07D491/10 , C07D493/10 , C07D495/10

摘要： The invention encompasses the novel compound of Formula (I) as well as a method of treating cyclooxygenase-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula (I). The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula (I).

摘要翻译： 本发明包括式（I）的新化合物以及治疗环加氧酶-2介导的疾病的方法，其包括向需要这种治疗无效治疗有效量的式（I）的化合物的患者施用。本发明还包括用于治疗包含式（I）化合物的环氧合酶-2介导的疾病的某些药物组合物。

7.

发明授权
Alkylated styrenes as prodrugs to COX-2 inhibitors 失效
标题翻译：烷基化苯乙烯作为前药转化为COX-2抑制剂

公开(公告)号：US5925631A

公开(公告)日：1999-07-20

申请号：US128140

申请日：1998-08-03

申请人： Cameron Black , Greg Hughes , Erich Grimm , Serge Leger , Petpiboon Prasit , Zhaoyin Wang

发明人： Cameron Black , Greg Hughes , Erich Grimm , Serge Leger , Petpiboon Prasit , Zhaoyin Wang

IPC分类号： C07C311/29 , C07C317/22 , C07C317/24 , C07C317/44 , C07C317/46 , C07D307/58 , C07D307/60 , C07D307/64 , C07D307/66 , C07D307/94 , C07D405/12 , C07D209/44 , A61K31/44 , A61K31/445 , A61K31/47 , C07D211/22 , C07D213/30 , C07D217/16 , C07D307/32

CPC分类号： C07D405/12 , C07C311/29 , C07C317/22 , C07C317/24 , C07C317/44 , C07C317/46 , C07D307/58 , C07D307/60 , C07D307/64 , C07D307/66 , C07D307/94

摘要： The invention encompasses the novel compound of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases. ##STR1## The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula I.

摘要翻译： 本发明包括可用于治疗环氧合酶-2介导的疾病的新颖的式I化合物。本发明还包括用于治疗包含式I化合物的环氧合酶-2介导的疾病的某些药物组合物。

8.

发明授权
Use of inhibitors of cyclooxygenase in the treatment of neurodegenerative diseases 失效
标题翻译：使用环氧合酶抑制剂治疗神经变性疾病

公开(公告)号：US06486194B2

公开(公告)日：2002-11-26

申请号：US09796211

申请日：2001-02-28

申请人： Yves Ducharme , Jacques Yves Gauthier , Petpiboon Prasit , Yves Leblanc , Zhaoyin Wang , Serge Leger , Michel Therien

发明人： Yves Ducharme , Jacques Yves Gauthier , Petpiboon Prasit , Yves Leblanc , Zhaoyin Wang , Serge Leger , Michel Therien

IPC分类号： A61K3138

CPC分类号： C07D275/02 , A61K31/10 , A61K31/341 , A61K31/381 , A61K31/425 , A61K31/426 , C07C311/29 , C07C311/46 , C07C311/49 , C07C317/24 , C07C2601/08 , C07D277/26 , C07D307/38 , C07D307/58 , C07D333/18 , C07D333/38 , C07D405/04

摘要： The present invention provides a method of treating a neurodegenerative disease and in particular Alzheimers disease which comprises administering to a human in need thereof a therapeutically effective amount of a non-steroid COX-II inhibitor. Although a wide range of COX-II inhibitors may be employed but it is preferred to employ compounds of the Formula I:

摘要翻译： 本发明提供治疗神经变性疾病，特别是阿尔茨海默病的方法，其包括向有需要的人施用治疗有效量的非类固醇COX-II抑制剂。尽管可以使用大范围的COX-II抑制剂，但优选使用式I的化合物：