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    SYNTHETIC NON-FOULING AMINO ACIDS
    5.
    发明申请
    SYNTHETIC NON-FOULING AMINO ACIDS 审中-公开
    合成不溶性氨基酸

    公开(公告)号：US20090149673A1

    公开(公告)日：2009-06-11

    申请号：US12329360

    申请日：2008-12-05

    申请人： Zheng Zhang ,  William Shannan O'Shaughnessey ,  Michael Hencke ,  Trevor Squier ,  Christopher R. Loose

    发明人： Zheng Zhang ,  William Shannan O'Shaughnessey ,  Michael Hencke ,  Trevor Squier ,  Christopher R. Loose

    IPC分类号： C07C229/06

    CPC分类号： C07C229/26 ,  C07C233/47

    摘要： Synthetic amino acids containing one or more non-fouling groups or moieties are described herein. In one embodiment, the amino acid has the following chemical formula: where L is a linker group and Z is a non-fouling group including, but not limited to, polyethylene glycol (PEG); oligoethylene glycol (OEG); zwitterionic group, such as phosphorycholine, carboxybetaine, and sulfobetaine; groups that are hydrogen bond acceptors but not hydrogen bond donors. The non-fouling amino acids can be incorporated into a bioactive peptide as single amino acid residues, multiples amino acid residues, or as blocks of amino acids. The non-fouling amino acids, or peptides containing one or more non-fouling amino acids, can be applied to surfaces in order to improve biocompatibility, reduce thrombogenesis, and/or reduce fouling by proteins or bacteria present in solution.

    摘要翻译： 含有一个或多个非结垢基团或部分的合成氨基酸在本文中描述。 在一个实施方案中，氨基酸具有以下化学式：其中L是连接基团，Z是非结垢基团，包括但不限于聚乙二醇（PEG）; 低聚乙二醇（OEG）; 两性离子基团，如磷酸胆碱，羧基甜菜碱和磺基甜菜碱; 基团是氢键受体而不是氢键供体。 非结垢的氨基酸可以作为单个氨基酸残基，多个氨基酸残基或作为氨基酸的嵌段结合到生物活性肽中。 含有一个或多个非结垢性氨基酸的非结垢性氨基酸或多肽可以施用于表面，以便提高溶液中存在的蛋白质或细菌的生物相容性，减少血栓发生和/或减少结垢。

    NON-LEACHING NON-FOULING ANTIMICROBIAL COATINGS
    6.
    发明申请
    NON-LEACHING NON-FOULING ANTIMICROBIAL COATINGS 审中-公开
    非浸出非防腐涂料

    公开(公告)号：US20090155335A1

    公开(公告)日：2009-06-18

    申请号：US12329344

    申请日：2008-12-05

    申请人： William Shannan O'Shaughnessey ,  Zheng Zhang ,  Michael Hencke ,  Kris Wood ,  Trevor Squier ,  Christopher R. Loose

    发明人： William Shannan O'Shaughnessey ,  Zheng Zhang ,  Michael Hencke ,  Kris Wood ,  Trevor Squier ,  Christopher R. Loose

    IPC分类号： A61L29/16 ,  A61K38/16 ,  A61K38/10 ,  C07K14/00 ,  C07K7/04 ,  A61L15/44 ,  A61L31/16 ,  A61L27/54 ,  A61P31/04

    CPC分类号： C07K17/08 ,  A61L15/46 ,  A61L27/54 ,  A61L29/16 ,  A61L31/16 ,  A61L2300/25 ,  A61L2300/252 ,  A61L2300/404 ,  C07K7/08 ,  C07K14/43563 ,  C09D5/1637

    摘要： Compositions containing one or more types of membrane-targeting antimicrobial agents immobilized on a substrate with activity in relevant biological environments, and methods of making and using thereof, are described herein. The antimicrobial agents retain their activity in the presence of blood proteins and/or in vivo due to improved molecular structures which allow for cooperative action of immobilized agents and hydrophilic chemistries which resist non-specific protein adsorption. Suitable molecular structures include branched structures, such as dendrimers and randomly branched polymers. The molecule structures may also include hydrophilic tethers which provide both flexibility and resistance to non-specific protein adsorption. The membrane targeting antimicrobial agent coatings can be applied to a variety of different types of substrates including medical implants such as vascular grafts, orthopedic devices, dialysis access grafts, and catheters; surgical tools, surgical garments; and bandages. The substrates can be composed of metallic materials, ceramics, polymers, fibers, inert materials such as silicon, and combinations thereof. The compositions described herein are substantially non-leaching, resistant to non-specific protein adsorption, and non-hemolytic.

    摘要翻译： 本文描述了包含固定在具有相关生物环境中的活性的基质上的一种或多种类型的膜靶向抗微生物剂的组合物及其制备和使用方法。 抗微生物剂在血液蛋白质存在下和/或体内保留其活性，因为改进的分子结构允许固定化剂和抵抗非特异性蛋白质吸附的亲水化学物质的协同作用。 合适的分子结构包括支链结构，例如树枝状聚合物和无规分支的聚合物。 分子结构还可以包括提供灵活性和对非特异性蛋白质吸附的抗性的亲水系链。 膜靶向抗微生物剂涂层可以应用于各种不同类型的基底，包括医疗植入物，例如血管移植物，矫形装置，透析入口移植物和导管; 手术工具，手术衣服; 和绷带。 基板可以由金属材料，陶瓷，聚合物，纤维，惰性材料如硅构成，以及它们的组合。 本文所述的组合物基本上是非浸出的，对非特异性蛋白质吸附抗性和非溶血性的。