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    Device for reaction or separation and a continuous esterification process using the device
    1.
    发明授权
    Device for reaction or separation and a continuous esterification process using the device 有权
    用于反应或分离的装置和使用该装置的连续酯化方法

    公开(公告)号：US07708952B2

    公开(公告)日：2010-05-04

    申请号：US10556042

    申请日：2004-01-02

    申请人： Zhenxin Chen ,  Mingkang Yu ,  Shaopeng Wang

    发明人： Zhenxin Chen ,  Mingkang Yu ,  Shaopeng Wang

    IPC分类号： B01J10/00 ,  B01F5/10 ,  C07C69/82 ,  C07C67/08 ,  C07B41/12

    CPC分类号： B01F5/10 ,  B01F5/0659 ,  B01J8/388

    摘要： The present invention relates to a reaction or separation device, wherein the materials circularly flow in a container and a pipe. Said device contains a container and an external circular pipe, wherein the container is a double-chamber structure. The inner chamber consists of an outer cylinder and an inner cylinder with the latter being jacketed by the former, and there is a space between the walls of the outer cylinder and the inner cylinder. The lower end of the outer cylinder is open and higher than the bottom of the container, and the outer cylinder is fixed to the wall or bottom of the container. The upper end of the inner cylinder is open and its lower end connects with the external circular pipe through the feed outlet. A continuous passage is sequentially formed from the spaces between the wall of the outer cylinder and that of the container, between the lower end of the outer cylinder and the bottom of the container, between the wall of the outer cylinder and that of the inner cylinder, and in the inner cylinder. The external circular pipe connects with the bottom of the container and leads to the inner chamber, and connects with the sidewall at the lower part of the container and leads to the outer chamber, respectively. The present invention also relates to a continuous esterification process, which comprises feeding liquid reaction materials to the reaction device and carrying out reaction under reaction conditions.

    摘要翻译： 本发明涉及一种反应或分离装置，其中所述材料在容器和管道中循环流动。 所述装置包含容器和外部圆形管，其中所述容器是双室结构。 内室由外筒和内筒构成，后筒由前者夹套，外筒和内筒之间有空间。 外筒的下端开口并高于容器的底部，外筒固定在容器的壁或底部。 内筒的上端开放，其下端通过进料口与外圆管连接。 从外筒的壁与外筒的下端与容器的底部之间的空间在外筒的壁与内筒的壁之间的空间依次形成连续的通道 ，在内筒中。 外圆管与容器的底部连接并通向内腔，并与容器下部的侧壁分别连接，并通向外腔。 本发明还涉及一种连续酯化方法，其包括将液体反应物料送入反应装置并在反应条件下进行反应。

    Device for reaction or separation and a continuous esterification process using the device
    2.
    发明申请
    Device for reaction or separation and a continuous esterification process using the device 有权
    用于反应或分离的装置和使用该装置的连续酯化方法

    公开(公告)号：US20070100126A1

    公开(公告)日：2007-05-03

    申请号：US10556042

    申请日：2004-01-02

    申请人： Zhenxin Chen ,  Mingkang Yu ,  Shaopeng Wang

    发明人： Zhenxin Chen ,  Mingkang Yu ,  Shaopeng Wang

    IPC分类号： C08G63/00 ,  B01J19/00 ,  C07C69/76

    CPC分类号： B01F5/10 ,  B01F5/0659 ,  B01J8/388

    摘要： The present invention relates to a reaction or separation device, wherein the materials circularly flow in a container and a pipe. Said device contains a container and an external circular pipe, wherein the container is a double-chamber structure. The inner chamber consists of an outer cylinder and an inner cylinder with the latter being jacketed by the former, and there is a space between the walls of the outer cylinder and the inner cylinder. The lower end of the outer cylinder is open and higher than the bottom of the container, and the outer cylinder is fixed to the wall or bottom of the container. The upper end of the inner cylinder is open and its lower end connects with the external circular pipe through the feed outlet. A continuous passage is sequentially formed from the spaces between the wall of the outer cylinder and that of the container, between the lower end of the outer cylinder and the bottom of the container, between the wall of the outer cylinder and that of the inner cylinder, and in the inner cylinder. The external circular pipe connects with the bottom of the container and leads to the inner chamber, and connects with the sidewall at the lower part of the container and leads to the outer chamber, respectively. The present invention also relates to a continuous esterification process, which comprises feeding liquid reaction materials to the reaction device and carrying out reaction under reaction conditions.

    摘要翻译： 本发明涉及一种反应或分离装置，其中所述材料在容器和管道中循环流动。 所述装置包含容器和外部圆形管，其中所述容器是双室结构。 内室由外筒和内筒构成，后筒由前者夹套，外筒和内筒之间有空间。 外筒的下端开口并高于容器的底部，外筒固定在容器的壁或底部。 内筒的上端开放，其下端通过进料口与外圆管连接。 从外筒的壁与外筒的下端与容器的底部之间的空间在外筒的壁与内筒的壁之间的空间依次形成连续的通道 ，在内筒中。 外圆管与容器的底部连接并通向内腔，并与容器下部的侧壁分别连接，并通向外腔。 本发明还涉及一种连续酯化方法，其包括将液体反应物料送入反应装置并在反应条件下进行反应。

    INTEGRATED MICROARRAY PRINTING AND DETECTION SYSTEM FOR MOLECULAR BINDING ANALYSIS
    3.
    发明申请
    INTEGRATED MICROARRAY PRINTING AND DETECTION SYSTEM FOR MOLECULAR BINDING ANALYSIS 审中-公开
    用于分子结合分析的综合微型打印和检测系统

    公开(公告)号：US20170038380A1

    公开(公告)日：2017-02-09

    申请号：US15204738

    申请日：2016-07-07

    申请人： Nongjian Tao ,  Shaopeng Wang

    发明人： Nongjian Tao ,  Shaopeng Wang

    IPC分类号： G01N33/557 ,  G01N21/552

    摘要： A method and system for analysis of protein interaction kinetics in microarray or whole-cell based formats includes positioning a sensor chip on a prism. The sensor chip is spotted with a plurality of target molecules. A movable printer head deposits a plurality of analyte droplets on predefined regions of the sensor chip surface. A light source transmits light through the prism to excite surface plasmon resonance on the sensor chip surface, whereby the plurality of target molecules bound to the upper surface are changing the SPR resonance angle and therefore the intensity of the reflected beam. A detector receives reflected light transmitted through the prism from the bottom surface. Signals from the detector are received and processed into kinetic data and microarray labeled data to determine molecular interactions and binding kinetic properties for the plurality of analyte droplets.

    摘要翻译： 用于分析微阵列或全细胞蛋白质相互作用动力学的方法和系统包括将传感器芯片定位在棱镜上。 传感器芯片被多个目标分子点样。 可移动打印头将多个分析物液滴沉积在传感器芯片表面的预定区域上。 光源通过棱镜透射光以激发传感器芯片表面上的表面等离子体共振，由此结合到上表面的多个靶分子改变SPR谐振角，并因此改变反射光束的强度。 检测器从底面接收透过棱镜的反射光。 来自检测器的信号被接收并处理成动力学数据和微阵列标记的数据，以确定多个分析物液滴的分子相互作用和结合动力学性质。

    Three dimensional micro-environments and methods of making and using same
    4.
    发明申请
    Three dimensional micro-environments and methods of making and using same 审中-公开
    三维微环境及其使用方法

    公开(公告)号：US20070003595A1

    公开(公告)日：2007-01-04

    申请号：US11407002

    申请日：2006-04-19

    申请人： Shaopeng Wang ,  Nicholas Kotov ,  Jun Zhang

    发明人： Shaopeng Wang ,  Nicholas Kotov ,  Jun Zhang

    IPC分类号： C12M3/00 ,  A61K35/12 ,  A61F2/02

    CPC分类号： C12N5/0068 ,  A61K38/00 ,  A61L27/52 ,  A61L27/54 ,  A61L2300/252 ,  A61L2300/258 ,  A61L2300/414 ,  A61L2300/426 ,  A61L2300/602 ,  C12M25/14 ,  C12N2533/30

    摘要： The presently claimed and disclosed invention relates, in general, to three dimensional micro-environments and, in particular, to three dimensional (“3D”) micro-environments found in inverted-opal scaffolds made from hydrogel therein for controlled release of nutrients. Specifically, the scaffolds have exceptionally ordered, three-dimensional organization that provides excellent porosity, permeability, and transportation properties can that are especially well suited for use as a nutrient carrier in the emerging technologies of drug delivery and cell culture. Methods for incorporation of or to control the release of nutrients and other substances from such scaffold materials are also herein disclosed and claimed.

    摘要翻译： 本发明要求和公开的发明一般涉及三维微环境，特别涉及在其中由其中的水凝胶制成的倒置蛋白石支架中发现的三维（“3D”）微环境，以控制营养物质的释放。 具体来说，支架具有非常有序的，提供优异的孔隙率，渗透性和运输性质的三维组织，特别适合用作药物递送和细胞培养的新兴技术中的营养载体。 还公开并要求保护并结合或控制营养物质和其他物质从这种支架材料释放的方法。

    Energy-transfer nanocomposite materials and methods of making and using same
    6.
    发明申请
    Energy-transfer nanocomposite materials and methods of making and using same 失效
    能量转移纳米复合材料及其制造和使用方法

    公开(公告)号：US20070063154A1

    公开(公告)日：2007-03-22

    申请号：US11262470

    申请日：2005-10-28

    申请人： Wei Chen ,  Shaopeng Wang ,  Sarah Westcott ,  Jun Zhang

    发明人： Wei Chen ,  Shaopeng Wang ,  Sarah Westcott ,  Jun Zhang

    IPC分类号： G01J1/58 ,  G01T1/10 ,  G01N21/64 ,  F21V9/16

    CPC分类号： A61B5/0059 ,  A61B6/00 ,  G01N21/76 ,  G01N2021/6495 ,  G01T1/10 ,  Y10S436/904 ,  Y10S977/904 ,  Y10S977/905

    摘要： The presently claimed and disclosed inventions relate, in general, to methods of radiation dosimetry and imaging using scintillation luminescence. More particularly, materials having a scintillation luminescence response to radiation that varies with total radiation dose received can be used for dosimetry monitoring, including, but not limited to nanoparticles for in vivo, real-time dosimetry. Energy-transfer nanocomposite materials as well as methods of making and using such materials in various applications including, but not limited to, in vivo radiation dosimetry and imaging, are disclosed. More particularly, the presently claimed and disclosed inventions relate to nanoparticle scintillation luminescence particles encapsulated in hosts of the general formula BaFX and BaFX:Eu2+ where X=Cl, Br and I.

    摘要翻译： 目前权利要求和公开的发明一般涉及使用闪烁发光的放射剂量测定法和成像方法。 更具体地，具有随所接收的总辐射剂量变化的对辐射的闪烁发光响应的材料可用于剂量测定监测，包括但不限于用于体内实时剂量测定的纳米颗粒。 公开了能量转移纳米复合材料以及在各种应用中制备和使用这些材料的方法，包括但不限于体内辐射剂量测定和成像。 更具体地说，本发明涉及纳米颗粒闪烁发光颗粒，其包封在通式为BaFX和BaFX：Eu 2+的主体中，其中X = Cl，Br和I.

    SMALL MOLECULE DETECTION IN NORMAL IONIC STRENGTH BUFFERS
    8.
    发明申请
    SMALL MOLECULE DETECTION IN NORMAL IONIC STRENGTH BUFFERS 有权

    公开(公告)号：US20220018808A1

    公开(公告)日：2022-01-20

    申请号：US17375231

    申请日：2021-07-14

    申请人： Shaopeng Wang ,  Runli Liang

    发明人： Nongjian Tao ,  Shaopeng Wang ,  Runli Liang

    IPC分类号： G01N27/447 ,  G01N21/64

    摘要： A system for detecting target molecules includes a sample well defining a sensing region and two electrode regions, a sensor positioned in the sensing region and sensitized to the target molecules, an electrode positioned in each electrode region and configured to expose the sensor to a frequency-modulated electric field, and a detector configured to detect both an amplitude of oscillation of the sensor at a frequency of the modulated electric field and a direction of a displacement of the sensor. The sensing region defines a channel between the electrodes, and a ratio of a current density at a center of the sensing region to a current density at one of the electrodes is at least 2. The system allows detection of target molecules in a normal ionic strength buffer (e.g., having an ionic strength in a range of about 10 mM to about 1 M).

    Integrated microarray printing and detection system for molecular binding analysis
    9.
    发明授权
    Integrated microarray printing and detection system for molecular binding analysis 有权

    公开(公告)号：US10823728B2

    公开(公告)日：2020-11-03

    申请号：US15204738

    申请日：2016-07-07

    申请人： Nongjian Tao ,  Shaopeng Wang

    发明人： Nongjian Tao ,  Shaopeng Wang

    IPC分类号： G01N21/00 ,  G01N33/557 ,  G01N21/552 ,  G01N33/543

    摘要： A method and system for analysis of protein interaction kinetics in microarray or whole-cell based formats includes positioning a sensor chip on a prism. The sensor chip is spotted with a plurality of target molecules. A movable printer head deposits a plurality of analyte droplets on predefined regions of the sensor chip surface. A light source transmits light through the prism to excite surface plasmon resonance on the sensor chip surface, whereby the plurality of target molecules bound to the upper surface are changing the SPR resonance angle and therefore the intensity of the reflected beam. A detector receives reflected light transmitted through the prism from the bottom surface. Signals from the detector are received and processed into kinetic data and microarray labeled data to determine molecular interactions and binding kinetic properties for the plurality of analyte droplets.