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    SPECIFICITY QUANTIFICATION OF BIOMOLECULAR RECOGNITION AND ITS APPLICATION FOR DRUG DISCOVERY
    1.
    发明申请
    SPECIFICITY QUANTIFICATION OF BIOMOLECULAR RECOGNITION AND ITS APPLICATION FOR DRUG DISCOVERY 审中-公开
    生物分子识别的特异性定量及其对药物发现的应用

    公开(公告)号：US20130166261A1

    公开(公告)日：2013-06-27

    申请号：US13722233

    申请日：2012-12-20

    Applicant: Zhiqiang Yan ,  Jin Wang

    Inventor： Zhiqiang Yan ,  Jin Wang

    IPC: G06F19/12

    CPC classification number: G16B5/00 ,  G16B15/00

    Abstract: A novel scoring function called SPA takes account of both specificity and affinity of highly efficient and specific protein-ligand binding. The method to develop SPA is based on the funneled energy landscape theory and employs affinity and specificity of biomolecular interactions. The quantified specificity of the native protein-ligand complex, which discriminates against “non-native” binding modes, and the affinity prediction are simultaneously optimized during the development. SPA is obtained by maximizing the specificity and affinity prediction of a large training set of “native” protein-ligand complexes with known structures and affinities. SPA can be employed to discriminate drugs from the diversity set, or to discriminate selective drugs from non-selective drugs. The remarkable performance of SPA makes it promising to be implemented in the docking software and widely applied in virtual screening for seeking the lead compounds.

    Abstract translation: 称为SPA的新型评分函数考虑到高效和特异性蛋白质 - 配体结合的特异性和亲和力。 开发SPA的方法是基于漏斗能量景观理论，并采用生物分子相互作用的亲和力和特异性。 在开发过程中同时优化天然蛋白质 - 配体复合物的定量特异性，其区分“非天然”结合模式和亲和力预测。 通过最大化具有已知结构和亲和力的大量训练集“天然”蛋白质 - 配体复合物的特异性和亲和力预测获得SPA。 可以使用SPA来区分药物与多样性集，或者区分选择性药物与非选择性药物。 SPA的卓越性能使其有望在对接软件中实现，并广泛应用于虚拟筛选寻求铅化合物。

    PORTAL FRAME PLATFORM AND CONSTRUCTION METHOD FOR LARGE OFFSHORE WIND TURBINES
    2.
    发明公开
    PORTAL FRAME PLATFORM AND CONSTRUCTION METHOD FOR LARGE OFFSHORE WIND TURBINES 审中-公开

    公开(公告)号：US20240084537A1

    公开(公告)日：2024-03-14

    申请号：US17941775

    申请日：2022-09-09

    Applicant: Jin Wang

    Inventor： Jin Wang

    IPC: E02B17/02 ,  E02D27/42 ,  E02D27/52 ,  F03D13/25

    CPC classification number: E02B17/027 ,  E02D27/425 ,  E02D27/525 ,  F03D13/25 ,  E02B2017/0047 ,  F05B2240/95

    Abstract: A portal frame platform comprises at least three elongate tubular legs extending vertically downward from a top above the waterline to the seabed without horizontal or diagonal bracing members in-between, and a horizontal deck with at least three circular sleeves concentrically coupled to the top of the legs supporting a wind turbine in an in-service configuration. The portal frame platform supporting the wind turbine has an installation configuration with two barges connected to opposite sides of the deck, and the legs extending vertically upward from a bottom above the waterline through the circular sleeves. A construction method includes twelve-steps for quayside assembling, sea-towing and self-installing the portal frame platform with the wind turbine and foundation piles wherein the portable frame platform is converted from the installation configuration to the in-service configuration by lowering the legs through the circular sleeves using wire and winch systems on the two barges.

    INTERNET MAP VIRTUAL MARKER DYNAMIC MANAGEMENT THEORY AND METHOD
    3.
    发明申请
    INTERNET MAP VIRTUAL MARKER DYNAMIC MANAGEMENT THEORY AND METHOD 审中-公开

    公开(公告)号：US20190155923A1

    公开(公告)日：2019-05-23

    申请号：US15821813

    申请日：2017-11-23

    Applicant: Qiang Wang ,  Yong Wang ,  Jin Wang ,  Xinwei Wang ,  Zhaoyang Wang

    Inventor： Qiang Wang ,  Yong Wang ,  Jin Wang ,  Xinwei Wang ,  Zhaoyang Wang

    IPC: G06F17/30 ,  H04W4/021 ,  H04L29/08

    Abstract: The present invention discloses a completely innovative theory and method of macroscopic dynamic management of internet/web map markers on mobile devices such as smartphones and PCs, which is characterized by using accurate latitude and longitude coordinates to represent virtual internet/web entities that do not exist here at all but somewhere else or completely do not exist in the real world, and the markers will realistically represent these virtual entities on the internet/web map and give users the same feeling as real entities and markers. By pioneering and implementing the concepts of internet/web virtual markers, virtual business, virtual business entities and virtual entity tables, the present invention can greatly stimulate the economic activities of the network to bring about tremendous commercial benefits to businesses and customers with low cost, high efficiency and quick response.

    Foundation Theory And Method of Internet Map/Platform Iconology/Markerology
    5.
    发明申请
    Foundation Theory And Method of Internet Map/Platform Iconology/Markerology 审中-公开

    公开(公告)号：US20190034468A1

    公开(公告)日：2019-01-31

    申请号：US16040917

    申请日：2018-07-20

    Applicant: Qiang Wang ,  Xinwei Wang ,  Yong Wang ,  Jin Wang ,  Zhaoyang Wang

    Inventor： Qiang Wang ,  Xinwei Wang ,  Yong Wang ,  Jin Wang ,  Zhaoyang Wang

    IPC: G06F17/30 ,  G06F17/24 ,  G06Q10/10

    Abstract: The present invention discloses the foundation theory and method of the internet map/platform Iconology/Markerology which is characterized in followings: the invention firstly establishes the foundation theory of internet map/platform iconology, its specification, standards and methods including a complete theoretical dynamic icon/marker management system, basic concepts, categories, judgments and inferences, definitions, rules and methods, According to the foundation theory and method of Internet Map/Platform Iconology/Markerology, the user can use the iconology theory and methods specified in the present invention to identify almost everything on the internet maps or platforms and to perform various operations and to control all of the icons/markers on the internet maps/platforms and also to connect to variety of external network resource and network platforms to get in touch with various network businesses through these internet map icons/markers enriched with infinite network resource spaces. Actually, Icon/marker economic activity that is currently limited with traditional Internet map technology so far will become main tendency in future with the present invention. In particular, the present invention assigns a unique icon/marker Identification (IID) number to each valid icon/marker on the internet map and in future we can use this IID to identify almost everything on any kinds of network platforms and can control all the targets/objects of both the Internet of Things (IoT) and the Internet just by controlling all the icons/markers on the internet map/platform through unique icon/marker Identification number (IID). The Cardinality of icon/marker Identification (IID) is Second Level Infinity.

    Evaporative condenser radiating module for steam exhaust of a steam turbine
    6.
    发明授权
    Evaporative condenser radiating module for steam exhaust of a steam turbine 有权

    公开(公告)号：US09618268B2

    公开(公告)日：2017-04-11

    申请号：US13882154

    申请日：2011-08-29

    Applicant: Honghui Shi ,  Qingzhong Ma ,  Jin Wang ,  Jiayong Lu ,  Longying Zhang ,  Zhigang Bai

    Inventor： Honghui Shi ,  Qingzhong Ma ,  Jin Wang ,  Jiayong Lu ,  Longying Zhang ,  Zhigang Bai

    IPC: F28F9/26 ,  F28B1/06 ,  F28B7/00 ,  F28D7/16 ,  F01K9/00

    CPC classification number: F28B1/06 ,  F01K9/00 ,  F28B7/00 ,  F28D7/163 ,  F28F9/26

    Abstract: An evaporative condenser radiating module for steam exhaust of a steam turbine comprises tube bundles and steam-water separating chambers. A steam-water separating chamber (4) between a section A and a section B, a section A downflow cooling section tube bundle (3), a section B downflow cooling section tube bundle (5), and a counter flow cooling section tube bundle (8) are disposes at the left side of a central steam-water separating chamber (7). An upper sealed space (10) of the steam-water separating chamber (4) between the section A and the section B is in communication with the central steam-water separating chamber (7) through the counter flow cooling section tube bundle (8). A lower sealed space of the steam-water separating chamber (4) between the section A and the section B is in communication with the central steam-water separating chamber (7) through the section B downflow cooling section tube bundle (5). A sealed section A steam entering chamber (2) is arranged on the left side of the steam-water separating chamber (4) between the section A and the section B. The section A downflow cooling section tube bundle (3) is arranged between the section A steam entering chamber (2) and the lower sealed space of the steam-water separating chamber (4) between the section A and the section B. The right side of the central steam-water separating chamber (7) is provided with tube bundles and steam-water separating chambers totally structurally identical with those arranged on the left side of the central steam-water separating chamber (7).

    Dual Horsehead Block And Tackle Pumping Unit
    8.
    发明申请
    Dual Horsehead Block And Tackle Pumping Unit 审中-公开
    双马头块和卸扣单元

    公开(公告)号：US20160123124A1

    公开(公告)日：2016-05-05

    申请号：US14876819

    申请日：2015-10-07

    Applicant: Yi Wang ,  Jin Wang ,  Zijiang Yang

    Inventor： Yi Wang ,  Jin Wang ,  Zijiang Yang

    IPC: E21B43/12 ,  F04B49/02 ,  F04B17/03 ,  F04B47/02

    CPC classification number: F04B17/03 ,  E21B43/127 ,  E21B2043/125 ,  F04B47/022 ,  F16H3/666

    Abstract: A dual horsehead block and tackle beam pumping unit including a steel frame, a walking beam installed on top of the steel frame, horseheads with movable pulleys, pulling wire ropes, load wire ropes, damping extension springs, a reversing reducer, an output drum, a counterweight box, reversing brake mechanisms, and an electric motor is provided for single well and dual well operations. The horseheads are installed on opposing ends of the walking beam. The movable pulley of each horsehead has a pulling wire rope. The first and second ends of each pulling wire rope are connected to the damping extension spring and the output drum respectively. A lower end of the load wire rope hanging on the right hand side horsehead is connected to the counterweight box. On the bottom of the steel frame, the electric motor, the reversing reducer, and the output drum are installed on a base.

    Abstract translation: 一种双马头块和滑车梁泵送单元，包括钢框架，安装在钢框架顶部的步进梁，带有活动滑轮的马头，拉绳绳，负载绳索，阻尼拉伸弹簧，换向减速器，输出滚筒， 为单井和双井操作提供了配重箱，反向制动机构和电动马达。 马头安装在步进梁的相对端。 每个马头的可动皮带轮都有拉绳。 每个牵引钢丝绳的第一和第二端分别连接到阻尼拉伸弹簧和输出鼓。 悬挂在右侧马头上的负载钢丝绳的下端连接到配重箱。 在钢框架的底部，电动机，换向减速器和输出鼓安装在基座上。

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