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    Disposable inhaler system
    1.
    发明授权
    Disposable inhaler system 有权
    一次性吸入器系统

    公开(公告)号：US07077130B2

    公开(公告)日：2006-07-18

    申请号：US10005155

    申请日：2001-12-07

    申请人： Walter A. Nichols ,  F. Murphy Sprinkel, Jr.

    发明人： Walter A. Nichols ,  F. Murphy Sprinkel, Jr.

    IPC分类号： A61M16/00

    CPC分类号： A61M11/041 ,  A61M11/002 ,  A61M11/007 ,  A61M11/042 ,  A61M15/0041 ,  A61M15/0045 ,  A61M15/0048 ,  A61M2205/3653

    摘要： A disposable aerosol generator for use with an inhaler device which includes a heater adapted to volatilize fluid stored in the disposable aerosol generator and method of using the inhaler. The disposable body includes a sealed chamber and an outlet, the chamber being located between first and second layers of material. The chamber holds a predetermined volume of a fluid which is expelled through the outlet when the fluid in the chamber is volatilized by the heater. The disposable body can include a series of spaced apart aerosol generators, each of which can be advanced to a release position at which the heater can heat one of the fluid containing chambers. Prior to heating the fluid, the outlet can be formed by severing the first and/or second layer with a piercing element and the volatilized fluid can be expelled from the outlet into a passage of a dispensing member.

    摘要翻译： 一种与吸入器装置一起使用的一次性气溶胶发生器，其包括适于使存储在一次性气雾发生器中的流体挥发的加热器和使用该吸入器的方法。 一次性主体包括密封室和出口，该室位于第一和第二层材料之间。 腔室容纳预定体积的流体，当腔室中的流体被加热器挥发时，流体通过出口排出。 一次性本体可以包括一系列间隔开的气溶胶发生器，每个气溶胶发生器可以前进到释放位置，在该释放位置加热器可以加热流体容纳腔中的一个。 在加热流体之前，可以通过用穿孔元件切断第一和/或第二层而形成出口，并且挥发的流体可以从出口排出到分配构件的通道中。

    Aerosol generator having heater arranged to vaporize fluid in fluid passage between bonded layers of laminate
    2.
    发明申请
    Aerosol generator having heater arranged to vaporize fluid in fluid passage between bonded layers of laminate 审中-公开
    具有加热器的气溶胶发生器，其布置成在层压体的接合层之间的流体通道中蒸发流体

    公开(公告)号：US20040170405A1

    公开(公告)日：2004-09-02

    申请号：US10795522

    申请日：2004-03-09

    申请人： Chrysalis Technologies Incorporated

    发明人： Timothy S. Sherwood ,  Scott A. Sowers ,  Sirisha P. Reddy ,  F. Murphy Sprinkel JR. ,  Kenneth A. Cox ,  Walter A. Nichols

    IPC分类号： F22B035/06

    CPC分类号： A61M11/041 ,  A61M11/007 ,  A61M11/042 ,  A61M15/00 ,  A61M15/025 ,  B05B17/04

    摘要： An aerosol generator includes a fluid supply which supplies fluid to a fluid passage and a heater, which heats the fluid into a gaseous state, the fluid passage being located between opposed layers of a laminate. The fluid passage can be a capillary sized passage formed by locating a mandrel between opposed layers of the laminate, bonding the layers together, and removing the mandrel such that the space previously occupied by the mandrel forms the fluid passage. The opposed layers of the laminate can be copper sheets, and ceramic layers can be provided on the outside of the copper layers. The aerosol generator can be used to generate aerosols containing medicated materials.

    摘要翻译： 气溶胶发生器包括向流体通道供应流体的流体供应器和将流体加热成气态的加热器，流体通道位于层压体的相对的层之间。 流体通道可以是通过将心轴定位在层压体的相对层之间而形成的毛细管尺寸通道，将层粘合在一起，并且移除心轴使得先前由心轴占据的空间形成流体通道。 层压体的相对层可以是铜片，并且可以在铜层的外侧设置陶瓷层。 气溶胶发生器可用于产生含有药物的气溶胶。

    Dual capillary fluid vaporizing device
    3.
    发明申请
    Dual capillary fluid vaporizing device 有权

    公开(公告)号：US20030205228A1

    公开(公告)日：2003-11-06

    申请号：US10430272

    申请日：2003-05-07

    申请人： Chrysalis Technologies Incorporated

    发明人： Walter A. Nichols ,  Kenneth A. Cox ,  Tung Tien Nguyen

    IPC分类号： A61M016/00 ,  F23D011/00

    CPC分类号： A61M15/00 ,  A61M11/007 ,  A61M11/042 ,  A61M15/025 ,  A61M2016/0024

    摘要： A fluid vaporizing device useful for vaporizing fluid into an aerosol and includes first and second capillary tubes connected electrically in series by providing separate electrodes at the inlet ends of each capillary tube, and connecting the outlet ends of the capillary tubes by an electrical connection that connects the outlet ends both electrically and thermally. The capillary tubes are heated by the flow of electricity therethrough, and liquid flowing through the tubes is vaporized. The outlet ends of the capillary tubes are easily maintained at a temperature for optimizing aerosol generation since there is minimal heat loss through the connection connecting the outlet ends.

    Fluid vaporizing device having controlled temperature profile heater/capillary tube
    5.
    发明申请
    Fluid vaporizing device having controlled temperature profile heater/capillary tube 有权
    具有受控温度曲线加热器/毛细管的流体蒸发装置

    公开(公告)号：US20050045179A1

    公开(公告)日：2005-03-03

    申请号：US10648282

    申请日：2003-08-27

    申请人： Gene Faison ,  Rajiv Gupta ,  Douglas McRae ,  Walter Nichols

    发明人： Gene Faison ,  Rajiv Gupta ,  Douglas McRae ,  Walter Nichols

    IPC分类号： A61M11/04 ,  A61M15/00 ,  A61M16/10

    CPC分类号： A61M11/041 ,  A61M11/007 ,  A61M11/042 ,  A61M15/025

    摘要： A fluid vaporizing device useful for vaporizing fluid into an aerosol includes a capillary tube made from an electrically conductive material, an upstream electrode connected to the capillary tube, and a downstream electrode connected to the tube and provided with an electrical resistivity sufficient to cause heating of the downstream electrode during operation. According to various manufacturing techniques (a) the downstream electrode can be made of a material having a resistivity that is approximately constant over a desired temperature range, (b) the ratio of the resistance of the downstream electrode to the resistance of the capillary tube can be selected as a function of a preset liquid flow rate through the capillary tube, (c) the tuning range over which a desired quality aerosol can be produced can be selected to compensate for dimensional tolerances during mass production, and (d) the total hot resistance of the downstream electrode and capillary tube can be adjusted to control the location of a meniscus of a liquid vaporized in the capillary tube to produce a desired quality aerosol.

    摘要翻译： 用于将流体蒸发成气溶胶的流体蒸发装置包括由导电材料制成的毛细管，连接到毛细管的上游电极和连接到管的下游电极，并且具有足以引起 操作期间的下游电极。 根据各种制造技术（a），下游电极可以由在所需温度范围内电阻率近似恒定的材料制成，（b）下游电极的电阻与毛细管的电阻的比率可以 作为通过毛细管的预设液体流速的函数来选择，（c）可以选择可以产生期望质量气溶胶的调谐范围以补偿大量生产期间的尺寸公差，以及（d）总热量 可以调节下游电极和毛细管的电阻以控制在毛细管中蒸发的液体的弯液面的位置以产生期望的质量气溶胶。

    Liquid aerosol formulations containing insulin and aerosol generating devices and methods for generating aerosolized insulin
    10.
    发明申请
    Liquid aerosol formulations containing insulin and aerosol generating devices and methods for generating aerosolized insulin 有权
    含有胰岛素和烟雾发生装置的液体气溶胶制剂和产生气雾化胰岛素的方法

    公开(公告)号：US20040223917A1

    公开(公告)日：2004-11-11

    申请号：US10829945

    申请日：2004-04-23

    申请人： Chrysalis Technologies Incorporated

    发明人： Michael Hindle ,  Kenneth A. Cox

    IPC分类号： A61K038/28 ,  A61L009/04

    CPC分类号： A61K9/007 ,  A61K38/28 ,  A61M11/007 ,  A61M11/041 ,  A61M11/042 ,  A61M15/0065 ,  A61M15/008 ,  A61M15/02 ,  A61M15/025 ,  A61M2016/0039 ,  A61M2205/8206 ,  A61M2205/8237

    摘要： Liquid aerosol formulations for generating aerosolized insulin include insulin and at least one high volatility carrier which protects the insulin from thermal degradation during vaporization of the carrier. The carrier can be a mixture of ethanol and water and the liquid aerosol formulation can be propellant free. An aerosol generating device generates the aerosolized insulin by passing the liquid aerosol formulation through a flow passage heated to convert the liquid into a vapor which entrains insulin particles which mix with air to form an aerosol. The insulin particles can be dry insulin particles produced by a hand held inhaler. By controlling the concentration of the insulin in the formulation, the size of the flow passage and/or the amount of heat which heats the flow passage, the aerosol can be provided with a selected mass median aerodynamic diameter of 1 to 3 nullm or less than 1 nullm so as to be delivered to a targeted portion of the lung using the inhaler.

    摘要翻译： 用于产生气雾化胰岛素的液体气溶胶制剂包括胰岛素和至少一种高挥发性载体，其保护胰岛素在载体蒸发期间的热降解。 载体可以是乙醇和水的混合物，液体气溶胶制剂可以不含推进剂。 烟雾发生装置通过使液体气溶胶制剂通过加热的流动通道将液体转化成蒸气，该蒸气夹带与空气混合以形成气溶胶的胰岛素颗粒，产生雾化的胰岛素。 胰岛素颗粒可以是由手持式吸入器产生的干性胰岛素颗粒。 通过控制制剂中胰岛素的浓度，流路的尺寸和/或加热流道的热量，气雾剂可以具有1至3μm或更小的所选质量中值空气动力学直径 1，以便使用吸入器输送到肺的目标部分。