公开(公告)号：US5177062A

公开(公告)日：1993-01-05

申请号：US325649

申请日：1989-03-20

申请人： Takeshi Miyata ,  Kazuo Takahama ,  Hirofumi Kai ,  Takayuki Ishii ,  Keiji Komatsu

发明人： Takeshi Miyata ,  Kazuo Takahama ,  Hirofumi Kai ,  Takayuki Ishii ,  Keiji Komatsu

IPC分类号： A61K31/70

CPC分类号： A61K31/7004

摘要： A preparation for treating immune complex diseases which comprises injection containing the following compound: ##STR1## wherein when n is 1, Z represents a hydrogen, lithium, potassium, sodium, ammonium or organic ammonium, and when n is 2, Z represents calcium, barium or magnesium, as an active ingredient and pharmacologically acceptable carrier. The preparation of the present invention may be used in any administration method such as hypodermic, intramuscular and intravenous.

摘要翻译： 一种用于治疗免疫复合物疾病的制剂，其包含含有以下化合物的注射剂：其中当n为1时，Z表示氢，锂，钾，钠，铵或有机铵，当n为2时，Z表示钙， 钡或镁，作为活性成分和药理学上可接受的载体。 本发明的制剂可以以任何施用方法如皮下注射，肌内注射和静脉内使用。

公开(公告)号：US5158886A

公开(公告)日：1992-10-27

申请号：US268895

申请日：1988-11-08

申请人： Atsushi Kawamura ,  Isao Suda ,  Kinji Takada ,  Masayoshi Ito ,  Yoshiyasu Shitori

发明人： Atsushi Kawamura ,  Isao Suda ,  Kinji Takada ,  Masayoshi Ito ,  Yoshiyasu Shitori

IPC分类号： G01N33/53 ,  A61K38/00 ,  A61K39/395 ,  C07K16/18 ,  C07K16/30 ,  C12N5/18 ,  C12N5/20 ,  C12P21/08 ,  C12R1/91 ,  G01N33/574

CPC分类号： C07K16/18 ,  C07K16/30 ,  A61K38/00

摘要： A hybridoma producing a monoclonal antibody specific for free N-acetylneuraminic acid or beta glycoconjugates thereof, is herein disclosed. The hybridoma can be generated by fusing (i) B cells of lymphocytes obtained by immunizing an animal with an N-acetylneuraminic acid or a beta-glycoconjugate thereof, and (ii) myeloma cells.

摘要翻译： 本文公开了产生对游离N-乙酰神经氨酸或其β-糖缀合物特异性的单克隆抗体的杂交瘤。 杂交瘤可以通过将（i）通过用N-乙酰神经氨酸或其β-糖结合物免疫动物获得的淋巴细胞的B细胞和（ii）骨髓瘤细胞融合来产生。

公开(公告)号：US5141864A

公开(公告)日：1992-08-25

申请号：US270205

申请日：1988-11-14

申请人： Yoshitaka Nagai ,  Hideki Yamamoto ,  Kinji Takada ,  ;Masayoshi Ito ,  Yoshiyasu Shitori

发明人： Yoshitaka Nagai ,  Hideki Yamamoto ,  Kinji Takada ,  ;Masayoshi Ito ,  Yoshiyasu Shitori

IPC分类号： A61K39/395 ,  A61P35/00 ,  C07K14/005 ,  C07K14/195 ,  C07K14/705 ,  C07K16/00 ,  C07K16/18 ,  C07K16/32 ,  C07K16/44 ,  C12N5/00 ,  C12N5/10 ,  C12N5/20 ,  C12N15/02 ,  C12P21/00 ,  C12P21/08 ,  C12R1/91 ,  G01N33/53 ,  G01N33/574 ,  G01N33/577 ,  G01N33/92

CPC分类号： G01N33/574 ,  G01N33/5743 ,  G01N33/57469 ,  G01N33/92 ,  Y10S424/807 ,  Y10S530/864

摘要： A hybridoma capable of producing a monoclonal antibody specific to a sialic acid containing glycolipid carrying N-acetylneuraminic acid residue having alpha 2.fwdarw.3 linkage is herein disclosed. The hybridoma can be generated by fusing (i) B cells or lymphocytes obtained by immunizing an animal with a sialic acid containing glycolipid carrying N-acetylneuraminic acid residue having alpha 2.fwdarw.3 linkage and (ii) myeloma cells. The monoclonal antibody produced by the hybridoma can be used for purifying gangliosides, for treating patients suffering from melanoma and for diagnosing sera.

公开(公告)号：US5077397A

公开(公告)日：1991-12-31

申请号：US441270

申请日：1989-11-27

申请人： Shoji Yoshimura ,  Makoto Tanaka

发明人： Shoji Yoshimura ,  Makoto Tanaka

IPC分类号： A61K31/70 ,  A61K31/7028 ,  A61K31/7034 ,  A61P43/00 ,  C07H15/20 ,  C07H15/203

CPC分类号： C07H15/203 ,  A61K47/48092 ,  C07H15/20

摘要： Sialic acid derivative with active ester groups expressed with the formula [I] ##STR1## Where R.sup.1 denotes hydrogen or an acetyl group, R.sup.2 denotes hydrogen or a lower alkyl group, R.sup.3 denotes C.sub.2 H.sub.4, C.sub.3 H.sub.6 or C.sub.2 H.sub.2, R.sup.4 denotes an hydroxyl group, the residue left after removing hydrogen from the alcohol portion of the active ester or alkyloxycarbonyloxy group, AC denotes an acetyl group, Ph denotes an phenyl group, and X denotes oxygen or sulfur. This sialic acid derivative has high reactivity because it has active ester groups in the molecules and can be used as a raw material or intermediate for synthesis of various sialic acid derivatives.

公开(公告)号：US4950750A

公开(公告)日：1990-08-21

申请号：US110133

申请日：1987-10-19

申请人： Tomoya Ogawa ,  Masaaki Numata ,  Mamoru Sugimoto ,  Shohei Shibayama ,  Shoji Yoshimura ,  Masayoshi Ito ,  Yoshiyasu Shitori

发明人： Tomoya Ogawa ,  Masaaki Numata ,  Mamoru Sugimoto ,  Shohei Shibayama ,  Shoji Yoshimura ,  Masayoshi Ito ,  Yoshiyasu Shitori

IPC分类号： C07H13/06 ,  C07H15/10

CPC分类号： C07H15/10

摘要： The present invention provides ganglioside-related compounds expressed by the following formula: ##STR1## (wherein R.sub.1 denotes a hydrogen atom or SiR.sub.3 R.sub.4 R.sub.5 (wherein R.sub.3 and R.sub.4 each denotes a methyl or phenyl group, and R.sub.5 denotes a tertiary butyl or dimethylphenylmethyl group), and R.sub.2 denotes a hydrogen atom, a trityl group, or ##STR2## (wherein M denotes an alkali metal atom)) and methods of producing the same. These ganglioside-related compounds are useful as markers for the early detection of cancer and in the immunotherapy for cancer.

摘要翻译： 本发明提供由下式表示的神经节苷脂相关化合物：其中R1表示氢原子或SiR3R4R5（其中R3和R4各自表示甲基或苯基，R5表示叔丁基或二甲基苯基甲基）， R2表示氢原子，三苯甲基或三苯甲基，或者其中M表示碱金属原子）及其制造方法。 这些神经节苷脂相关化合物可用作早期检测癌症和癌症免疫治疗的标志物。

公开(公告)号：US4918177A

公开(公告)日：1990-04-17

申请号：US136144

申请日：1987-12-21

申请人： Shoji Yoshimura ,  Shohei Shibayama ,  Masaaki Numata ,  Masayoshi Ito ,  Yoshiyasu Shitori ,  Tomoya Ogawa

发明人： Shoji Yoshimura ,  Shohei Shibayama ,  Masaaki Numata ,  Masayoshi Ito ,  Yoshiyasu Shitori ,  Tomoya Ogawa

IPC分类号： A61K31/70 ,  A61K31/7028 ,  A61K47/26 ,  A61P43/00 ,  C07H15/04

CPC分类号： C07H15/04 ,  A61K47/26

摘要： A sialic acid derivative having an active carbonyl group represented by the formula [I]: ##STR1## wherein R.sup.1 represents hydrogen or acetyl group; R.sup.2 represents hydrogen, a metal or a lower alkyl group; R.sup.3 represents hydrogen, hydroxyl group, or a residue removed hydrogen from an alcohol portion of an active ester; Ac represents acetyl group; and n is 1 to 20, respectively. This sialic acid derivative [I] can be utilized as a starting material for various complex having a sialic acid in the molecule since it has an active carbonyl group in the molecules so that it shows high reactivity.

公开(公告)号：US4826850A

公开(公告)日：1989-05-02

申请号：US110222

申请日：1987-10-19

申请人： Masatoshi Yamato

发明人： Masatoshi Yamato

IPC分类号： C07D498/04 ,  A61K31/47 ,  A61K31/473 ,  A61P35/00 ,  C07D221/18 ,  C07D491/04 ,  C07D491/048 ,  C07D495/04 ,  C07D221/04

CPC分类号： C07D491/04 ,  C07D221/18 ,  C07D495/04

摘要： The present invention provides a quinoline base compound represented by the following general formula (1) of: ##STR1## wherein X is CH.sub.2, O or S. Further provided are the process for the preparation of the aforementioned quinoline base compound and an anticancer agent including the same as a pharmacologically efficacious component.

公开(公告)号：US5516764A

公开(公告)日：1996-05-14

申请号：US219236

申请日：1994-03-28

申请人： Ryoichi Osawa ,  Isao Suda ,  Masaaki Numata ,  Mamoru Sugimoto ,  Kenkichi Tomita ,  Nobuyuki Kibushi ,  Takayuki Ishii ,  Naokazu Sugiyama ,  Makiko Kasano ,  Tae Yasunaga ,  Makoto Tanaka ,  Tomoya Ogawa ,  Mariko Ishii

发明人： Ryoichi Osawa ,  Isao Suda ,  Masaaki Numata ,  Mamoru Sugimoto ,  Kenkichi Tomita ,  Nobuyuki Kibushi ,  Takayuki Ishii ,  Naokazu Sugiyama ,  Makiko Kasano ,  Tae Yasunaga ,  Makoto Tanaka ,  Tomoya Ogawa ,  Mariko Ishii

IPC分类号： C12P19/04 ,  A61K31/70 ,  A61K31/715 ,  A61P7/02 ,  A61P13/02 ,  A61P15/00 ,  A61P37/08 ,  C07H13/04 ,  C12R1/01 ,  A01N43/04 ,  C07H1/00

CPC分类号： A61K31/715 ,  A61K31/70 ,  A61K31/7012 ,  A61K31/7016 ,  A61K31/702 ,  C07H13/04 ,  Y10S514/825 ,  Y10S514/885

摘要： An anti-inflammatory drug comprising as the effective component at least one compound selected from the group consisting of colominic acid, partial hydrolysis products of colominic acid and pharmaceutically acceptable salts thereof. The drug is used as a drug for renal diseases, a drug for hepatitis, an immunomodulator and a drug for inhibiting the chemotaxis of neutrophil.

摘要翻译： 一种抗炎药，其包含选自科洛芬酸，聚洛米酸的部分水解产物和其药学上可接受的盐中的至少一种化合物作为有效成分。 该药用作肾脏疾病的药物，用于肝炎的药物，免疫调节剂和抑制嗜中性粒细胞趋化性的药物。

公开(公告)号：US5231177A

公开(公告)日：1993-07-27

申请号：US488860

申请日：1990-03-05

申请人： Kinichi Saito ,  Hideo Mizu ,  Naokazu Sugiyama ,  Shikoh Minagawa ,  Motoaki Goto ,  Kenji Abiko

发明人： Kinichi Saito ,  Hideo Mizu ,  Naokazu Sugiyama ,  Shikoh Minagawa ,  Motoaki Goto ,  Kenji Abiko

IPC分类号： C07H13/06 ,  A61K31/70 ,  A61K31/7024 ,  A61P11/10 ,  C07H13/04

CPC分类号： C07H13/04

摘要： Sodium N-acetylneuraminate trihydrate herein provided is represented by the following formula: ##STR1## The sodium N-acetylneuraminate trihydrate can be prepared, for instance, according to a method which comprises the steps of: dissolving sodium N-acetylneuraminate in water or in a mixture of water and an organic solvent; allowing the resulting solution to stand; precipitating and separating the resulting crystals of sodium N-acetylneuraminate.trihydrate; and then drying the separated crystals. The sodium N-acetylneuraminate trihydrate has very low hygroscopicity and hence can be handled without any difficulty in the form of powder.

公开(公告)号：US5126330A

公开(公告)日：1992-06-30

申请号：US649531

申请日：1991-02-01

申请人： Haruo Ogura ,  Kimio Furuhata ,  Shingo Sato ,  Masayoshi Ito ,  Yoshiyasu Shitori ,  Yoshitaka Nagai

发明人： Haruo Ogura ,  Kimio Furuhata ,  Shingo Sato ,  Masayoshi Ito ,  Yoshiyasu Shitori ,  Yoshitaka Nagai

IPC分类号： C07J41/00 ,  C07J51/00

CPC分类号： C07J41/0055 ,  C07J51/00

摘要： The present invention relates to a sodium salt of sialosyl cholesterol. The present compound has an excellent high water solubility, and therefore the compound is very useful as a medicine to be used for treating various diseases derived from lesions of peripheral or central nerves.