Halogenated Xanthenes as Vaccine Adjuvants
    2.
    发明公开

    公开(公告)号:US20240316191A1

    公开(公告)日:2024-09-26

    申请号:US18581095

    申请日:2024-02-19

    IPC分类号: A61K39/39 A61K39/00

    摘要: A method of inducing a Type I interferon response in a mammalian subject that presents with a microbial infection, cancerous tumor or hematological malignancy that comprises administering an amount of a halogenated xanthene as discussed above, effective to induce the Type I interferon response. A method of enhancing a mammalian immunogen-specific immune response that comprises contacting mammalian cells, in vivo or present in a mammalian cell growth supporting medium, with an adjuvant-effective amount of a halogenated xanthene, and an immunogen to which that response is to be enhanced. A mammalian HX compound-adjuvanted vaccine composition that contains an immunogen present in a vaccine-effective amount along with an adjuvant-effective amount of a halogenated xanthene (HX) compound and one or more excipients present at about 0.001% by weight to 10% by weight of the vaccine composition dissolved or dispersed in a pharmaceutically acceptable diluent.

    Gyroscope using torus shaped channels and image processing

    公开(公告)号:US11879735B2

    公开(公告)日:2024-01-23

    申请号:US17298655

    申请日:2020-01-23

    IPC分类号: G01C19/14 G01C19/42

    CPC分类号: G01C19/14 G01C19/42

    摘要: Systems and methods related to gyroscope related applications. A platform having at least one torus shaped channel that is filled with a liquid is used in conjunction with at least one marker to determine the direction of forces applied to the platform. Each marker is neutrally buoyant within the liquid and a marker tracking system is used to determine the displacement of the marker from its resting place after a force has been applied to the platform. The tracking system may be based on at least one digital camera in conjunction with suitable image processing software to determine the marker's position before, during, and after the force has been applied. A gyroscope can be constructed using three such platforms with each platform being orthogonal to the other two. Each platform may have multiple concentric channels with a common center with each channel having a different sensitivity to the applied forces.

    ENHANCED SETTLING AND DEWATERING OF OIL SANDS MATURE FINE TAILINGS WITH TITANOMAGNETITE NANOPARTICLES GRAFTED WITH POLYACRYLAMIDE AND LAURYL SULFATE

    公开(公告)号:US20230094535A1

    公开(公告)日:2023-03-30

    申请号:US17879892

    申请日:2022-08-03

    IPC分类号: C02F1/52

    摘要: Nanoflocculants are provided that are comprised of nanoparticles of titanomagnetite having anionic surface moieties associated with electrostatically bound polymerized chains of cationic polyacrylamide, further comprising lauryl sulfate moieties adsorbed to the surface of nanoparticles of the titanomagnetite nanoparticles and/or adsorbed to the bound cationic polyacrylamide polymers. These nanoflocculants combine the dual functionalities of the polyacrylamide/lauryl sulfate moieties, as well as the surface activity of titanomagnetite nanomaterials. Process are provided for making and using the disclosed nanoflocculants, including uses for flocculating intimate aqueous dispersions of solids and bitumen.