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公开(公告)号：US20030207188A1
公开(公告)日：2003-11-06
申请号：US10382392
申请日：2003-03-06
发明人： Nusrallah Jubran , Zbigniew Tokarski , Kam W. Law
IPC分类号： G03G005/047 , C07D43/02 , C07D257/10
CPC分类号： C07D209/68 , C07D403/14 , C07D409/12 , C07D409/14 , G03G5/0612 , G03G5/0629 , G03G5/0661
摘要： Improved organophotoreceptors have: (a) a charge transport compound having the formula 1 where R1 is hydrogen, a branched or linear alkyl group, a branched or linear unsaturated hydrocarbon group, an ether group, or an aryl group; and R2 and R3 independently have a structure of: 2 in which Ar is selected form the group consisting of; 3 R4 is a hydrogen, or an aromatic group; (b) a charge generating compound; and (c) an electrically conductive substrate.
摘要翻译： 改进的有机光感受器具有：（a）具有下式的电荷传输化合物，其中R 1是氢，支链或直链烷基，支链或直链不饱和烃基，醚基或芳基; 并且R2和R3独立地具有以下结构：其中Ar选自由以下组成的组： R4是氢或芳基; （b）电荷产生化合物; 和（c）导电基板。
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2.发明授权Substituted 4-biarylbutyric acid derivatives as matrix metalloprotease inhibitors 失效取代的4-联芳基丁酸衍生物作为基质金属蛋白酶抑制剂
公开(公告)号：US5886043A
公开(公告)日：1999-03-23
申请号：US866778
申请日：1997-05-30
申请人： Harold Clinton Eugene Kluender , Brian Richard Dixon , Michael Christopher VanZandt , Scott McClelland Wilhelm , Donald John Wolanin , William Harrison Bullock
发明人： Harold Clinton Eugene Kluender , Brian Richard Dixon , Michael Christopher VanZandt , Scott McClelland Wilhelm , Donald John Wolanin , William Harrison Bullock
IPC分类号： A61K31/19 , A61K31/215 , A61K31/275 , A61K31/4035 , A61K31/47 , A61P35/00 , A61P43/00 , C07C17/12 , C07C17/16 , C07C17/20 , C07C22/04 , C07C25/18 , C07C45/28 , C07C45/46 , C07C45/56 , C07C45/72 , C07C47/228 , C07C47/277 , C07C49/813 , C07C55/02 , C07C57/38 , C07C59/48 , C07C59/56 , C07C59/68 , C07C59/84 , C07C59/88 , C07C59/90 , C07C59/92 , C07C61/04 , C07C61/06 , C07C62/22 , C07C62/38 , C07C63/72 , C07C65/24 , C07C65/34 , C07C69/145 , C07C69/616 , C07C69/63 , C07C69/712 , C07C69/738 , C07C69/757 , C07C205/34 , C07C205/56 , C07C229/34 , C07C229/40 , C07C233/54 , C07C235/18 , C07C235/84 , C07C255/21 , C07C255/57 , C07C271/22 , C07C271/26 , C07C271/28 , C07C271/58 , C07C317/44 , C07C323/52 , C07C323/61 , C07C323/62 , C07C327/32 , C07D207/08 , C07D207/16 , C07D207/40 , C07D207/404 , C07D209/48 , C07D209/68 , C07D213/00 , C07D213/30 , C07D213/50 , C07D213/70 , C07D215/36 , C07D221/14 , C07D257/04 , C07D263/32 , C07D277/30 , C07D277/74 , C07D295/192 , C07D307/28 , C07D307/32 , C07D307/33 , C07D307/54 , C07D307/68 , C07D307/93 , C07D307/935 , C07D311/96 , C07D317/30 , C07D317/60 , C07D333/00 , C07D333/22 , C07D333/28 , C07D333/34 , C07D405/06 , C07D409/12 , C07D413/06 , C07D471/04 , C07D491/04 , C07D498/04 , C07F9/141 , C07F9/40 , A61K31/235 , C07C59/74 , C07C67/76
CPC分类号： C07D207/08 , A61K31/4035 , A61K31/47 , C07C17/12 , C07C17/16 , C07C17/208 , C07C205/34 , C07C205/56 , C07C22/04 , C07C229/34 , C07C229/40 , C07C233/54 , C07C235/84 , C07C25/18 , C07C255/21 , C07C255/57 , C07C271/22 , C07C271/26 , C07C271/28 , C07C271/58 , C07C317/44 , C07C323/52 , C07C323/61 , C07C323/62 , C07C327/32 , C07C45/28 , C07C45/46 , C07C45/56 , C07C45/72 , C07C47/228 , C07C47/277 , C07C49/813 , C07C55/02 , C07C59/56 , C07C59/84 , C07C59/88 , C07C59/90 , C07C59/92 , C07C61/04 , C07C61/06 , C07C62/22 , C07C62/38 , C07C63/72 , C07C65/24 , C07C65/34 , C07C69/616 , C07C69/712 , C07C69/738 , C07C69/757 , C07D207/16 , C07D207/404 , C07D209/48 , C07D209/68 , C07D213/30 , C07D213/50 , C07D213/70 , C07D215/36 , C07D221/14 , C07D257/04 , C07D263/32 , C07D277/30 , C07D277/74 , C07D295/192 , C07D307/28 , C07D307/32 , C07D307/33 , C07D307/54 , C07D307/68 , C07D307/93 , C07D307/935 , C07D311/96 , C07D317/30 , C07D317/60 , C07D333/22 , C07D333/28 , C07D333/34 , C07D405/06 , C07D409/12 , C07D413/06 , C07D471/04 , C07D491/04 , C07F9/1415 , C07F9/4059 , C07C2101/04 , C07C2101/08 , C07C2101/14
摘要： Inhibitors for matrix metalloproteases, pharmaceutical compositions containing them, and a process for using them to treat a variety of physiological conditions. The compounds of the invention have the generalized formula ##STR1## wherein each T is a substituent group; x is 0, 1, or 2; the group D represents ##STR2## the group R6 represents variety of possible substituent groups on the carbon chain between D and G, and the group G represents M, ##STR3## in which M represents --CO.sub.2 H, --CON(R.sup.11).sub.2, or --CO.sub.2 R.sup.12, and R.sup.13 represents any of the side chains of the 19 noncyclic naturally occurring amino acids.
摘要翻译： 基质金属蛋白酶抑制剂，含有它们的药物组合物，以及使用它们治疗各种生理条件的方法。 本发明的化合物具有通用化合物“IMAGE”，其中每个T是取代基; x为0,1或2; 基团D表示基团R6表示D和G之间碳链上各种可能的取代基，基团G表示M，其中M表示-CO 2 H，-CON（R 11）2或 -CO 2 R 12，R 13表示19个非环状天然存在的氨基酸的任一侧链。
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3.发明授权Substituted 4-biarylbutyric acid derivatives as matrix metalloprotease inhibitors 失效取代的4-联芳基丁酸衍生物作为基质金属蛋白酶抑制剂
公开(公告)号：US5861428A
公开(公告)日：1999-01-19
申请号：US866680
申请日：1997-05-30
申请人： Harold Clinton Eugene Kluender , Brian Richard Dixon , Michael Christopher VanZandt , Scott McClelland Wilhelm , Donald John Wolanin , Jill Elizabeth Wood
发明人： Harold Clinton Eugene Kluender , Brian Richard Dixon , Michael Christopher VanZandt , Scott McClelland Wilhelm , Donald John Wolanin , Jill Elizabeth Wood
IPC分类号： A61K31/19 , A61K31/215 , A61K31/275 , A61K31/4035 , A61K31/47 , A61P35/00 , A61P43/00 , C07C17/12 , C07C17/16 , C07C17/20 , C07C22/04 , C07C25/18 , C07C45/28 , C07C45/46 , C07C45/56 , C07C45/72 , C07C47/228 , C07C47/277 , C07C49/813 , C07C55/02 , C07C57/38 , C07C59/48 , C07C59/56 , C07C59/68 , C07C59/84 , C07C59/88 , C07C59/90 , C07C59/92 , C07C61/04 , C07C61/06 , C07C62/22 , C07C62/38 , C07C63/72 , C07C65/24 , C07C65/34 , C07C69/145 , C07C69/616 , C07C69/63 , C07C69/712 , C07C69/738 , C07C69/757 , C07C205/34 , C07C205/56 , C07C229/34 , C07C229/40 , C07C233/54 , C07C235/18 , C07C235/84 , C07C255/21 , C07C255/57 , C07C271/22 , C07C271/26 , C07C271/28 , C07C271/58 , C07C317/44 , C07C323/52 , C07C323/61 , C07C323/62 , C07C327/32 , C07D207/08 , C07D207/16 , C07D207/40 , C07D207/404 , C07D209/48 , C07D209/68 , C07D213/00 , C07D213/30 , C07D213/50 , C07D213/70 , C07D215/36 , C07D221/14 , C07D257/04 , C07D263/32 , C07D277/30 , C07D277/74 , C07D295/192 , C07D307/28 , C07D307/32 , C07D307/33 , C07D307/54 , C07D307/68 , C07D307/93 , C07D307/935 , C07D311/96 , C07D317/30 , C07D317/60 , C07D333/00 , C07D333/22 , C07D333/28 , C07D333/34 , C07D405/06 , C07D409/12 , C07D413/06 , C07D471/04 , C07D491/04 , C07D498/04 , C07F9/141 , C07F9/40 , A61K31/38 , A61K31/24 , A61K31/44
CPC分类号： C07D207/08 , A61K31/4035 , A61K31/47 , C07C17/12 , C07C17/16 , C07C17/208 , C07C205/34 , C07C205/56 , C07C22/04 , C07C229/34 , C07C229/40 , C07C233/54 , C07C235/84 , C07C25/18 , C07C255/21 , C07C255/57 , C07C271/22 , C07C271/26 , C07C271/28 , C07C271/58 , C07C317/44 , C07C323/52 , C07C323/61 , C07C323/62 , C07C327/32 , C07C45/28 , C07C45/46 , C07C45/56 , C07C45/72 , C07C47/228 , C07C47/277 , C07C49/813 , C07C55/02 , C07C59/56 , C07C59/84 , C07C59/88 , C07C59/90 , C07C59/92 , C07C61/04 , C07C61/06 , C07C62/22 , C07C62/38 , C07C63/72 , C07C65/24 , C07C65/34 , C07C69/616 , C07C69/712 , C07C69/738 , C07C69/757 , C07D207/16 , C07D207/404 , C07D209/48 , C07D209/68 , C07D213/30 , C07D213/50 , C07D213/70 , C07D215/36 , C07D221/14 , C07D257/04 , C07D263/32 , C07D277/30 , C07D277/74 , C07D295/192 , C07D307/28 , C07D307/32 , C07D307/33 , C07D307/54 , C07D307/68 , C07D307/93 , C07D307/935 , C07D311/96 , C07D317/30 , C07D317/60 , C07D333/22 , C07D333/28 , C07D333/34 , C07D405/06 , C07D409/12 , C07D413/06 , C07D471/04 , C07D491/04 , C07F9/1415 , C07F9/4059 , C07C2101/04 , C07C2101/08 , C07C2101/14
摘要： Inhibitors for matrix metalloproteases, pharmaueutical compositions containing them, and a process for using them to treat a variety of physiological conditions. The compounds of the invention have the generalized formula ##STR1## wherein each Tis a substituent group; x is 0, 1, or 2; the group D represents ##STR2## the group R6 reresents a variety of possible substituent groups on the carbon chain between D and G, and the group G represents M, ##STR3## in which M represents --CO.sub.2 H, --CON(R.sup.11).sub.2, or --CO.sub.2 R.sup.12, and R.sup.13 represents any of the side chains of the 19 noncyclic naturally occurring amino acids.
摘要翻译： 用于基质金属蛋白酶的抑制剂，含有它们的制药组合物，以及使用它们处理各种生理条件的方法。 本发明的化合物具有通用化合物“IMAGE”，其中每个是取代基; x为0,1或2; 基团D表示
基团R6表示D和G之间的碳链上的各种可能的取代基，且基团G表示M，其中M表示-CO 2 H，-CON（R 11）2， 或-CO 2 R 12，R 13表示19个非环状天然存在的氨基酸的任一侧链。 -
4.发明授权Thiophene-containing butonic acid derivatives as matrix metalloprotease inhibitors 失效含噻吩的丁酸衍生物作为基质金属蛋白酶抑制剂
公开(公告)号：US5886024A
公开(公告)日：1999-03-23
申请号：US865325
申请日：1997-05-28
IPC分类号： A61K31/19 , A61K31/215 , A61K31/275 , A61K31/4035 , A61K31/47 , A61P35/00 , A61P43/00 , C07C17/12 , C07C17/16 , C07C17/20 , C07C22/04 , C07C25/18 , C07C45/28 , C07C45/46 , C07C45/56 , C07C45/72 , C07C47/228 , C07C47/277 , C07C49/813 , C07C55/02 , C07C57/38 , C07C59/48 , C07C59/56 , C07C59/68 , C07C59/84 , C07C59/88 , C07C59/90 , C07C59/92 , C07C61/04 , C07C61/06 , C07C62/22 , C07C62/38 , C07C63/72 , C07C65/24 , C07C65/34 , C07C69/145 , C07C69/616 , C07C69/63 , C07C69/712 , C07C69/738 , C07C69/757 , C07C205/34 , C07C205/56 , C07C229/34 , C07C229/40 , C07C233/54 , C07C235/18 , C07C235/84 , C07C255/21 , C07C255/57 , C07C271/22 , C07C271/26 , C07C271/28 , C07C271/58 , C07C317/44 , C07C323/52 , C07C323/61 , C07C323/62 , C07C327/32 , C07D207/08 , C07D207/16 , C07D207/40 , C07D207/404 , C07D209/48 , C07D209/68 , C07D213/00 , C07D213/30 , C07D213/50 , C07D213/70 , C07D215/36 , C07D221/14 , C07D257/04 , C07D263/32 , C07D277/30 , C07D277/74 , C07D295/192 , C07D307/28 , C07D307/32 , C07D307/33 , C07D307/54 , C07D307/68 , C07D307/93 , C07D307/935 , C07D311/96 , C07D317/30 , C07D317/60 , C07D333/00 , C07D333/22 , C07D333/28 , C07D333/34 , C07D405/06 , C07D409/12 , C07D413/06 , C07D471/04 , C07D491/04 , C07D498/04 , C07F9/141 , C07F9/40 , A61K31/38 , A61K31/40 , C07D409/00
CPC分类号： C07D207/08 , A61K31/4035 , A61K31/47 , C07C17/12 , C07C17/16 , C07C17/208 , C07C205/34 , C07C205/56 , C07C22/04 , C07C229/34 , C07C229/40 , C07C233/54 , C07C235/84 , C07C25/18 , C07C255/21 , C07C255/57 , C07C271/22 , C07C271/26 , C07C271/28 , C07C271/58 , C07C317/44 , C07C323/52 , C07C323/61 , C07C323/62 , C07C327/32 , C07C45/28 , C07C45/46 , C07C45/56 , C07C45/72 , C07C47/228 , C07C47/277 , C07C49/813 , C07C55/02 , C07C59/56 , C07C59/84 , C07C59/88 , C07C59/90 , C07C59/92 , C07C61/04 , C07C61/06 , C07C62/22 , C07C62/38 , C07C63/72 , C07C65/24 , C07C65/34 , C07C69/616 , C07C69/712 , C07C69/738 , C07C69/757 , C07D207/16 , C07D207/404 , C07D209/48 , C07D209/68 , C07D213/30 , C07D213/50 , C07D213/70 , C07D215/36 , C07D221/14 , C07D257/04 , C07D263/32 , C07D277/30 , C07D277/74 , C07D295/192 , C07D307/28 , C07D307/32 , C07D307/33 , C07D307/54 , C07D307/68 , C07D307/93 , C07D307/935 , C07D311/96 , C07D317/30 , C07D317/60 , C07D333/22 , C07D333/28 , C07D333/34 , C07D405/06 , C07D409/12 , C07D413/06 , C07D471/04 , C07D491/04 , C07F9/1415 , C07F9/4059 , C07C2101/04 , C07C2101/08 , C07C2101/14
摘要： Inhibitors for matrix metalloproteases, pharmaceutical compositions containing them, and a process for using them to treat a variety of physiological conditions. The compounds of the invention have the generalized formula ##STR1## wherein each T is a substituent group; x is 0, 1, or 2; the group D represents ##STR2## the group R6 represents a variety of possible substituent groups on the carbon chain between D and G, and the group G represents M, ##STR3## in which M represents --CO.sub.2 H, --CON(R.sup.11).sub.2, or --CO.sub.2 R.sup.12; and R.sup.13 represents any of the side chains of the 19 noncyclic naturally occurring amino acids.
摘要翻译： 基质金属蛋白酶抑制剂，含有它们的药物组合物，以及使用它们治疗各种生理条件的方法。 本发明的化合物具有通用化合物“IMAGE”，其中每个T是取代基; x为0,1或2; 基团D表示基团R6表示D和G之间的碳链上的各种可能的取代基，基团G表示M，其中M表示-CO 2 H，-CON（R 11）2， 或-CO 2 R 12; R13表示19个非环状天然氨基酸的任一侧链。
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5.发明授权Derivatives of substituted 4-biarylbutyric acid as matrix metalloprotease inhibitors 失效取代的4-联芳基丁酸的衍生物作为基质金属蛋白酶抑制剂
公开(公告)号：US5789434A
公开(公告)日：1998-08-04
申请号：US539409
申请日：1995-11-06
申请人： Harold Clinton Eugene Kluender , Guenter Hans Heinz Herbert Benz , David Ross Brittelli , William Harrison Bullock , Kerry Jeanne Combs , Brian Richard Dixon , Stephan Schneider , Jill Elizabeth Wood , Michael Christopher VanZandt , Donald John Wolanin , Scott M. Wilhelm
发明人： Harold Clinton Eugene Kluender , Guenter Hans Heinz Herbert Benz , David Ross Brittelli , William Harrison Bullock , Kerry Jeanne Combs , Brian Richard Dixon , Stephan Schneider , Jill Elizabeth Wood , Michael Christopher VanZandt , Donald John Wolanin , Scott M. Wilhelm
IPC分类号： A61K31/19 , A61K31/215 , A61K31/275 , A61K31/4035 , A61K31/47 , A61P35/00 , A61P43/00 , C07C17/12 , C07C17/16 , C07C17/20 , C07C22/04 , C07C25/18 , C07C45/28 , C07C45/46 , C07C45/56 , C07C45/72 , C07C47/228 , C07C47/277 , C07C49/813 , C07C55/02 , C07C57/38 , C07C59/48 , C07C59/56 , C07C59/68 , C07C59/84 , C07C59/88 , C07C59/90 , C07C59/92 , C07C61/04 , C07C61/06 , C07C62/22 , C07C62/38 , C07C63/72 , C07C65/24 , C07C65/34 , C07C69/145 , C07C69/616 , C07C69/63 , C07C69/712 , C07C69/738 , C07C69/757 , C07C205/34 , C07C205/56 , C07C229/34 , C07C229/40 , C07C233/54 , C07C235/18 , C07C235/84 , C07C255/21 , C07C255/57 , C07C271/22 , C07C271/26 , C07C271/28 , C07C271/58 , C07C317/44 , C07C323/52 , C07C323/61 , C07C323/62 , C07C327/32 , C07D207/08 , C07D207/16 , C07D207/40 , C07D207/404 , C07D209/48 , C07D209/68 , C07D213/00 , C07D213/30 , C07D213/50 , C07D213/70 , C07D215/36 , C07D221/14 , C07D257/04 , C07D263/32 , C07D277/30 , C07D277/74 , C07D295/192 , C07D307/28 , C07D307/32 , C07D307/33 , C07D307/54 , C07D307/68 , C07D307/93 , C07D307/935 , C07D311/96 , C07D317/30 , C07D317/60 , C07D333/00 , C07D333/22 , C07D333/28 , C07D333/34 , C07D405/06 , C07D409/12 , C07D413/06 , C07D471/04 , C07D491/04 , C07D498/04 , C07F9/141 , C07F9/40 , A61K31/405 , A61K31/40
CPC分类号： C07D207/08 , A61K31/4035 , A61K31/47 , C07C17/12 , C07C17/16 , C07C17/208 , C07C205/34 , C07C205/56 , C07C22/04 , C07C229/34 , C07C229/40 , C07C233/54 , C07C235/84 , C07C25/18 , C07C255/21 , C07C255/57 , C07C271/22 , C07C271/26 , C07C271/28 , C07C271/58 , C07C317/44 , C07C323/52 , C07C323/61 , C07C323/62 , C07C327/32 , C07C45/28 , C07C45/46 , C07C45/56 , C07C45/72 , C07C47/228 , C07C47/277 , C07C49/813 , C07C55/02 , C07C59/56 , C07C59/84 , C07C59/88 , C07C59/90 , C07C59/92 , C07C61/04 , C07C61/06 , C07C62/22 , C07C62/38 , C07C63/72 , C07C65/24 , C07C65/34 , C07C69/616 , C07C69/712 , C07C69/738 , C07C69/757 , C07D207/16 , C07D207/404 , C07D209/48 , C07D209/68 , C07D213/30 , C07D213/50 , C07D213/70 , C07D215/36 , C07D221/14 , C07D257/04 , C07D263/32 , C07D277/30 , C07D277/74 , C07D295/192 , C07D307/28 , C07D307/32 , C07D307/33 , C07D307/54 , C07D307/68 , C07D307/93 , C07D307/935 , C07D311/96 , C07D317/30 , C07D317/60 , C07D333/22 , C07D333/28 , C07D333/34 , C07D405/06 , C07D409/12 , C07D413/06 , C07D471/04 , C07D491/04 , C07F9/1415 , C07F9/4059 , C07C2101/04 , C07C2101/08 , C07C2101/14
摘要： Inhibitors for matrix metalloproteases, pharmaceutical compositions containing them, and a process for using them to treat a variety of physiological conditions. The presently claimed compounds have the generalized formula ##STR1## in which each T represents a substituent group; x is 0, 1, or 2; D represents ##STR2## .delta. is 0 or 1; U' represents O, S, or N, with the proviso that when U' is N, then .delta.=0, and when U' is O or S, then .delta.=1; R.sup.14 is any of a variety of substituent groups; and G represents M, ##STR3## in which M represents --CO.sub.2 H, --CON(R.sup.11).sub.2, or --CO.sub.2 R.sup.12, R.sup.11 represents H or an alkyl group, R.sup.12 represents an alkyl group, and R.sup.13 represents any of the side chains of the 19 noncyclic naturally occurring amino acids; and pharmaceutically acceptable salts thereof.
摘要翻译： 基质金属蛋白酶抑制剂，含有它们的药物组合物，以及使用它们治疗各种生理条件的方法。 目前要求保护的化合物具有其中每个T表示取代基的广义化学式“IMAGE”; x为0,1或2; D表示
delta为0或1; U'表示O，S或N，条件是当U'为N时，则δ= 0，当U'为O或S时，则δ= 1; R14是各种取代基中的任意一种; 和G表示M，其中M表示-CO 2 H，-CON（R 11）2或-CO 2 R 12，R 11表示H或烷基，R 12表示烷基，R 13表示任何侧链的M， 19个非环状天然存在的氨基酸; 及其药学上可接受的盐。 -
6.发明授权Substituted 4-biarylbutyric acid derivatives as matrix metalloprotease inhibitors 失效取代的4-联芳基丁酸衍生物作为基质金属蛋白酶抑制剂
公开(公告)号：US5861427A
公开(公告)日：1999-01-19
申请号：US866679
申请日：1997-05-30
申请人： Harold Clinton Eugene Kluender , Guenter Hans Herbert Heinz Benz , David Ross Brittelli , Brian Richard Dixon , Michael Christopher VanZandt , Scott McClelland Wilhelm , Donald John Wolanin
发明人： Harold Clinton Eugene Kluender , Guenter Hans Herbert Heinz Benz , David Ross Brittelli , Brian Richard Dixon , Michael Christopher VanZandt , Scott McClelland Wilhelm , Donald John Wolanin
IPC分类号： A61K31/19 , A61K31/215 , A61K31/275 , A61K31/4035 , A61K31/47 , A61P35/00 , A61P43/00 , C07C17/12 , C07C17/16 , C07C17/20 , C07C22/04 , C07C25/18 , C07C45/28 , C07C45/46 , C07C45/56 , C07C45/72 , C07C47/228 , C07C47/277 , C07C49/813 , C07C55/02 , C07C57/38 , C07C59/48 , C07C59/56 , C07C59/68 , C07C59/84 , C07C59/88 , C07C59/90 , C07C59/92 , C07C61/04 , C07C61/06 , C07C62/22 , C07C62/38 , C07C63/72 , C07C65/24 , C07C65/34 , C07C69/145 , C07C69/616 , C07C69/63 , C07C69/712 , C07C69/738 , C07C69/757 , C07C205/34 , C07C205/56 , C07C229/34 , C07C229/40 , C07C233/54 , C07C235/18 , C07C235/84 , C07C255/21 , C07C255/57 , C07C271/22 , C07C271/26 , C07C271/28 , C07C271/58 , C07C317/44 , C07C323/52 , C07C323/61 , C07C323/62 , C07C327/32 , C07D207/08 , C07D207/16 , C07D207/40 , C07D207/404 , C07D209/48 , C07D209/68 , C07D213/00 , C07D213/30 , C07D213/50 , C07D213/70 , C07D215/36 , C07D221/14 , C07D257/04 , C07D263/32 , C07D277/30 , C07D277/74 , C07D295/192 , C07D307/28 , C07D307/32 , C07D307/33 , C07D307/54 , C07D307/68 , C07D307/93 , C07D307/935 , C07D311/96 , C07D317/30 , C07D317/60 , C07D333/00 , C07D333/22 , C07D333/28 , C07D333/34 , C07D405/06 , C07D409/12 , C07D413/06 , C07D471/04 , C07D491/04 , C07D498/04 , C07F9/141 , C07F9/40 , A61K31/40 , A61K31/535 , C07D241/00 , C07D265/30
CPC分类号： C07D207/08 , A61K31/4035 , A61K31/47 , C07C17/12 , C07C17/16 , C07C17/208 , C07C205/34 , C07C205/56 , C07C22/04 , C07C229/34 , C07C229/40 , C07C233/54 , C07C235/84 , C07C25/18 , C07C255/21 , C07C255/57 , C07C271/22 , C07C271/26 , C07C271/28 , C07C271/58 , C07C317/44 , C07C323/52 , C07C323/61 , C07C323/62 , C07C327/32 , C07C45/28 , C07C45/46 , C07C45/56 , C07C45/72 , C07C47/228 , C07C47/277 , C07C49/813 , C07C55/02 , C07C59/56 , C07C59/84 , C07C59/88 , C07C59/90 , C07C59/92 , C07C61/04 , C07C61/06 , C07C62/22 , C07C62/38 , C07C63/72 , C07C65/24 , C07C65/34 , C07C69/616 , C07C69/712 , C07C69/738 , C07C69/757 , C07D207/16 , C07D207/404 , C07D209/48 , C07D209/68 , C07D213/30 , C07D213/50 , C07D213/70 , C07D215/36 , C07D221/14 , C07D257/04 , C07D263/32 , C07D277/30 , C07D277/74 , C07D295/192 , C07D307/28 , C07D307/32 , C07D307/33 , C07D307/54 , C07D307/68 , C07D307/93 , C07D307/935 , C07D311/96 , C07D317/30 , C07D317/60 , C07D333/22 , C07D333/28 , C07D333/34 , C07D405/06 , C07D409/12 , C07D413/06 , C07D471/04 , C07D491/04 , C07F9/1415 , C07F9/4059 , C07C2101/04 , C07C2101/08 , C07C2101/14
摘要： Inhibitors for matrix metalloproteases, pharmaceutical compositions containing them, and a process for using them treat a variety of physiological conditions. The compounds of the invention have the generalized formula ##STR1## wherein each T is a substituent group; x is 0, 1, or 2; the group D represents ##STR2## the group R6 represents a variety of possible substituent groups on the carbon chain between D and G, and the group G represents M, ##STR3## in which M represents --CO.sub.2 H, --CON(R.sup.11).sub.2, or --CO.sub.2 R.sup.12 ; and R.sup.13 represents any of the side chains of the 19 noncyclic naturally occurring amino acids.
摘要翻译： 基质金属蛋白酶抑制剂，含有它们的药物组合物和使用它们的方法可以处理各种生理条件。 本发明的化合物具有通用化合物“IMAGE”，其中每个T是取代基; x为0,1或2; 基团D表示基团R6表示D和G之间的碳链上的各种可能的取代基，基团G表示M，其中M表示-CO 2 H，-CON（R 11）2， 或-CO 2 R 12; R13表示19个非环状天然氨基酸的任一侧链。
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7.发明授权Substituted 4-biarylbutyric acid derivatives as matrix metalloprotease inhibitors 失效取代的4-联芳基丁酸衍生物作为基质金属蛋白酶抑制剂
公开(公告)号：US5859047A
公开(公告)日：1999-01-12
申请号：US866798
申请日：1997-05-30
申请人： Harold Clinton Eugene Kluender , David Ross Brittelli , William Harrison Bullock , Kerry Jeanne Combs , Brian Richard Dixon , Michael Christopher VanZandt , Scott McClelland Wilhelm , Donald John Wolanin
发明人： Harold Clinton Eugene Kluender , David Ross Brittelli , William Harrison Bullock , Kerry Jeanne Combs , Brian Richard Dixon , Michael Christopher VanZandt , Scott McClelland Wilhelm , Donald John Wolanin
IPC分类号： A61K31/19 , A61K31/215 , A61K31/275 , A61K31/4035 , A61K31/47 , A61P35/00 , A61P43/00 , C07C17/12 , C07C17/16 , C07C17/20 , C07C22/04 , C07C25/18 , C07C45/28 , C07C45/46 , C07C45/56 , C07C45/72 , C07C47/228 , C07C47/277 , C07C49/813 , C07C55/02 , C07C57/38 , C07C59/48 , C07C59/56 , C07C59/68 , C07C59/84 , C07C59/88 , C07C59/90 , C07C59/92 , C07C61/04 , C07C61/06 , C07C62/22 , C07C62/38 , C07C63/72 , C07C65/24 , C07C65/34 , C07C69/145 , C07C69/616 , C07C69/63 , C07C69/712 , C07C69/738 , C07C69/757 , C07C205/34 , C07C205/56 , C07C229/34 , C07C229/40 , C07C233/54 , C07C235/18 , C07C235/84 , C07C255/21 , C07C255/57 , C07C271/22 , C07C271/26 , C07C271/28 , C07C271/58 , C07C317/44 , C07C323/52 , C07C323/61 , C07C323/62 , C07C327/32 , C07D207/08 , C07D207/16 , C07D207/40 , C07D207/404 , C07D209/48 , C07D209/68 , C07D213/00 , C07D213/30 , C07D213/50 , C07D213/70 , C07D215/36 , C07D221/14 , C07D257/04 , C07D263/32 , C07D277/30 , C07D277/74 , C07D295/192 , C07D307/28 , C07D307/32 , C07D307/33 , C07D307/54 , C07D307/68 , C07D307/93 , C07D307/935 , C07D311/96 , C07D317/30 , C07D317/60 , C07D333/00 , C07D333/22 , C07D333/28 , C07D333/34 , C07D405/06 , C07D409/12 , C07D413/06 , C07D471/04 , C07D491/04 , C07D498/04 , C07F9/141 , C07F9/40 , A61K31/40 , A61K31/165 , A61K31/24 , C07D207/00
CPC分类号： C07D207/08 , A61K31/4035 , A61K31/47 , C07C17/12 , C07C17/16 , C07C17/208 , C07C205/34 , C07C205/56 , C07C22/04 , C07C229/34 , C07C229/40 , C07C233/54 , C07C235/84 , C07C25/18 , C07C255/21 , C07C255/57 , C07C271/22 , C07C271/26 , C07C271/28 , C07C271/58 , C07C317/44 , C07C323/52 , C07C323/61 , C07C323/62 , C07C327/32 , C07C45/28 , C07C45/46 , C07C45/56 , C07C45/72 , C07C47/228 , C07C47/277 , C07C49/813 , C07C55/02 , C07C59/56 , C07C59/84 , C07C59/88 , C07C59/90 , C07C59/92 , C07C61/04 , C07C61/06 , C07C62/22 , C07C62/38 , C07C63/72 , C07C65/24 , C07C65/34 , C07C69/616 , C07C69/712 , C07C69/738 , C07C69/757 , C07D207/16 , C07D207/404 , C07D209/48 , C07D209/68 , C07D213/30 , C07D213/50 , C07D213/70 , C07D215/36 , C07D221/14 , C07D257/04 , C07D263/32 , C07D277/30 , C07D277/74 , C07D295/192 , C07D307/28 , C07D307/32 , C07D307/33 , C07D307/54 , C07D307/68 , C07D307/93 , C07D307/935 , C07D311/96 , C07D317/30 , C07D317/60 , C07D333/22 , C07D333/28 , C07D333/34 , C07D405/06 , C07D409/12 , C07D413/06 , C07D471/04 , C07D491/04 , C07F9/1415 , C07F9/4059 , C07C2101/04 , C07C2101/08 , C07C2101/14
摘要： Inhibitors for matrix metalloproteases, pharmaceutical compositions containing them, and a process for using them to treat a variety of physiological conditions. The compounds of the invention have the generalized formula ##STR1## wherein each T is a substituted group; x is 0, 1, or 2; the group D represents ##STR2## the group R6 represents a variety of possible substituent groups on the carbon chain between D and G, and the group G represents M, ##STR3## in which M represents --CO.sub.2 H, --CON(R.sup.11).sub.2, or --CO.sub.2 R.sup.12 ; and R.sup.13 represents any of the side chains of the 19 noncyclic naturally occurring amino acids.
摘要翻译： 基质金属蛋白酶抑制剂，含有它们的药物组合物，以及使用它们治疗各种生理条件的方法。 本发明的化合物具有通用化合物“IMAGE”，其中每个T是取代基; x为0,1或2; 基团D表示基团R6表示D和G之间的碳链上的各种可能的取代基，基团G表示M，其中M表示-CO 2 H，-CON（R 11）2， 或-CO 2 R 12; R13表示19个非环状天然氨基酸的任一侧链。
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8.发明授权Organoelectroluminescent compound and organoelectroluminescent device employing the same 有权有机电致发光化合物和使用其的有机电致发光器件公开(公告)号：US07854999B2
公开(公告)日：2010-12-21
申请号：US11826790
申请日：2007-07-18
申请人： Sang-Hoon Park , Yu-Jin Kim , Jhun-Mo Son
发明人： Sang-Hoon Park , Yu-Jin Kim , Jhun-Mo Son
CPC分类号： C07C49/697 , C07C13/62 , C07C13/66 , C07C13/72 , C07C17/12 , C07C17/263 , C07C17/269 , C07C211/58 , C07C211/61 , C07C2603/18 , C07C2603/40 , C07C2603/50 , C07C2603/52 , C07C2603/94 , C07D209/68 , C07D235/18 , C07D265/38 , C07D307/91 , C07D333/72 , C07D333/76 , C09K11/06 , C09K2211/1011 , C09K2211/1029 , C09K2211/1033 , C09K2211/1037 , C09K2211/104 , C09K2211/1044 , C09K2211/1059 , C09K2211/1088 , C09K2211/1092 , H05B33/14 , C07C25/22
摘要： Provided are a cyclopentaphenanthrene-based compound and an organoelectroluminescent device employing the same. The cyclopentaphenanthrene-based compound is easy to prepare and excellent in solubility, color purity, color stability, and thermal stability. The cyclopentaphenanthrene-based compound is useful as a material for forming an organic layer, in particular, an emitting layer, in an organoelectroluminescent device, and as an organic dye or an electronic material such as a nonlinear optical material.
摘要翻译： 提供了一种环戊二烯类化合物和使用该化合物的有机电致发光器件。 环戊二烯类化合物易于制备，溶解性，色纯度，色稳定性和热稳定性优异。 环戊二烯类化合物可用作在有机电致发光器件中形成有机层，特别是发光层的材料，以及作为有机染料或诸如非线性光学材料的电子材料。
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9.发明申请Organoelectroluminescent compound and organoelectroluminescent device employing the same 有权有机电致发光化合物和使用其的有机电致发光器件公开(公告)号：US20080100207A1
公开(公告)日：2008-05-01
申请号：US11826790
申请日：2007-07-18
申请人： Sang-Hoon Park , Yu-Jin Kim , Jhun-Mo Son
发明人： Sang-Hoon Park , Yu-Jin Kim , Jhun-Mo Son
IPC分类号： H01J1/62 , C07C13/62 , C07C211/58 , C07C25/22 , C07D235/18 , C07D265/38 , C07D307/91 , C07D333/72 , C07D333/76
CPC分类号： C07C49/697 , C07C13/62 , C07C13/66 , C07C13/72 , C07C17/12 , C07C17/263 , C07C17/269 , C07C211/58 , C07C211/61 , C07C2603/18 , C07C2603/40 , C07C2603/50 , C07C2603/52 , C07C2603/94 , C07D209/68 , C07D235/18 , C07D265/38 , C07D307/91 , C07D333/72 , C07D333/76 , C09K11/06 , C09K2211/1011 , C09K2211/1029 , C09K2211/1033 , C09K2211/1037 , C09K2211/104 , C09K2211/1044 , C09K2211/1059 , C09K2211/1088 , C09K2211/1092 , H05B33/14 , C07C25/22
摘要： Provided are a cyclopentaphenanthrene-based compound and an organoelectroluminescent device employing the same. The cyclopentaphenanthrene-based compound is easy to prepare and excellent in solubility, color purity, color stability, and thermal stability. The cyclopentaphenanthrene-based compound is useful as a material for forming an organic layer, in particular, an emitting layer, in an organoelectroluminescent device, and as an organic dye or an electronic material such as a nonlinear optical material.
摘要翻译： 提供了一种环戊二烯类化合物和使用该化合物的有机电致发光器件。 环戊二烯类化合物易于制备，溶解性，色纯度，色稳定性和热稳定性优异。 环戊二烯类化合物可用作在有机电致发光器件中形成有机层，特别是发光层的材料，以及作为有机染料或诸如非线性光学材料的电子材料。
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公开(公告)号：US06835513B2
公开(公告)日：2004-12-28
申请号：US10382392
申请日：2003-03-06
申请人： Nusrallah Jubran , Zbigniew Tokarski , Kam W. Law
发明人： Nusrallah Jubran , Zbigniew Tokarski , Kam W. Law
IPC分类号： G03G5047
CPC分类号： C07D209/68 , C07D403/14 , C07D409/12 , C07D409/14 , G03G5/0612 , G03G5/0629 , G03G5/0661
摘要： Improved organophotoreceptors have: (a) a charge transport compound having the formula: where R1 is hydrogen, a branched or linear alkyl group, a branched or linear unsaturated hydrocarbon group, an ether group, or an aryl group; and R2 and R3 independently have a structure of: in which Ar is selected form the group consisting of; R4 is a hydrogen, or an aromatic group; (b) a charge generating compound; and (c) an electrically conductive substrate.
摘要翻译： 改进的有机光感受器具有：（a）具有下式的电荷传输化合物：其中R 1是氢，支链或直链烷基，支链或直链不饱和烃基，醚基或芳基; 和R 2和R 3独立地具有以下结构：其中Ar选自：R4是氢或芳族基团;（b）电荷产生化合物; 和（c）导电基板。
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