公开(公告)号：US20030235515A1

公开(公告)日：2003-12-25

申请号：US10176938

申请日：2002-06-21

发明人： Randall Stuart Fike

IPC分类号： G01N030/00

CPC分类号： G01N1/2214 ,  G01N1/24 ,  G01N1/405 ,  Y10T436/25875

摘要： An encapsulated sorbent tube includes a sampling sorbent tube having an open end and containing a sorbent material therein enclosed within an independent encapsulation element that has a body portion and an end portion. The body portion of the encapsulation element has an inner diameter greater than the outer diameter of the sampling sorbent tube sufficient to accommodate the sampling sorbent tube therein. The end portion of the encapsulation element is formed and defined by the longitudinal length of the encapsulation element in excess of the sampling sorbent tube, and includes a proximal frangible element and a distal closure seal, each being independent of and separated from the sampling sorbent tube.

公开(公告)号：US20020116988A1

公开(公告)日：2002-08-29

申请号：US09794772

申请日：2001-02-27

申请人： Isco, Inc.

发明人： Dale A Davison ,  Scott L. Blakley

IPC分类号： G01N030/00

CPC分类号： G01N35/1097 ,  B01D15/12 ,  B01D15/166 ,  B01D15/247 ,  G01N1/38 ,  G01N30/32 ,  G01N30/466 ,  G01N2001/383 ,  G01N2030/324 ,  G01N2030/326

摘要： To economically perform preparatory chromatography, a plurality of pumps each having a corresponding one of a plurality of pistons and a corresponding one of a plurality of cylinders are driven by one motor to draw and pump solvent simultaneously into corresponding columns. To form a gradient the pumps are connected to two-way valves that are connected alternately to a first solvent and a second solvent, whereby the time said valve is in a first position controls the amount of solvent drawn from said first reservoir into said pumps and the amount of time in said second position controls the amount of said second solvent drawn into said pumps and the solvent is mixed in the pumping systems. The detectors are photodiodes mounted to light guides in the flow cells that generate signals related to light absorbance and communicate with a controller, whereby said controller receives signals indicating solute between the light guides and causes collection of solute.

摘要翻译： 为了经济地进行准备色谱，每个具有多个活塞中的相应一个活塞和多个气缸中的相应一个的多个泵由一个电动机驱动，以将溶剂同时泵送到相应的列中。 为了形成梯度，泵连接到交替地连接到第一溶剂和第二溶剂的双向阀，由此所述阀处于第一位置的时间控制从所述第一储存器抽入所述泵中的溶剂的量， 所述第二位置中的时间量控制吸入所述泵中的所述第二溶剂的量并且所述溶剂在所述泵送系统中混合。 检测器是安装在流动池中的光导的光电二极管，其产生与吸光度相关的信号并与控制器通信，由此所述控制器接收指示光导之间的溶质并引起溶质的收集的信号。

公开(公告)号：US20020062683A1

公开(公告)日：2002-05-30

申请号：US10006892

申请日：2001-12-10

发明人： Kimihiko Ishii ,  Yoshiaki Yamada ,  Kiyotoshi Mori

IPC分类号： G01N030/00 ,  B01D015/08

CPC分类号： G01N30/8624 ,  G01N30/74 ,  G01N30/82 ,  G01N30/8631

摘要： In a chromatograph comprising a pump, a sample injecting unit, a column, a photo-diode array detector and a data processing unit having a spectrum library of registered spectrums of known components, a spectrum selected in advance from the spectrum library is compared with a spectrum of each of the peaks in an actual sample. Thereby, it is possible to reduce the number of spectrum comparisons required for identification, and it is further possible to perform identification quickly since the identification can be performed during analysis.

摘要翻译： 在包括泵，样品注入单元，色谱柱，光电二极管阵列检测器和具有已知组分的注册光谱的谱图的数据处理单元的色谱仪中，将从光谱库预先选择的光谱与 实际样品中每个峰的光谱。 因此，可以减少识别所需的频谱比较的数量，并且进一步可以快速地进行识别，因为可以在分析期间执行识别。

公开(公告)号：US20020011096A1

公开(公告)日：2002-01-31

申请号：US09791242

申请日：2001-02-23

申请人： JMIC, Inc.

发明人： John E. Johnson ,  Mark Steinert

IPC分类号： G01N030/00

CPC分类号： G01N30/96 ,  G01N2030/085 ,  G01N2030/626 ,  G01N2030/965 ,  G01N30/02 ,  B01D15/363

摘要： An analytical apparatus for measuring a low concentration of a constituent in a stream at a parts per billion level is provided. The apparatus comprises a sample loop having a predetermined volume for receiving a sample from the stream, a purifier for producing substantially pure carrier liquid from a sample of the stream, a first and a second multi-path valve, a preconcentrator column for absorbing and increasing the concentration of the low concentration constituent, an eluent, and a detector. In one embodiment, the apparatus is an ion chromatograph and may be used to analyze ions at concentrations as low as about 10 to about 1 part per billion. A method for analyzing a stream for a low concentration constituent present in a stream at a parts per billion level is also provided. The invention also includes methods for single- and multi-point calibration of a detector in an analytical apparatus for measuring a low concentration of a constituent in a stream at a parts per billion level.

摘要翻译： 提供了一种分析装置，用于以十亿分之几的等级测量流中成分的低浓度。 该设备包括具有用于从流中接收样品的预定体积的样品回路，用于从流的样品产生基本上纯的载液的净化器，第一和第二多通道阀，用于吸收和增加的预浓缩器柱 低浓度组分的浓度，洗脱液和检测器。 在一个实施方案中，该装置是离子色谱仪，并且可以用于分析浓度低至约10至约十亿分之一的离子。 还提供了用于分析以十亿分之几级别存在于流中的低浓度成分的流的方法。 本发明还包括用于在分析仪器中用于单位和多点校准的方法，该分析仪器用于测量流中每十亿分之一级的低浓度成分。

公开(公告)号：US20030172724A1

公开(公告)日：2003-09-18

申请号：US10099452

申请日：2002-03-15

申请人： Symyx Technologies, Inc.

发明人： Miroslav Petro ,  Son Hoai Nguyen

IPC分类号： G01N030/00

CPC分类号： G01N30/6017 ,  G01N30/02 ,  B01D15/14

摘要： A liquid chromatography column distributor spreads liquid over the internal cross sectional area of the column to facilitate separation of the liquid in the column into its constituent components for analysis, particularly where the volume of liquid is small and the rate of flow through the column is high. The distributor is useful for small volumes, less than 100 micro liters. The distribution is preferably done in two or more stages by two or more plates arranged in series. This arrangement keeps the flow paths short and volumes of channels in the plate carrying the liquid small. The distributor may be used in a high performance liquid chromatography (HPLC) in which liquid flows at high rates through the column. The distributor is constructed to protect the liquid sample from damage.

摘要翻译： 液相色谱柱分配器将液体扩散到柱的内部横截面积上，以便于将柱中的液体分离成其组分成分用于分析，特别是在液体体积小并且流过柱的流量高时 。 经销商对小体积，小于100微升有用。 分布优选通过串联布置的两个或更多个板在两个或更多个阶段中进行。 这种布置保持流动路径短，并且载运液体的板中的通道的体积小。 分配器可用于高效液相色谱（HPLC），其中液体以高速通过柱流动。 分配器被构造成保护液体样品免受损坏。

公开(公告)号：US20030017611A1

公开(公告)日：2003-01-23

申请号：US09905593

申请日：2001-07-13

发明人： Lynn E. Vanatta

IPC分类号： G01N030/00

CPC分类号： G01N30/96 ,  G01N30/461 ,  G01N30/7233 ,  G01N2030/965 ,  Y10T436/15 ,  Y10T436/153333 ,  Y10T436/156666 ,  Y10T436/24 ,  Y10T436/255 ,  Y10T436/2575 ,  G01N30/02 ,  B01D15/363

摘要： This invention relates to methods and apparatus for detecting, quantifying, and/or identifying trace quantities of an anion in the presence of an excess of another anion. One apparatus comprises a sample loop having a first end adapted to be connected to a sample-injection device and a second end adapted to be connected to an inlet of a first separator. An outlet of the first separator has connections to a first waste port and to an inlet of a first anion suppressor. An outlet of the first anion suppressor is connected to a first end of a concentrator and alternatively to waste, the concentrator connected at a second end to a second waste port and alternatively to a pump. The first end of the concentrator is alternatively connected to a second separator inlet, and the second separator is connected at an outlet thereof to an inlet of a second anion suppressor; and an outlet of the second anion suppressor is connected to a mass spectrometer.

摘要翻译： 本发明涉及用于在过量的另一种阴离子存在下检测，定量和/或鉴定痕量的阴离子的方法和装置。 一种装置包括样品环，其具有适于连接到样品注射装置的第一端和适于连接到第一分离器的入口的第二端。 第一分离器的出口连接到第一废物端口和第一阴离子抑制器的入口。 第一阴离子抑制器的出口连接到浓缩器的第一端，并且可选地废物，浓缩器在第二端连接到第二废物端口，并且可选地连接到泵。 集中器的第一端交替地连接到第二分离器入口，并且第二分离器在其出口处连接到第二阴离子抑制器的入口; 并且第二阴离子抑制器的出口连接到质谱仪。

公开(公告)号：US20020174713A1

公开(公告)日：2002-11-28

申请号：US10073687

申请日：2002-02-11

发明人： Miroslav Petro ,  Adam Safir ,  Ralph B. Nielsen ,  G. Cameron Dales ,  Eric D. Carlson ,  Thomas S. Lee

IPC分类号： G01N030/00

CPC分类号： G01N35/1097 ,  B01D15/08 ,  B01D15/14 ,  B01D15/161 ,  B01D15/26 ,  B01D15/265 ,  B01D15/325 ,  B01D15/34 ,  B01J19/0046 ,  B01J19/26 ,  B01J2219/00274 ,  B01J2219/00585 ,  B01J2219/00587 ,  B01J2219/00707 ,  B01J2219/00722 ,  C40B40/14 ,  G01N15/0205 ,  G01N30/02 ,  G01N30/16 ,  G01N30/24 ,  G01N30/30 ,  G01N30/461 ,  G01N30/466 ,  G01N30/54 ,  G01N30/6052 ,  G01N30/88 ,  G01N33/44 ,  G01N33/442 ,  G01N35/028 ,  G01N35/085 ,  G01N2015/0288 ,  G01N2015/0294 ,  G01N2030/324 ,  G01N2030/885 ,  Y10S210/13

摘要： Rapid characterization and screening of polymer samples to determine average molecular weight, molecular weight distribution and other properties is disclosed. Rapid flow characterization systems and methods, including liquid chromatography and flow-injection analysis systems and methods are preferably employed. High throughput, automated sampling systems and methods, high-temperature characterization systems and methods, and rapid, indirect calibration compositions and methods are also disclosed. The described methods, systems, and devices have primary applications in combinatorial polymer research and in industrial process control.

摘要翻译： 公开了聚合物样品的快速表征和筛选以确定平均分子量，分子量分布和其它性质。 优选采用快速流动表征系统和方法，包括液相色谱和流动注射分析系统和方法。 还公开了高通量，自动采样系统和方法，高温表征系统和方法以及快速，间接校准组合物和方法。 所描述的方法，系统和装置在组合聚合物研究和工业过程控制中具有主要应用。

公开(公告)号：US20020123155A1

公开(公告)日：2002-09-05

申请号：US10022735

申请日：2001-12-20

发明人： Michael Himmelhaus ,  Kenko Uchida ,  Hiroyuki Takei

IPC分类号： G01N030/00

CPC分类号： G01N33/54313 ,  Y10T436/25 ,  Y10T436/255

摘要： The invention provides a biochemical sensor with probes uniformly caught in each section. The probes used for detecting a substance of interest are caught in advance on particles, and the particles are fixed in each of sections arranged in form of lattice using a chemical patterning method on the surface of a baseplate. In each section, the particles attached with probes caught on the surface are fixed in single layer and tightly packed. The quantity of the particles fixed on the baseplate is determined by using a light scattering from the particles or by labeling the particles in advance with fluorescent substance. Therefore, the number of probes caught in each section of individual biochemical sensor is determined so as to allow the substance of interest to be detected with high accuracy.

摘要翻译： 本发明提供一种生物化学传感器，其中每个部分均匀地夹有探针。 用于检测感兴趣物质的探针被预先捕获在颗粒上，并且在基板的表面上使用化学图案化方法将颗粒固定在格子形式的每个部分中。 在每个部分中，附着在表面上的探针附着的颗粒固定在单层中并紧密包装。 通过使用来自颗粒的光散射或通过用荧光物质预先标记颗粒来确定固定在基板上的颗粒的量。 因此，确定各个生物化学传感器的每个部分中捕获的探针的数量，以便能高精度地检测感兴趣的物质。

公开(公告)号：US20020029619A1

公开(公告)日：2002-03-14

申请号：US09820134

申请日：2001-03-28

发明人： Dian Y. Lee

IPC分类号： G01N030/00

CPC分类号： G01N30/82 ,  G01N2030/77

摘要： Methods and devices for stop flow detection and measurement of radioactivity in liquid samples are provided. In some embodiments, the invention includes precise positioning of fractions within a flow cell detection area. Novel flow cells and methods providing for flushing samples with gas are also provided.

摘要翻译： 提供了用于停止流量检测和液体样品放射性测量的方法和装置。 在一些实施例中，本发明包括在流动池检测区域内精确定位馏分。 还提供了新颖的流动池和提供用气体冲洗样品的方法。

公开(公告)号：US20040071595A1

公开(公告)日：2004-04-15

申请号：US10059082

申请日：2002-01-28

发明人： Rob Neeper ,  John Lillig

IPC分类号： G01N030/00

CPC分类号： G01N35/02 ,  B01L3/0293 ,  G01N35/028 ,  G01N35/1074 ,  G01N2035/00504 ,  Y10T436/11 ,  Y10T436/111666 ,  Y10T436/114998 ,  Y10T436/25375

摘要： The automated sample-on-solid-support processing system of the present invention comprises a computer-based control unit and a main unit comprising a variable-speed centrifuge having an openable vacuum-tight chamber and a centrifuge rotor with a plurality of multi-sample holding positions, a liquid solvent supply subsystem which feeds solvent to a plurality of dispensing stations in the centrifuge chamber, a temperature control subsystem, and a vacuum subsystem. A sample/collection container includes a plurality of wells, each for separating a sample from its solid support when solvent is dispensed into the wells and the centrifuge is activated at a low speed. Operation of the centrifuge at high speed concentrates the cleaved sample in collection wells. In the preferred embodiment bar code reader or other identification means, preferably a non-contact reader, can be included in the chamber to allow sample carriers to be identified.