公开(公告)号：US20240335509A1

公开(公告)日：2024-10-10

申请号：US18712842

申请日：2022-11-25

申请人： RED ROCK REGENERATION INC.

发明人： Sean A.F. Peel ,  Sowmya Shivanna

IPC分类号： A61K38/18 ,  A61K35/32 ,  A61P19/08 ,  C07K14/51 ,  C12N5/077

CPC分类号： A61K38/18 ,  A61K35/32 ,  A61P19/08 ,  C07K14/51 ,  C12N5/0654 ,  C12N2500/14 ,  C12N2500/46

摘要： A process is provided for treating demineralized bone (DB) comprising incubating the DB with a solution of a chaotropic agent at a temperature in the range of about 12° C. to about 30° C. to increase the release of a bone growth factor followed by selectively removing the chaotropic agent while retaining the released growth factor and the DB. A product prepared by the process is also provided as is the use of said product to promote bone formation or bone fusion in a subject in need thereof.

公开(公告)号：US12090250B2

公开(公告)日：2024-09-17

申请号：US17321904

申请日：2021-05-17

申请人： LifeNet Health

发明人： Silvia Chen ,  Grant Cleavenger ,  Dennis Phelps ,  Evans Wralstad ,  Breanne Gjurich ,  Austin Johnson ,  Alana Sampson ,  Adam Entsminger ,  Jingsong Chen

IPC分类号： A61L27/36 ,  A61K35/32

CPC分类号： A61L27/3608 ,  A61K35/32 ,  A61L27/365 ,  A61L27/3687 ,  A61L2430/02

摘要： The present invention provides demineralized bone fibers exhibiting optimal handling properties (e.g., high moldability and low elastic modulus) and biological activities (e.g., osteoinductivity) as well as non-demineralized bone fibers useful for preparing the demineralized bone fibers. A well-controlled demineralization process for preparing the demineralized bone of fibers is also provided. Products comprising the demineralized bone fibers and uses thereof are further provided.

公开(公告)号：US20240252600A1

公开(公告)日：2024-08-01

申请号：US18627182

申请日：2024-04-04

申请人： New York Society for the Relief of the Ruptured and Crippled, Maintaining the Ho

发明人： Matthew E. Cunningham ,  Agata Krzyzanowska

IPC分类号： A61K38/46 ,  A61K9/00 ,  A61K31/195 ,  A61K31/675 ,  A61K31/7076 ,  A61K31/7088 ,  A61K31/713 ,  A61K35/32 ,  A61K38/19 ,  A61K38/20 ,  A61K39/00 ,  A61K45/06 ,  A61K48/00 ,  A61L27/36 ,  A61L27/38 ,  A61L27/54 ,  A61L27/58 ,  C07K14/47 ,  C12N5/077 ,  C12N15/113 ,  C12N15/86

CPC分类号： A61K38/465 ,  A61K9/0019 ,  A61K9/0085 ,  A61K31/195 ,  A61K31/675 ,  A61K31/7076 ,  A61K31/7088 ,  A61K31/713 ,  A61K35/32 ,  A61K38/191 ,  A61K38/2006 ,  A61K39/00 ,  A61K45/06 ,  A61K48/00 ,  A61L27/3658 ,  A61L27/3687 ,  A61L27/3821 ,  A61L27/3856 ,  A61L27/3895 ,  A61L27/54 ,  A61L27/58 ,  C07K14/4702 ,  C12N5/0655 ,  C12N15/1138 ,  C12N15/86 ,  A61L2300/412 ,  A61L2300/45 ,  A61L2300/604 ,  A61L2300/64 ,  A61L2400/06 ,  A61L2430/38 ,  C12N2310/122 ,  C12N2310/14 ,  C12N2310/531 ,  C12N2320/31 ,  C12N2320/32 ,  C12N2501/2301 ,  C12N2501/73 ,  C12N2740/16043 ,  C12Y301/03001

摘要： This invention relates to compositions and methods for activating and promoting mineralization in tissue that does not normally mineralize, specifically intervertebral discs. The composition comprises agents that increase the expression of the gene that encodes TNAP and/or the activation, amount or activity of INAP protein, and agents that decrease the expression of ANK and/or ENPP and/or the activation, amount or activity of these proteins. The composition can be in the form of a cell or cells. The invention also relates to methods of using the composition.

公开(公告)号：US20240245727A1

公开(公告)日：2024-07-25

申请号：US18604446

申请日：2024-03-13

申请人： AVITA INTERNATIONAL LTD. ,  FUNDAÇÃO BUTANTAN

发明人： Irina Kerkis ,  Alexandre Kerkis

IPC分类号： A61K35/28 ,  A61K9/00 ,  A61K35/30 ,  A61K35/32 ,  C12N5/071 ,  C12N5/0775 ,  C12N5/079 ,  C12N5/0793 ,  C12N5/0797

CPC分类号： A61K35/28 ,  A61K9/0019 ,  A61K35/30 ,  A61K35/32 ,  C12N5/0619 ,  C12N5/0621 ,  C12N5/0623 ,  C12N5/0664 ,  C12N5/0678 ,  C12N2500/25 ,  C12N2500/38 ,  C12N2500/84 ,  C12N2500/90 ,  C12N2501/385 ,  C12N2501/39 ,  C12N2501/392 ,  C12N2501/395 ,  C12N2506/1361 ,  C12N2533/76

摘要： The present disclosure relates to a cryopreserved pharmaceutical composition comprising immature dental pulp stem cells (IDPSCs) expressing CD13 and CD44 and methods of treating a neurological disease or condition comprising systemically administering to a subject a cryopreserved pharmaceutical composition comprising IDPSCs expressing CD13 and CD44. In some aspects, the IDPSCs in the cryopreserved pharmaceutical composition described herein further expresses beta-3-tubulin. In some aspects, the IDPSCs secrete brain-derived neurotrophic factor.

公开(公告)号：US20240216441A1

公开(公告)日：2024-07-04

申请号：US18562767

申请日：2022-01-17

申请人： DEXON PHARMACEUTICALS INC.

发明人： Shoji KOGA

IPC分类号： A61K35/32 ,  A61P3/00

CPC分类号： A61K35/32 ,  A61P3/00

摘要： An agent for improving cancer cachexia used for administration to a subject with cancer cachexia which is a composition containing a culture supernatant of dental pulp-derived stem cells and in which the culture supernatant contains microparticles derived from the dental pulp-derived stem cells is a novel agent for improving cancer cachexia.

公开(公告)号：US20240200032A1

公开(公告)日：2024-06-20

申请号：US17925826

申请日：2022-06-03

申请人： CELLOID CO., LTD.

发明人： Dong Sung KIM ,  Ji Hyeon JU ,  Yoo Jun NAM ,  Yeri RIM ,  Seong Jin LEE ,  Do Hui KIM

IPC分类号： C12N5/077 ,  A61K35/32 ,  A61P19/02 ,  C12M1/04 ,  C12M1/12 ,  C12N5/071

CPC分类号： C12N5/0655 ,  A61K35/32 ,  A61P19/02 ,  C12M23/24 ,  C12M25/14 ,  C12N5/0697

摘要： The present invention relates to a culture method for culturing three-dimensional cell aggregates, and a culture device therefor, and more particularly, to a method and an device for differentiating stem cells in aggregate form into hyaline chondrocyte aggregates, and the use of differentiated hyaline chondrocyte aggregates.

公开(公告)号：US11944532B2

公开(公告)日：2024-04-02

申请号：US18062738

申请日：2022-12-07

申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN

发明人： Lisa M. Larkin ,  Ellen M. Arruda ,  Michael Smietana ,  Asheesh Bedi ,  Stoyna Novakova

IPC分类号： A61F2/08 ,  A61K35/32 ,  A61L27/36 ,  A61L27/38 ,  C12N5/077 ,  A61F2/00

CPC分类号： A61F2/0811 ,  A61F2/08 ,  A61K35/32 ,  A61L27/3662 ,  A61L27/3687 ,  A61L27/3834 ,  A61L27/386 ,  C12N5/066 ,  C12N5/0669 ,  A61F2/0095 ,  A61F2002/087 ,  A61F2220/0008 ,  A61F2240/001 ,  A61F2250/0067 ,  A61L2430/10 ,  A61L2430/40 ,  C12N2500/33 ,  C12N2501/115 ,  C12N2501/999 ,  C12N2513/00

摘要： The present disclosure relates to tissue engineering, and more particularly to a method for treating or repairing rotator cuff or other tendon tears or damage using scaffold-free, 3-dimensional engineered tendon constructs.

公开(公告)号：US20240024643A1

公开(公告)日：2024-01-25

申请号：US18254912

申请日：2021-12-01

申请人： DAEGU GYEONGBUK INSTITUTE OF SCIENCE AND TECHNOLOGY ,  THE CATHOLIC UNIVERSITY OF KOREA INDUSTRY-ACADEMIC COOPERATION FOUNDATION

发明人： Hong Soo CHOI ,  Sung Woong JEON ,  Sung Won KIM ,  Sun Hwa PARK ,  Jin Young KIM

IPC分类号： A61M31/00 ,  A61K9/00 ,  A61K35/32 ,  A61K9/51

CPC分类号： A61M31/002 ,  A61K9/0043 ,  A61K35/32 ,  A61K9/5115

摘要： Disclosed are a method for fabricating a microrobot for delivery of a cell therapy product and a microrobot for delivery of a cell therapy product according thereto. A method for fabricating a microrobot for delivery of a cell therapy product is configured to comprise the steps of: coating a magnetic material with a coating material capable of promoting adhesion, proliferation, and differentiation of stem cells; and internalizing or attaching the coated magnetic material into stem cells. The microrobot for delivery of a cell therapy product, fabricated by the fabrication method, is configured to comprise: a stem cell; a magnetic material attached to the surface of the stem cell or injected into the stem cell and enabling migration in response to an external magnetic field; and a coating material applied to the surface of the magnetic material and promoting attachment, proliferation, and differentiation of the stem cell.

公开(公告)号：US20240009353A1

公开(公告)日：2024-01-11

申请号：US18451977

申请日：2023-08-18

申请人： GLOBUS MEDICAL, INC.

发明人： Archana Bhat ,  Shairali Rao ,  Daniel Laskowitz

IPC分类号： A61L27/38 ,  A61K35/28 ,  A61K35/32 ,  A61L27/36 ,  C12N5/077 ,  C12N5/0775

CPC分类号： A61L27/3834 ,  A61K35/28 ,  A61K35/32 ,  A61L27/365 ,  A61L27/3608 ,  A61L27/3687 ,  C12N5/0654 ,  C12N5/0663 ,  A61L27/3847 ,  C12N2533/54 ,  A61K2035/124

摘要： Bone grafts and constructs including stem cells are provided. Example bone grafts include osteogenic stem cells seeded on a scaffold of osteoconductive cortico-cancellous chips and/or osteoinductive demineralized bone. Example constructs include extracellular matrix on a synthetic scaffold, in which the ECM is secreted from MSCs seeded onto the synthetic scaffold. Also provided are methods of making the present bone grafts and scaffolds. Further provided are methods of promoting bone healing and treating wound healing, by administering the present bone grafts and constructs to a mammal in need thereof. Also provided are kits that include the present bone grafts and/or constructs, or components thereof.

公开(公告)号：US11859210B2

公开(公告)日：2024-01-02

申请号：US16894738

申请日：2020-06-05

申请人： Scripps Health

发明人： Darryl D. D'Lima ,  Tsaiwei Olee ,  Clifford W. Colwell

IPC分类号： C12N5/077 ,  A61K35/32

CPC分类号： C12N5/0655 ,  A61K35/32 ,  C12N2501/15 ,  C12N2506/02 ,  C12N2533/54 ,  C12N2533/90 ,  C12N2537/10

摘要： Disclosed herein are methods of producing chondrocytes from pluripotent stem cells. The invention further provides methods of regenerating cartilaginous tissue.