公开(公告)号：US20240299311A1

公开(公告)日：2024-09-12

申请号：US18610897

申请日：2024-03-20

申请人： Priya Prakash KARMALI ,  Steven TANIS

发明人： Priya Prakash KARMALI ,  Steven TANIS

IPC分类号： A61K9/51 ,  A61K31/7105 ,  C07C271/16 ,  C07C275/14 ,  C07D211/46 ,  C07D295/088

CPC分类号： A61K9/5123 ,  A61K31/7105 ,  C07C271/16 ,  C07C275/14 ,  C07D211/46 ,  C07D295/088

摘要： Ionizable cationic lipids, methods for synthesizing them, as well as intermediates useful in synthesis of these lipids and methods of synthesizing the intermediates are disclosed. The ionizable cationic lipids are useful as a component of lipid nanoparticles (LNP), which in turn can be used for the delivery of nucleic acids into cells in vivo or ex vivo. LNP compositions are also disclosed, including LNP comprising a functionalized lipid to enable conjugation of a binding moiety, and targeted LNP (tLNP), that is a LNP in which a binding moiety has been conjugated to the functionalized lipid and can serve as a targeting moiety to direct the tLNP to a desired tissue or cell type.

公开(公告)号：US20240124388A1

公开(公告)日：2024-04-18

申请号：US18467190

申请日：2023-09-14

申请人： ModernaTX, Inc.

发明人： Kerry E. BENENATO ,  Mark CORNEBISE

IPC分类号： C07C229/12 ,  A61K9/00 ,  A61K9/127 ,  A61K9/16 ,  A61K9/51 ,  A61K31/7105 ,  A61K38/17 ,  A61K38/18 ,  A61K47/54 ,  A61K47/69 ,  A61K48/00 ,  C07C227/16 ,  C07C227/18 ,  C07C229/16 ,  C07C233/36 ,  C07C233/72 ,  C07C235/10 ,  C07C255/24 ,  C07C263/20 ,  C07C271/20 ,  C07C275/14 ,  C07C279/12 ,  C07C279/24 ,  C07C279/28 ,  C07C279/32 ,  C07C311/05 ,  C07C335/08 ,  C07D207/27 ,  C07D233/72 ,  C07D249/04 ,  C07D263/20 ,  C07D265/33 ,  C07D271/06 ,  C07D271/10 ,  C07D277/38 ,  C07F9/09 ,  C07K14/505

CPC分类号： C07C229/12 ,  A61K9/0019 ,  A61K9/0043 ,  A61K9/0073 ,  A61K9/127 ,  A61K9/1272 ,  A61K9/1617 ,  A61K9/1641 ,  A61K9/5123 ,  A61K9/5146 ,  A61K31/7105 ,  A61K38/1725 ,  A61K38/1816 ,  A61K47/543 ,  A61K47/6911 ,  A61K48/0033 ,  A61K48/005 ,  C07C227/16 ,  C07C227/18 ,  C07C229/16 ,  C07C233/36 ,  C07C233/72 ,  C07C235/10 ,  C07C255/24 ,  C07C263/20 ,  C07C271/20 ,  C07C275/14 ,  C07C279/12 ,  C07C279/24 ,  C07C279/28 ,  C07C279/32 ,  C07C311/05 ,  C07C335/08 ,  C07D207/27 ,  C07D233/72 ,  C07D249/04 ,  C07D263/20 ,  C07D265/33 ,  C07D271/06 ,  C07D271/10 ,  C07D277/38 ,  C07F9/091 ,  C07K14/505 ,  A61K9/1271 ,  A61K48/00 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/14 ,  C07C2601/18

摘要： The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Nanoparticle compositions further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.

公开(公告)号：US20230286911A1

公开(公告)日：2023-09-14

申请号：US18141968

申请日：2023-05-01

申请人： THE BOEING COMPANY

发明人： Michael MONTEIRO ,  Daloar HOSSAIN

IPC分类号： C07C275/14 ,  C08F220/18 ,  C08F120/36 ,  C07C273/18 ,  C08F220/36

CPC分类号： C07C275/14 ,  C08F220/1804 ,  C08F120/36 ,  C07C273/1827 ,  C08F220/365 ,  C08F2438/03

摘要： Aspects generally relate to a temperature responsive polymer, more specifically to a polymer exhibiting an upper critical solution temperature (UCST) in an aqueous solution. In one aspect, a monomer compound includes one or more amide or thioamide groups; one or more ureido or thioureido groups; and one or more ethylenically unsaturated groups. In one aspect, a polymer, such as a homopolymer or a copolymer, is produced by polymerization of the monomer compound. The copolymer is produced by polymerization of the monomer compound and a comonomer, such as a hydrophobic comonomer, a hydrophilic comonomer, a pH responsive comonomer, a light responsive comonomer, and combinations thereof. The polymer exhibits a UCST from about 1° C. to about 100° C. in an aqueous solution at 1 atm.

公开(公告)号：US20230234917A1

公开(公告)日：2023-07-27

申请号：US18001238

申请日：2021-06-09

申请人： SENDA BIOSCIENCES, INC.

发明人： Spencer Cory PECK ,  Jenny LIU ,  Timothy F. BRIGGS ,  John Robert PROUDFOOT ,  William MCELROY ,  Robert Walter MYERS ,  Steven John TAYLOR

IPC分类号： C07C237/10 ,  A61P35/00 ,  C07K5/062 ,  C07D305/08 ,  C07C275/14 ,  C07C271/20 ,  C07F9/40 ,  C07F9/42 ,  C07C317/08 ,  C07F5/02 ,  C07C237/22 ,  C07D263/32 ,  C07D233/64 ,  C07D257/04 ,  C07D249/08 ,  C07D271/06 ,  C07D271/10 ,  C07D249/04 ,  C07C255/29 ,  C07D213/40 ,  C07D333/20 ,  C07D235/16

CPC分类号： C07C237/10 ,  A61P35/00 ,  C07K5/06026 ,  C07D305/08 ,  C07C275/14 ,  C07C271/20 ,  C07F9/4006 ,  C07F9/425 ,  C07C317/08 ,  C07F5/027 ,  C07C237/22 ,  C07D263/32 ,  C07D233/64 ,  C07D257/04 ,  C07D249/08 ,  C07D271/06 ,  C07D271/10 ,  C07D249/04 ,  C07C255/29 ,  C07D213/40 ,  C07D333/20 ,  C07D235/16 ,  C07C2601/14

摘要： The present disclosure relates to compounds of formulas (A) and (I), pharmaceutically acceptable salts thereof, and solvates of any of the foregoing, pharmaceutical compositions comprising the same, methods of preparing the same, intermediate compounds useful for preparing the same, and methods for treating or prophylaxis of diseases, in particular cancer, such as colorectal cancer, using the same.

公开(公告)号：US20220409536A1

公开(公告)日：2022-12-29

申请号：US17278040

申请日：2019-09-19

申请人： ModernaTX, Inc.

发明人： Kerry E. BENENATO ,  Mark CORNEBISE ,  Edward HENNESSY

IPC分类号： A61K9/127 ,  A61K47/10 ,  A61K47/28 ,  A61K47/24 ,  A61K31/7105 ,  A61K31/573 ,  A61K31/519 ,  A61K31/167 ,  A61K45/06 ,  C07C229/12 ,  C07C229/16 ,  C07D239/54 ,  C07D239/47 ,  C07D473/34 ,  C07C233/47 ,  C07C275/14 ,  C07C335/08 ,  C07D233/61 ,  C07C311/05 ,  C07D473/18 ,  C07C229/14 ,  C07C311/64 ,  C07D249/04 ,  C07D209/48 ,  C07D295/13 ,  C07C279/36 ,  C07C279/28 ,  C07C215/08 ,  C07C235/10 ,  C07F9/09 ,  C07C311/14

摘要： The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Nanoparticle compositions further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.

公开(公告)号：US20220315567A1

公开(公告)日：2022-10-06

申请号：US17520350

申请日：2021-11-05

申请人： Mebias Discovery, Inc.

发明人： Brett A. Tounge ,  Shariff Bayoumy ,  Lawrence C. Kuo ,  Scott Dax

IPC分类号： C07D409/12 ,  C07D405/12 ,  C07D209/44 ,  C07C275/14 ,  C07C275/06 ,  A61P29/00 ,  C07C275/26 ,  C07C273/18 ,  C07D215/08 ,  C07D333/20 ,  C07D215/18 ,  C07C275/28 ,  C07D207/09 ,  C07D215/14 ,  C07D333/22

摘要： The invention relates to substituted ureas, and compositions comprising the same, which in certain embodiments are useful for treating and/or preventing pain in a subject in need thereof.

公开(公告)号：US11365183B2

公开(公告)日：2022-06-21

申请号：US16363022

申请日：2019-03-25

申请人： MAX-DELBRUECK-CENTRUM FUER MOLEKULARE MEDIZIN ,  BOARD OF REGENTS OF UNIVERSITY OF TEXAS SYSTEM

发明人： Wolf-Hagen Schunck ,  Gerd Wallukat ,  Robert Fischer ,  Cosima Arnold ,  Dominik N. Mueller ,  Narender Puli ,  John R. Falck

IPC分类号： C07D303/38 ,  C07C235/76 ,  C07C275/20 ,  C07C233/09 ,  C07C233/49 ,  C07C275/14 ,  C07C233/47 ,  C07C275/16 ,  C07C235/28

摘要： The present invention provides compounds (n-3 PUFA derivatives) of formula (I): that modulate conditions associated with cardiac damage, especially cardiac arrhythmias.

公开(公告)号：US20220009878A1

公开(公告)日：2022-01-13

申请号：US17282157

申请日：2019-10-02

申请人： Intellia Therapeutics, Inc.

发明人： Rubina Giare Parmar ,  Stephen S. Scully ,  Micah Maetani ,  Derek LaPlaca

IPC分类号： C07C229/12 ,  C07C229/30 ,  C07C229/26 ,  C07C271/12 ,  C07C233/36 ,  C07C271/20 ,  C07C275/14 ,  C07C311/05 ,  C12N9/22 ,  C12N15/11 ,  A61K9/51

摘要： The disclosure provides ionizable amine lipids and salts thereof (e.g., pharmaceutically acceptable salts thereof) useful for the delivery of biologically active agents, for example delivering biologically active agents to cells to prepare engineered cells. The ionizable amine lipids disclosed herein are useful as ionizable lipids in the formulation of lipid nanoparticle-based compositions.

公开(公告)号：US11198685B2

公开(公告)日：2021-12-14

申请号：US16876222

申请日：2020-05-18

申请人： Mebias Discovery, Inc.

发明人： Brett A. Tounge ,  Shariff Bayoumy ,  Lawrence C. Kuo ,  Scott Dax

IPC分类号： C07D409/12 ,  C07D405/12 ,  C07D209/44 ,  C07C275/14 ,  C07C275/06 ,  A61P29/00 ,  C07C275/26 ,  C07C273/18 ,  C07D215/08 ,  C07D333/20 ,  C07D215/18 ,  C07C275/28 ,  C07D207/09 ,  C07D215/14 ,  C07D333/22

摘要： The invention relates to substituted ureas, and compositions comprising the same, which in certain embodiments are useful for treating and/or preventing pain in a subject in need thereof.

公开(公告)号：US10683283B2

公开(公告)日：2020-06-16

申请号：US16329984

申请日：2017-08-31

申请人： MEBIAS DISCOVERY, INC.

发明人： Brett A. Tounge ,  Shariff Bayoumy ,  Lawrence C. Kuo ,  Scott Dax

IPC分类号： C07D409/12 ,  C07D405/12 ,  C07D209/44 ,  C07C275/14 ,  C07C275/06 ,  A61P29/00 ,  C07C275/26 ,  C07C273/18 ,  C07D215/08 ,  C07D333/20 ,  C07D215/18 ,  C07C275/28 ,  C07D207/09 ,  C07D215/14 ,  C07D333/22

摘要： The invention relates to substituted ureas, and compositions comprising the same, which in certain embodiments are useful for treating and/or preventing pain in a subject in need thereof.