公开(公告)号：US20230365851A1

公开(公告)日：2023-11-16

申请号：US18029287

申请日：2021-10-08

申请人： AUTONETWORKS TECHNOLOGIES, LTD. ,  SUMITOMO WIRING SYSTEMS, LTD. ,  SUMITOMO ELECTRIC INDUSTRIES, LTD. ,  KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION

发明人： Naoyuki OSHIUMI ,  Takehiro HOSOKAWA ,  Makoto MIZOGUCHI

IPC分类号： C09K5/14 ,  C09C1/02 ,  C09C3/08 ,  C08K5/00 ,  C08K9/04 ,  C07C49/78 ,  C07C49/84 ,  C07C49/213 ,  C07C49/825 ,  C07C49/83 ,  C07C49/14 ,  H01B7/00 ,  H01B7/42

CPC分类号： C09K5/14 ,  C09C1/028 ,  C09C3/08 ,  C08K5/0091 ,  C08K9/04 ,  C07C49/78 ,  C07C49/84 ,  C07C49/213 ,  C07C49/825 ,  C07C49/83 ,  C07C49/14 ,  H01B7/0045 ,  H01B7/421 ,  C08K2201/001 ,  C01P2006/32 ,  C01P2004/10 ,  C01P2004/02

摘要： A thermally conductive additive is excellent in thermal conductivity improvement effect and has high processability, and a thermally conductive composite material and a wire harness each contain such a thermally conductive additive. The thermally conductive additive includes an organic component and a metal-containing component, where the organic component is configured as an organic compound including a coordination part that can multidentate-coordinate to a metal, and at least one functional group bonded to the coordination part and having a conjugated π-electron system, and the organic component coordinates in the coordination part to a metal atom constituting the metal-containing component to form a coordination complex. The thermally conductive composite material includes the thermally conductive additive and a matrix material, where the thermally conductive additive is dispersed in the matrix material. The wire harness includes the thermally conductive composite material.

公开(公告)号：US20230192908A1

公开(公告)日：2023-06-22

申请号：US17926337

申请日：2021-05-18

申请人： Bowling Green State University

发明人： Jayaraman Sivaguru ,  Ravichandranath Singathi

IPC分类号： C08F2/50 ,  C08F120/14 ,  C08F120/28 ,  C08F122/20 ,  C07C49/84 ,  C07D307/42

CPC分类号： C08F2/50 ,  C08F120/14 ,  C08F120/28 ,  C08F122/20 ,  C07C49/84 ,  C07D307/42

摘要： Biomass derived benzophenone derivatives, and methods of making and using the same, are described. In accordance with the present disclosure, biomass derived benzophenone derivatives are useful as visible light photoinitiators.

公开(公告)号：US11639325B2

公开(公告)日：2023-05-02

申请号：US17116427

申请日：2020-12-09

申请人： Massachusetts Institute of Technology ,  The General Hospital Corporation

发明人： Li-Huei Tsai ,  Stephen J. Haggarty ,  Debasis Patnaik ,  Ping-Chieh Pao

IPC分类号： C07C49/83 ,  A61K9/00 ,  A61K45/06 ,  A61K31/12 ,  C07C49/84 ,  C07C215/20 ,  C07C69/017 ,  A61P25/28 ,  C07C65/34

摘要： The present invention relates to polyhydroxylated benzophenone compounds useful in the treatment of neurodegenerative, neurological, psychiatric, and cognitive diseases, in particular those associated with a deficiency in HDAC1 deacetylase activity.

公开(公告)号：USRE49222E1

公开(公告)日：2022-09-27

申请号：US16668703

申请日：2019-10-30

申请人： DAIKIN INDUSTRIES, LTD. ,  OSAKA UNIVERSITY

发明人： Kenji Adachi ,  Takashi Shibanuma ,  Takabumi Nagai ,  Sensuke Ogoshi ,  Masato Ohashi

IPC分类号： C07F1/08 ,  C07B37/04 ,  C07C17/263 ,  C07C25/13 ,  C07C37/18 ,  C07C39/367 ,  C07C41/30 ,  C07C43/225 ,  C07C45/45 ,  C07C45/61 ,  C07C45/68 ,  C07C47/55 ,  C07C49/233 ,  C07C49/235 ,  C07C49/84 ,  C07C67/00 ,  C07C67/30 ,  C07C67/343 ,  C07C69/65 ,  C07C69/76 ,  C07C69/78 ,  C07C209/68 ,  C07C253/30 ,  C07C255/50 ,  C07C381/00 ,  C07D213/26 ,  C07D307/87 ,  C07D333/12 ,  C07F5/02 ,  C07F5/04 ,  C07F7/08 ,  C07F7/12 ,  C07F7/18

摘要： An object of the present invention is to enable the synthesis of various fluorine-containing compounds having an organic group at both terminals of their tetrafluoroethylene structure (—CF2—CF2—). The present invention provides a fluorine-containing complex compound including a fluorine-containing organic metal compound represented by formula (1a): R1—CF2—CF2-M1  (1a) wherein M1 is a metal selected from the group consisting of copper, zinc, nickel, iron, cobalt, and tin; and R1 represents an organic group, and at least one ligand selected from the group consisting of pyridine ring-containing compounds and phosphines.

公开(公告)号：US11413255B2

公开(公告)日：2022-08-16

申请号：US15735214

申请日：2016-06-27

申请人： Montefiore Medical Center

发明人： Richard M. LoPachin ,  Terrence Gavin ,  Brian Geohagen

IPC分类号： A61K31/167 ,  A61K31/191 ,  A61K31/122 ,  A61K31/12 ,  C07C49/825 ,  C07C49/82 ,  C07C49/835 ,  C07C49/78 ,  C07C233/33 ,  C07C323/22 ,  A61K31/495 ,  A61K31/05 ,  A61K31/095 ,  A61K31/36 ,  A61P39/06 ,  A01N1/02 ,  A61K31/381 ,  A61K31/402 ,  A61K31/5375 ,  C07C49/80 ,  C07C49/807 ,  C07C49/84 ,  C07D207/04 ,  C07D207/325 ,  C07D295/112 ,  C07D333/22

摘要： Methods, filters and compositions are disclosed for treating toxicity due to oxidative stress and toxic electrophiles.

公开(公告)号：US11203580B2

公开(公告)日：2021-12-21

申请号：US16603534

申请日：2018-04-19

申请人： IGM GROUP B.V.

发明人： Reinhard Sommerlade

IPC分类号： C07D301/02 ,  C07C41/56 ,  C07C43/315 ,  C07D265/30 ,  C07D303/02 ,  C07C49/84

摘要： The present invention refers to a process for reacting an alkyl aryl ketone obtaining thereby the corresponding aryl oxirane or α-functionalized alkyl aryl ketal, the aryl oxirane or α-functionalized alkyl aryl ketal obtained by the process as well as the α-functionalized ketone obtained by the process.

公开(公告)号：US20190315721A1

公开(公告)日：2019-10-17

申请号：US16394284

申请日：2019-04-25

申请人： Miyoshi Oil & Fat Co., Ltd. ,  Tokai Optical Co., Ltd.

发明人： Koji KAWAI ,  Kotaro KANEKO ,  Nobuhiro KANEKO ,  Yuichi SHISHINO ,  Kuniyoshi OKAMOTO

IPC分类号： C07D403/12 ,  C07D251/24 ,  C07D249/20 ,  C07C321/28 ,  C07C321/26 ,  C07C69/94 ,  C08K5/3475 ,  C08L101/00 ,  C09K3/00 ,  C08K5/372 ,  C08K5/37 ,  C07C49/84

摘要： Provided is an additive for imparting ultraviolet absorbency, or an additive for imparting a high refractive index, which has satisfactory compatibility with a resin serving as a matrix and can maintain high transparency even if added in high concentrations. Also provided is an additive with which the function of imparting both ultraviolet absorbency and a high refractive index can be realized by means of one kind of additive. This additive is represented by the following Formula (I): wherein at least one of R1a to R9a is a monovalent sulfur-containing group represented by the following Formula (i-1) or Formula (i-2): wherein R10a to R12a each represent a divalent hydrocarbon group or the like; and R13a represents a monovalent hydrocarbon group or the like.

公开(公告)号：US20190298746A1

公开(公告)日：2019-10-03

申请号：US16366469

申请日：2019-03-27

申请人： Augusta University Research Institute, Inc.

发明人： Hasan Korkaya ,  Eunmi Lee ,  Mustafa Guzel

IPC分类号： A61K31/675 ,  A61P35/04 ,  A61K31/122 ,  A61K31/404 ,  C07C49/84 ,  C07D209/94

摘要： Calprotectin inhibitors and derivatives thereof, and methods of using them for inhibiting or reducing metastatis and treating cancer are provided. The pharmaceutical formulations prepared from the compounds can be used in the treatment of cancer either as a single agent or in combination with at least one other cancer therapeutic, chemotherapeutic or anti-cancer agent.

公开(公告)号：US20190248766A1

公开(公告)日：2019-08-15

申请号：US16394302

申请日：2019-04-25

申请人： Miyoshi Oil & Fat Co., Ltd. ,  Tokai Optical Co., Ltd.

发明人： Koji KAWAI ,  Kotaro KANEKO ,  Nobuhiro KANEKO ,  Yuichi SHISHINO ,  Kuniyoshi OKAMOTO

IPC分类号： C07D403/12 ,  C07D251/24 ,  C07D249/20 ,  C07C321/28 ,  C07C321/26 ,  C07C69/94 ,  C08K5/3475 ,  C08L101/00 ,  C09K3/00 ,  C08K5/372 ,  C08K5/37 ,  C07C49/84

CPC分类号： C07D403/12 ,  C07C49/84 ,  C07C69/94 ,  C07C321/26 ,  C07C321/28 ,  C07D249/20 ,  C07D251/24 ,  C08K5/3475 ,  C08K5/37 ,  C08K5/372 ,  C08L101/00 ,  C09K3/00

摘要： Provided is an additive for imparting ultraviolet absorbency, or an additive for imparting a high refractive index, which has satisfactory compatibility with a resin serving as a matrix and can maintain high transparency even if added in high concentrations. Also provided is an additive with which the function of imparting both ultraviolet absorbency and a high refractive index can be realized by means of one kind of additive. This additive is represented by the following Formula (I): wherein at least one of R1a to R9a is a monovalent sulfur-containing group represented by the following Formula (i-1) or Formula (i-2): R10amSH  (i-1) R11anSR12a—SpR13a  (i-2) wherein R10a to R12a each represent a divalent hydrocarbon group or the like; and R13a represents a monovalent hydrocarbon group or the like.

公开(公告)号：US10377695B2

公开(公告)日：2019-08-13

申请号：US15820194

申请日：2017-11-21

申请人： Sanford Burnham Prebys Medical Research Institute

发明人： Raveendra Panickar Dhanya ,  Douglas J. Sheffler ,  Nicholas D. P. Cosford

IPC分类号： C07D333/24 ,  C07C65/40 ,  C07D257/04 ,  C07D271/06 ,  C07C259/10 ,  C07C311/51 ,  C07C235/46 ,  C07C235/54 ,  C07D213/79 ,  C07D213/80 ,  C07D239/26 ,  C07D241/12 ,  C07D271/07 ,  C07D285/08 ,  C07D295/108 ,  C07D213/50 ,  C07D213/68 ,  C07D213/70 ,  C07D307/42 ,  C07D307/68 ,  C07F7/02 ,  C07D213/64 ,  C07C49/84 ,  C07C59/90 ,  C07C69/92 ,  C07C251/48 ,  C07C255/56 ,  C07D213/55 ,  C07D241/24 ,  C07D277/24 ,  C07D285/12 ,  C07D295/16 ,  C07D295/26 ,  C07D307/54 ,  C07D311/16 ,  C07F5/02 ,  C07F5/04

摘要： Provided herein are small molecule active metabotropic glutamate subtype-2 and -3 receptor positive allosteric modulators (PAMS), compositions comprising the compounds, and methods of using the compounds and compositions comprising the compounds.