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公开(公告)号：US20210078932A1
公开(公告)日：2021-03-18
申请号：US17013539
申请日：2020-09-05
发明人： JIAN-GANG LONG , YA-CHONG HU , YONG-YAO WANG , ZHEN WANG , QING-QING MA , YU-XIA ZHANG , QING-LIN JIANG , XIAO-HONG XU , TING-HUA ZHANG , JIAN-KANG LIU
IPC分类号： C07C69/612 , C07C67/03 , C07C41/09 , C07C43/205
摘要： The present disclosure discloses a novel compound, 3,4-dihydroxyphenethyl 3-hydroxybutanoate, a method for preparing the same and use of the same, and in particular, a compound of formula I, use of the compound of formula I, optically pure isomers of the compound, a mixture of enantiomers in any ratio, or pharmaceutically acceptable salts thereof in preparing health food and drug for relieving brain fatigue, improving learning and memory abilities, and ameliorating mania mood related to brain fatigue.
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公开(公告)号：US10519098B2
公开(公告)日：2019-12-31
申请号：US15520989
申请日：2015-10-21
IPC分类号： C07C233/73 , C07C233/18 , C07C233/22 , C07C69/612 , C07C69/618 , C07C69/92 , C07C67/08 , C07C231/02 , C07D317/60 , C07F7/18 , A61P33/06
摘要： The present invention discloses anti-malarial compound of formula (I) Formula (I) wherein, X is selected from O or NH; R1, R2, R3, R4 and R5 is selected from H or OMe or CH3, —CH2—O—CH2— or —CH═CH—CH═CH—; Y is selected from O or NH and R6, R7 is selected from the following compounds: or pharmaceutically acceptable salts thereof, process for preparation and a pharmaceutical composition containing the same.
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公开(公告)号：US20190263728A1
公开(公告)日：2019-08-29
申请号：US16408874
申请日：2019-05-10
申请人： TOYO GOSEI CO., LTD.
发明人： Takashi MIYAZAWA , Shin-ya TASHITA
IPC分类号： C07B37/04 , C07B47/00 , B01J37/02 , C07C67/293 , C07C67/303 , C07C69/157 , C07C69/612 , C07B61/00 , C07C209/36 , C07C1/00 , C07C45/32 , C07C2/00 , C07C49/04 , C07C51/353 , B01J23/42 , B01J23/46 , B01J23/44 , C08K3/36 , C08K3/22 , C08K3/10 , C08K3/04 , C07F7/18 , C07C45/34 , C07C5/08 , C07C2/86 , C07C1/32 , B01J31/06 , C07B41/06 , B01J37/18 , B01J37/16 , B01J37/06 , B01J37/03 , B01J23/755 , B01J23/52
摘要： A long life catalyst is provided that is conveniently and inexpensively capable of being produced and that is highly active and has inhibited metal leakage. According to aspects of the present invention, a catalyst is provided that includes: a polymer including a plurality of first structural units and a plurality of second structural units; and metal acting as a catalytic center, wherein at least part of the metal is covered with the polymer, each of the plurality of first structural units has a first atom constituting a main chain of the polymer and a first substituent group bonded to the first atom, a second atom included in each of the plurality of second structural units is bonded to the first atom, and the second atom is different from the first atom, or at least one of all substituent groups on the second atom is different from the first substituent group.
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公开(公告)号：US20180297934A1
公开(公告)日：2018-10-18
申请号：US15823448
申请日：2017-11-27
IPC分类号： C07C225/14 , C07C49/743 , C07C49/707 , C07C69/612 , C07C69/28 , A61K31/122 , C07C69/78 , C07C69/96 , C07C59/90 , A61K31/135 , C07C251/42
CPC分类号： C07C225/14 , A61K31/122 , A61K31/135 , C07C49/707 , C07C49/743 , C07C59/90 , C07C69/02 , C07C69/22 , C07C69/28 , C07C69/612 , C07C69/614 , C07C69/78 , C07C69/96 , C07C251/42 , C07C2601/08 , C07C2601/10
摘要： The present application provides novel tetrahydro-isohumulone (THIAA) derivatives and substantially enantiomerically pure compositions and pharmaceutical formulations thereof. The application further provides methods of using the disclosed compounds and compositions to activate PPARγ, inhibit inflammation, and treat conditions associated with inflammation and conditions responsive to PPARγ modulation such as diabetes.
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公开(公告)号：US20180271822A1
公开(公告)日：2018-09-27
申请号：US15991596
申请日：2018-05-29
发明人： Zheng Tao HAN , Hung-Fong CHEN
IPC分类号： A61K31/23 , A61K31/22 , C07C69/33 , A61K31/225 , C07C69/21 , A61K31/216 , A61K45/06 , C07C69/612
CPC分类号： A61K31/23 , A61K31/216 , A61K31/22 , A61K31/225 , A61K45/06 , C07C69/21 , C07C69/33 , C07C69/612 , A61K2300/00
摘要： Methods and compositions containing a phorbol ester or a derivative of a phorbol ester are provided for the treatment and prevention of stroke and the sequelae of stroke. Additional compositions and methods are provided which employ a phorbol ester or derivative compound in combination with at least one additional agent to yield more effective treatment tools to treat or prevent stroke and the long term effects of stroke in mammalian subjects.
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公开(公告)号：US10010519B2
公开(公告)日：2018-07-03
申请号：US15358388
申请日：2016-11-22
发明人： Zheng Tao Han , Hung-Fong Chen
IPC分类号： A61K31/215 , A61K31/23 , A61K31/235 , A61K45/06 , A61K31/22 , A61K31/216 , C07C69/18 , C07C69/21 , C07C69/612 , C07C69/533 , C07C69/33 , A61K31/225
CPC分类号： A61K31/23 , A61K31/216 , A61K31/22 , A61K31/225 , A61K45/06 , C07C69/21 , C07C69/33 , C07C69/612 , A61K2300/00
摘要： Methods and compositions containing a phorbol ester or a derivative of a phorbol ester are provided for the treatment and prevention of stroke and the sequelae of stroke. Additional compositions and methods are provided which employ a phorbol ester or derivative compound in combination with at least one additional agent to yield more effective treatment tools to treat or prevent stroke and the long term effects of stroke in mammalian subjects.
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公开(公告)号：US09976099B2
公开(公告)日：2018-05-22
申请号：US15384471
申请日：2016-12-20
发明人： Man Kit Ng , Halou Oumar-Mahamat , Hong Cheng , David A. Blain
IPC分类号： C10M105/34 , C07C69/24 , C07C69/612 , C07C69/614 , C07C69/734 , C07C69/78 , C10M111/02 , C10M129/70 , C10M129/95
CPC分类号： C10M105/34 , C07C69/24 , C07C69/612 , C07C69/614 , C07C69/734 , C07C69/78 , C10M111/02 , C10M129/70 , C10M129/95 , C10M2203/024 , C10M2207/281 , C10M2207/2815 , C10M2207/284 , C10M2207/2845 , C10N2220/022 , C10N2230/02 , C10N2230/04 , C10N2230/06 , C10N2230/08 , C10N2230/10 , C10N2230/74 , C10N2240/04 , C10N2240/10
摘要： A composition including one or more aromatic alkanoate monoester compounds represented by the formulae (I) and (II) as defined herein. The composition has a viscosity (Kv100) from about 1 cSt to about 10 cSt at 100° C. as determined by ASTM D445, a viscosity index (VI) from about −100 to about 300 as determined by ASTM D2270, and a Noack volatility of no greater than 50 percent as determined by ASTM D5800. A process for producing the composition, a lubricating oil base stock and lubricating oil containing the composition, and a method for improving one or more of thermal and oxidative stability, solubility and dispersancy of polar additives, deposit control and traction control in a lubricating oil by using as the lubricating oil a formulated oil containing the composition.
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公开(公告)号：US20180019411A1
公开(公告)日：2018-01-18
申请号：US15647609
申请日：2017-07-12
发明人： Eiji OTSUKI , Masanori WAKITA , Fumiaki KATO , Satoshi INAYAMA , Norihito ISHII , Katsunori SHIBATA , Mitsunori ITO
IPC分类号： H01L51/00 , C07D209/82 , C07C69/612 , C07C43/18 , C07C49/213
摘要： An ink composition for an organic light-emitting device, the ink composition including a luminescent host material and a solvent, wherein the luminescent host material includes at least one compound represented by Formula (1), and wherein the solvent includes at least one selected from an aromatic ether, an aromatic ester, and an aromatic ketone: wherein, in Formula (1), groups and variables are the same as described in the specification.
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公开(公告)号：US20170369780A1
公开(公告)日：2017-12-28
申请号：US15525616
申请日：2015-10-23
申请人： Merck Patent GmbH
发明人： Kevin ADLEM , Owain Llyr PARRI , Rachel TUFFIN , Hassan ARASI , Thomas MACGREGOR
IPC分类号： C09K19/02 , C09K19/20 , C09K19/14 , C07C255/55 , C07C69/612 , C07C43/205 , C07C23/18 , C07C15/12 , C09K19/30 , C07C255/54 , C07C2601/14
CPC分类号： C09K19/0258 , C07C15/12 , C07C23/18 , C07C43/2055 , C07C69/612 , C07C255/54 , C07C255/55 , C07C2601/14 , C09K19/14 , C09K19/20 , C09K19/2014 , C09K19/3028 , C09K19/3068 , C09K2019/0444
摘要： The invention relates to bimesogenic compounds of formula I to the use of bimesogenic compounds of formula I in liquid crystal media and particular to flexoelectric liquid crystal devices comprising a liquid crystal medium according to the present invention.
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10.发明授权Chiral phosphines for palladium-catalyzed asymmetric α-arylation of ester enolates to produce tertiary stereocenters in high enantioselectivity 有权用于钯催化的酯烯醇化物的不对称α-芳基化的手性膦以产生高对映体选择性的三元立体中心公开(公告)号：US09512155B2
公开(公告)日：2016-12-06
申请号：US14239541
申请日：2012-08-17
申请人： Steve Jianrong Zhou , Zhiyan Huang
发明人： Steve Jianrong Zhou , Zhiyan Huang
IPC分类号： C07C69/95 , C07F9/50 , C07D215/14 , C07D333/38 , C07F9/53 , C07C253/30 , C07C67/00 , C07C51/09 , C07C51/00 , C07C69/612 , C07C69/616
CPC分类号： C07F9/5022 , C07B2200/07 , C07C51/00 , C07C51/09 , C07C67/00 , C07C69/612 , C07C69/616 , C07C253/30 , C07C2601/14 , C07D215/14 , C07D333/38 , C07F9/509 , C07F9/5325 , C07C255/57 , C07C69/738 , C07C69/608 , C07C69/76 , C07C69/734 , C07C59/64
摘要： The disclosure provides new and improved methods for the Pd-catalyzed asymmetric α-arylation of ester compounds, which produce the corresponding α-aryl moiety in high enantioselectivity (generally >90% ee). The present methods utilize a palladium catalyst supported by new (R)—H8-BINOL-derived monophosphine ligands. The method is applicable to a wide variety of aryl triflate substrates having variations in both electronic and steric properties. These aryl triflate substrates react with various α-alkyl (Z)- and/or (E)-0-trimethylsilyl ketene acetals in the presence of a Pd catalyst, (R)—H8-BINOL-derived monophosphine ligand, and a mild activator, for example, LiOAC, to provide the asymmetric α-arylation of ester compounds in high ee.
摘要翻译： 本公开提供了用于酯化合物的Pd催化的不对称α-芳基化的新的和改进的方法，其产生具有高对映体选择性（通常> 90％ee）的相应的α-芳基部分。 本发明的方法利用由新的（R）-H8-BINOL衍生的单膦配体支持的钯催化剂。 该方法适用于各种具有电子和空间特性变化的三氟甲磺酸芳基酯基材。 这些芳基三氟甲磺酸酯底物在Pd催化剂，（R）-H8-BINOL衍生的单膦配体和温和活化剂的存在下，与各种α-烷基（Z） - 和/或（E）-O-三甲基甲硅烷基乙烯酮缩醛反应 ，例如LiOAC，以提供酯化合物在高ee中的不对称α-芳基化。
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