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    Apparatus and Process for the Automated Chemical Synthesis of Compounds
    1.
    发明申请
    Apparatus and Process for the Automated Chemical Synthesis of Compounds 有权

    公开(公告)号：US20230072608A1

    公开(公告)日：2023-03-09

    申请号：US17944462

    申请日：2022-09-14

    申请人： ETH Zurich

    发明人： Jeffrey William Bode ,  Benedikt Matthias Wanner ,  Kuang-Yen Chen ,  Vijaya Pattabiraman ,  Paula Louise Nichols

    IPC分类号： B01J19/00 ,  B01J14/00 ,  B01J20/22 ,  B01J20/26 ,  B01J47/024 ,  C07D213/36 ,  C07D295/027

    摘要： Provided is an process for the automated synthesis of at least one chemical compound including providing at least one substrate in at least one solvent in the at least one reaction container; automatically passing the at least one substrate through at least one first compartment of the at least one cartridge once or several times and collecting a formed substrate-reagent intermediate product in the at least one reaction container prior to passing the substrate-reagent intermediate product into a subsequent compartment; automatically passing the substrate-reagent intermediate product through at least one second compartment once or several times and collecting a formed reaction product prior to passing the reaction product into a subsequent compartment; automatically passing the reaction product through at least one third compartment for purifying the product once or several times and collecting a purified product in the at least one reaction container.

    Method for depleting 2-methoxyethanol (MOE)
    2.
    发明授权
    Method for depleting 2-methoxyethanol (MOE) 有权

    公开(公告)号：US11214555B2

    公开(公告)日：2022-01-04

    申请号：US16971660

    申请日：2019-02-11

    申请人： BASF SE

    发明人： Eva Koch ,  Oliver Bussmann ,  Joachim Pfeffinger ,  Joerg Pastre ,  Johann-Peter Melder

    IPC分类号： C07D295/023 ,  C07D295/027 ,  C07C41/42

    摘要： A process for the depletion of 2-methoxyethanol (MOE) from a mixture comprising predominantly morpholine (MO) (crude morpholine), wherein crude morpholine is distilled in a distillation column in the presence of an alkali metal compound of the general formula M+[RO−] (M+ is alkali metal cation and R is hydrogen (H), methyl, ethyl, propyl, isopropyl, n-butyl, isobutyl, sec-butyl or tert-butyl), where MO and a compound of the general formula R—OH are distilled off and an alkali metal methoxyethoxide of the general formula M+[MeOEtO−] is obtained in the bottom of the column.

    Energetic materials comprising perovskite compound ABX3
    3.
    发明授权
    Energetic materials comprising perovskite compound ABX3 有权

    公开(公告)号：US10913693B2

    公开(公告)日：2021-02-09

    申请号：US16099486

    申请日：2017-08-11

    申请人： XI'AN CRYSTEN MATERIALS TECHNOLOGY CORPORATION LIMITED

    发明人： Weixiong Zhang ,  Shaoli Chen ,  Xiaoming Chen

    IPC分类号： C07D241/04 ,  C07D487/08 ,  C06B43/00 ,  C06B31/00 ,  C06B29/00 ,  C07D295/027

    摘要： The present application belongs to the field of energetic compounds, and particularly relates to the use of a perovskite-type compound ABX3 as an energetic material. As a finding of the present application, the structural characteristics of the perovskite type enables the type of compound to be highly stable, thus overcoming the unsafety of an explosive having poor stability in the prior art. Meanwhile, the structural characteristics of the compound, such as rich energetic ligands, as well as the alternately arranged oxidizing energetic anions and reducing organic cations in the space, endow the compound with excellent performance on instantaneously releasing energy at detonation. The resulting three-dimensional structure allows the compound to not only have an energetic material effect but also overcome shortcomings of some existing energetic materials.

    COMPOSITIONS AND METHODS FOR THE TREATMENT OF MULTIPLE SCLEROSIS
    8.
    发明申请
    COMPOSITIONS AND METHODS FOR THE TREATMENT OF MULTIPLE SCLEROSIS 有权
    用于治疗多发性硬化症的组合物和方法

    公开(公告)号：US20160115115A1

    公开(公告)日：2016-04-28

    申请号：US14591016

    申请日：2015-01-07

    申请人： Mahesh Kandula

    发明人： Mahesh Kandula

    IPC分类号： C07C69/604 ,  C07C57/03 ,  C07C211/10 ,  C07D295/027

    CPC分类号： C07C211/10 ,  A61K47/541 ,  A61K47/542 ,  C07C57/03 ,  C07C69/587 ,  C07C69/60 ,  C07D295/02 ,  C07D295/027

    摘要： The invention relates to the compounds of formula I and formula II or its pharmaceutical acceptable polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of salts of formula I or formula II; and methods for treating or preventing multiple sclerosis may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of neurodegenerative diseases and psoriasis.

    摘要翻译： 本发明涉及式I和式II化合物或其药学上可接受的多晶型物，溶剂合物，对映体，立体异构体和水合物。 包含有效量的式I或式II的盐的药物组合物; 并且可以配制用于治疗或预防多发性硬化的方法用于口服，口腔，直肠，局部，透皮，经粘膜，静脉内，肠胃外给药，糖浆或注射。 这样的组合物可用于治疗神经变性疾病和牛皮癣。