公开(公告)号：US20240269289A1

公开(公告)日：2024-08-15

申请号：US18589688

申请日：2024-02-28

申请人： ALNYLAM PHARMACEUTICALS, INC.

发明人： Martin MAIER ,  Muthusamy JAYARAMAN ,  Akin AKINC ,  Shigeo MATSUDA ,  Pachamuthu KANDASAMY ,  Kallanthottathil G. RAJEEV ,  Muthiah MANOHARAN ,  Jayaprakash K. NAIR ,  Thomas A. BAILLIE

IPC分类号： A61K47/18 ,  A61K9/127 ,  A61K9/51 ,  A61K31/7088 ,  A61K31/7105 ,  A61K31/713 ,  C07C31/125 ,  C07C211/09 ,  C07C211/10 ,  C07C211/11 ,  C07C217/08 ,  C07C229/12 ,  C07C235/06 ,  C07C251/38 ,  C07C323/12 ,  C07C323/58 ,  C07C327/22 ,  C07C327/28 ,  C07C327/32 ,  C07D207/32 ,  C07D233/54 ,  C07D295/08 ,  C07D295/12 ,  C07D295/14 ,  C07D317/30 ,  C07F5/02

CPC分类号： A61K47/18 ,  A61K9/1272 ,  A61K9/5123 ,  A61K31/7088 ,  A61K31/7105 ,  A61K31/713 ,  C07C31/125 ,  C07C211/09 ,  C07C211/10 ,  C07C211/11 ,  C07C217/08 ,  C07C229/12 ,  C07C235/06 ,  C07C251/38 ,  C07C323/12 ,  C07C323/58 ,  C07C327/22 ,  C07C327/28 ,  C07C327/32 ,  C07D207/32 ,  C07D233/54 ,  C07D295/08 ,  C07D295/12 ,  C07D295/14 ,  C07D317/30 ,  C07F5/022

摘要： The present invention relates to a cationic lipid having one or more biodegradable groups located in a lipidic moiety (e.g., a hydrophobic chain) of the cationic lipid. These cationic lipids may be incorporated into a lipid particle for delivering an active agent, such as a nucleic acid. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggregation, a cationic lipid of the present invention, and optionally, a sterol. The lipid particle may further include a therapeutic agent such as a nucleic acid.

公开(公告)号：US12002950B2

公开(公告)日：2024-06-04

申请号：US17475058

申请日：2021-09-14

申请人： SK INNOVATION CO., LTD.

发明人： Jik Soo Kim ,  Sang Bok Kim ,  Hyo Shin Kwak ,  Myoung Lae Kim ,  Se Rah Moon ,  Jin Seok Seo ,  Mi Jung Noh ,  Duck Chul Hwang

IPC分类号： H01M4/36 ,  C07D277/36 ,  C07D295/14 ,  H01M4/52 ,  H01M4/525 ,  H01M4/62 ,  H01M10/05 ,  H01M10/0525 ,  H01M4/02

CPC分类号： H01M4/366 ,  C07D277/36 ,  C07D295/14 ,  H01M4/525 ,  H01M4/628 ,  H01M10/0525 ,  H01M2004/028

摘要： A cathode active material for a lithium secondary battery includes a lithium metal oxide particle and a thio-based compound formed on at least portion of a surface of the lithium metal oxide particle. The thio-based compound has a double bond that contains a sulfur atom. Chemical stability of the lithium metal oxide particle may be improved and surface residues may be reduced by the thio-based compound.

公开(公告)号：US11978893B2

公开(公告)日：2024-05-07

申请号：US18303577

申请日：2023-04-20

申请人： SK On Co., Ltd.

发明人： Jik Soo Kim ,  Sang Bok Kim ,  Hyo Shin Kwak ,  Myoung Lae Kim ,  Se Rah Moon ,  Jin Seok Seo ,  Mi Jung Noh ,  Duck Chul Hwang

IPC分类号： H01M4/36 ,  C07D277/36 ,  C07D295/14 ,  H01M4/525 ,  H01M4/62 ,  H01M10/0525 ,  H01M10/62 ,  H01M4/02

CPC分类号： H01M4/366 ,  C07D277/36 ,  C07D295/14 ,  H01M4/525 ,  H01M4/628 ,  H01M10/0525 ,  H01M2004/028

摘要： A cathode active material for a lithium secondary battery includes a lithium metal oxide particle and a thio-based compound formed on at least portion of a surface of the lithium metal oxide particle. The thio-based compound has a double bond that contains a sulfur atom. Chemical stability of the lithium metal oxide particle may be improved and surface residues may be reduced by the thio-based compound.

公开(公告)号：US11633480B2

公开(公告)日：2023-04-25

申请号：US17651023

申请日：2022-02-14

申请人： ALNYLAM PHARMACEUTICALS, INC.

发明人： Martin Maier ,  Muthusamy Jayaraman ,  Akin Akinc ,  Shigeo Matsuda ,  Pachamuthu Kandasamy ,  Kallanthottathil G. Rajeev ,  Muthiah Manoharan

IPC分类号： A61K47/18 ,  A61K9/127 ,  A61K9/51 ,  A61K31/713 ,  C07D317/30 ,  C07C211/09 ,  C07C211/10 ,  C07C211/11 ,  C07C217/08 ,  C07C229/12 ,  C07C327/22 ,  C07C327/28 ,  C07C327/32 ,  C07C235/06 ,  C07C251/38 ,  C07F5/02 ,  C07D233/54 ,  C07D207/32 ,  C07D295/08 ,  C07D295/12 ,  C07D295/14 ,  C07C323/12 ,  C07C323/58 ,  C07C31/125 ,  A61K31/7088 ,  A61K31/7105

摘要： The present invention relates to a cationic lipid having one or more biodegradable groups located in a lipidic moiety (e.g., a hydrophobic chain) of the cationic lipid. These cationic lipids may be incorporated into a lipid particle for delivering an active agent, such as a nucleic acid. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggregation, a cationic lipid of the present invention, and optionally, a sterol. The lipid particle may further include a therapeutic agent such as a nucleic acid.

公开(公告)号：US11612657B2

公开(公告)日：2023-03-28

申请号：US17651038

申请日：2022-02-14

申请人： ALNYLAM PHARMACEUTICALS, INC.

发明人： Martin Maier ,  Muthusamy Jayaraman ,  Akin Akinc ,  Shigeo Matsuda ,  Pachamuthu Kandasamy ,  Kallanthottathil G. Rajeev ,  Muthiah Manoharan

IPC分类号： A61K47/18 ,  A61K9/127 ,  A61K9/51 ,  A61K31/713 ,  C07C211/09 ,  C07C211/10 ,  C07C211/11 ,  C07C217/08 ,  C07C229/12 ,  C07C327/22 ,  C07C327/28 ,  C07C327/32 ,  C07C235/06 ,  C07C251/38 ,  C07D317/30 ,  C07F5/02 ,  C07D233/54 ,  C07D207/32 ,  C07D295/08 ,  C07D295/12 ,  C07D295/14 ,  C07C323/12 ,  C07C323/58 ,  C07C31/125 ,  A61K31/7088 ,  A61K31/7105

摘要： The present invention relates to a cationic lipid having one or more biodegradable groups located in a lipidic moiety (e.g., a hydrophobic chain) of the cationic lipid. These cationic lipids may be incorporated into a lipid particle for delivering an active agent, such as a nucleic acid. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggregation, a cationic lipid of the present invention, and optionally, a sterol. The lipid particle may further include a therapeutic agent such as a nucleic acid.

公开(公告)号：US20220249670A1

公开(公告)日：2022-08-11

申请号：US17651017

申请日：2022-02-14

申请人： ALNYLAM PHARMACEUTICALS, INC.

发明人： Martin Maier ,  Muthusamy Jayaraman ,  Akin Akinc ,  Shigeo Matsuda ,  Pachamuthu Kandasamy ,  Kallanthottahil G. Rajeev ,  Muthiah Manoharan

IPC分类号： A61K47/18 ,  A61K9/127 ,  A61K9/51 ,  A61K31/713 ,  C07D317/30 ,  C07C211/09 ,  C07C211/10 ,  C07C211/11 ,  C07C217/08 ,  C07C229/12 ,  C07C327/22 ,  C07C327/28 ,  C07C327/32 ,  C07C235/06 ,  C07C251/38 ,  C07F5/02 ,  C07D233/54 ,  C07D207/32 ,  C07D295/08 ,  C07D295/12 ,  C07D295/14 ,  C07C323/12 ,  C07C323/58 ,  C07C31/125 ,  A61K31/7088 ,  A61K31/7105

摘要： The present invention relates to a cationic lipid having one or more biodegradable groups located in a lipidic moiety (e.g., a hydrophobic chain) of the cationic lipid. These cationic lipids may be incorporated into a lipid particle for delivering an active agent, such as a nucleic acid. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggregation, a cationic lipid of the present invention, and optionally, a sterol. The lipid particle may further include a therapeutic agent such as a nucleic acid.

公开(公告)号：US20210277030A1

公开(公告)日：2021-09-09

申请号：US17316185

申请日：2021-05-10

申请人： TAKEDA PHARMACEUTICAL COMPANY LIMITED

发明人： Satoshi Yamamoto ,  Junya Shirai ,  Mitsunori Kono ,  Yoshihide Tomata ,  Ayumu Sato ,  Atsuko Ochida ,  Yoshiyuki Fukase ,  Shoji Fukumoto ,  Tsuneo Oda ,  Hidekazu Tokuhara ,  Naoki Ishii ,  Yusuke Sasaki

IPC分类号： C07F7/08 ,  C07D205/04 ,  C07D207/12 ,  C07K5/065 ,  C07D239/36 ,  C07D213/64 ,  C07D309/06 ,  C07D333/38 ,  C07F7/10 ,  C07D403/06 ,  C07D271/10 ,  C07C237/22 ,  C07D295/14 ,  C07D207/26 ,  C07D413/12 ,  C07F7/30 ,  C07D233/72 ,  C07D309/08 ,  C07D231/56 ,  C07D261/08 ,  C07D209/18 ,  C07D405/12 ,  C07D261/12 ,  C07D239/54 ,  C07D211/62 ,  C07D237/14 ,  C07D231/12 ,  C07D487/04 ,  A61P43/00 ,  A61P29/00 ,  A61P25/00 ,  A61P19/02 ,  A61P17/06 ,  A61P1/04 ,  C07K5/087

摘要： The present invention relates to compound (I) or a salt thereof which has a RORγt inhibitory action. In the formula (I), each symbol is as defined in the specification.

公开(公告)号：US20180065943A1

公开(公告)日：2018-03-08

申请号：US15808242

申请日：2017-11-09

申请人： PFIZER INC.

发明人： CHRISTOPHER RYAN BUTLER ,  LAURA ANN MCALLISTER ,  ELIZABETH MARY BECK ,  MICHAEL AARON BRODNEY ,  ADAM MATTHEW GILBERT ,  CHRISTOPHER JOHN HELAL ,  DOUGLAS SCOTT JOHNSON ,  JUSTIN IAN MONTGOMERY ,  STEVEN VICTOR O'NEIL ,  BRUCE NELSEN ROGERS ,  PATRICK ROBERT VERHOEST ,  DAMIEN WEBB

IPC分类号： C07D295/14 ,  C07D405/14 ,  C07D413/14 ,  C07D515/10 ,  C07D471/08 ,  C07D211/48 ,  C07D487/04 ,  C07D471/10 ,  C07D401/12 ,  C07D491/107 ,  C07D498/10 ,  C07D403/04 ,  C07D401/04 ,  C07D401/14 ,  C07D493/10 ,  C07D405/12 ,  C07F9/6561

CPC分类号： C07D295/14 ,  C07D211/48 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D405/12 ,  C07D405/14 ,  C07D413/14 ,  C07D471/08 ,  C07D471/10 ,  C07D487/04 ,  C07D491/107 ,  C07D493/10 ,  C07D498/10 ,  C07D515/10 ,  C07F9/6561

摘要： The present invention provides, in part, compounds of Formula I: and pharmaceutically acceptable salts thereof; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compounds or salts, and their uses for treating MAGL-mediated diseases and disorders including, e.g., pain, an inflammatory disorder, traumatic brain injury, depression, anxiety, Alzheimer's disease, a metabolic disorder, stroke, or cancer.

公开(公告)号：US09223210B2

公开(公告)日：2015-12-29

申请号：US14391170

申请日：2013-02-28

申请人： TOYO GOSEI CO., LTD.

发明人： Toru Shibuya

IPC分类号： G03F7/12 ,  C08F116/06 ,  C07D233/60 ,  C07D263/38 ,  C07C247/16 ,  G03F7/012 ,  C07D233/61 ,  C07C233/83 ,  C07D263/42 ,  C07C247/18 ,  C07D295/14 ,  G03F7/008 ,  G03F7/038

CPC分类号： G03F7/012 ,  C07C233/83 ,  C07C247/16 ,  C07C247/18 ,  C07D233/60 ,  C07D233/61 ,  C07D263/38 ,  C07D263/42 ,  C07D295/14 ,  C08F116/06 ,  G03F7/008 ,  G03F7/0125 ,  G03F7/0388

摘要： A photosensitive compound represented by formula (1) or formula (2). (Chemical formula 1) (In formula (1) and formula (2), n is an integer of 1-3; R1 is a linear or branched alkyl group having 1-6 carbon atoms or an alkylene group having 2-6 carbon atoms formed from two R1 together; R2 is —NR3R4; R3 and R4 are each independently a linear or branched alkyl group or alkenyl group having 1-6 carbon atoms, a linear or branched alkylene group having 2-6 carbon atoms formed by R3 and R4 together, or a linear or branched alkylene group or alkenylene group having 3-8 carbon atoms optionally containing an oxygen atom or nitrogen atom.)

摘要翻译： 由式（1）或式（2）表示的光敏化合物。 （化学式1）（式（1）和式（2）中，n为1〜3的整数，R 1为碳原子数1〜6的直链或支链烷基或碳原子数2〜6的亚烷基 由两个R 1一起形成; R 2是-NR 3 R 4; R 3和R 4各自独立地是具有1-6个碳原子的直链或支链烷基或烯基，由R3和R4形成的具有2-6个碳原子的直链或支链亚烷基 一起或具有任选含有氧原子或氮原子的具有3-8个碳原子的直链或支链亚烷基或亚烯基）

公开(公告)号：US09125913B2

公开(公告)日：2015-09-08

申请号：US14058159

申请日：2013-10-18

申请人： AbbVie Inc.

发明人： Milan Bruncko ,  Hong Ding ,  George A. Doherty ,  Steven W. Elmore ,  Lisa Hasvold ,  Laura A. Hexamer ,  Aaron R. Kunzer ,  Robert A. Mantei ,  William J. McClellan ,  Chang H. Park ,  Cheol-Min Park ,  Andrew M. Petros ,  Xiaohong Song ,  Andrew J. Souers ,  Gerard M. Sullivan ,  Zhi-Fu Tao ,  Gary T. Wang ,  Le Wang ,  Xilu Wang ,  Michael D. Wendt

IPC分类号： A61K31/495 ,  A61K31/496 ,  A61K31/501 ,  A61K31/5377 ,  C07D209/32 ,  C07D211/96 ,  C07D213/64 ,  C07D215/20 ,  C07D217/16 ,  C07D231/56 ,  C07D235/26 ,  C07D249/04 ,  C07D295/125 ,  C07D295/14 ,  C07D309/14 ,  C07D401/12 ,  C07D405/12 ,  C07D405/14 ,  C07D417/12 ,  C07D471/04 ,  A61K31/407 ,  A61K45/06 ,  C07D241/04 ,  C07D401/06 ,  C07D403/06 ,  C07D405/06 ,  C07D413/06 ,  C07D487/04

CPC分类号： C07D401/12 ,  A61K31/407 ,  A61K31/495 ,  A61K31/496 ,  A61K31/501 ,  A61K31/5377 ,  A61K45/06 ,  C07D209/08 ,  C07D209/32 ,  C07D211/58 ,  C07D211/96 ,  C07D213/64 ,  C07D215/20 ,  C07D217/16 ,  C07D231/56 ,  C07D235/26 ,  C07D241/04 ,  C07D249/04 ,  C07D295/125 ,  C07D295/14 ,  C07D295/155 ,  C07D309/04 ,  C07D309/14 ,  C07D401/06 ,  C07D403/06 ,  C07D405/06 ,  C07D405/12 ,  C07D405/14 ,  C07D413/06 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04

摘要： Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 or Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which are expressed anti-apoptotic Bcl-2 protein.

摘要翻译： 公开了抑制抗凋亡Bcl-2或Bcl-xL蛋白的活性的化合物，含有该化合物的组合物和治疗疾病的方法，其中表达抗凋亡Bcl-2蛋白。