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    End-functionalized polymers
    3.
    发明授权
    End-functionalized polymers 有权

    公开(公告)号：US10316114B2

    公开(公告)日：2019-06-11

    申请号：US13638191

    申请日：2011-03-29

    申请人： Huiguang Kou ,  Andreas Moeck ,  Clemens Auschra ,  Peter Nesvadba ,  Frank Oliver Heinrich Pirrung ,  Andreas Gernandt

    发明人： Huiguang Kou ,  Andreas Moeck ,  Clemens Auschra ,  Peter Nesvadba ,  Frank Oliver Heinrich Pirrung ,  Andreas Gernandt

    IPC分类号： C08F16/12 ,  C08F12/08 ,  C08F20/12 ,  C08F293/00 ,  C08F8/44 ,  C08F8/00 ,  C08F8/30 ,  C08F8/42 ,  C08F2/00 ,  C08F20/54 ,  C08F26/10 ,  C08F36/06 ,  C08F36/08

    摘要： This invention relates to end-functionalized living polymers or copolymers having a structure represented by the general formula 1 or 2, wherein R1 is a hydrogen atom, a methyl group, or a radically non-polymerizable organic group containing 1 to 20 carbon atoms. R2 is a functional end group of a vinyl hetero monomer selected from the group consisting of hydroxy, epoxy, silyl, NH2, NH(C1-C6alkyl), N(C1-C6alkyl)2, —CH═CH2, —C≡CH, —C(CH3)═CH2, —O—CH═CH2, (—O—CH2—CH2)1-10—OH, —OR20, —COOR20, —CONHR20, —OCONHR20, —OCOR20 and —NH—CO—R20, wherein R20 is linear or branched C1-C20 alkyl or linear or branched C1-C20 alkyl substituted with hydroxy, epoxy, silyl, NH2 or N(C1-C6alkyl)2; or R20 is phenyl, benzyl, —CH═CH2, —C≡CH or —C(CH3)═CH2, or R2 is a residue of an acrylic acid (CH2═CH—COO—*), methacrylic acid, (CH2═C(CH3)—COO—*) or CH(CH3)═CH—COO—* or R2 is a residue of a dicarboxylic acid HOOC—Rc—COO—* or C1-C6alkyl-OOC—Rc—COO—* wherein Rc is C1-C20 alkylene, C1-C20alkenylene or phenylene; or R2 is a residue derived from the reaction of an isocyanate Ra—NCO with the hydroxy group or with the amine group of the vinyl hetero monomer, said residue being Ra—NHCOO—* or Ra—NHCO—NH—* wherein Ra is unsubstituted C1-C20alkyl, C1-C20cycloalkyl or C1-C20alkyl substituted with hydroxy, epoxy, silyl, NH2, NH(C1-C6alkyl) or N(C1-C6alkyl)2; or R2 is a residue derived from the reaction of a diisocyanate residue OCN—Rb—NCO with the hydroxy group or with the amine group of the vinyl hetero monomer, said residue being *—OOC—NH—Rb—NCO or *—HNOC—NH—Rb—NCO or *—OOC—NH—Rb—NHCOR30 wherein Rb is C1-C20 alkylene or C1-C20cycloalkylene or phenylene and R30 is a residue of hydroxyethylacrylate (CH2═CH—COO—(CH2)2—O*), hydroxyethylmethacrylate (CH2═C(CH3)—COO—(CH2)2—O*), hydroxybutylacrylate (CH2═CH—COO—(CH2)4—O*) or hydroxybutylmethacrylate (CH2═C(CH3)—COO—(CH2)4—O*), A is the hetero atom of the vinyl hetero monomer selected from the group consisting of oxygen, nitrogen, sulfur and silicon; and if R2 is silyl and M is a direct bond, A is a direct bond; M is a bond or a divalent group linking the heteroatom of the vinyl hetero monomer and the functional end group of the vinyl hetero monomer said M being selected from the group consisting of C1-50 alkylene, C1-50 (hetero)alkylene, arylene and heteroarylene; X is a halogen atom, a nitroxide group or a sulphide group, Zn is a polymer or copolymer segment of random-, gradient- or block-type structure, which is built up from vinylic monomers selected from the group consisting of isoprene, 1,3-butadiene, α-C5-18alkene, 4-vinyl-pyridine, 2-vinyl-pyridine, vinyl-imidazole, N-vinylpyrrolidone, dimethylacrylamide, 3-dimethylamino-propylmethacrylamide, styrene, substituted styrene and a compound of formula CH2═C(R3)—C(═R4)—R5, wherein R3 is a hydrogen atom or a methyl group, R4 is oxygen atom or sulfur atom; R5 is NH2, hydroxy, unsubstituted C1-18 alkoxy, C2-100alkoxy interrupted by at least one N and/or O atom, hydroxy-substituted C1-18alkoxy, unsubstituted C1-18alkylamino, di(C1-18alkyl)amino, hydroxy-substituted C1-18alkylamino, hydroxy-substituted di(C1-18alkyl)amino or —O—CH2—CH2—N(CH3)2; Y is the chain terminus of the polymer/copolymer Zn and Y represents the fragment of a polymerization initiator capable of initiating polymerization; Y1 represents a di-, tri- or polyvalent fragment of a di-, tri-, or polyfunctional NMP initiator; m is 2, 3 or 4, preferably 2; n is the number of monomer units Z and is between 10 and 5000.

    POLY AND COPOLY(N-VINYLAMIDE)S AND THEIR USE IN CAPILLARY ELECTROPHORESIS
    6.
    发明申请
    POLY AND COPOLY(N-VINYLAMIDE)S AND THEIR USE IN CAPILLARY ELECTROPHORESIS 审中-公开

    公开(公告)号：US20170356877A1

    公开(公告)日：2017-12-14

    申请号：US15595439

    申请日：2017-05-15

    申请人： Applied Biosystems, LLC

    发明人： Aldrich N.K. Lau

    IPC分类号： G01N27/447 ,  C08F20/54

    CPC分类号： G01N27/44747 ,  C08F20/54 ,  G01N27/44752

    摘要： The invention relates generally to polymers and copolymers comprising N-vinylamide-type monomers, their preparation, and compositions, such as electrophoresis separation media, containing the same; to supports, such as capillaries, containing these polymers; and methods for separating a mixture of biomolecules, especially polynucleotides, using capillary electrophoresis. Separation media comprising such polymers yield advantageous performance in the analysis and separation of biomolecules by capillary electrophoresis.

    Poly and copoly(N-vinylamide)s and their use in capillary electrophoresis
    7.
    发明授权
    Poly and copoly(N-vinylamide)s and their use in capillary electrophoresis 有权

    公开(公告)号：US09671367B2

    公开(公告)日：2017-06-06

    申请号：US14148401

    申请日：2014-01-06

    申请人： Applied Biosystems, LLC

    发明人： Aldrich N. K. Lau

    IPC分类号： G01N27/447 ,  C08F20/54

    CPC分类号： G01N27/44747 ,  C08F20/54 ,  G01N27/44752

    摘要： The invention relates generally to polymers and copolymers comprising N-vinylamide-type monomers, their preparation, and compositions, such as electrophoresis separation media, containing the same; to supports, such as capillaries, containing these polymers; and methods for separating a mixture of biomolecules, especially polynucleotides, using capillary electrophoresis. Separation media comprising such polymers yield advantageous performance in the analysis and separation of biomolecules by capillary electrophoresis.