-
公开(公告)号：WO2009079052A3
公开(公告)日：2009-08-20
申请号：PCT/US2008077092
申请日：2008-09-19
Applicant: APPLIED BIOSYSTEMS , YANG JOON MO , LIU DAVID M , CHIANG YUH-MIN , SCHEMBRI CAROL , LAU ALDRICH N K , ULMANELLA UMBERTO , BEARD NIGEL P , SHARIATI MARYAM , NURSE JAMES C , HAGA DOUWE D , HARDING IAN A , FOCARACCI JULIO P
Inventor： YANG JOON MO , LIU DAVID M , CHIANG YUH-MIN , SCHEMBRI CAROL , LAU ALDRICH N K , ULMANELLA UMBERTO , BEARD NIGEL P , SHARIATI MARYAM , NURSE JAMES C , HAGA DOUWE D , HARDING IAN A , FOCARACCI JULIO P
IPC: B01L3/00
CPC classification number: B01L3/502707 , B01L7/52 , B01L2200/141 , B01L2300/0816 , B01L2300/1805 , B01L2300/1861 , B01L2400/0677
Abstract: An assay card and devices and methods for isolating chambers on the assay card are described. The assay card comprises a substrate formed of one or more materials, e.g., plastic, having a softening temperature, the substrate defining channels communicating with respective reaction chambers. The assay card may be heated in a region of the channels to at least the softening temperature. The softened plastic may be deformed, e.g., with a tool which may or may not also provide the heat for softening the substrate. In this manner, the plastic of the substrate may be caused to at least partially obstruct the channels, thereby isolating the reaction chambers. The invention also relates to a method of manufacturing a tool device that includes pins for heating and deforming an assay card.
Abstract translation: 描述了用于在测试卡上隔离室的测定卡和装置和方法。 测定卡包括由一种或多种具有软化温度的材料（例如塑料）形成的衬底，衬底限定通道与各个反应室连通。 测定卡可以在通道的区域中被加热到至少软化温度。 软化的塑料可能变形，例如用可能也可能不提供用于软化基底的热量的工具。 以这种方式，可以使衬底的塑料至少部分地阻碍通道，从而隔离反应室。 本发明还涉及一种制造工具装置的方法，该工具装置包括用于加热和变形分析卡的销。
-
公开(公告)号：WO2007002588A2
公开(公告)日：2007-01-04
申请号：PCT/US2006/024809
申请日：2006-06-23
Applicant: APPLERA CORPORATION , SANDALL, Donald R. , SOMACK, Ralph , HARDING, Ian A. , LEHTO, Dennis
Inventor： SANDALL, Donald R. , SOMACK, Ralph , HARDING, Ian A. , LEHTO, Dennis
IPC: B01L3/02
CPC classification number: B01L3/502 , B01L3/0275 , B01L7/52 , B01L2200/0642 , B01L2300/0809 , B01L2300/0864 , B01L2400/0478 , B01L2400/0487 , B01L2400/0638 , B01L2400/0644 , G01N2035/103 , G01N2035/1032 , G01N2035/1034 , G01N2035/1062
Abstract: A pipette tip and system for aspiration of a biological sample, distribution to a plurality of sample chambers, and thermal cycling in the pipette tip.
Abstract translation: 用于抽吸生物样品的移液管尖端和系统，分配到多个样品室，以及移液管尖端中的热循环。
-
公开(公告)号：WO2006102352A3
公开(公告)日：2006-09-28
申请号：PCT/US2006/010291
申请日：2006-03-21
Applicant: APPLERA CORPORATION , KAO, H. Pin , HARDING, Ian A. , KARGER, Achim , OLDHAM, Mark F. , OSTADAN, Omead , YOUNG, Greg , HAYASHIBARA, Kathleen C. , LAIRD HYLAND, Fiona C. , PRATT, Mark R. , STEVENS, Junco F. , TOMANEY, Austin B.
Inventor： KAO, H. Pin , HARDING, Ian A. , KARGER, Achim , OLDHAM, Mark F. , OSTADAN, Omead , YOUNG, Greg , HAYASHIBARA, Kathleen C. , LAIRD HYLAND, Fiona C. , PRATT, Mark R. , STEVENS, Junco F. , TOMANEY, Austin B.
Abstract: A method of using a standard to correct for variability in sample handling, can comprise (a) adding a template of known concentration to an assay comprising a sample; (b) preamplifying the assay; (c) amplifying the assay; (d) collecting data during the amplifying; and (e) correcting the data using a comparison of data collected from the template to data collected from the sample.
-
公开(公告)号：WO2005072873A3
公开(公告)日：2005-09-15
申请号：PCT/US2004043770
申请日：2004-12-29
Applicant: APPLERA CORP , OLDHAM MARK F , HARDING IAN A , BODNER KEVIN S
Inventor： OLDHAM MARK F , HARDING IAN A , BODNER KEVIN S
IPC: B01L3/00
CPC classification number: B01L3/502723 , B01L2200/027 , B01L2200/0684 , B01L2300/0636 , B01L2300/0816 , B01L2300/087 , B01L2300/0887 , B01L2400/0406 , B01L2400/049 , B01L2400/06
Abstract: Microfluidic devices having a diffusion-aided system for loading samples into the microfluidic device (50) are provided. Methods of gas-venting a microfluidic device through a non-porous, gas permeable material sealing cover layer (54), for example, during liquid sample loading, are also provided. The non-porous, gas-permeable material can be, for example, a polysiloxane, for example, polydimethylsiloxane.
Abstract translation: 提供具有用于将样品加载到微流体装置（50）中的扩散辅助系统的微流体装置。 还提供了例如在液体样品加载期间通过无孔透气材料密封覆盖层（54）排气微流体装置的方法。 无孔透气材料可以是例如聚硅氧烷，例如聚二甲基硅氧烷。
-
5.发明申请
公开(公告)号：WO2009079052A2
公开(公告)日：2009-06-25
申请号：PCT/US2008/077092
申请日：2008-09-19
Applicant: APPLIED BIOSYSTEMS INC. , YANG, Joon Mo , LIU, David, M. , CHIANG, Yuh-Min , SCHEMBRI, Carol , LAU, Aldrich, N. K. , ULMANELLA, Umberto , BEARD, Nigel, P. , SHARIATI, Maryam , NURSE, James, C. , HAGA, Douwe, D. , HARDING, Ian, A. , FOCARACCI, Julio, P.
Inventor： YANG, Joon Mo , LIU, David, M. , CHIANG, Yuh-Min , SCHEMBRI, Carol , LAU, Aldrich, N. K. , ULMANELLA, Umberto , BEARD, Nigel, P. , SHARIATI, Maryam , NURSE, James, C. , HAGA, Douwe, D. , HARDING, Ian, A. , FOCARACCI, Julio, P.
CPC classification number: B01L3/502707 , B01L7/52 , B01L2200/141 , B01L2300/0816 , B01L2300/1805 , B01L2300/1861 , B01L2400/0677
Abstract: An assay card and devices and methods for isolating chambers on the assay card are described. The assay card comprises a substrate formed of one or more materials, e.g., plastic, having a softening temperature, the substrate defining channels communicating with respective reaction chambers. The assay card may be heated in a region of the channels to at least the softening temperature. The softened plastic may be deformed, e.g., with a tool which may or may not also provide the heat for softening the substrate. In this manner, the plastic of the substrate may be caused to at least partially obstruct the channels, thereby isolating the reaction chambers. The invention also relates to a method of manufacturing a tool device that includes pins for heating and deforming an assay card.
Abstract translation: 描述了用于隔离化验卡上的室的化验卡和装置以及方法。 测定卡包括由具有软化温度的一种或多种材料（例如塑料）形成的基底，基底限定与相应反应室连通的通道。 可以在通道的区域中将测定卡加热到至少软化温度。 软化的塑料可以变形，例如用可以或不可以提供软化基材的热量的工具。 以这种方式，可以使衬底的塑料至少部分地阻塞通道，从而隔离反应室。 本发明还涉及一种制造工具装置的方法，所述工具装置包括用于加热和使检定卡变形的销。
-
Patent Agency Ranking
公开(公告)号：WO2006116616A3
公开(公告)日：2007-09-27
申请号：PCT/US2006016060
申请日：2006-04-26
Applicant: APPLERA CORP , YUE MIN , LIU DAVID M , CHIANG YUH-MIN , YANG JOON MO , LEHTO DENNIS , VANN CHARLES S , BEARD NIGEL P , HARDING IAN A , VAN CAMP JOHN , DROMARETSKY ALEXANDER , ERMAKOV SERGEY V , OLDHAM MARK F , ROY JOY , SHARIATI MARYAM , ULMANELLA UMBERTO
Inventor： YUE MIN , LIU DAVID M , CHIANG YUH-MIN , YANG JOON MO , LEHTO DENNIS , VANN CHARLES S , BEARD NIGEL P , HARDING IAN A , VAN CAMP JOHN , DROMARETSKY ALEXANDER , ERMAKOV SERGEY V , OLDHAM MARK F , ROY JOY , SHARIATI MARYAM , ULMANELLA UMBERTO
IPC: C12M1/38
CPC classification number: C12Q1/6806 , B01J2219/00317 , B01J2219/00722 , B01L3/502707 , B01L3/502723 , B01L3/50853 , B01L2200/0684 , B01L2200/0689 , B01L2200/16 , B01L2300/041 , B01L2300/048 , B01L2300/0636 , B01L2300/0816 , B01L2300/0829 , B01L2300/0864 , B01L2300/087 , B01L2400/0481 , B01L2400/0487 , B01L2400/0655 , B01L2400/0694 , G01N35/028 , Y10T436/2575
Abstract: Systems and methods for multiple analyte detection include a system for distribution of a biological sample that includes a substrate, wherein the substrate includes a plurality of sample chambers, a sample introduction channel for each sample chamber, and a venting channel for each sample chamber. The system may further include a preloaded reagent contained in each sample chamber and configured for nucleic acid analysis of a biological sample that enters the substrate and a sealing instrument configured to be placed in contact with the substrate to seal each sample chamber so as to substantially prevent sample contained in each sample chamber from flowing out of each sample chamber. The substrate can be constructed of detection-compatible and assay-compatible materials.
Abstract translation: 用于多个分析物检测的系统和方法包括用于分配包括衬底的生物样品的系统，其中所述衬底包括多个样品室，用于每个样品室的样品引入通道和用于每个样品室的排气通道。 该系统可以进一步包括包含在每个样品室中并被配置用于进入基底的生物样品的核酸分析的预加载试剂和被配置为与基底接触以密封每个样品室以便基本上防止 每个样品室中包含的样品从每个样品室流出。 底物可以由检测兼容和测定相容的材料构成。
-
公开(公告)号：WO2006102421A2
公开(公告)日：2006-09-28
申请号：PCT/US2006010424
申请日：2006-03-21
Applicant: APPLERA CORP , CARRILLO ALBERT L , FAWCETT ADRIAN , HARDING IAN A , LU MIKE Y , OLDHAM MARK F
Inventor： CARRILLO ALBERT L , FAWCETT ADRIAN , HARDING IAN A , LU MIKE Y , OLDHAM MARK F
CPC classification number: B01L3/0268 , B01L3/5025 , B01L3/5027 , B01L3/50851 , B01L3/50853 , B01L7/52 , B01L2200/021 , B01L2200/0605 , B01L2200/0642 , B01L2200/0689 , B01L2200/142 , B01L2300/021 , B01L2300/044 , B01L2300/0829 , B01L2300/0864 , B01L2400/0406 , B01L2400/0409 , B01L2400/0487 , G01N35/04
Abstract: In a high-density sequence detection system, an apparatus for transporting a microplate. A control system provides a thermocycler control signal to regulate a desired thermal output of a thermocycler block. A frame has a first side, a second side, and an opening that extends through the first side and the second side. A window is positioned in the opening and a circumferential seal is positioned around a periphery of the opening at the second side. The seal has a peripheral lip that seals against the microplate. A clamp is adapted to engage and displace the frame from an unclamped position to a clamped position, wherein in the unclamped position, the microplate is displaced away from the thermocycler block and in the clamped position, the clamp urges the microplate against the thermocycler block. In some embodiments the peripheral lip is positioned radially inward of the periphery of the opening.
Abstract translation: 在高密度序列检测系统中，用于运输微板的设备。 控制系统提供热循环仪控制信号以调节热循环仪模块的期望热输出。 框架具有第一侧，第二侧以及延伸穿过第一侧和第二侧的开口。 窗口定位在开口中并且周向密封件围绕第二侧的开口的周边定位。 该密封件具有密封在微板上的周边唇缘。 夹具适合于将框架从非夹紧位置接合和移位到夹紧位置，其中在未夹紧位置中，微板远离热循环器块移动，并且在夹紧位置，夹子促使微板抵靠热循环器块。 在一些实施例中，外围唇缘位于开口周边的径向内侧。
-
公开(公告)号：WO2006102297A1
公开(公告)日：2006-09-28
申请号：PCT/US2006/010172
申请日：2006-03-21
Applicant: APPLERA CORPORATION , SANDELL, Donald , CARRILLO, Albert, L. , FAWCETT, Adrian , HARDING, Ian, A. , LIM, Gary
Inventor： SANDELL, Donald , CARRILLO, Albert, L. , FAWCETT, Adrian , HARDING, Ian, A. , LIM, Gary
CPC classification number: B01L3/0268 , B01L3/50851 , B01L3/50853 , B01L7/52 , B01L9/523 , B01L2200/021 , B01L2200/025 , B01L2200/0605 , B01L2200/0642 , B01L2200/142 , B01L2300/021 , B01L2300/044 , B01L2300/0829 , B01L2300/0864 , B01L2300/1883 , B01L2400/0406 , B01L2400/0409 , B01L2400/0487 , G01N21/6452 , G01N35/028 , G01N2035/00287
Abstract: An automated seal applicator for applying a sealing cover to a microplate. The microplate can comprise a plurality of wells for receiving an assay. The automated seal applicator can comprise a housing and a removable sealing cover cassette containing a sealing cover roll. The sealing cover roll can comprise an elongated carrier liner and a plurality of individual sealing covers releasably carried on the elongated carrier liner. The sealing cover cassette can be selectively engagable with the housing. A sealing cover drive system can engage the sealing cover roll and maintain a predetermined alignment of each of the plurality of individual sealing covers relative to the microplate.
Abstract translation: 一种用于将密封盖施加到微孔板的自动密封施加器。 微孔板可以包括用于接收测定的多个孔。 自动密封施加器可以包括容纳密封盖辊的壳体和可移除的密封盖盒。 密封盖辊可以包括细长的载体衬里和可释放地承载在细长载体衬套上的多个单独的密封盖。 密封盖盒可以选择性地与壳体接合。 密封盖驱动系统可以接合密封盖辊并且保持多个单个密封盖中的每一个相对于微板的预定对准。
-
公开(公告)号：WO2007002588A3
公开(公告)日：2008-04-17
申请号：PCT/US2006024809
申请日：2006-06-23
Applicant: APPLERA CORP , SANDALL DONALD R , SOMACK RALPH , HARDING IAN A , LEHTO DENNIS
Inventor： SANDALL DONALD R , SOMACK RALPH , HARDING IAN A , LEHTO DENNIS
IPC: B01L3/02
CPC classification number: B01L3/502 , B01L3/0275 , B01L7/52 , B01L2200/0642 , B01L2300/0809 , B01L2300/0864 , B01L2400/0478 , B01L2400/0487 , B01L2400/0638 , B01L2400/0644 , G01N2035/103 , G01N2035/1032 , G01N2035/1034 , G01N2035/1062
Abstract: A pipette tip and system for aspiration of a biological sample, distribution to a plurality of sample chambers, and thermal cycling in the pipette tip.
Abstract translation: 用于抽吸生物样品的移液管尖端和系统，分配到多个样品室，以及移液管尖端中的热循环。
-
公开(公告)号：WO2006116616A2
公开(公告)日：2006-11-02
申请号：PCT/US2006/016060
申请日：2006-04-26
Applicant: APPLERA CORPORATION , YUE, Min , LIU, David M. , CHIANG, Yuh-Min , YANG, Joon Mo , LEHTO, Dennis , VANN, Charles S. , BEARD, Nigel P. , HARDING, Ian A. , VAN CAMP, John , DROMARETSKY, Alexander , ERMAKOV, Sergey V. , OLDHAM, Mark F. , ROY, Joy , SHARIATI, Maryam , ULMANELLA, Umberto
Inventor： YUE, Min , LIU, David M. , CHIANG, Yuh-Min , YANG, Joon Mo , LEHTO, Dennis , VANN, Charles S. , BEARD, Nigel P. , HARDING, Ian A. , VAN CAMP, John , DROMARETSKY, Alexander , ERMAKOV, Sergey V. , OLDHAM, Mark F. , ROY, Joy , SHARIATI, Maryam , ULMANELLA, Umberto
IPC: G01N33/00
CPC classification number: C12Q1/6806 , B01J2219/00317 , B01J2219/00722 , B01L3/502707 , B01L3/502723 , B01L3/50853 , B01L2200/0684 , B01L2200/0689 , B01L2200/16 , B01L2300/041 , B01L2300/048 , B01L2300/0636 , B01L2300/0816 , B01L2300/0829 , B01L2300/0864 , B01L2300/087 , B01L2400/0481 , B01L2400/0487 , B01L2400/0655 , B01L2400/0694 , G01N35/028 , Y10T436/2575
Abstract: Systems and methods for multiple analyte detection include a system for distribution of a biological sample that includes a substrate, wherein the substrate includes a plurality of sample chambers, a sample introduction channel for each sample chamber, and a venting channel for each sample chamber. The system may further include a preloaded reagent contained in each sample chamber and configured for nucleic acid analysis of a biological sample that enters the substrate and a sealing instrument configured to be placed in contact with the substrate to seal each sample chamber so as to substantially prevent sample contained in each sample chamber from flowing out of each sample chamber. The substrate can be constructed of detection-compatible and assay-compatible materials.
Abstract translation: 用于多个分析物检测的系统和方法包括用于分配包括衬底的生物样品的系统，其中所述衬底包括多个样品室，用于每个样品室的样品引入通道和用于每个样品室的排气通道。 该系统可以进一步包括包含在每个样品室中并被配置用于进入基底的生物样品的核酸分析的预加载试剂和被配置为与基底接触以密封每个样品室以便基本上防止 每个样品室中包含的样品从每个样品室流出。 底物可以由检测兼容和测定相容的材料构成。
-
-
-
-
-
-
-
-
-
Search Results
19
records
(took 0.023 seconds)
