摘要:
Disclosed herein are gemini surfactants, and methods for making and using these gemini surfactants. These gemini surfactants may be incorporated in paints and coatings to provide hydrophilic and/or self-cleaning properties. Coatings and paints are routinely used to beautify and protect substrates. The most simple coatings and paints are made of a polymer (the binder) in a solvent (the vehicle), which is commonly called a lacquer. Paints and coatings modify the appearance of an object by adding color, gloss, or texture, and by blending with or differentiating from a surrounding environment.
摘要:
The invention relates to a process wherein one or more polyamines, each with one or more -NH 2 functions and one or more second amine functions, said second amine functions having a lower lactone reactivity than said -NH 2 functions, is reacted in a first step with one or more lactones, hydroxyacids, cyclic carbonates, or mixtures thereof, to form a polyamine-derived compound with amide and/or urethane groups, which polyamine-derived compound is reacted in a second step with one or more at least bifunctional amine-specific reagents to form an intermediate optionally comprising ester and/or carbonate groups, wherein in the second step optionally an additional amine modifier is co-reacted and in the intermediate at least two polyamine residues, or if a modifier is coreacted, at least one polyamine residue and at least one optional amine modifier residue, are linked by said bifunctional amine-specific reagent. The invention further relates to polyamine derivatives and the use thereof as a pigment dispersant.
摘要:
The invention provides a compound containing a head group based on urea, glycerol or glycerate and a tail selected from the group consisting of a branched alkyl chain, a branched alkyloxy chain or an alkenyl chain. The compounds may be used as surfactants to form a lyotropic phase that is stable in excess polar solution.
摘要:
Compounds of formula (I) and salts and prodrugs thereof wherein, Q is optionally substituted phenyl, heteroaryl or naphthyl; X and Y are each H, C1-6 alkyl, C2-6 alkenyl or X and Y are together =O; Z is O or S; R is H, optionally substituted C1-6 alkyl, optionally substituted phenyl(C1-4 alkyl), C2-6 alkylene, COC1-6 alkylhalo, COR , COOR , CONHR , COC1-6alkylNR R or CONR C1-6alkylCONR R ; R is substituted C1-6 alkyl, optionally substituted phenyl(C1-4 alkyl), C2-6 alkylene, C1-6alkylhalo, COR , COOR , CONHR , COC1-6alkylNR R or CONR C1-6alkylCONR R ; or R and R together form a chain (CH2)p optionally substituted by oxo; R is H or C1-6 alkyl; R is H, C1-6 alkyl or phenyl; and R is optionally substituted (CH2)qphenyl; are tachykinin antagonists useful for treating pain.
摘要翻译:式(I)化合物及其盐和前药,其中Q为任选取代的苯基,杂芳基或萘基; X和Y各自为H,C 1-6烷基,C 2-6烯基或X和Y一起为= O; Z是O或S; R 1是H,任选取代的C 1-6烷基,任选取代的苯基(C 1-4烷基),C 2-6亚烷基,COC 1-6烷基卤素,COR a,COOR a,CONHR a,COCl C 1-6烷基NR a R a或CONR a C 1-6烷基CONR a R b; R 2是取代的C 1-6烷基,任选取代的苯基(C 1-4烷基),C 2-6亚烷基,C 1-6烷基卤素,COR a,COOR a,CONHR a,COC 1-6烷基, R b或CONR C 1-6烷基CONR a R b; 或R 1和R 2一起形成任选被氧代取代的链(CH 2)p; R 3是H或C 1-6烷基; R 4是H,C 1-6烷基或苯基; 和R 5是任选取代的(CH 2)q苯基; 是用于治疗疼痛的速激肽拮抗剂。
摘要:
Compounds of formula (I), and salts and prodrugs thereof, wherein Q represents a group (a) where W represents a bond, O, S, -CH2CH2-, -CH=CH- or NR ; and one or both of the phenyl rings may be replaced by a heteroaryl moiety; X and Y each represent H or X and Y together are =O; Z represents O, S or NR ; R and R independently represent H; optionally substituted C1-6 alkyl, optionally substituted phenyl(C0-4alkyl), C2-6 alkylene; COC1-6alkylhalo; COR ; COOR ; CONHR ; COC1-4alkylNR R ; or CONR C1-4alkylCONR R ; R represents H or C1-6alkyl; R represents H, C1-6 alkyl or phenyl; R represents optionally substituted (CH2)qphenyl; are tachykinin antagonists, useful for treating pain.
摘要:
Aryloxy- and heteroaryloxy-alkylene derivatives of amines of formula (I), wherein each of A and B is a group of formula (i) to (iii), wherein Y is -O-, -S- or -NR- in which R is hydrogen or C1-C6 alkyl; each of R3, R4, R5 and R6 is independently: a) hydrogen, halogen, hydroxy, cyano or nitro; b) C1-C6 alkyl unsubstituted or substituted by halogen; c) C1-C6 alkoxy or C1-C6 alkylthio; d) C1-C6 alkyl-sulfonyl; e) a substituted amine group -NR7R8; f) a -COR12 group; or g) two adjacent groups of R3, R4, R5 and R6, taken together, form a C1-C4 alkylenedioxy group; each of R1 and R2 independently is hydrogen, C3-C6 alkynyl, C3-C6 alkenyl or C1-C6 alkyl unsubstituted or substituted by phenyl; or R1 and R2 taken together with the nitrogen atom to which they are linked, form a substituted or unsubstituted, saturated heterocyclic ring; and the pharmaceutically acceptable salts thereof; are active on the central nervous system, in particular as antidepressant, antiobesity, antismoking and anti-alcoholabuse agents.
摘要:
The invention describes novel crosslinking compounds that include photoactivatable moieties. Several families of compounds are disclosed that can include one or more hydrophilic moieties that help to solubilize the compounds in aqueous environments.