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1.发明专利Enhanced production of lipid containing polyenoic fatty acid by high density culture of eukaryotic microorganism in fermentor 审中-公开通过高密度文化在发酵过程中增强含有多糖脂肪酸的脂肪酸
公开(公告)号：JP2014087375A
公开(公告)日：2014-05-15
申请号：JP2014027674
申请日：2014-02-17
Applicant: Dsm Ip Assets Bv , ディーエスエム アイピー アセッツ ビー.ブイ.
Inventor： REUCKER CRAIG M , DIMASI DON , HANSEN JON M , MIRRASOUL PETER J , BAILEY RICHARD B , VEEDER GEORGE T III , KANEKO TATSUO , BARCLAY WILLIAM R
IPC: C12N15/09 , C12P7/64 , A23B7/10 , A23D9/00 , A23L1/03 , C12N1/00 , C12N1/12 , C12N1/13 , C12N1/14 , C12N1/15 , C12R1/645 , C12R1/89
CPC classification number: A23K50/80 , A23D9/00 , A23K20/158 , A23L29/065 , A23V2002/00 , C11B1/10 , C12N1/00 , C12N1/12 , C12P7/6409 , C12P7/6427 , C12P7/6472 , Y10S435/911
Abstract: PROBLEM TO BE SOLVED: To provide a method for proliferating eukaryotic microorganisms which can produce lipids, in particular lipids containing polyenoic fatty acids, and a method for producing lipids of the eukaryotic microorganisms.SOLUTION: There are provided the method for proliferating eukaryotic microorganisms capable of producing at least about 20% of eukaryotic microorganism biomass as lipids, and the method for producing lipids of the same. The lipids preferably contain one or more polyenoic fatty acids, and a carbon source, preferably a non-alcohol carbon source, and restricted nutrient sources are added to a fermentation medium containing the eukaryotic microorganisms. The carbon source and the restricted nutrient sources are preferably added at a sufficient rate to increase biomass density of the fermentation medium at least at about 100 g/L.
Abstract translation: 要解决的问题：提供一种增殖能够产生脂质的真核微生物的方法，特别是含有多烯脂肪酸的脂质，以及用于生产真核微生物脂质的方法。提供了增殖真核微生物的方法，其能够 产生作为脂质的至少约20％的真核生物微生物，以及其生产脂质的方法。 脂质优选含有一种或多种多烯脂肪酸，并将碳源，优选非醇碳源和限制性营养源加入到含有真核微生物的发酵培养基中。 优选以足够的速率加入碳源和受限营养源，以将发酵培养基的生物质密度提高至至少约100g / L。
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2.发明专利Enhanced production of lipids containing polyenoic fatty acids by very high density cultures of eukaryotic microbes in fermentors 审中-公开通过非常高密度的文化产品，增加包含多烯酸脂肪酸的脂肪的生产
公开(公告)号：JP2013099366A
公开(公告)日：2013-05-23
申请号：JP2013041515
申请日：2013-03-04
Applicant: Dsm Ip Assets Bv , ディーエスエム アイピー アセッツ ビー.ブイ.
Inventor： REUCKER CRAIG M , DIMASI DON , HANSEN JON M , MIRRASOUL PETER J , BAILEY RICHARD B , VEEDER GEORGE T III , KANEKO TATSUO , BARCLAY WILLIAM R
IPC: C12N15/09 , C12P7/40 , A23B7/10 , A23D9/00 , A23L1/03 , C12N1/00 , C12N1/12 , C12N1/13 , C12P7/64 , C12R1/89
CPC classification number: A23K50/80 , A23D9/00 , A23K20/158 , A23L29/065 , A23V2002/00 , C11B1/10 , C12N1/00 , C12N1/12 , C12P7/6409 , C12P7/6427 , C12P7/6472 , Y10S435/911
Abstract: PROBLEM TO BE SOLVED: To provide a process for growing eukaryotic microorganisms which are capable of producing lipids, in particular lipids containing polyenoic fatty acids, and to provide a process for producing eukaryotic microbial lipids.SOLUTION: The present invention provides a process for growing eukaryotic microorganisms which are capable of producing at least about 20% of their biomass as lipids and a method for producing the lipids. Preferably the lipids contain one or more polyenoic fatty acids. The process comprises adding to a fermentation medium comprising eukaryotic microorganisms a carbon source, preferably a non-alcoholic carbon source, and a limited nutrient source. Preferably, the carbon source and the limited nutrient source are added at a rate sufficient to increase the biomass density of the fermentation medium to at least about 100 g/L.
Abstract translation: 待解决的问题：提供一种能够生产能够产生脂质的真核微生物的方法，特别是含有多烯脂肪酸的脂质，并提供一种生产真核微生物脂质的方法。 解决方案：本发明提供一种能够生产至少约20％的生物质作为脂质的真核微生物的方法和一种生产脂质的方法。 优选地，脂质含有一种或多种多烯脂肪酸。 该方法包括向包含真核微生物的发酵培养基中加入碳源，优选非酒精性碳源和有限营养源。 优选地，碳源和有限营养源以足以将发酵培养基的生物质密度增加至至少约100g / L的速率加入。 版权所有（C）2013，JPO＆INPIT
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公开(公告)号：JP4996033B2
公开(公告)日：2012-08-08
申请号：JP2002511601
申请日：2001-07-13
Applicant: アーチ パーソナル ケア プロダクツ、エル.ピー.
Inventor： シャエファー、ハンス , ショルツ、デュラント、ビー , パリシュ、デレク
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公开(公告)号：JP4486883B2
公开(公告)日：2010-06-23
申请号：JP2004514618
申请日：2003-04-10
Applicant: ディーエスエム アイピー アセッツ ビー.ブイ.
CPC classification number: C12N9/1085 , C12P23/00 , C12Y205/01021 , Y10S435/911
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公开(公告)号：JP2010042024A
公开(公告)日：2010-02-25
申请号：JP2009259658
申请日：2009-11-13
Applicant: Martek Biosciences Corp , マーテック・バイオサイエンシズ・コーポレイション
Inventor： BARCLAY WILLIAM R
IPC: C12P7/40 , A01N63/00 , A23B4/12 , A23C9/152 , A23L1/30 , A61K9/08 , A61K9/48 , A61K31/20 , A61K31/202 , A61K31/23 , A61K31/27 , A61K36/06 , A61P3/00 , A61P7/00 , A61P7/04 , A61P9/00 , A61P37/02 , A61P43/00 , C12N1/12 , C12P1/02 , C12P7/64 , C12R1/645
CPC classification number: C12P7/6472 , A23K10/18 , A23K20/158 , A23L29/065 , A23L33/12 , A23L33/40 , A23V2002/00 , A61K35/68 , A61K36/06 , C11B1/10 , C12P7/6427 , Y10S435/911 , Y10S435/946 , A23V2250/1862
Abstract: PROBLEM TO BE SOLVED: To economically produce arachidonic acid, and to provide a food formulated therewith. SOLUTION: Microorganisms of the genus Mortierella sect. schmuckeri are cultured in a fermentation medium preferably containing composite nitrogen source components. The arachidonic acid is a precursor of eicosanoid important as a nutriment for infants, and a mixed milk for infants and a baby food having the improved content of the arachidonic acid are produced by formulating the microorganisms of the genus Mortierella sect. schmuckeri or a lipid isolated from such microorganisms to food products. COPYRIGHT: (C)2010,JPO&INPIT
Abstract translation: 待解决的问题：经济地生产花生四烯酸，并提供配制的食品。 解决方案：被孢霉属的微生物。 在具有复合氮源组分的发酵培养基中培养schmuckeri。 花生四烯酸是作为婴幼儿营养重要的类花生酸的前体，通过配制高山被孢霉属的微生物，可以生产具有改善的花生四烯酸含量的婴儿混合奶和婴儿食品。 schmuckeri或从这种微生物分离到食品中的脂质。 版权所有（C）2010，JPO＆INPIT
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Patent Agency Ranking
公开(公告)号：JP4287142B2
公开(公告)日：2009-07-01
申请号：JP2002516345
申请日：2001-07-18
Applicant: ビタテネ、ソシエダッド アノニマ
Inventor： カストロ，アントニオ エステッラ , モラレス，マヌエル エステバン , ペレス，ハビエル コスタ , デ ラ ビエハ，アルフォンソ コラドス , デ プラド，ホータ．エミリアノ ゴンザレス , セソン，エンリケ エー． ペイロ , ロドリゲス，アナ テレサ マルコス
CPC classification number: A23L1/2753 , A23L5/44 , C09B61/00 , C12P23/00 , Y10S435/911 , Y10S435/931
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7.发明专利Method for preparation of substituted aryl lactic acid containing cyclodepsipeptides with 24 ring atoms 审中-公开含24个环状体的含有CYCLODEPSIPEPTIPES的取代芳香酸乳酸的方法
公开(公告)号：JP2008092952A
公开(公告)日：2008-04-24
申请号：JP2007271390
申请日：2007-10-18
Applicant: Bayer Ag , バイエル アクチェンゲゼルシャフトBayer Aktiengesellschaft
Inventor： JESCHKE PETER , BONSE GERHARD , THIELKING GERHARD , ETZEL WINFRIED , HARDER ACHIM , MENCKE NORBERT , KLEINKAUF HORST , ZOCHER RAINER , IINUMA KATSUHARU , MIYAMOTO KOICHI
CPC classification number: C07D273/00 , C12P1/00 , C12P17/14 , Y10S435/911
Abstract: PROBLEM TO BE SOLVED: To provide an effective method for preparation of substituted aryl lactic acid containing cyclodepsipeptides.
SOLUTION: The invention relates to the new method for the preparation of substituted aryl lactic acid containing cyclodepsipeptides with 24 ring atoms, comprising addition of 4-nitrophnyl lactate to a main culture liquid of Mycelia sterilia, a fungal strain of the Agonomycetales class under an asceptic condition, continuing fermentation and extracting and purifying the culture, or adding substrates such as leucine, lactic acid, ATP, S-adenosyl-L-methionine, 4-nitrophenyl lactate, etc., to the enzymatic preparation isolated from the fungal strain to carry out an in vitro reaction.
COPYRIGHT: (C)2008,JPO&INPITAbstract translation: 待解决的问题：提供一种制备含取代芳基乳酸的环糊精肽的有效方法。 解决方案：本发明涉及制备具有24个环原子的取代芳基乳酸含环糊精肽的新方法，该方法包括向主体培养液中加入4-硝基丙酸乳酸菌，该菌株是菌丝体灭菌菌的一种真菌菌株 在无菌条件下，继续发酵并提取和纯化培养物，或将底物如亮氨酸，乳酸，ATP，S-腺苷-L-甲硫氨酸，4-硝基苯基乳酸等添加到从真菌中分离的酶制剂 菌株进行体外反应。 版权所有（C）2008，JPO＆INPIT
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8.发明专利
公开(公告)号：JP4040519B2
公开(公告)日：2008-01-30
申请号：JP2003099758
申请日：2003-04-02
Applicant: アプレラ コーポレイション
Inventor： イー． メイランド ポール
IPC: C12N15/09 , C07H21/04 , C12P19/34 , C12Q1/68 , G01N21/64 , G01N21/77 , G01N21/78 , G01N33/53 , G01N33/566
CPC classification number: C12Q1/6818 , C07H21/04 , C12Q1/6853 , C12Q1/686 , Y10S435/81 , Y10S435/911 , C12Q2565/107 , C12Q2565/1015 , C12Q2525/186 , C12Q2525/125 , C12Q2543/101 , C12Q2537/101 , C12Q2563/113 , C12Q2531/113 , C12Q2527/101 , C12Q2521/513
Abstract: An oligonucleotide probe is disclosed, the probe including an oligonucleotide, a fluorescer molecule attached to a first end of the oligonucleotide and a quencher molecule attached to the opposite end of the oligonucleotide. The probe is rendered impervious to digestion by the 5′→3′ exonuclease activity of a polymerase and the 5′→3′ extension of by a polymerase. The invention also includes methods for performing combined PCR amplification and hybridization probing, one such method including the steps of contacting a target nucleic acid sequence with PCR reagents and an oligonucleotide probe as described above, and subjecting these reagents to thermal cycling. One preferred refinement of the above method further includes the addition of a strand displacer to facilitate amplification. Additional similar combined PCR hybridization methods are disclosed, such methods not requiring probes having their 5′ ends protected, wherein (i) the polymerase lacks 5′→3′ exonuclease activity, (ii) a 5′→3′ exonuclease inhibitor is included, and (iii) an exonuclease deactivation step is performed.
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9.发明专利
公开(公告)号：JP4040087B2
公开(公告)日：2008-01-30
申请号：JP53330996
申请日：1996-04-05
Applicant: アプレラ コーポレイション
Inventor： イー． メイランド，ポール
IPC: C12N15/09 , C12Q1/68 , C07H21/04 , C12P19/34 , G01N21/64 , G01N21/77 , G01N21/78 , G01N33/53 , G01N33/566
CPC classification number: C12Q1/6818 , C07H21/04 , C12Q1/6853 , C12Q1/686 , Y10S435/81 , Y10S435/911 , C12Q2565/107 , C12Q2565/1015 , C12Q2525/186 , C12Q2525/125 , C12Q2543/101 , C12Q2537/101 , C12Q2563/113 , C12Q2531/113 , C12Q2527/101 , C12Q2521/513
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10.发明专利
公开(公告)号：JP4012217B2
公开(公告)日：2007-11-21
申请号：JP2005168232
申请日：2005-06-08
Applicant: マーテック・バイオサイエンシズ・コーポレイション
Inventor： アール． バークレイ，ウィリアム
IPC: A01K61/00 , C12N1/14 , A23K1/00 , A23K1/16 , A23K1/18 , A23L1/03 , A23L1/20 , A23L1/212 , A23L1/30 , A23L1/31 , A23L1/314 , A23L1/315 , A23L1/32 , A23L1/325 , A23L1/33 , A23L1/36 , A61K31/20 , A61K31/202 , C11B1/10 , C12N1/12 , C12N1/38 , C12P7/64 , C12R1/645
CPC classification number: A23K10/16 , A23K20/158 , A23K40/20 , A23K40/25 , A23K50/00 , A23K50/10 , A23K50/75 , A23K50/80 , A23L11/07 , A23L13/00 , A23L13/43 , A23L13/50 , A23L15/20 , A23L17/00 , A23L17/40 , A23L17/65 , A23L19/09 , A23L25/30 , A23L29/065 , A23L33/12 , A61K31/20 , A61K31/202 , C11B1/10 , C12N1/10 , C12N1/14 , C12P7/6409 , C12P7/6427 , C12P7/6463 , C12P7/6472 , C12P7/649 , Y02A40/818 , Y02E50/13 , Y10S426/805 , Y10S426/807 , Y10S435/911 , Y10S435/946
Abstract: Disclosed is a process for growing the microflora Thraustochytrium, Schizochytrium, and mixtures thereof, which includes the growing of the microflora in fermentation medium containing non-chloride containing sodium salts, in particular sodium sulfate. In a preferred embodiment of the present invention, the process produces microflora having a cell aggregate size useful for the production of food products for use in aquaculture. Further disclosed is a food product which includes Thraustochytrium, Schizochytrium, and mixtures thereof, and a component selected from flaxseed, rapeseed, soybean and avocado meal. Such a food product includes a balance of long chain and short chain omega-3 highly unsaturated fatty acids.
Abstract translation: 本发明公开了一种生长微囊藻毒裂症，裂殖壶菌及其混合物的方法，其包括在含有非氯化钠的钠盐，特别是硫酸钠的发酵培养基中生长微生物群落。 在本发明的优选实施方案中，该方法产生具有可用于生产用于水产养殖的食品的细胞聚集体尺寸的微生物群落。 还公开了一种食品，其包括破囊壶菌，裂殖壶菌及其混合物，以及选自亚麻籽，菜籽，大豆和鳄梨粉的成分。 这种食品包括长链和短链ω-3高度不饱和脂肪酸的平衡。
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