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公开(公告)号：US20090175921A1
公开(公告)日：2009-07-09
申请号：US11992340
申请日：2006-09-20
IPC分类号： A61L27/54 , C07C69/675 , C07C69/732 , C09K3/00 , C08G18/67 , C08G18/32
CPC分类号： C08G18/3221 , A61L27/18 , A61L31/06 , C07C69/40 , C07C69/60 , C07C69/675 , C08G18/10 , C08G18/4277 , C08G18/6603 , C08G18/664 , C08G18/6674 , C08G18/73 , C08G18/771 , C08L75/04
摘要： The present invention relates to chain extenders, processes for their preparation and their use in the preparation of biocompatible biodegradable polyurethanes and polyurethane ureas for biomedical applications such as stents, scaffolds for tissue engineering. The chain extenders comprise a compound of formula (I)
摘要翻译： 本发明涉及扩链剂，其制备方法及其在制备用于生物相容的可生物降解的聚氨酯和用于生物医学应用的聚氨酯脲（例如支架，用于组织工程的支架）中的用途。 扩链剂包括式（I）化合物，
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公开(公告)号：US20210100933A1
公开(公告)日：2021-04-08
申请号：US17122155
申请日：2020-12-15
发明人： Timothy Graeme MOORE
摘要： There are provided tissue repair laminates which promote cellular in-growth but also prevent or mitigate tissue adhesion. The laminates comprise a biodegradable polyurethane foam layer which facilitates cellular infiltration and a polyurethane barrier layer which is non-adhesive to tissue. The laminates resist shrinkage under in vivo conditions and possess desirable mechanical properties. The laminates find use in, for example, the repair of herniated tissue, particularly, but not limited to hernias in the abdominal wall.
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公开(公告)号：US20210069374A1
公开(公告)日：2021-03-11
申请号：US16955942
申请日：2018-12-21
发明人： Paul BRENNAN , Timothy Graeme MOORE
摘要： There is provided a soft tissue implant pocket which reduces the incidence of capsular contracture. The pocket is manufactured from a biodegradable, biocompatible polyurethane foam. The polyurethane contains biodegradable polyols and the foam has a pore size configured for cellular infiltration. The soft tissue implant pocket find use in, for example, breast augmentation and reconstruction.
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公开(公告)号：US10898614B2
公开(公告)日：2021-01-26
申请号：US16625294
申请日：2018-12-21
发明人： Timothy Graeme Moore
摘要： There are provided tissue repair laminates which promote cellular in-growth but also prevent or mitigate tissue adhesion. The laminates comprise a biodegradable polyurethane foam layer which facilitates cellular infiltration and a polyurethane barrier layer which is non-adhesive to tissue. The laminates resist shrinkage under in vivo conditions and possess desirable mechanical properties. The laminates find use in, for example, the repair of herniated tissue, particularly, but not limited to hernias in the abdominal wall.
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公开(公告)号：US09695268B2
公开(公告)日：2017-07-04
申请号：US14573733
申请日：2014-12-17
IPC分类号： C08G18/32 , C08G18/66 , A61L27/18 , A61L31/06 , C07C69/40 , C07C69/60 , C07C69/675 , C08G18/10 , C08G18/42 , C08G18/77 , C08G18/73
CPC分类号： C08G18/3221 , A61L27/18 , A61L31/06 , C07C69/40 , C07C69/60 , C07C69/675 , C08G18/10 , C08G18/4277 , C08G18/6603 , C08G18/664 , C08G18/6674 , C08G18/73 , C08G18/771 , C08L75/04
摘要： The present invention relates to chain extenders, processes for their preparation and their use in the preparation of biocompatible biodegradable polyurethanes and polyurethane ureas for biomedical applications such as stents, scaffolds for tissue engineering.The chain extenders comprise a compound of formula (I)
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公开(公告)号：US20130121969A1
公开(公告)日：2013-05-16
申请号：US13665531
申请日：2012-10-31
CPC分类号： A61K47/482 , A61F2/30 , A61F2/30756 , A61K31/74 , A61L27/18 , A61L27/3817 , A61L27/3834 , A61L27/50 , A61L27/58 , C08G18/3206 , C08G18/8022 , C08L75/04
摘要： The present invention relates to biocompatible, biodegradable polyurethane/urea polymeric compositions that are capable of in-vivo curing with low heat generation to form materials suitable for use in scaffolds in tissue engineering applications such as bone and cartilage repair. The polymers are desirably flowable and injectable and can support living biological components to aid in the healing process. They may be cured ex-vivo for invasive surgical repair methods, or alternatively utilized for relatively non-invasive surgical repair methods such as by arthroscope. The invention also relates to prepolymers useful in the preparation of the polymeric compositions, and to methods of treatment of damaged tissue using the polymers of the invention.
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公开(公告)号：US12129333B2
公开(公告)日：2024-10-29
申请号：US17416691
申请日：2018-12-21
发明人： Timothy Graeme Moore
IPC分类号： C08G18/42 , C08G18/10 , C08G18/22 , C08G18/73 , C08J5/18 , A61L27/16 , A61L27/58 , B29C48/00 , B29C48/08 , B29C55/04 , B29C55/12 , B29C55/28 , B29K75/00
CPC分类号： C08G18/73 , C08G18/10 , C08G18/222 , C08G18/4277 , C08G18/428 , C08J5/18 , A61L27/16 , A61L27/58 , B29C48/0018 , B29C48/08 , B29C55/04 , B29C55/12 , B29C55/28 , B29K2075/00 , B29K2995/0051 , B29K2995/0053 , C08J2375/06
摘要： Provided are oriented biodegradable thermoplastic polyurethane films. The films may be prepared by extruding and drawing biodegradable polyurethane films. The polyurethanes may be prepared from biodegradable polyols and/or biodegradable chain extenders. The films possess high tensile strength yet are degradable under biological conditions. The films may be utilized in the fabrication of devices, particularly implantable medical devices.
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公开(公告)号：US09084827B2
公开(公告)日：2015-07-21
申请号：US14098831
申请日：2013-12-06
IPC分类号： A61K31/74 , A61K47/48 , A61L27/18 , A61L27/58 , C08G18/32 , C08G18/80 , A61L27/38 , A61L27/50 , A61F2/30
CPC分类号： A61K47/482 , A61F2/30 , A61F2/30756 , A61K31/74 , A61L27/18 , A61L27/3817 , A61L27/3834 , A61L27/50 , A61L27/58 , C08G18/3206 , C08G18/8022 , C08L75/04
摘要： The present invention relates to biocompatible, biodegradable polyurethane/urea polymeric compositions that are capable of in-vivo curing with low heat generation to form materials suitable for use in scaffolds in tissue engineering applications such as bone and cartilage repair. The polymers are desirably flowable and injectable and can support living biological components to aid in the healing process. They may be cured ex-vivo for invasive surgical repair methods, or alternatively utilized for relatively non-invasive surgical repair methods such as by arthroscope. The invention also relates to prepolymers useful in the preparation of the polymeric compositions, and to methods of treatment of damaged tissue using the polymers of the invention.
摘要翻译： 本发明涉及生物相容的，可生物降解的聚氨酯/尿素聚合物组合物，其能够在低发热下体内固化以形成适用于组织工程应用如骨和软骨修复中的支架的材料。 聚合物理想地是可流动和可注射的，并且可以支持活的生物组分以帮助愈合过程。 它们可以用于侵入性外科手术修复方法离体固化，或者替代地用于相对非侵入性的手术修复方法，例如通过关节镜。 本发明还涉及可用于制备聚合物组合物的预聚物，以及使用本发明的聚合物处理受损组织的方法。
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公开(公告)号：US20140099277A1
公开(公告)日：2014-04-10
申请号：US14098831
申请日：2013-12-06
IPC分类号： A61K47/48
CPC分类号： A61K47/482 , A61F2/30 , A61F2/30756 , A61K31/74 , A61L27/18 , A61L27/3817 , A61L27/3834 , A61L27/50 , A61L27/58 , C08G18/3206 , C08G18/8022 , C08L75/04
摘要： The present invention relates to biocompatible, biodegradable polyurethane/urea polymeric compositions that are capable of in-vivo curing with low heat generation to form materials suitable for use in scaffolds in tissue engineering applications such as bone and cartilage repair. The polymers are desirably flowable and injectable and can support living biological components to aid in the healing process. They may be cured ex-vivo for invasive surgical repair methods, or alternatively utilized for relatively non-invasive surgical repair methods such as by arthroscope. The invention also relates to prepolymers useful in the preparation of the polymeric compositions, and to methods of treatment of damaged tissue using the polymers of the invention.
摘要翻译： 本发明涉及生物相容的，可生物降解的聚氨酯/尿素聚合物组合物，其能够在低发热下体内固化以形成适用于组织工程应用如骨和软骨修复中的支架的材料。 聚合物理想地是可流动和可注射的，并且可以支持活的生物组分以帮助愈合过程。 它们可以用于侵入性外科手术修复方法离体固化，或者替代地用于相对非侵入性的手术修复方法，例如通过关节镜。 本发明还涉及可用于制备聚合物组合物的预聚物，以及使用本发明的聚合物处理受损组织的方法。
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公开(公告)号：US20110287102A1
公开(公告)日：2011-11-24
申请号：US13164316
申请日：2011-06-20
IPC分类号： A61K9/14 , C07C69/732 , A61K47/34 , C12N5/071 , C08G18/68 , C08G18/66 , A61L27/34 , A61L27/18 , C07C69/675 , A61P43/00
CPC分类号： C08G18/3221 , A61L27/18 , A61L31/06 , C07C69/40 , C07C69/60 , C07C69/675 , C08G18/10 , C08G18/4277 , C08G18/6603 , C08G18/664 , C08G18/6674 , C08G18/73 , C08G18/771 , C08L75/04
摘要： The present invention relates to chain extenders, processes for their preparation and their use in the preparation of biocompatible biodegradable polyurethanes and polyurethane ureas for biomedical applications such as stents, scaffolds for tissue engineering.The chain extenders comprise a compound of formula.(I)
摘要翻译： 本发明涉及扩链剂，其制备方法及其在制备用于生物相容的可生物降解的聚氨酯和用于生物医学应用的聚氨酯脲（例如支架，用于组织工程的支架）中的用途。 扩链剂包括式（I）化合物：
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