利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

32 条记录 (耗时 0.033 秒)

    Method of prolonging cancerous patient survival in humans with hydrazine sulfate
    2.
    发明授权
    Method of prolonging cancerous patient survival in humans with hydrazine sulfate 失效
    用硫酸肼延长人类癌症患者存活的方法

    公开(公告)号：US4867978A

    公开(公告)日：1989-09-19

    申请号：US276059

    申请日：1988-11-25

    申请人： Joseph Gold

    发明人： Joseph Gold

    IPC分类号： A61K33/02 ,  A61K33/04

    CPC分类号： A61K33/04 ,  A61K33/02

    摘要： Hydrazine sulfate, alone or formulated with liquid or solid carriers, will prolong patient survival when administered to early-stage human cancer patients parenterally or orally.

    摘要翻译： 单独使用或与液体或固体载体一起配制的硫酸肼将在肠胃外或口服给予早期人类癌症患者时延长患者的存活时间。

    Method and system for indoor RF mapping
    4.
    发明授权
    Method and system for indoor RF mapping 有权
    室内RF映射方法和系统

    公开(公告)号：US08977287B1

    公开(公告)日：2015-03-10

    申请号：US13457265

    申请日：2012-04-26

    申请人： Andrew Joseph Gold ,  Graham Tyler Cantin ,  James Eric Greenhaw, Jr. ,  Tesh Tesfaye

    发明人： Andrew Joseph Gold ,  Graham Tyler Cantin ,  James Eric Greenhaw, Jr. ,  Tesh Tesfaye

    IPC分类号： H04W24/00

    CPC分类号： H04W64/00

    摘要： A method for determining a location of a mobile electronic device includes receiving from said device, at a first electronic device, a first RF signal comprising a wireless signal according to a first standard other than a GPS standard. First RF fingerprint data is provided based on the first RF signal. A second RF signal comprising a wireless signal according to a second standard other than a GPS standard is received from said device at a second electronic device. Second RF fingerprint data is provided based on the second RF signal. Device specific RF signal fingerprint data is determined in dependence upon each of the first and second RF fingerprint data. The location of the device is determined using the first RF signal, the device specific RF signal fingerprint data for the first standard, the second wireless signal, and the device specific RF signal fingerprint data for the second standard.

    摘要翻译： 一种用于确定移动电子设备的位置的方法包括从第一电子设备从所述设备接收包括除了GPS标准之外的第一标准的无线信号的第一RF信号。 基于第一RF信号提供第一RF指纹数据。 在第二电子设备处从所述设备接收包括根据除了GPS标准之外的第二标准的无线信号的第二RF信号。 基于第二RF信号提供第二RF指纹数据。 根据第一和第二RF指纹数据中的每一个来确定器件特定的RF信号指纹数据。 使用第一标准的第一RF信号，用于第一标准的设备专用RF信号指纹数据，第二无线信号和用于第二标准的设备特定RF信号指纹数据确定设备的位置。

    Selective antibody targeting of undifferentiated stem cells
    6.
    发明申请
    Selective antibody targeting of undifferentiated stem cells 审中-公开
    未分化干细胞的选择性抗体靶向

    公开(公告)号：US20070202596A1

    公开(公告)日：2007-08-30

    申请号：US11710864

    申请日：2007-02-26

    申请人： Jim McWhir ,  Joseph Gold ,  J. Schiff

    发明人： Jim McWhir ,  Joseph Gold ,  J. Schiff

    IPC分类号： C12N5/08 ,  C12N5/00

    CPC分类号： C12N9/1276 ,  A61K35/12 ,  A61K48/00 ,  C12N5/0606 ,  C12N9/1048 ,  C12N2502/13 ,  C12N2510/00 ,  C12N2799/022 ,  C12Y204/01087

    摘要： This invention provides a system for producing differentiated cells from a stem cell population for use wherever a relatively homogenous cell population is desirable. The cells contain an effector gene under control of a transcriptional control element (such as the TERT promoter) that causes the gene to be expressed in relatively undifferentiated cells in the population. Expression of the effector gene results in expression of a cell-surface antigen that can be used to deplete the undifferentiated cells. Model effector sequences encode glycosyl transferases that synthesize carbohydrate xenoantigen or alloantigen, which can be used for immunoseparation or as a target for complement-mediated lysis. The differentiated cell populations produced are suitable for use in tissue regeneration and non-therapeutic applications such as drug screening.

    摘要翻译： 本发明提供了一种用于从干细胞群体产生分化细胞的系统，用于需要相对均匀细胞群体的地方。 细胞含有在转录控制元件（例如TERT启动子）的控制下的效应基因，其导致基因在群体中相对未分化的细胞中表达。 效应基因的表达导致可用于消耗未分化细胞的细胞表面抗原的表达。 模型效应序列编码糖基转移酶，其合成碳水化合物异种抗原或同种异体抗原，其可用于免疫分离或作为补体介导的裂解的靶标。 产生的分化细胞群体适用于组织再生和非治疗应用，如药物筛选。

    Differentiated cells suitable for human therapy
    7.
    发明申请
    Differentiated cells suitable for human therapy 有权
    分化细胞适合人类治疗

    公开(公告)号：US20060134782A1

    公开(公告)日：2006-06-22

    申请号：US11359341

    申请日：2006-02-21

    申请人： Joseph Gold ,  Jane Lebkowski

    发明人： Joseph Gold ,  Jane Lebkowski

    IPC分类号： C12N5/08

    CPC分类号： C12N15/85 ,  A61K35/12 ,  C12N5/0606 ,  C12N2502/13 ,  C12N2510/00

    摘要： This invention provides a system for producing differentiated cells from a stem cell population for use wherever a relatively homogenous cell population is desirable. The cells contain an effector gene under control of a transcriptional control element (such as the TERT promoter) that causes the gene to be expressed in relatively undifferentiated cells in the population. Expression of the effector gene results in depletion of undifferentiated cells, or expression of a marker that can be used to remove them later. Suitable effector sequences encode a toxin, a protein that induces apoptosis; a cell-surface antigen, or an enzyme (such as thymidine kinase) that converts a prodrug into a substance that is lethal to the cell. The differentiated cell populations produced according to this disclosure are suitable for use in tissue regeneration, and non-therapeutic applications such as drug screening.

    摘要翻译： 本发明提供了一种用于从干细胞群体产生分化细胞的系统，用于需要相对均匀细胞群体的地方。 细胞含有在转录控制元件（例如TERT启动子）的控制下的效应基因，其导致基因在群体中相对未分化的细胞中表达。 效应基因的表达导致未分化细胞的消耗或可以用于稍后去除它们的标记物的表达。 合适的效应序列编码毒素，诱导细胞凋亡的蛋白质; 细胞表面抗原或将前药转化为对细胞致死的物质的酶（例如胸苷激酶）。 根据本公开生产的分化细胞群体适用于组织再生和非治疗应用，例如药物筛选。

    Cardiac bodies: clusters of spontaneously contracting cells for regenerating cardiac function
    8.
    发明申请
    Cardiac bodies: clusters of spontaneously contracting cells for regenerating cardiac function 审中-公开
    心脏体：用于再生心脏功能的自发收缩细胞簇

    公开(公告)号：US20050214938A1

    公开(公告)日：2005-09-29

    申请号：US11085899

    申请日：2005-03-21

    申请人： Joseph Gold ,  Chunhui Xu

    发明人： Joseph Gold ,  Chunhui Xu

    IPC分类号： C12N5/077 ,  C12N5/08

    CPC分类号： C12N5/0657 ,  C12N2500/33 ,  C12N2501/33 ,  C12N2506/02 ,  C12N2533/50 ,  C12N2533/90

    摘要： This disclosure describes clusters of cardiomyocyte lineage cells referred to as cardiac bodies. They can be obtained by differentiating human embryonic stem cells into cells that express cardiomyocyte markers, and separating cells according to their density. Single suspended cells are removed, leaving self-aggregating clusters that can be propagated and enriched in further separation steps. The resulting cardiac bodies express cardiomyocyte markers at levels ˜100-fold above the starting cell population, and undergo spontaneous periodic contraction. The clusters can be used intact or dispersed into single-cell suspensions for use in research, drug screening or the preparation of pharmaceutical compositions for the treatment of cardiac disease.

    摘要翻译： 本公开描述了称为心脏体的心肌细胞谱系细胞簇。 它们可以通过将人胚胎干细胞分化成表达心肌细胞标记的细胞，并根据其密度分离细胞来获得。 去除单个悬浮细胞，留下可以进一步分离步骤繁殖和富集的自聚集簇。 所产生的心脏体表达高于起始细胞群高100倍的心肌细胞标志物，并经历自发性周期性收缩。 这些簇可以完整使用或分散在单细胞悬浮液中，用于研究，药物筛选或用于治疗心脏病的药物组合物的制备。