公开(公告)号：US20240092863A1

公开(公告)日：2024-03-21

申请号：US17909318

申请日：2021-03-02

Applicant: UNIVERSITY OF SHEFFIELD

Inventor： Peter Nigel Monk ,  Rahaf Issa ,  Barbara Ciani

IPC: C07K14/705 ,  A61P31/04

CPC classification number: C07K14/70596 ,  A61P31/04

Abstract: The present invention relates to a peptide for reducing pathogen adhesion. Specifically, a peptide comprising an amino acid sequence having at least 75% sequence identity to SEQ ID NO: 1. The peptide also comprises at least one staple between two or more residues equivalent to residues 3, 7, 10 or 14 of SEQ ID NO: 1.

公开(公告)号：US20240060960A1

公开(公告)日：2024-02-22

申请号：US18271980

申请日：2022-01-13

Applicant: RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL ,  THE UNIVERSITY OF SHEFFIELD

Inventor： Kathrin Christine Meyer ,  Cassandra Nicole Dennys-Rivers ,  Laura Ferraiuolo

IPC: G01N33/50

CPC classification number: G01N33/5005 ,  G01N2800/56 ,  G01N2800/52

Abstract: The disclosure provides for methods of predicting disease progression comprising detecting a modification of one or more disease markers in a glial cell or neuronal cell generated from a skin cell of the subject. The disclosed methods include methods of identifying subjects that are responsive to a therapeutic agent and methods of determining effectiveness of a therapeutic agent.

公开(公告)号：US11815477B2

公开(公告)日：2023-11-14

申请号：US17606995

申请日：2020-03-25

Applicant: THE UNIVERSITY OF SHEFFIELD

Inventor： Matthew Brown ,  Peter Lawrence Crawforth ,  Bradley Peter Wynne ,  Hassan Ghadbeigi

IPC: G01N23/207 ,  G01N23/20 ,  G01N33/20 ,  G01N23/20025 ,  G01N33/2045

CPC classification number: G01N23/2073 ,  G01N23/207 ,  G01N23/20025 ,  G01N33/20 ,  G01N33/2045 ,  G01N2223/1003 ,  G01N2223/204 ,  G01N2223/646 ,  G01N2223/6462

Abstract: A method of non-destructive detection of surface and near surface abnormalities in a metallic product. The method comprises positioning a sample having a surface under a source of an incident radiation. The surface of the sample is then irradiated with the incident radiation from the source. A scattered radiation is detected and a radiation pattern from the detected scattered radiation is produced. Said radiation pattern is then analysed and the output indicative of the scattered radiation from the sample is produced. Said produced output is then compared with a threshold value, the threshold value indicative of a maximum acceptable detected surface abnormality. Finally, the presence of a surface abnormality is identified when the output exceeds the threshold value.

公开(公告)号：US20230172496A1

公开(公告)日：2023-06-08

申请号：US17947603

申请日：2022-09-19

Applicant: Smith & Nephew PLC ,  University Of Sheffield

Inventor： John Kenneth Hicks ,  Richard Hoskins ,  Stephen Rimmer ,  Dorothy McCulloch

IPC: A61B5/145 ,  A61L15/22 ,  C08G18/48 ,  C08G18/24 ,  C08G18/76 ,  A61L15/56 ,  C08L75/04 ,  C08G18/28 ,  A61F13/00 ,  C08G18/73 ,  C08G18/10 ,  A61B5/00 ,  A61F13/84 ,  A61F15/00 ,  A61L15/26 ,  A61L15/42 ,  C08J5/18 ,  C08J9/00 ,  C08J9/30 ,  C09J11/08 ,  C09J175/04 ,  G01N33/84

CPC classification number: A61B5/14539 ,  A61L15/225 ,  C08G18/4837 ,  C08G18/246 ,  C08G18/7664 ,  A61L15/56 ,  C08L75/04 ,  C08G18/283 ,  A61F13/00063 ,  C08G18/73 ,  C08G18/244 ,  C08G18/10 ,  A61B5/445 ,  A61F13/84 ,  A61F15/001 ,  A61L15/26 ,  A61L15/42 ,  A61L15/425 ,  C08G18/7671 ,  C08J5/18 ,  C08J9/0061 ,  C08J9/30 ,  C09J11/08 ,  C09J175/04 ,  G01N33/84 ,  C08L2205/04 ,  A61B2562/0295 ,  A61F2013/00089 ,  A61F2013/8473 ,  C08J2205/028 ,  C08J2207/10 ,  C08J2375/04 ,  C08J2433/14 ,  C08J2433/26 ,  C08L2203/02 ,  C08L2203/14

Abstract: Polyurethane material for indicating pH at a locus, preferably as indication of presence of microbes, comprising a polyurethane network having immobilised therein one or more hydrophilic copolymers, the or each said copolymer comprising:
hydrophilic monomer; and

indicating monomer, which provides an indication in response to a change in hydrophilic state of said hydrophilic monomer and/or copolymer;

characterised in that the or each copolymer further comprises one or a plurality of ionisable groups or moieties or polymerisable monomers having one or more characteristic pKa values in the range 5 to 10 and which are responsive to pH at the locus in the range pH 5 to pH 10

and in that hydrophilic state of hydrophilic copolymer is dependent on ionisation of said ionisable groups, moieties or monomers; kit and device comprising the material and process for preparation thereof; and use in detecting or sensing microbes or pH.

公开(公告)号：US20220416110A1

公开(公告)日：2022-12-29

申请号：US17777775

申请日：2020-11-18

Applicant: THE UNIVERSITY OF SHEFFIELD

Inventor： Chee Hing TAN

IPC: H01L31/107 ,  H01L31/0304 ,  H01L31/0352

Abstract: An avalanche photodiode (APD) structure, comprising an absorption layer comprising InGaAs, InGaAlAs, InGaAsP, or an InGaAs/GaAsSb type-II superlattice, an avalanche layer comprising AlGaAsSb, and a transition portion disposed between the absorption layer and the avalanche layer is disclosed. The transition portion comprises a first grading layer of InAlGaAs or InGaAsP and a first field control layer disposed between the first grading layer and the avalanche layer. The first field control layer has a bandgap between the bandgap of the absorption layer and the bandgap of the avalanche layer. In an alternative embodiment, an avalanche photodiode (APD) structure, comprising an absorption layer comprising GaAsSb, an avalanche layer comprising AlGaAsSb, and a transition portion disposed between the absorption layer and the avalanche layer. The transition portion comprises a first grading layer and one or more field control layers having a bandgap between the bandgaps of the absorption layer and the avalanche layer.

公开(公告)号：US11504033B2

公开(公告)日：2022-11-22

申请号：US16070257

申请日：2017-01-13

Applicant: Smith & Nephew PLC ,  University of Sheffield

Inventor： John Kenneth Hicks ,  Richard Hoskins ,  Stephen Rimmer ,  Dorothy McCulloch

IPC: A61L15/22 ,  A61L15/56 ,  C08L75/04 ,  A61F13/00 ,  A61B5/00 ,  A61F13/84 ,  A61L15/26 ,  A61L15/42 ,  C08J9/00 ,  C08J5/18 ,  A61B5/145 ,  C08G18/48 ,  C08G18/24 ,  C08G18/76 ,  C08G18/28 ,  C08G18/73 ,  C08G18/10 ,  A61F15/00 ,  C08J9/30 ,  C09J11/08 ,  C09J175/04 ,  G01N33/84

Abstract: Polyurethane material for indicating pH at a locus, preferably as indication of presence of microbes, comprising a polyurethane network having immobilised therein one or more hydrophilic copolymers, the or each said copolymer comprising: hydrophilic monomer; and indicating monomer, which provides an indication in response to a change in hydrophilic state of said hydrophilic monomer and/or copolymer; characterised in that the or each copolymer further comprises one or a plurality of ionisable groups or moieties or polymerisable monomers having one or more characteristic pKa values in the range 5 to 10 and which are responsive to pH at the locus in the range pH 5 to pH 10 and in that hydrophilic state of hydrophilic copolymer is dependent on ionisation of said ionisable groups, moieties or monomers; kit and device comprising the material and process for preparation thereof; and use in detecting or sensing microbes or pH.

公开(公告)号：US20220278165A1

公开(公告)日：2022-09-01

申请号：US17597699

申请日：2020-07-14

Applicant: The University of Sheffield

Inventor： Tao Wang

IPC: H01L27/15 ,  H01L33/08 ,  H01L33/60

Abstract: A method of producing a light emitting diode (LED) array comprises: forming a plurality of layers (100, 101, 103) of semiconductor material; forming a dielectric mask layer (104) over the plurality of layers, the dielectric mask layer having an array of holes (106) through it each exposing an area of one of the layers of semiconductor material, and growing an LED structure (110, 112, 114) in each of the holes arranged to emit light over a range of wavelengths. At least some of the plurality layers (101) form a distributed Bragg reflector (DBR) arranged to reflect light of at least some of said range of wavelengths.

公开(公告)号：US20210321888A1

公开(公告)日：2021-10-21

申请号：US17267751

申请日：2019-08-08

Applicant: THE UNIVERSITY OF SHEFFIELD

Inventor： Paul Morris ,  Julian Gunn ,  David Rodney Hose ,  Patricia Lawford

IPC: A61B5/0215 ,  A61B5/026 ,  A61B34/10

Abstract: A computer-implemented method of determining data indicating volumetric flow rate within an artery. The method comprises receiving data indicating a proximal pressure measurement relative to a direction of blood flow; receiving data indicating a distal pressure measurement relative to the direction of blood flow; wherein the proximal pressure measurement and the distal pressure measurement are obtained using at least one pressure transducer; receiving geometric model data representing the artery, wherein the geometric model data is generated based upon image data indicative of the artery; and computing a volumetric flow rate with in the artery, wherein computing comprises performing a numerical simulation of blood flow through the artery based upon the geometric model data, the data indicating a proximal pressure measurement and the data indicating a distal pressure measurement.

公开(公告)号：US20210244848A1

公开(公告)日：2021-08-12

申请号：US17271107

申请日：2019-08-27

Applicant: THE UNIVERSITY OF SHEFFIELD

Inventor： Caroline Joanne Harrison ,  Paul Vincent Hatton ,  Rebecca Louise Hutchinson ,  Cheryl Ann Miller

IPC: A61L27/04 ,  A61L27/12 ,  A61L27/58 ,  A61L27/10

Abstract: A solid suspension for use in bone regeneration and/or the repair of bone defects, comprising a source of at least one group II metal cation and a source of zinc cations, wherein the source of zinc cations comprises zinc oxide and wherein where there is only one group II metal cation this is strontium. A bone graft comprising a solid suspension, a method of preparation of a solid suspension and a use of a solid suspension in bone regeneration and/or in the repair of bone defects.

公开(公告)号：US20210154206A1

公开(公告)日：2021-05-27

申请号：US16491683

申请日：2018-03-07

Applicant: The University of Sheffield ,  Comsats Intitute of Information Technology

Inventor： Muhammad Yar ,  Sheila Macneil

IPC: A61K31/565 ,  A61K31/7004 ,  A61K47/36 ,  A61K47/42 ,  A61K47/32 ,  A61K47/34 ,  A61K47/38 ,  A61K45/06 ,  A61K9/70 ,  A61P17/02 ,  A61L26/00

Abstract: The invention provides a D-deoxyribose sugar for use in promoting wound healing wherein the sugar is provided in a carrier and wherein the carrier is a biocompatible matrix material or a hydrogel.