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    METHOD AND APPARATUS FOR MONITORING ANESTHESIA DRUG DOSAGES, CONCENTRATIONS, AND EFFECTS USING N-DIMENSIONAL REPRESENTATIONS OF CRITICAL FUNCTIONS
    4.
    发明申请
    METHOD AND APPARATUS FOR MONITORING ANESTHESIA DRUG DOSAGES, CONCENTRATIONS, AND EFFECTS USING N-DIMENSIONAL REPRESENTATIONS OF CRITICAL FUNCTIONS 审中-公开
    用于监测麻醉药物剂量，浓度和效果的方法和装置，使用关键功能的三维表示

    公开(公告)号：US20080033661A1

    公开(公告)日：2008-02-07

    申请号：US11843524

    申请日：2007-08-22

    申请人： Noah Syroid ,  Dwayne Westenskow ,  Julio Bermudez ,  James Agutter ,  David Strayer ,  Robert Albert ,  Michael Holmes ,  Frank Drews ,  Haunke Prenzel

    发明人： Noah Syroid ,  Dwayne Westenskow ,  Julio Bermudez ,  James Agutter ,  David Strayer ,  Robert Albert ,  Michael Holmes ,  Frank Drews ,  Haunke Prenzel

    IPC分类号： G06F19/00

    CPC分类号： G09B23/28 ,  A61B5/00 ,  A61M5/142 ,  A61M16/021 ,  A61M2202/048 ,  A61M2205/3576 ,  A61M2205/6072 ,  G06F19/3456 ,  G16H50/50

    摘要： A method, system and apparatus for the monitoring, diagnosis and evaluation of the state of a dynamic system is disclosed. This method and system provides the processing means for receiving sensed and/or simulated data, converting such data into a displayable object format and displaying such objects in a manner such that the interrelationships between the respective variables can be correlated and identified by a user. This invention provides for the rapid cognitive grasp of the overall state of a critical function with respect to a dynamic system. The system provides for displayed objects, which change in real-time to show the changes of the functions of the system. It is a highly flexible system which works with a wide variety of applications, including biological systems, environmental systems, engineering systems, economic systems, mechanical systems, chemical systems and the like. In particular, this invention is directed to the processing and display of drug data for the use of doctors in the process of monitoring or administering drugs to patients.

    摘要翻译： 公开了一种用于动态系统状态的监视，诊断和评估的方法，系统和装置。 该方法和系统提供了用于接收感测和/或模拟数据的处理装置，将这些数据转换成可显示对象格式，并以这样一种方式显示这些对象，使得各个变量之间的相互关系可以由用户相关和识别。 本发明提供了关于动态系统的关键功能的总体状态的快速认知掌握。 系统提供显示对象，实时更改以显示系统功能的更改。 它是一个高度灵活的系统，适用于各种应用，包括生物系统，环境系统，工程系统，经济系统，机械系统，化学系统等。 特别地，本发明涉及在向患者监测或给予药物的过程中使用医生的药物数据的处理和显示。

    Methods and compositions for targeted cleavage and recombination
    6.
    发明申请
    Methods and compositions for targeted cleavage and recombination 有权
    用于靶向切割和重组的方法和组合物

    公开(公告)号：US20050064474A1

    公开(公告)日：2005-03-24

    申请号：US10912932

    申请日：2004-08-06

    申请人： Fyodor Urnov ,  Michael Holmes ,  Jeffrey Miller ,  Carl Pabo

    发明人： Fyodor Urnov ,  Michael Holmes ,  Jeffrey Miller ,  Carl Pabo

    IPC分类号： C07K14/435 ,  C07K14/47 ,  C07K14/715 ,  C12N9/14 ,  C12N9/22 ,  C12N15/62 ,  C12P19/34 ,  C12Q1/68

    CPC分类号： A61K35/12 ,  C07K14/43595 ,  C07K14/4717 ,  C07K14/715 ,  C07K2319/00 ,  C07K2319/09 ,  C07K2319/81 ,  C12N9/14 ,  C12N9/22 ,  C12N15/62 ,  C12N15/85 ,  C12N2800/80

    摘要： Disclosed herein are methods and compositions for targeted cleavage of a genomic sequence, targeted alteration of a genomic sequence, and targeted recombination between a genomic region and an exogenous polynucleotide homologous to the genomic region. The compositions include fusion proteins comprising a cleavage domain (or cleavage half-domain) and an engineered zinc finger domain and polynucleotides encoding same. Methods for targeted cleavage include introduction of such fusion proteins, or polynucleotides encoding same, into a cell. Methods for targeted recombination additionally include introduction of an exogenous polynucleotide homologous to a genomic region into cells comprising the disclosed fusion proteins.

    摘要翻译： 本文公开了用于基因组序列的靶向切割，基因组序列的靶向改变以及基因组区域和与该基因组区域同源的外源多核苷酸之间的靶向重组的方法和组合物。 组合物包括包含切割结构域（或切割半结构域）和工程化锌指结构域的融合蛋白和编码它们的多核苷酸。 用于靶向切割的方法包括将这种融合蛋白或其编码的多核苷酸引入细胞。 用于靶向重组的方法另外包括将与基因组区域同源的外源多核苷酸引入包含所公开的融合蛋白的细胞中。

    System and method for automatically generating a hierarchical register consolidation structure
    7.
    发明申请
    System and method for automatically generating a hierarchical register consolidation structure 有权
    自动生成分层寄存器整合结构的系统和方法

    公开(公告)号：US20050015755A1

    公开(公告)日：2005-01-20

    申请号：US10801792

    申请日：2004-03-16

    申请人： Michael Holmes ,  Gerald Williams

    发明人： Michael Holmes ,  Gerald Williams

    IPC分类号： G06F9/45

    CPC分类号： G06F17/5045

    摘要： A system for, and method of, automatically generating a hierarchical register consolidation structure. In one embodiment, the system includes: (1) a graph generator that parses a High-level Design Language (HDL) file to generate an intermediate graph containing definitions of microprocessor-accessible registers, node interrelationships and summary bits and masks associated with alarm registers, (2) a graph converter, associated with the graph generator, that selectively adds virtual elements and nodes to the intermediate graph to transform the intermediate graph into a mathematical tree and (3) a description generator, associated with the graph converter, that employs the mathematical tree to generate a static tree description in a programming language suitable for use by a device-independent condition management structure.

    摘要翻译： 一种自动生成分层寄存器整合结构的系统和方法。 在一个实施例中，系统包括：（1）图形生成器，其解析高级设计语言（HDL）文件以生成包含微处理器可访问寄存器，节点相互关系和与报警寄存器相关联的摘要位和掩码的定义的中间图 ，（2）与图形生成器相关联的图形转换器，其选择性地将虚拟元素和节点添加到中间图，以将中间图变换成数学树;以及（3）与图形转换器相关联的描述生成器，其使用 数学树在适合于与设备无关的条件管理结构使用的编程语言中生成静态树描述。

    Targeted deletion of cellular DNA sequences
    10.
    发明申请
    Targeted deletion of cellular DNA sequences 有权

    公开(公告)号：US20060188987A1

    公开(公告)日：2006-08-24

    申请号：US11304981

    申请日：2005-12-15

    申请人： Dmitry Guschin ,  Michael Holmes

    发明人： Dmitry Guschin ,  Michael Holmes

    IPC分类号： C12N5/08 ,  C12N15/87

    CPC分类号： C12N15/85 ,  C07K14/4702 ,  C07K2319/81 ,  C12N9/22 ,  C12N15/10

    摘要： Disclosed herein are methods and compositions for targeted deletion of double-stranded DNA. The compositions include fusion proteins comprising a cleavage domain (or cleavage half-domain) and an engineered zinc finger domain, and polynucleotides encoding same. Methods for targeted deletion include introduction of such fusion proteins, or polynucleotides encoding same, into a cell such that two targeted cleavage events occur. Subsequent cellular repair mechanisms result in deletion of sequences between the two cleavage sites.