公开(公告)号：US4700298A

公开(公告)日：1987-10-13

申请号：US650512

申请日：1984-09-14

申请人： Branko Palcic ,  Bruno Jaggi ,  Jan Nordin

发明人： Branko Palcic ,  Bruno Jaggi ,  Jan Nordin

IPC分类号： G01N33/48 ,  G02B21/00 ,  G02B21/26 ,  G06T1/00 ,  G06F15/42 ,  G06G7/60 ,  G06K9/00

CPC分类号： G02B21/002

摘要： An image scanner for microscopic objects. The image scanner has a microscope with a high precision computer controlled motor driven stage to provide X,Y plane displacements in order to scan microscopic objects under the microscope. There is an image sensor and a digitizer in association with the microscope to sense a horizontal image line or a two dimensional image and provide a digital representation of the line or image. A digital signal processor processes digitized signals from the sensor. There is a computer to control the mechanical and electronic scanning and to store and display information from the digital signal processor. Methods of scanning a microscopic object are also described. The methods comprise positioning the object on a motorized stage of a microscope having an image sensor in a focal plane. The object is scanned and signals received from the sensor during scanning are digitized. The digitized signals are processed with a digital signal processor in order to automatically recognize objects while the sample is being scanned. The processed information contained in the signals and the location coordinates of objects are stored. The methods include automatical revisiting of recognized objects for further analysis.

摘要翻译： 用于微观物体的图像扫描仪。 图像扫描仪具有高精度计算机控制电机驱动平台的显微镜，以提供X，Y平面位移，以便在显微镜下扫描微观物体。 存在与显微镜相关联的图像传感器和数字化仪，以感测水平图像线或二维图像并提供线或图像的数字表示。 数字信号处理器处理来自传感器的数字化信号。 有一台计算机可以控制机械和电子扫描，并存储和显示来自数字信号处理器的信息。 还描述了扫描微观物体的方法。 所述方法包括将物体放置在具有在焦平面中的图像传感器的显微镜的机动台上。 扫描对象并扫描期间从传感器接收的信号被数字化。 数字信号用数字信号处理器处理，以便在扫描样品时自动识别对象。 信息中包含的处理信息和对象的位置坐标被存储。 这些方法包括自动重新识别被识别的对象进行进一步的分析。

公开(公告)号：US5507287A

公开(公告)日：1996-04-16

申请号：US428494

申请日：1995-04-27

申请人： Branko Palcic ,  Calum MacAulay ,  Bruno Jaggi ,  Stephen Lam ,  Amedeus E. Profio ,  Jaclyn Hung

发明人： Branko Palcic ,  Calum MacAulay ,  Bruno Jaggi ,  Stephen Lam ,  Amedeus E. Profio ,  Jaclyn Hung

IPC分类号： A61B1/00 ,  A61B1/04 ,  A61B5/00 ,  A61B1/06 ,  A61B1/267 ,  G01N21/64

CPC分类号： A61B1/043 ,  A61B1/00186 ,  A61B1/042 ,  A61B1/0638 ,  A61B1/0646 ,  A61B5/0071 ,  A61B5/0084 ,  A61B1/063 ,  G01N2021/6463

摘要： Apparatus for imaging diseases in tissue comprising a light source for generating excitation light that includes wavelengths capable of generating characteristic autofluorescence for abnormal and normal tissue. A fibreoptic illuminating light guide is used to illuminate tissue with light that includes at least the excitation light thereby exciting the tissue to emit the characteristic autofluorescence. An imaging bundle collects emitted autofluorescence light from the tissue. The autofluorescence light is filtered into spectral bands in which the autofluorescence intensity for abnormal tissue is substantially different from normal tissue and the autofluorescence intensity for abnormal tissue is substantially similar to normal tissue. An optical system is used to intercept the filtered autofluorescence light to acquire at least two filtered emitted autofluorescence images of the tissue. The acquired images are displayed in real time on a display monitor in such a manner as to delineate abnormal and normal tissue.

摘要翻译： 用于在组织中成像疾病的装置，包括用于产生激发光的光源，所述激发光包括能够产生用于异常和正常组织的特征性自发荧光的波长。 光纤照明光导用于用至少包括激发光的光照射组织，从而激发组织以发出特征自发荧光。 成像束从组织中收集发射的自发荧光。 自发荧光被过滤到光谱带，其中异常组织的自发荧光强度与正常组织基本不同，异常组织的自发荧光强度基本上与正常组织相似。 光学系统用于截取滤波的自发荧光以获得组织的至少两个经滤波的发射的自发荧光图像。 所获取的图像以描绘异常和正常组织的方式在显示监视器上实时显示。

公开(公告)号：US4845552A

公开(公告)日：1989-07-04

申请号：US087387

申请日：1987-08-20

申请人： Bruno Jaggi ,  Mohammed J. Deen ,  Branko Palcic

发明人： Bruno Jaggi ,  Mohammed J. Deen ,  Branko Palcic

IPC分类号： G01N21/59 ,  G02B21/00

CPC分类号： G02B21/002 ,  G01N21/5911 ,  G01N2021/5938 ,  G01N2021/5957 ,  G01N2201/103

摘要： A solid state microscope for viewing and scanning microscopic objects. The solid state microscope has a light source with a condensor and diffusion filter. A moveable stage is provided to allow X, Y, Z plane displacements in order to scan objects under the microscope. There is an objective to magnify the image of the object and project this image onto a two dimensional solid state image sensor. The solid state image sensor sends signals to an analog-to-digital converter where the signals are digitized and sent to a frame memory. A monitor is used to display the image of the object as stored in frame memory. The present invention can be interfaced with a computer to allow for automatic focusing and scanning of an image. The computer also houses storage means to store images. Methods of scanning an object are also described. A prism element can be used to obtain spectral scans of an object. In another scanning method, a first edge row of pixels is used to detect an object of interest in the scanned image. This first detection row activates an area of the sensor array at a later time to capture the entire image. In this way, only relevant information is collected and processed.

摘要翻译： 用于观察和扫描微观物体的固态显微镜。 固态显微镜具有带有聚光器和扩散滤光片的光源。 提供可移动台以允许X，Y，Z平面位移，以便在显微镜下扫描物体。 目的是放大对象的图像并将该图像投影到二维固态图像传感器上。 固态图像传感器将信号发送到模数转换器，其中信号被数字化并发送到帧存储器。 显示器用于显示存储在帧存储器中的对象的图像。 本发明可以与计算机接口以允许图像的自动聚焦和扫描。 计算机还容纳存储图像的存储装置。 还描述了扫描对象的方法。 可以使用棱镜元件来获得物体的光谱扫描。 在另一种扫描方法中，第一边缘像素行用于检测扫描图像中的感兴趣对象。 该第一检测行在稍后时间激活传感器阵列的区域以捕获整个图像。 这样，只收集和处理相关信息。

公开(公告)号：US5590660A

公开(公告)日：1997-01-07

申请号：US218662

申请日：1994-03-28

申请人： Calum MacAulay ,  Branko Palcic ,  Stephen Lam ,  Bruno Jaggi

发明人： Calum MacAulay ,  Branko Palcic ,  Stephen Lam ,  Bruno Jaggi

IPC分类号： A61B10/00 ,  A61B1/00 ,  A61B1/05 ,  A61B5/00 ,  G01N21/64 ,  A61B1/06 ,  A61B6/00

CPC分类号： A61B1/043 ,  A61B1/05 ,  A61B5/0071 ,  A61B5/0084 ,  A61B5/0086 ,  H04N2005/2255

摘要： An apparatus and method for imaging diseases in tissue are presented. The apparatus employs a light source for producing excitation light to excite the tissue to generate autofluorescence light and for producing illumination light to generate reflected and back scattered light (remittance light) from the tissue. Optical sensors are used to receive the autofluorescence light and the remittance light to collect an autofluorescence light image and a remittance light image. A filter acts to integrate the autofluorescence image over a range of wavelengths in which the autofluorescence intensity for normal tissue is substantially different from the autofluorescence intensity for diseased tissue to establish an integrated autofluorescence image of the tissue. The remittance light image provides a background image to normalize the autofluorescence image to account for image non-uniformity due to changes in distance, angle and illumination intensity. A monitor displays the integrated autofluorescence image and the remittance light image to produce a normalized image in which diseased tissue is distinguishable from normal tissue. The optical sensor can be installed adjacent the end of an endoscope probe inserted into a body cavity. A method for imaging diseased tissue using an integrated fluorescence image and a normalizing remittance image is also disclosed.

摘要翻译： 提出了一种用于成像组织疾病成像的装置和方法。 该装置采用光源产生激发光以激发组织以产生自发荧光并产生照明光，以从组织产生反射和反向散射光（汇流光）。 光传感器用于接收自发荧光和汇流光以收集自发荧光图像和汇流光图像。 滤光器用于将自发荧光图像整合在一定波长范围内，其中正常组织的自发荧光强度基本上不同于患病组织的自发荧光强度，以建立组织的集成自发荧光图像。 汇款光图像提供背景图像以归一化自发荧光图像，以解决由于距离，角度和照明强度的变化引起的图像不均匀性。 监视器显示集成的自发荧光图像和汇流光图像以产生其中患病组织与正常组织区分开的标准化图像。 光学传感器可以安装在插入体腔的内窥镜探针的末端附近。 还公开了使用集成荧光图像和归一化汇款图像对患病组织进行成像的方法。

公开(公告)号：US5827190A

公开(公告)日：1998-10-27

申请号：US699607

申请日：1996-08-19

申请人： Branko Palcic ,  Calum MacAulay ,  Stephen Lam ,  Bruno Jaggi

发明人： Branko Palcic ,  Calum MacAulay ,  Stephen Lam ,  Bruno Jaggi

IPC分类号： A61B10/00 ,  A61B1/00 ,  A61B1/05 ,  A61B5/00 ,  G01N21/64 ,  A61B6/00

CPC分类号： A61B1/043 ,  A61B1/05 ,  A61B5/0071 ,  A61B5/0084 ,  A61B5/0086 ,  H04N2005/2255

摘要： An apparatus and method for imaging diseases in tissue are presented. The apparatus employs a light source for producing excitation light to excite the tissue to generate autofluorescence light and for producing illumination light to generate reflected and back scattered light (remittance light) from the tissue. Optical sensors are used to receive the autofluorescence light and the remittance light to collect an autofluorescence light image and a remittance light image. A filter acts to integrate the autofluorescence image over a range of wavelengths in which the autofluorescence intensity for normal tissue is substantially different from the autofluorescence intensity for diseased tissue to establish an integrated autofluorescence image of the tissue. The remittance light image provides a background image to normalize the autofluorescence image to account for image non-uniformity due to changes in distance, angle and illumination intensity. A monitor displays the integrated autofluorescence image and the remittance light image to produce a normalized image in which diseased tissue is distinguishable from normal tissue. The optical sensor can be installed adjacent the end of an endoscope probe inserted into a body cavity. A method for imaging diseased tissue using an integrated fluorescence image and a normalizing remittance image is also disclosed.

摘要翻译： 提出了一种用于成像组织疾病成像的装置和方法。 该装置采用光源产生激发光以激发组织以产生自发荧光并产生照明光，以从组织产生反射和反向散射光（汇流光）。 光传感器用于接收自发荧光和汇流光以收集自发荧光图像和汇流光图像。 滤光器用于将自发荧光图像整合在一定波长范围内，其中正常组织的自发荧光强度基本上不同于患病组织的自发荧光强度，以建立组织的集成自发荧光图像。 汇款光图像提供背景图像以归一化自发荧光图像，以解决由于距离，角度和照明强度的变化引起的图像不均匀性。 监视器显示集成的自发荧光图像和汇流光图像以产生其中患病组织与正常组织区分开的标准化图像。 光学传感器可以安装在插入体腔的内窥镜探针的末端附近。 还公开了使用集成荧光图像和归一化汇款图像对患病组织进行成像的方法。

公开(公告)号：US6021344A

公开(公告)日：2000-02-01

申请号：US984391

申请日：1997-12-03

申请人： Harvey Lui ,  Haishan Zeng ,  Calum E. MacAulay ,  Branko Palcic ,  David I. McLean

发明人： Harvey Lui ,  Haishan Zeng ,  Calum E. MacAulay ,  Branko Palcic ,  David I. McLean

IPC分类号： A61B5/00 ,  A61B5/103 ,  A61B10/00

CPC分类号： A61B5/444 ,  A61B5/0059 ,  A61B5/0071 ,  A61B2090/502

摘要： Apparatus for the diagnosis of a skin disease site by visual fluorescence inspection comprising an excitation light source for illuminating the disease site, a light guide for transmitting the excitation light directly to the disease site to generate fluorescence light and viewing goggles for processing the excitation light reflected and the fluorescence light emitted from the disease site to provide a fluorescence image of the disease site to a user. The fluorescence image is used to aid the medical assessment of skin conditions and the diagnosis of cutaneous diseases by supplementing the visual assessment of skin lesions made by the naked eye. The apparatus can be used in several modes of operation that permit the viewing of full color fluorescence images and enhanced two color images. The apparatus can also use image intensifying equipment to amplify fluorescence light so that even very weak fluorescing objects can be seen. A method for acquiring and viewing the fluorescence images is also disclosed.

摘要翻译： 用于通过视觉荧光检查诊断皮肤疾病部位的装置，包括用于照射疾病部位的激发光源，用于将激发光直接传播到疾病部位以产生荧光的光导和观察用于处理反射的激发光的护目镜 以及从疾病部位发出的荧光，向用户提供疾病部位的荧光图像。 荧光图像用于通过补充肉眼皮肤损伤的视觉评估来帮助对皮肤状况的医学评估和皮肤疾病的诊断。 该装置可以用于允许观看全色荧光图像和增强的双色图像的几种操作模式。 该装置还可以使用图像增强设备来放大荧光，使得甚至可以看到非常弱的荧光物体。 还公开了一种用于获取和观察荧光图像的方法。

公开(公告)号：US20050167621A1

公开(公告)日：2005-08-04

申请号：US11057965

申请日：2005-02-14

申请人： Haishan Zeng ,  Stephen Lam ,  Branko Palcic

发明人： Haishan Zeng ,  Stephen Lam ,  Branko Palcic

IPC分类号： G01N21/64 ,  A61B1/00 ,  A61B1/04 ,  G01J3/02 ,  G01J3/10 ,  G01J3/36 ,  G01N23/223 ,  G21K1/12 ,  A61B6/00 ,  G01N23/00 ,  G01N23/04 ,  G03C5/16 ,  G21K4/00 ,  H05G1/60

CPC分类号： G01J3/02 ,  G01J3/021 ,  G01J3/0218 ,  G01J3/0235 ,  G01J3/0243 ,  G01J3/0289 ,  G01J3/10 ,  G01J3/36 ,  G01N23/223 ,  G01N2223/076

摘要： Optical systems that provide for simultaneous images and spectra from an object, such as a tissue sample, an industrial object such as a computer chip, or any other object that can be viewed with an optical system such as a microscope, endoscope, telescope or camera. In some embodiments, the systems provide multiple images corresponding to various desired wavelength ranges within an original image of the object, as well as, if desired, directional pointer(s) that can provide both an identification of the precise location from which a spectrum is being obtained, as well as enhancing the ability to point the device.

摘要翻译： 提供来自物体的同时图像和光谱的光学系统，例如组织样本，诸如计算机芯片的工业对象或可以用诸如显微镜，内窥镜，望远镜或照相机的光学系统观察的任何其它物体 。 在一些实施例中，系统提供对应于对象的原始图像内的各种期望波长范围的多个图像，以及如果需要的方向指针，其可以提供频谱的精确位置的识别 获得，以及增强指向设备的能力。

公开(公告)号：US6069689A

公开(公告)日：2000-05-30

申请号：US59885

申请日：1998-04-14

申请人： Haishan Zeng ,  Harvey Lui ,  Calum MacAulay ,  Branko Palcic ,  David I. McLean

发明人： Haishan Zeng ,  Harvey Lui ,  Calum MacAulay ,  Branko Palcic ,  David I. McLean

IPC分类号： A61B5/00 ,  A61B5/103 ,  G01N21/64 ,  G01N21/65 ,  G01B9/02 ,  G01N11/00

CPC分类号： G01N21/474 ,  A61B5/0059 ,  A61B5/0071 ,  A61B5/444 ,  G01N21/645 ,  G01N21/6486 ,  G01N21/65 ,  G01N2021/475 ,  G01N2021/6417 ,  G01N2021/656 ,  G01N2201/0627

摘要： Apparatus for diagnosis of a skin disease site using spectral analysis includes a light source for generating light to illuminate the disease site and a probe unit optically connected to the light source for exposing the disease site to light to generate fluorescence and reflectance light. The probe unit also collects the generated fluorescence and reflectance light and transmits this light to a spectrometer to be analyzed. The spectrometer generates and displays spectral measurements of the fluorescence light and the reflectance light which in together assist the user in diagnosing the disease site. The apparatus makes use of a conventional personal computer using a plug-in spectrometer card to provide a compact and low costs system. The system performs combined fluorescence and reflectance spectral analysis in a quick and efficient manner to provide a powerful tool for dermatologic diagnosis.

摘要翻译： 用于使用光谱分析诊断皮肤疾病部位的装置包括用于产生照亮疾病部位的光的光源和与光源光学连接的探针单元，用于将疾病部位暴露于光以产生荧光和反射光。 探针单元还收集产生的荧光和反射光，并将该光传输到要分析的光谱仪。 光谱仪产生和显示荧光和反射光的光谱测量，这些在一起协助用户诊断疾病部位。 该装置利用使用插入式光谱仪卡的常规个人计算机来提供紧凑且低成本的系统。 该系统以快速有效的方式进行组合荧光和反射光谱分析，为皮肤病诊断提供强大的工具。

公开(公告)号：US5769792A

公开(公告)日：1998-06-23

申请号：US632018

申请日：1996-04-15

申请人： Branko Palcic ,  Calum E. MacAulay ,  Bruno W. Jaggi ,  Stephen C-T Lam ,  Amedeus E. Profio ,  Jaclyn Y-C Hung

发明人： Branko Palcic ,  Calum E. MacAulay ,  Bruno W. Jaggi ,  Stephen C-T Lam ,  Amedeus E. Profio ,  Jaclyn Y-C Hung

IPC分类号： A61B5/00 ,  A61B6/00

CPC分类号： A61B5/0084 ,  A61B5/0071 ,  G01N2021/6463

摘要： Apparatus for imaging diseases in tissue comprising a light source for generating excitation light that includes wavelengths capable of generating characteristic autofluorescence for abnormal and normal tissue. A fiber-optic illuminating light guide is used to illuminate tissue with light that includes at least the excitation light thereby exciting the tissue to emit the characteristic autofluorescence. An imaging bundle collects emitted autofluorescence light from the tissue. The autofluorescence light is filtered into spectral bands in which the autofluorescence intensity for abnormal tissue is substantially different from normal tissue and the autofluorescence intensity for abnormal tissue is substantially similar to normal tissue. An optical system is used to intercept the filtered autofluorescence light to acquire at least two filtered emitted autofluorescence images of the tissue. The acquired images are displayed in real time on a display monitor in such a manner as to delineate abnormal and normal tissue.

摘要翻译： 用于在组织中成像疾病的装置，包括用于产生激发光的光源，所述激发光包括能够产生用于异常和正常组织的特征性自发荧光的波长。 光纤照明光导用于用至少包含激发光的光照射组织，从而激发组织以发出特征自发荧光。 成像束从组织中收集发射的自发荧光。 自发荧光被过滤到光谱带，其中异常组织的自发荧光强度与正常组织基本不同，异常组织的自发荧光强度基本上与正常组织相似。 光学系统用于截取滤波的自发荧光以获得组织的至少两个经滤波的发射的自发荧光图像。 所获取的图像以描绘异常和正常组织的方式在显示监视器上实时显示。

公开(公告)号：US20050203421A1

公开(公告)日：2005-09-15

申请号：US11053263

申请日：2005-02-07

申请人： Haishan Zeng ,  Stephen Lam ,  Branko Palcic

发明人： Haishan Zeng ,  Stephen Lam ,  Branko Palcic

IPC分类号： G01N21/64 ,  A61B1/00 ,  A61B1/04 ,  G01J3/02 ,  G01J3/10 ,  G01J3/36 ,  G01N23/223 ,  G01N23/00 ,  A61B6/00 ,  G21K1/12 ,  H05G1/60

CPC分类号： G01J3/02 ,  G01J3/021 ,  G01J3/0218 ,  G01J3/0235 ,  G01J3/0243 ,  G01J3/0289 ,  G01J3/10 ,  G01J3/36 ,  G01N23/223 ,  G01N2223/076

摘要： Optical systems that provide for simultaneous images and spectra from an object, such as a tissue sample, an industrial object such as a computer chip, or any other object that can be viewed with an optical system such as a microscope, endoscope, telescope or camera. In some embodiments, the systems provide multiple images corresponding to various desired wavelength ranges within an original image of the object, as well as, if desired, directional pointer(s) that can provide both an identification of the precise location from which a spectrum is being obtained, as well as enhancing the ability to point the device.

摘要翻译： 提供来自物体的同时图像和光谱的光学系统，例如组织样本，诸如计算机芯片的工业对象或可以用诸如显微镜，内窥镜，望远镜或照相机的光学系统观察的任何其它物体 。 在一些实施例中，系统提供对应于对象的原始图像内的各种期望波长范围的多个图像，以及如果需要的方向指针，其可以提供频谱的精确位置的识别 获得，以及增强指向设备的能力。