公开(公告)号：US20220339555A1

公开(公告)日：2022-10-27

申请号：US17617059

申请日：2020-06-12

Applicant: DAICEL CORPORATION

Inventor： Toru Shibata ,  Satoshi Shinkura ,  Atsushi Ohnishi

IPC: B01D15/36 ,  B01D15/38 ,  B01J41/20

Abstract: Provided is a separation method for amine, the separation method including performing liquid chromatography, wherein a separating agent in which a ligand having a crown ether-like cyclic structure is supported on a carrier is used as a stationary phase, and wherein a mobile phase contains an aqueous solution of at least one salt of a hydrophobic anion selected from the group consisting of a salt of a chaotropic anion and a salt of a hydrophobic organic acid.

公开(公告)号：US12290796B2

公开(公告)日：2025-05-06

申请号：US17619250

申请日：2020-06-19

Applicant: Daicel Corporation

Inventor： Hiromichi Okura ,  Toru Shibata ,  Yuki Hirabayashi

IPC: B01J20/28 ,  B01D15/34 ,  B01J2/06 ,  B01J20/24 ,  B01J20/285 ,  B01J20/30

Abstract: Provided is a novel porous cellulose medium that can efficiently separate a large target molecule in a calibration standard. A porous cellulose medium including a porous cellulose particle having a particle size from 1 to 600 μm, wherein, in sieving the porous cellulose medium for classification and using a fraction corresponding to aperture openings between 53 μm and 106 μm as a support for size exclusion chromatography, a polyethylene oxide standard is run through size exclusion chromatography with pure water as a mobile phase, and a weight average molecular weight Mw and a gel partition coefficient Kav of the polyethylene oxide standard satisfy Relationships (A) and (B) above: in a case where 4.80≤log Mw≤5.50,Kav>−0.445×log Mw+2.55  (A) in a case where 5.75≤log Mw,0≤Kav

公开(公告)号：US09327269B2

公开(公告)日：2016-05-03

申请号：US14416381

申请日：2013-07-08

Applicant: DAICEL CORPORATION

Inventor： Toru Shibata ,  Satoshi Shinkura

IPC: B01J20/285 ,  B01D15/40 ,  B01J20/26 ,  B01J20/286 ,  B01J20/32 ,  B01J20/28 ,  C08G63/00 ,  C08G63/183 ,  C08G63/02

CPC classification number: B01J20/285 ,  B01D15/40 ,  B01J20/262 ,  B01J20/264 ,  B01J20/28016 ,  B01J20/28059 ,  B01J20/28061 ,  B01J20/28064 ,  B01J20/286 ,  B01J20/3204 ,  B01J20/3272 ,  B01J2220/80 ,  C08G63/00 ,  C08G63/183

Abstract: A stationary phase that increases the number of column stages and that exhibits an excellent molecular discrimination ability is realized by a stationary phase that contains a polymer having, in main chain repeat units, an aromatic ring that forms a portion of the main chain and a bipolar atomic group that forms a portion of the main chain, wherein the stationary phase has a specific surface area of 5 to 1000 m2/g.

Abstract translation: 通过含有主链重复单元的形成一部分主链的芳环和双极性的聚合物的固定相实现了增加柱级数并且表现出优异的分子鉴别能力的固定相 原子团，其形成主链的一部分，其中固定相的比表面积为5〜1000m2 / g。

公开(公告)号：US10695747B2

公开(公告)日：2020-06-30

申请号：US15560962

申请日：2016-04-01

Applicant: DAICEL CORPORATION

Inventor： Toru Shibata ,  Yasuto Morishita ,  Keiji Nishihara

IPC: B01J20/285 ,  B01J20/286 ,  C07K1/22 ,  C08J9/28 ,  B01D15/38 ,  C08B15/00 ,  B01J20/30 ,  B01J20/24 ,  B01J20/26 ,  B01J20/288

Abstract: Provided are a technique for preparing a porous cellulose medium without using a special gelling agent for a solution in which cellulose acetate serving as a raw material is dissolved; and a porous cellulose medium and the like produced using the technique. A method for producing a porous cellulose medium comprises the step of preparing a flowable homogeneous composition comprising cellulose acetate, a basic compound, and a solvent including water, and gelling the composition by deacetylation reaction of the cellulose acetate.

公开(公告)号：US11040330B2

公开(公告)日：2021-06-22

申请号：US16087178

申请日：2017-03-23

Applicant: DAICEL CORPORATION

Inventor： Toru Shibata ,  Satoshi Shinkura

IPC: B01J20/285 ,  B01J20/287 ,  B01J20/28 ,  B01J20/30 ,  B01J20/32 ,  G01N30/02 ,  B01J20/288 ,  B01J20/289 ,  B01J20/26 ,  G01N30/52 ,  B01D15/40

Abstract: Provided is a chromatography stationary phase having an excellent molecule discriminating ability. Specifically, provided is a chromatography stationary phase including a carrier carrying a copolymer that has a pyrrolidone backbone or a piperidone backbone, and an imide backbone in a repeating unit of the main chain.

公开(公告)号：US11021588B2

公开(公告)日：2021-06-01

申请号：US15327940

申请日：2015-07-22

Applicant: DAICEL CORPORATION

Inventor： Toru Shibata ,  Yasuto Morishita ,  Yosuke Ito

IPC: C08J9/26 ,  C08J3/16 ,  B01J20/28 ,  B01J20/30 ,  B01J20/285 ,  B01J20/24 ,  C08J3/075 ,  B01J20/32 ,  B01J20/286 ,  B01D15/38 ,  C07K1/22 ,  C07K16/00

Abstract: The present invention provides a technique for preparing a porous cellulose medium, through the gelation of a solution in which cellulose acetate as a raw material is dissolved, which does not cause a reaction involving the migration of substances. Specifically, a method for producing a porous cellulose medium is provided which includes the steps of gelling a flowable homogeneous composition containing cellulose acetate, an organic solvent, and water through a decrease in temperature; and hydrolyzing the cellulose acetate contained in the resulting gel.

公开(公告)号：US12134684B2

公开(公告)日：2024-11-05

申请号：US17297322

申请日：2019-11-26

Applicant: DAICEL CORPORATION

Inventor： Toru Shibata ,  Hiromichi Okura

IPC: C08J3/16

Abstract: Provided is a novel method for producing cellulose beads, the method being capable of suitably producing spherical cellulose beads. The method for producing cellulose beads includes: (Step 1) preparing a coagulating bath having a first liquid medium phase and a second liquid medium phase; (Step 2) forming a particulate cellulose solution in the first liquid medium phase by supplying a cellulose solution to the first liquid medium phase of the coagulating bath; and (Step 3) coagulating the particulate cellulose solution by supplying the particulate cellulose solution in the first liquid medium phase to the second liquid medium phase.

公开(公告)号：US12115467B2

公开(公告)日：2024-10-15

申请号：US17617059

申请日：2020-06-12

Applicant: DAICEL CORPORATION

Inventor： Toru Shibata ,  Satoshi Shinkura ,  Atsushi Ohnishi

IPC: B01D15/36 ,  B01D15/16 ,  B01D15/32 ,  B01D15/38 ,  B01J20/28 ,  B01J20/286 ,  B01J20/29 ,  B01J20/32 ,  B01J41/20 ,  G01N30/02

CPC classification number: B01D15/36 ,  B01D15/166 ,  B01D15/32 ,  B01D15/38 ,  B01D15/3833 ,  B01J20/286 ,  B01J20/29 ,  B01J20/3204 ,  B01J20/321 ,  B01J20/3212 ,  B01J20/3219 ,  B01J20/3255 ,  B01J41/20 ,  G01N30/02 ,  G01N2030/027

Abstract: Provided is a separation method for amine, the separation method including performing liquid chromatography, wherein a separating agent in which a ligand having a crown ether-like cyclic structure is supported on a carrier is used as a stationary phase, and wherein a mobile phase contains an aqueous solution of at least one salt of a hydrophobic anion selected from the group consisting of a salt of a chaotropic anion and a salt of a hydrophobic organic acid.

公开(公告)号：US11097251B2

公开(公告)日：2021-08-24

申请号：US16097924

申请日：2017-05-12

Applicant: DAICEL CORPORATION

Inventor： Toru Shibata ,  Yuki Hirabayashi

IPC: B01J20/24 ,  B01D15/34 ,  C08J9/28 ,  B01J20/30 ,  B01D15/38 ,  B01J20/28 ,  C07K1/22 ,  C07K16/06

Abstract: Provided is a novel method by which a porous cellulose medium is able to be suitably produced from cellulose acetate. A method for producing a porous cellulose medium, which comprises: a step for preparing a cellulose acetate solution wherein cellulose acetate is dissolved in a solvent; and a step for obtaining a mixed solution by mixing the cellulose acetate solution, a deacetylating agent and a catalyst with each other.

公开(公告)号：US11014019B2

公开(公告)日：2021-05-25

申请号：US15748958

申请日：2016-07-29

Applicant: DAICEL CORPORATION

Inventor： Toru Shibata ,  Satoshi Shinkura

IPC: B01D15/40 ,  B01J20/286 ,  B01J20/281 ,  B01J20/30 ,  G01N30/02 ,  C08F292/00 ,  G01N30/88 ,  B01J20/32

Abstract: Provided is a stationary phase for supercritical fluid chromatography that includes a carrier on which is supported a polymer that includes a pyrrolidone backbone in the repeating units of the main chain.