Patent search ap:("EMD Millipore Corporation") AND inv:"Christopher Gillespie" Page 1

1.

发明申请
Method Of Maintaining Narrow Residence Time Distributions In Continuous Flow Systems 审中-公开

公开(公告)号：US20200061495A1

公开(公告)日：2020-02-27

申请号：US16610595

申请日：2018-04-18

Applicant: EMD Millipore Corporation

Inventor： Ronald Tuccelli , John Caulmare , Melissa Holstein , Kristen Cotoni , Christopher Gillespie

IPC: B01D15/24 , B01D15/38 , B01D15/36 , C07K1/22 , C07K1/18

Abstract: Methods of maintaining narrow residence time distributions in continuous flow systems, particularly applicable to virus inactivation such as during a protein purification process. Fluid sample is introduced into an axial flow channel and caused to flow therein in discrete packets or zones to minimize residence time distribution and axial dispersion. Embodiments described herein obviate or minimize the need for using large tanks or reservoirs for performing virus inactivation during a protein purification process; reduce the overall time required for virus inactivation, and/or reduce the overall physical space required to perform the virus inactivation operation during a protein purification process, which in turn reduces the overall footprint for the purification process.

2.

发明授权
Methods of reducing level of one or more impurities in a sample during protein purification 有权

公开(公告)号：US10287314B2

公开(公告)日：2019-05-14

申请号：US14747029

申请日：2015-06-23

Applicant: EMD Millipore Corporation

Inventor： Nanying Bian , Christopher Gillespie , Matthew T. Stone , Mikhail Kozlov , Jie Chen , Martin Siwak

IPC: B01D15/36 , B01D15/12 , B01D15/18 , B01D15/38 , B01J39/26 , B01J41/20 , C07K1/36 , C07K1/16 , B01J20/282 , C07K1/20 , B01J43/00 , B01J47/04 , C07K16/00 , B01J20/20

Abstract: The present invention provides novel and improved protein purification processes which incorporate certain types of carbonaceous materials and result in effective and selective removal of certain undesirable impurities without adversely effecting the yield of the desired protein product.

3.

发明授权
Mechanical method of maintaining narrow residence time distributions in continuous flow systems 有权

公开(公告)号：US11732003B2

公开(公告)日：2023-08-22

申请号：US16610616

申请日：2018-04-18

Applicant: EMD Millipore Corporation

Inventor： Ronald Tuccelli , John Caulmare , Luc Messier , Melissa Holstein , Christopher Gillespie , Roger Hill

IPC: A61L2/00 , A61L2/26 , B01D15/24 , B01L3/00 , C12N7/00 , C07K1/22 , B01D15/36 , B01D15/38

CPC classification number: C07K1/22 , A61L2/0088 , A61L2/26 , B01D15/245 , B01D15/361 , B01D15/3809 , B01L3/502 , C12N7/00 , A61L2202/21 , B01L2400/0481 , B01L2400/082 , C12N2740/10063 , C12N2740/10064 , C12N2795/00063 , C12N2795/00064

Abstract: Methods of maintaining narrow residence time distributions in continuous flow systems, particularly applicable to virus inactivation such as during a protein purification process. Fluid sample is introduced into an axial flow channel and caused to flow therein in discrete packets or zones to minimize residence time distribution and axial dispersion. Embodiments described herein obviate or minimize the need for using large tanks or reservoirs for performing virus inactivation during a protein purification process; reduce the overall time required for virus inactivation, and/or reduce the overall physical space required to perform the virus inactivation operation during a protein purification process, which in turn reduces the overall footprint for the purification process.

4.

发明授权
Method of maintaining narrow residence time distributions in continuous flow systems 有权

公开(公告)号：US11547957B2

公开(公告)日：2023-01-10

申请号：US16610595

申请日：2018-04-18

Applicant: EMD Millipore Corporation

Inventor： Ronald Tuccelli , John Caulmare , Melissa Holstein , Kristen Cotoni , Christopher Gillespie

IPC: B01D15/24 , B01D15/38 , C07K1/18 , C07K1/22 , B01D15/36

Abstract: Methods of maintaining narrow residence time distributions in continuous flow systems, particularly applicable to virus inactivation such as during a protein purification process. Fluid sample is introduced into an axial flow channel and caused to flow therein in discrete packets or zones to minimize residence time distribution and axial dispersion. Embodiments described herein obviate or minimize the need for using large tanks or reservoirs for performing virus inactivation during a protein purification process; reduce the overall time required for virus inactivation, and/or reduce the overall physical space required to perform the virus inactivation operation during a protein purification process, which in turn reduces the overall footprint for the purification process.

5.

发明申请
Methods of Reducing Level of One or More Impurities in a Sample During Protein Purification 审中-公开
Title translation: 降低蛋白质纯化过程中样品中一种或多种杂质水平的方法

公开(公告)号：US20160016992A1

公开(公告)日：2016-01-21

申请号：US14747029

申请日：2015-06-23

Applicant: EMD Millipore Corporation

Inventor： Nanying Bian , Christopher Gillespie , Matthew T. Stone , Mikhail Kozlov , Jie Chen , Martin Siwak

IPC: C07K1/36 , B01J41/20 , B01J39/26 , B01J20/20

CPC classification number: C07K1/36 , B01D15/125 , B01D15/1871 , B01D15/362 , B01D15/363 , B01D15/3809 , B01J20/20 , B01J20/282 , B01J39/26 , B01J41/20 , B01J43/00 , B01J47/04 , C07K1/16 , C07K1/20 , C07K16/00 , C07K2317/10

Abstract: The present invention provides novel and improved protein purification processes which incorporate certain types of carbonaceous materials and result in effective and selective removal of certain undesirable impurities without adversely effecting the yield of the desired protein product.

Abstract translation: 本发明提供新颖和改进的蛋白质纯化方法，其包含某些类型的碳质材料，并且导致有效和选择性地除去某些不需要的杂质，而不会不利地影响所需蛋白质产物的产率。

6.

发明申请
USE OF CHARGED FLUOROCARBON COMPOSITIONS IN METHODS FOR PURIFICATION OF BIOMOLECULES 审中-公开
Title translation: 在生物分子纯化方法中使用充电氟化物组合物

公开(公告)号：US20150125929A1

公开(公告)日：2015-05-07

申请号：US14362964

申请日：2013-03-18

Applicant: EMD Millipore Corporation

Inventor： Mikhail Kozlov , Wilson Moya , Jad Jaber , William Cataldo , Ajish Potty , Christopher Gillespie

IPC: C07K1/22 , C07K16/00 , C12N7/00

CPC classification number: C07K1/22 , C07K16/00 , C12N7/00

Abstract: The present invention relates to novel and improved methods for the purification of biomolecules. In particular, the present invention relates to methods of protein purification which employ a porous solid support modified with a charged fluorocarbon composition.

Abstract translation: 本发明涉及用于纯化生物分子的新颖和改进的方法。特别地，本发明涉及蛋白质纯化方法，该方法采用用带电的碳氟化合物组合物改性的多孔固体支持物。

7.

发明授权
Methods of reducing level of one or more impurities in a sample during protein purification 有权

公开(公告)号：US11634457B2

公开(公告)日：2023-04-25

申请号：US16358845

申请日：2019-03-20

Applicant: EMD Millipore Corporation

Inventor： Nanying Bian , Christopher Gillespie , Matthew T. Stone , Mikhail Kozlov , Jie Chen , Martin Siwak

IPC: B01D15/36 , C07K1/36 , C07K1/16 , B01D15/18 , C07K1/18 , C07K1/22 , C07K16/00 , B01J20/282 , C07K1/20 , B01D15/12 , B01J39/26 , B01J41/20 , B01J43/00 , B01J47/04 , B01J20/20 , B01D15/38

Abstract: The present invention provides novel and improved protein purification processes which incorporate certain types of carbonaceous materials and result in effective and selective removal of certain undesirable impurities without adversely affecting the yield of the desired protein product.

8.

发明申请
Mechanical Method Of Maintaining Narrow Residence Time Distributions In Continuous Flow Systems 审中-公开

公开(公告)号：US20200172568A1

公开(公告)日：2020-06-04

申请号：US16610616

申请日：2018-04-18

Applicant: EMD Millipore Corporation

Inventor： Ronald Tuccelli , John Caulmare , Luc Messier , Melissa Holstein , Christopher Gillespie , Roger Hill

IPC: C07K1/22 , B01L3/00 , C12N7/00 , A61L2/00 , A61L2/26 , B01D15/38 , B01D15/36 , B01D15/24

Abstract: Methods of maintaining narrow residence time distributions in continuous flow systems, particularly applicable to virus inactivation such as during a protein purification process. Fluid sample is introduced into an axial flow channel and caused to flow therein in discrete packets or zones to minimize residence time distribution and axial dispersion. Embodiments described herein obviate or minimize the need for using large tanks or reservoirs for performing virus inactivation during a protein purification process; reduce the overall time required for virus inactivation, and/or reduce the overall physical space required to perform the virus inactivation operation during a protein purification process, which in turn reduces the overall footprint for the purification process.