公开(公告)号：US20190148122A1

公开(公告)日：2019-05-16

申请号：US16228982

申请日：2018-12-21

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Masuyuki SUGIYAMA ,  Hideki HASEGAWA ,  Masao SUGA ,  Hiroyuki SATAKE ,  Yuichiro HASHIMOTO

IPC: H01J49/06 ,  H01J49/42

CPC classification number: H01J49/063 ,  H01J49/42

Abstract: A first rod electrode set has a first center axis, into which ions and air current are introduced. A second rod electrode set has a second center axis at a distance from the first center axis, from which the ions are discharged. A power supply applies voltages to the first rod electrode set and the second rod electrode set. The first rod electrode set and the second rod electrode set have a region where the sets overlap each other in the longitudinal direction, and form a single multipole ion guide by being combined to each other in the region. Different offset DC voltages are applied to the first rod electrode set and the second rod electrode set, respectively, and a DC potential for moving the ions to the second rod electrode set in the region is formed, the ions having been guided by the first rod electrode set.

公开(公告)号：US20150041641A1

公开(公告)日：2015-02-12

申请号：US14491298

申请日：2014-09-19

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Hidetoshi MOROKUMA ,  Yuichiro HASHIMOTO ,  Masuyuki SUGIYAMA ,  Masuyoshi YAMADA ,  Hideki HASEGAWA

IPC: H01J49/00 ,  H01J49/04 ,  H01J49/10 ,  H01J49/26

CPC classification number: H01J49/0013 ,  H01J49/0031 ,  H01J49/0422 ,  H01J49/0495 ,  H01J49/10 ,  H01J49/105 ,  H01J49/24 ,  H01J49/26

Abstract: A mass spectrometer of reduced size and weight is provided which is capable to conduct highly accurate mass spectroscopy. The mass spectrometer includes an ion source adapted to ionize gas flowing in from outside in order to ionize a measurement sample and a mass spectroscopy section for separating the ionized measurement sample. The ion source has its interior reduced in pressure by differential pumping from the mass spectroscopy section and ionizes the gas when the interior pressure rises as it inhales the gas, and the mass spectroscopy section separates the ionized measurement sample when its interior pressure falls after inhale of the gas. The mass spectrometer may further include a restriction device for suppressing a flow rate of the gas the ion source inhales and an open/close device for opening and closing a flow of the gas the ion source inhales.

Abstract translation: 提供了减小尺寸和重量的质谱仪，其能够进行高精度的质谱。 质谱仪包括离子源，其适于使从外部流入的气体电离，以便电离测量样品和用于分离离子化测量样品的质谱部分。 离子源的内部通过从质谱分析部分的差分泵送而在内部减压，并且当吸入气体时内部压力升高时电离气体，质谱仪分离离子化测量样品，当其内部压力在吸入后 气体。 质谱仪还可以包括用于抑制离子源吸入的气体的流量的限制装置和用于打开和关闭离子源吸入的气体流的打开/关闭装置。

公开(公告)号：US20170336357A1

公开(公告)日：2017-11-23

申请号：US15534607

申请日：2014-12-24

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Hiroyuki SATAKE ,  Hideki HASEGAWA ,  Masao SUGA ,  Yuichiro HASHIMOTO

IPC: G01N27/62 ,  H01J49/04

CPC classification number: G01N27/624 ,  H01J49/004 ,  H01J49/04

Abstract: A mass spectrometer device comprising an ion mobility separation device and a mass spectrometer that are coupled together. In order to achieve high efficiency, high throughput, and high sensitivity, the mass spectrometer is provided with: a first flow passageway 24 through which ions from an ion source 1 are introduced into the mass spectrometer 11 by passing through an ion mobility separation unit 2; a second flow passageway 21 through which the ions from the ion source are introduced into the mass spectrometer without passing through the ion mobility separation unit; and a switch means, such as shield units 4, 5, for switching between the first flow passageway 24 and the second flow passageway 21.

公开(公告)号：US20180114682A1

公开(公告)日：2018-04-26

申请号：US15568529

申请日：2016-03-30

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Hideki HASEGAWA ,  Shun KUMANO ,  Yuichiro HASHIMOTO

IPC: H01J49/00 ,  H01J49/04

CPC classification number: H01J49/0045 ,  G01N30/30 ,  G01N30/32 ,  H01J49/0468

Abstract: For increasing a speed of fragmentation of a sample, such as a protein and a peptide, to enhance introduction efficiency into a detector, such as a mass spectrometer, a liquid feeding pump 2, a sample injector 3, and a separation column 6 that are connected via pipes are included, and further, a heating unit 4 for heating a pipe between the sample injector 3 and the separation column 6, and a pressure regulating unit 5 provided between the heating unit 4 and the separation column 6 for regulating the inner pressure of the pipe heated by the heating unit 4, are included.

公开(公告)号：US20160196965A1

公开(公告)日：2016-07-07

申请号：US14911411

申请日：2014-07-09

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Hiroyuki SATAKE ,  Hideki HASEGAWA ,  Yukiko HIRABAYASHI ,  Yuichiro HASHIMOTO

IPC: H01J49/10 ,  H01J49/16 ,  H01J49/04

CPC classification number: H01J49/107 ,  H01J49/0468 ,  H01J49/165 ,  H01J49/168

Abstract: In order to provide an ion source that can be easily switched with high sensitivity and in a short time, the ion source includes an ionization probe for spraying a sample, a heating chamber for heating and vaporizing a sample; and driving portions and for changing the distance between an outlet end (i.e., an end on the spray side) of the ionization probe and an inlet end (i.e., an end on the ionization probe side) of the heating chamber. The positions of the ionization probe and the heating chamber are controlled by the driving portions so that an ionization region that uses the ionization probe or an ionization region that uses the heating chamber is positioned near the ion inlet port of the mass spectrometer.

Abstract translation: 为了提供能够以高灵敏度和短时间容易切换​​的离子源，离子源包括用于喷射样品的电离探针，用于加热和蒸发样品的加热室; 和驱动部分，并且用于改变电离探针的出口端（即，喷射侧的端部）与加热室的入口端（即电离探针侧的端部）之间的距离。 离子化探针和加热室的位置由驱动部分控制，使得使用离子化探针的电离区域或使用加热室的电离区域位于质谱仪的离子入口附近。

公开(公告)号：US20180025896A1

公开(公告)日：2018-01-25

申请号：US15549228

申请日：2015-02-23

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Masuyuki SUGIYAMA ,  Hideki HASEGAWA ,  Masao SUGA ,  Hiroyuki SATAKE ,  Yuichiro HASHIMOTO

IPC: H01J49/06 ,  H01J49/42

CPC classification number: H01J49/063 ,  H01J49/42

Abstract: A first rod electrode set has a first center axis, into which ions and air current are introduced. A second rod electrode set has a second center axis at a distance from the first center axis, from which the ions are discharged. A power supply applies voltages to the first rod electrode set and the second rod electrode set. The first rod electrode set and the second rod electrode set have a region where the sets overlap each other in the longitudinal direction, and form a single multipole ion guide by being combined to each other in the region. Different offset DC voltages are applied to the first rod electrode set and the second rod electrode set, respectively, and a DC potential for moving the ions to the second rod electrode set in the region is formed, the ions having been guided by the first rod electrode set.

公开(公告)号：US20190178841A1

公开(公告)日：2019-06-13

申请号：US16323168

申请日：2016-08-19

Applicant: Hitachi High-Technologies Corporation

Inventor： Kazushige NISHIMURA ,  Masuyuki SUGIYAMA ,  Hideki HASEGAWA ,  Yuichiro HASHIMOTO

IPC: G01N27/62 ,  H01J49/06 ,  H01J49/26 ,  H01J49/00 ,  H01J49/04

Abstract: An ion analysis device includes: an ion source that ionizes an analyte in a liquid sample; an ion guide into which droplets and ions produced in the ion source are introduced, the ion guide having different outlets, one outlet being an ion outlet for the ions and the other outlet being a droplet outlet for the droplets; an ion analysis unit that analyzes ions ejected from the ion outlet; a droplet measurement unit that is placed on an axis of the droplet outlet, and measures the amount of droplets; and an analysis control section that compares the amount of droplets measured at the droplet measurement unit with a threshold.

公开(公告)号：US20170162375A1

公开(公告)日：2017-06-08

申请号：US15324092

申请日：2015-06-15

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Hideki HASEGAWA ,  Hiroyuki SATAKE ,  Masao SUGA ,  Yuichiro HASHIMOTO

IPC: H01J49/24 ,  H01J49/16 ,  H01J49/04 ,  H01J49/34

CPC classification number: H01J49/24 ,  G01N27/62 ,  H01J49/0404 ,  H01J49/0422 ,  H01J49/067 ,  H01J49/165 ,  H01J49/34

Abstract: A mass spectrometry device that can perform highly robust, highly sensitive, and low-noise analysis and addresses the problems of preventing reductions in ion transfer efficiency and of suppressing the introduction of noise components from droplets, etc. An ion source generates ions, a vacuum chamber is evacuated by an evacuation means and for analyzing the mass of ions, and an ion introduction electrode introduces ions into the vacuum chamber. The ion introduction electrode has an ion-source-side front-stage pore, a vacuum-chamber-side rear-stage pore, and an intermediate pressure chamber between the front-stage pore and the rear-stage pore, the cross-sectional area of an ion inlet of the intermediate pressure chamber is larger than the cross-sectional area of the front-stage pore, the position of the central axis of the front-stage pore and the position of the central axis of the rear-stage pore are eccentric, and the cross-sectional area of an ion outlet of the intermediate pressure chamber is smaller than the cross-sectional area of the ion inlet.

公开(公告)号：US20160300703A1

公开(公告)日：2016-10-13

申请号：US14442199

申请日：2013-11-07

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Hideki HASEGAWA ,  Hiroyuki SATAKE ,  Masao SUGA ,  Yuichiro HASHIMOTO

IPC: H01J49/10 ,  H01J49/16

CPC classification number: H01J49/107 ,  G01N27/62 ,  H01J49/165 ,  H01J49/168

Abstract: Provided is an ion source achieving high sensitivity and high robustness while executing a plurality of types of ionization schemes. To this end, a hybrid ion source (1) includes: a chamber (24); a first ion source (2) to spray a sample solution (5) for ionization; a second ion source (3) to ionize droplets and/or a gas component sprayed from the first ion source (2); a first electrode (11) to introduce a first ion (7) generated by the first ion source (2), and a second ion generated by the second ion source (3); and an exhaust pump (27) that generates air flow (26) in a direction from a first space area (23) where the first ion (7) is generated to a second space area (19) in the second ion source (3) where the second ion is generated.

Abstract translation: 提供了在执行多种类型的电离方案时实现高灵敏度和高鲁棒性的离子源。 为此，混合离子源（1）包括：室（24）; 用于喷射用于电离的样品溶液（5）的第一离子源（2）; 第二离子源（3），用于离子化从第一离子源（2）喷射的液滴和/或气体成分; 引入由第一离子源（2）产生的第一离子（7）和由第二离子源（3）产生的第二离子的第一电极（11）。 和从第一离子（7）的第一空间区域（23）向第二离子源（3）的第二空间区域（19）的方向产生空气流（26）的排气泵（27） 其中产生第二离子。

公开(公告)号：US20160025692A1

公开(公告)日：2016-01-28

申请号：US14782424

申请日：2014-04-10

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Hiroyuki SATAKE ,  Yuichiro HASHIMOTO ,  Masao SUGA ,  Hideki HASEGAWA

IPC: G01N30/72 ,  H01J49/00 ,  G01N27/62

CPC classification number: G01N30/7233 ,  G01N27/624 ,  H01J49/0027 ,  H01J49/004

Abstract: An analysis system is provided with: a storage unit that stores first information associating mass spectrometry result information with an analysis condition concerning ion mobility separation; and a control unit that determines, as a first analysis condition for an ion to be measured, the analysis condition associated with the mass spectrometry result information of the first information corresponding to the mass spectrometry result information of the ion to be measured.

Abstract translation: 分析系统具有：存储单元，存储将质谱结果信息与关于离子迁移率分离的分析条件相关联的第一信息; 以及控制单元，其确定与要测量的离子的质谱结果信息对应的第一信息的质谱结果信息相关联的作为待测离子的第一分析条件的分析条件。