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公开(公告)号:US20230201624A1
公开(公告)日:2023-06-29
申请号:US17850425
申请日:2022-06-27
申请人: Immunolight, LLC , Duke University
发明人: Tuan VO-DINH , Jonathan P. SCAFFIDI , Venkata Gopal Reddy CHADA , Benoit LAULY , Yan ZHANG , Molly K. GREGAS , Ian Nicholas STANTON , Joshua T. STECHER , Michael J. THERIEN , Frederic A. BOURKE, JR. , Harold WALDER , Zak FATHI , Jennifer A. AYRES , Zhenyuan ZHANG , Joseph H. SIMMONS , Stephen John NORTON
IPC分类号: A61N5/06 , A61K49/00 , A61N1/40 , A61N5/02 , A61B5/00 , A61B5/055 , A61B6/00 , A61K41/00 , A61M5/00 , A61L2/00
CPC分类号: A61N5/062 , A61K49/0039 , A61N1/406 , A61N5/02 , A61N5/0601 , A61B5/0059 , A61B5/0071 , A61B5/055 , A61B5/4848 , A61B6/481 , A61K41/0052 , A61M5/007 , A61K41/0042 , A61K41/0061 , A61L2/0047 , A61L2/08
摘要: Products, compositions, systems, and methods for modifying a target structure which mediates or is associated with a biological activity, including treatment of conditions, disorders, or diseases mediated by or associated with a target structure, such as a virus, cell, subcellular structure or extracellular structure. The methods may be performed in situ in a non-invasive manner by placing a nanoparticle having a metallic shell on at least a fraction of a surface in a vicinity of a target structure in a subject and applying an initiation energy to a subject thus producing an effect on or change to the target structure directly or via a modulation agent. The nanoparticle is configured, upon exposure to a first wavelength λ1, to generate a second wavelength λ2 of radiation having a higher energy than the first wavelength λ1. The methods may further be performed by application of an initiation energy to a subject in situ to activate a pharmaceutical agent directly or via an energy modulation agent, optionally in the presence of one or more plasmonics active agents, thus producing an effect on or change to the target structure. Kits containing products or compositions formulated or configured and systems for use in practicing these methods.
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公开(公告)号:US20220315809A1
公开(公告)日:2022-10-06
申请号:US17433734
申请日:2020-02-27
申请人: IMMUNOLIGHT, LLC
发明人: Frederic A. BOURKE, JR. , Harold WALDER , Zakaryae FATHI , Wayne F. BEYER , Ronald A. RUDDER , Joseph H. SIMMONS
IPC分类号: C09J133/08
摘要: An emission enhancement structure having at least one energy augmentation structure; and an energy converter capable of receiving energy from an energy source, converting the energy and emitting therefrom a light of a different energy than the received energy. The energy converter is disposed in a vicinity of the at least one energy augmentation structure such that the emitted light is emitted with an intensity larger than if the converter were remote from the at least one energy augmentation structure. Also described are various uses for the energy emitters, energy augmentation structures and energy collectors in a wide array of fields, including various adhesives applications.
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公开(公告)号:US20220181292A1
公开(公告)日:2022-06-09
申请号:US17647275
申请日:2022-01-06
申请人: IMMUNOLIGHT, LLC
IPC分类号: H01L23/00 , C08K3/00 , B41J2/175 , C09J4/00 , A61B17/00 , A61L24/06 , B32B37/12 , B32B37/18 , B32B38/00 , C09J133/08 , C09K11/02 , C09K11/77 , H01L25/065 , H01L25/00 , B32B3/26 , B32B7/14 , B32B9/04 , C09J9/02 , C09J11/04 , C09J11/06 , H01L23/522
摘要: A polymerizable composition includes at least one monomer, a photoinitiator capable of initiating polymerization of the monomer when exposed to light, and a phosphor capable of producing light when exposed to radiation (typically X-rays). The material is particularly suitable for bonding components at ambient temperature in situations where the bond joint is not accessible to an external light source. An associated method includes: placing a polymerizable adhesive composition, including a photoinitiator and energy converting material, such as a down-converting phosphor, in contact with at least two components to be bonded to form an assembly; and, irradiating the assembly with radiation at a first wavelength, capable of conversion (down-conversion by the phosphor) to a second wavelength capable of activating the photoinitiator, to prepare items such as inkjet cartridges, wafer-to-wafer assemblies, semiconductors, integrated circuits, and the like.
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4.
公开(公告)号:US20220146076A1
公开(公告)日:2022-05-12
申请号:US17433827
申请日:2020-02-27
申请人: IMMUNOLIGHT, LLC
发明人: Frederic A. BOURKE, Jr. , Harold WALDER , Zakaryae FATHI , Wayne F. BEYER , Ronald A. RUDDER , Daniel I. BECKER , Joseph H. SIMMONS
IPC分类号: F21V9/30 , H01L31/06 , H01L31/0352 , F21S11/00 , F21V9/40
摘要: An emission enhancement structure having at least one energy augmentation structure; and an energy converter capable of receiving energy from an energy source, converting the energy and emitting therefrom a light of a different energy than the received energy. The energy converter is disposed in a vicinity of the at least one energy augmentation structure such that the emitted light is emitted with an intensity larger than if the converter were remote from the at least one energy augmentation structure. Also described are various uses for the energy emitters, energy augmentation structures and energy collectors in a wide array of fields, especially in the field of solar cells and other energy conversion devices.
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公开(公告)号:US20220134131A1
公开(公告)日:2022-05-05
申请号:US17433911
申请日:2020-02-28
申请人: IMMUNOLIGHT, LLC
发明人: Frederic A. BOURKE, Jr. , Harold WALDER , Zakaryae FATHI , Wayne F. BEYER , Ronald A. RUDDER , Joseph H. SIMMONS
摘要: An emission enhancement structure having at least one energy augmentation structure; and an energy converter capable of receiving energy from an energy source, converting the energy and emitting therefrom a light of a different energy than the received energy. The energy converter is disposed in a vicinity of the at least one energy augmentation structure such that the emitted light is emitted with an intensity larger than if the converter were remote from the at least one energy augmentation structure. Also described are various uses for the energy emitters, energy augmentation structures and energy collectors in a wide array of fields.
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公开(公告)号:US20220062419A1
公开(公告)日:2022-03-03
申请号:US17227753
申请日:2021-04-12
申请人: IMMUNOLIGHT, LLC , DUKE UNIVERSITY
发明人: Mark OLDHAM , Justus ADAMSON , Mark W. DEWHIRST , Paul YOON , Harold WALDER , Frederic A. Bourke, JR. , Zakaryae FATHI , Wayne F. BEYER, JR.
IPC分类号: A61K41/00 , A61N5/06 , A61K31/655 , A61K33/02 , A61K31/409 , A61K31/525 , A61K31/352 , A61K31/403 , A61K33/242 , A61K33/244 , A61K33/24 , A61N5/10
摘要: A method and system for treating a subject with a disorder which provides within the subject at least one photoactivatable drug for treatment of the subject, applies initiation energy from at least one source to generate inside the subject a preferential x-ray flux for generation of Cherenkov radiation (CR) light capable of activating at least one photoactivatable drug, and from the CR light, activating inside the subject the at least one photoactivatable drug to thereby treat the disorder.
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公开(公告)号:US20200215611A1
公开(公告)日:2020-07-09
申请号:US16819806
申请日:2020-03-16
申请人: IMMUNOLIGHT, LLC.
IPC分类号: B22F3/105 , B33Y30/00 , B23K26/354 , B33Y10/00 , B22F7/06 , B23K26/34 , B33Y80/00 , B33Y50/02 , B22F5/04
摘要: A curable resin or adhesive composition includes at least one monomer, a photoinitiator capable of initiating polymerization of the monomer when exposed to light, and at least one energy converting material, preferably a phosphor, capable of producing light when exposed to radiation (typically X-rays). The material is particularly suitable for bonding components at ambient temperature in situations where the bond joint is not accessible to an external light source. An associated method includes: placing a polymerizable adhesive composition, including a photoinitiator and energy converting material, such as a down-converting phosphor, in contact with at least two components to be bonded to form an assembly; and, irradiating the assembly with radiation at a first wavelength, capable of conversion (down-conversion by the phosphor) to a second wavelength capable of activating the photoinitiator, to prepare items such as inkjet cartridges, wafer-to-wafer assemblies, semiconductors, integrated circuits, and the like.
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8.
公开(公告)号:US20190022221A1
公开(公告)日:2019-01-24
申请号:US15543297
申请日:2016-01-13
申请人: IMMUNOLIGHT, LLC.
IPC分类号: A61K41/00
摘要: Products, compositions, systems, and methods for treating a subject carrying a virus or bacterium. The methods may be performed in situ in a non-invasive manner by application of an initiation energy to the subject thus producing an effect on or change to a target structure of the subject directly or indirectly. The methods may further be performed by application of an initiation energy to a subject to activate within the subject a photoactivatable drug directly or indirectly, optionally in the presence of one or more plasmonics active agents, thus treating the virus or bacterium. Also provided are kits containing products or compositions formulated or configured and systems for use in practicing these methods.
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9.
公开(公告)号:US20160325111A1
公开(公告)日:2016-11-10
申请号:US15151642
申请日:2016-05-11
申请人: IMMUNOLIGHT, LLC , DUKE UNIVERSITY
CPC分类号: A61N5/062 , A61K41/0057 , A61K41/0061 , A61K47/6923 , A61N5/022 , A61N5/0618 , A61N5/0622 , A61N5/10 , A61N2005/0642 , A61N2005/0659 , A61N2005/0661 , A61N2005/0662 , A61N2005/1098
摘要: Products, compositions, systems, and methods for modifying a target structure which mediates or is associated with a biological activity, including treatment of conditions, disorders, or diseases mediated by or associated with a target structure, such as a virus, cell, subcellular structure or extracellular structure. The methods may be performed in situ in a non-invasive manner by application of an initiation energy to a subject thus producing an effect on or change to the target structure directly or via a modulation agent. The methods may further be performed by application of an initiation energy to a subject in situ to activate a pharmaceutical agent directly or via an energy modulation agent, optionally in the presence of one or more plasmonics active agents, thus producing an effect on or change to the target structure. Kits containing products or compositions formulated or configured and systems for use in practicing these methods.
摘要翻译: 用于修饰介导或与生物活性相关的靶结构的产物,组合物,系统和方法,包括治疗由病毒,细胞,亚细胞结构介导或与靶结构相关的疾病,病症或疾病 或胞外结构。 所述方法可以通过向受试者施加起始能量以非侵入性方式原位进行,从而直接或经由调节剂产生对靶结构的作用或改变。 所述方法还可以通过向受试者原位施加引发能量来直接或经由能量调节剂活化药剂,任选地在存在一种或多种等离子体激元活性剂的情况下进行,从而产生效果或改变 目标结构。 包含配制或配置的产品或组合的套件以及用于实施这些方法的系统。
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公开(公告)号:US20240042233A1
公开(公告)日:2024-02-08
申请号:US18360187
申请日:2023-07-27
申请人: Immunolight, LLC , DUKE UNIVERSITY
发明人: Harold WALDER , Frederic A. BOURKE, JR. , Zakaryae FATHI , Wayne F. BEYER, JR. , Mark DEWHIRST , Mark OLDHAM , Justus ADAMSON , Michael NOLAN
CPC分类号: A61N5/062 , A61K41/17 , A61K39/0011 , A61K41/0066 , A61K49/0423 , A61N5/022 , A61N5/10 , A61N5/1081 , A61K2039/585 , A61N2005/0627 , A61N2005/0659 , A61N2005/0661 , A61N2005/0662 , A61N2005/1089 , A61N2005/1098
摘要: A system and method for imaging or treating a disease in a human or animal body. The system provides to the human or animal body a pharmaceutical carrier including one or more phosphors which are capable of emitting ultraviolet or visible light into the body and which provide x-ray contrast. The system includes one or more devices which infuse a diseased site with a photoactivatable drug and the pharmaceutical carrier, an initiation energy source comprising an x-ray or high energy source which irradiates the diseased site with at least one of x-rays, gamma rays, or electrons to thereby initiate emission of said ultraviolet or visible light into the body, and a processor programmed to at least one of 1) produce images of the diseased site or 2) control a dose of said x-rays, gamma rays, or electrons to the diseased site for production of said ultraviolet or visible light at the diseased site to activate the photoactivatable drug.
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