公开(公告)号：US10183936B2

公开(公告)日：2019-01-22

申请号：US15125911

申请日：2015-03-13

Applicant: Indiana University Research and Technology Corporation ,  Assembly Biosciences, Inc.

Inventor： William W. Turner, Jr. ,  Lee Daniel Arnold ,  Hans Maag ,  Adam Zlotnick

IPC: C07D417/12 ,  C07D403/12 ,  C07D223/20 ,  C07D401/12 ,  C07D413/12 ,  C07D243/38 ,  C07D281/14 ,  A61K31/55 ,  A61K31/5513 ,  A61K31/553 ,  A61K31/554 ,  A61K45/06 ,  C07D281/16

Abstract: The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.

公开(公告)号：US20150218182A1

公开(公告)日：2015-08-06

申请号：US14236428

申请日：2012-08-02

Applicant: INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION

Inventor： Adam Zlotnick ,  M.G. Finn

IPC: C07D491/113 ,  C07D401/12 ,  C07D401/14 ,  C07D471/04 ,  C07D401/04

CPC classification number: C07D493/10 ,  A61K31/496 ,  C07D239/20 ,  C07D239/22 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D417/04 ,  C07D471/04 ,  C07D491/10 ,  C07D491/113

Abstract: In addition to containing and protecting the viral genome, the capsid (protein shell) of hepatitis B virus (HBV) plays critical roles in the viral life cycle including regulation of intracellular trafficking and nucleic acid metabolism. Substituted pyrimidine modulators of the assembly of the HBV capsid structure and methods for their use are described.

Abstract translation: 除了含有和保护病毒基因组外，乙型肝炎病毒（HBV）的衣壳（蛋白质外壳）在病毒生命周期中起关键作用，包括调节细胞内运输和核酸代谢。 描述了HBV衣壳结构组装的取代嘧啶调节剂及其使用方法。

公开(公告)号：US10947224B2

公开(公告)日：2021-03-16

申请号：US15965655

申请日：2018-04-27

Applicant: Indiana University Research and Technology Corporation ,  Assembly Biosciences, Inc.

Inventor： William W. Turner, Jr. ,  Lee Daniel Arnold ,  Hans Maag ,  Adam Zlotnick

IPC: A61P31/12 ,  C07D417/12 ,  C07D403/12 ,  C07D223/20 ,  C07D401/12 ,  C07D413/12 ,  C07D243/38 ,  C07D281/14 ,  A61K31/55 ,  A61K31/5513 ,  A61K31/553 ,  A61K31/554 ,  A61K45/06 ,  C07D281/16

Abstract: The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.

公开(公告)号：US09796722B1

公开(公告)日：2017-10-24

申请号：US15294010

申请日：2016-10-14

Applicant: Indiana University Research and Technology Corporation

Inventor： Adam Zlotnick ,  Lichun Li ,  William W. Turner, Jr.

IPC: C07D487/04 ,  A61K47/00 ,  A61K31/519 ,  A61K45/06

CPC classification number: C07D487/04 ,  A61K31/519 ,  A61K45/06

Abstract: Novel virus assembly effector compounds having a therapeutic effect against Hepatitis B viral infection are disclosed. Assembly effector molecules described herein can lead to defective viral assembly and also may affect other viral activities associated with chronic HBV infection. Also disclosed are pharmaceutical compositions including the disclosed compounds, methods of treatment of HBV infection, and a process to synthesize the disclosed compounds.

公开(公告)号：US20230019129A1

公开(公告)日：2023-01-19

申请号：US17154721

申请日：2021-01-21

Applicant: Indiana University Research and Technology Corporation ,  Assembly Biosciences, Inc.

Inventor： William W. Turner, JR. ,  Lee Daniel Arnold ,  Hans Maag ,  Adam Zlotnick

IPC: C07D417/12 ,  C07D403/12 ,  C07D223/20 ,  C07D401/12 ,  C07D413/12 ,  C07D243/38 ,  C07D281/14 ,  A61P31/12 ,  A61K31/55 ,  A61K31/5513 ,  A61K31/553 ,  A61K31/554 ,  A61K45/06 ,  C07D281/16

Abstract: The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.

公开(公告)号：US10208358B2

公开(公告)日：2019-02-19

申请号：US15304019

申请日：2015-04-14

Applicant: Indiana University Research and Technology Corporation

Inventor： Adam Zlotnick ,  Stella Vieweger

IPC: C12N7/04 ,  A61K39/12 ,  A61K39/17 ,  C12N7/00 ,  C12Q1/68 ,  C12Q1/70 ,  C12Q1/6818

Abstract: Virus capsids protect the viral genome and play roles in its delivery and intracellular transport, making them an attractive target for antiviral therapeutics. The difficulty in targeting capsid assembly is to identify molecules that interfere with the weak protein-protein interactions that drive the reaction. We have developed an in vitro assay for capsid assembly that works on a range of viruses at biologically relevant protein concentrations to facilitate screening large libraries of chemicals for lead compounds.

公开(公告)号：US20170266197A1

公开(公告)日：2017-09-21

申请号：US15310070

申请日：2015-05-11

Applicant: Indiana University Research and Technology Corporation ,  Assembly Biosciences, Inc.

Inventor： Adam Zlotnick ,  William W. Turner ,  Lee Daniel Arnold

IPC: A61K31/5377 ,  A61K31/506 ,  G01N33/50 ,  A61K31/445 ,  G01N33/576 ,  A61K45/06 ,  A61K31/18

CPC classification number: A61K31/5377 ,  A61K31/18 ,  A61K31/445 ,  A61K31/506 ,  A61K31/713 ,  A61K45/06 ,  G01N33/5023 ,  G01N33/5032 ,  G01N33/5762 ,  G01N2500/04

Abstract: Described herein are methods for identifying compounds useful for the treatment of infection by hepatitis B virus (HBV) and for identifying compounds useful for the same.

公开(公告)号：US20170029907A1

公开(公告)日：2017-02-02

申请号：US15304019

申请日：2015-04-14

Applicant: Indiana University Research and Technology Corporation

Inventor： Adam Zlotnick ,  Stella Vieweger

IPC: C12Q1/70 ,  C12Q1/68

CPC classification number: C12Q1/703 ,  C12Q1/6818 ,  C12Q1/70 ,  C12Q2600/136 ,  Y02A50/53

Abstract: Virus capsids protect the viral genome and play roles in its delivery and intracellular transport, making them an attractive target for antiviral therapeutics. The difficulty in targetting capsid assembly is to identify molecules that interfere with the weak protein-protein interactions that drive the reaction. We have developed an in vitro assay for capsid assembly that works on a range of viruses at biologically relevant protein concentrations to facilitate screening large libraries of chemicals for lead compounds.

Abstract translation: 病毒衣壳保护病毒基因组并在其递送和细胞内运输中发挥作用，使其成为抗病毒治疗的有吸引力的靶标。 靶向衣壳装配的困难是确定干扰促进反应的弱蛋白质 - 蛋白质相互作用的分子。 我们开发了一种用于衣壳组装的体外测定法，其用于生物相关蛋白浓度的一系列病毒，以便筛选铅化合物的大型化学物质文库。

公开(公告)号：US20180273521A1

公开(公告)日：2018-09-27

申请号：US15965655

申请日：2018-04-27

Applicant: Indiana University Research and Technology Corporation ,  Assembly Biosciences, Inc.

Inventor： William W. Turner, JR. ,  Lee Daniel Arnold ,  Hans Maag ,  Adam Zlotnick

IPC: C07D417/12 ,  C07D281/14 ,  A61K45/06 ,  C07D281/16 ,  A61K31/554 ,  C07D401/12 ,  A61K31/5513 ,  A61K31/553 ,  C07D413/12 ,  C07D223/20 ,  C07D403/12 ,  A61K31/55 ,  C07D243/38

Abstract: The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.

公开(公告)号：US10006913B2

公开(公告)日：2018-06-26

申请号：US14777636

申请日：2014-03-20

Applicant: INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION

Inventor： Adam Zlotnick ,  Lichun Li ,  Michael S. Van Nieuwenhze ,  William W. Turner

IPC: A61B5/00 ,  A61B8/00 ,  A61B10/00 ,  G01N33/569 ,  C09B11/08 ,  C09B11/24 ,  C09B23/02 ,  C09B57/00 ,  C09B57/02 ,  C09B57/10 ,  C12Q1/18 ,  A61K49/00

CPC classification number: G01N33/56983 ,  A61K49/0017 ,  C09B11/08 ,  C09B11/24 ,  C09B23/02 ,  C09B57/00 ,  C09B57/02 ,  C09B57/10 ,  C12Q1/18 ,  G01N2333/02 ,  G01N2500/02 ,  G01N2500/04 ,  G01N2500/10

Abstract: Heteroaryldihydropyrimidine (HAP)-based fluorescent stains (compounds), as well as uses of such stains as diagnostic reagents, viral-tracking agents, and/or tools for drug discovery are described. The present invention relates to heteroaryldihydropyrimidine (HAP)-based fluorescent stains (compounds), as well as uses of such stains as diagnostic reagents, viral-tracking agents, and/or tools for drug discovery.