Antiviral agents
    3.
    发明授权
    Antiviral agents 失效
    抗病毒剂

    公开(公告)号:US4859769A

    公开(公告)日:1989-08-22

    申请号:US916542

    申请日:1986-11-05

    摘要: A second-step virus binding receptor is found in nature on the surface of animal and plant cells. This receptor is thought to be needed for virus penetration into target cells. The second-step receptor has been found to bind a wide variety of viruses belonging to a number of different families. The second-step receptor and natural or synthetic substances which correspond to or are analogous to the binding epitope of the second-step receptor in that they are able to bind to a site on the virus which recognizes the binding epitope of the natural second-step receptor, are therefore indicated for the diagnosis, prophylaxis or treatment of viral infections.

    摘要翻译: PCT No.PCT / DK86 / 00007 Sec。 371日期:1986年11月5日 102(e)日期1986年11月5日PCT申请日1986年1月13日PCT公布。 出版物WO86 / 03971 日期1986年7月17日。在动物和植物细胞表面上发现自然界中的第二步病毒结合受体。 认为该受体是病毒渗入靶细胞所必需的。 已经发现第二步受体结合属于多个不同家族的各种病毒。 第二步受体和天然或合成物质对应于或类似于第二步受体的结合表位,因为它们能够结合识别天然第二步的结合表位的病毒位点 受体,因此被指示用于诊断,预防或治疗病毒感染。

    Tumor specific oligosaccharide sequences and use thereof
    9.
    发明授权
    Tumor specific oligosaccharide sequences and use thereof 有权
    肿瘤特异性寡糖序列及其用途

    公开(公告)号:US08236487B2

    公开(公告)日:2012-08-07

    申请号:US10487203

    申请日:2002-08-20

    IPC分类号: C12Q1/00

    摘要: The present invention describes oligosaccharide sequences, which are specifically expressed by human tumors. The present invention is related to a method of determining an oligosaccharide sequence, which comprises a tumor specific terminal N-acetylglucosamine residue, in a biological sample, the presence of said sequence in said sample being an indication of the presence of cancer. The present invention provides antigenic substances comprising said oligosaccharide sequences in a polyvalent form and it further provides diagnostic agents, pharmaceutical compositions and cancer vaccines comprising said oligosaccharide sequences or substances binding to said oligosaccharide sequences. The present invention is also related to methods for the treatment of cancer.

    摘要翻译: 本发明描述了由人肿瘤特异性表达的寡糖序列。 本发明涉及在生物样品中测定包含肿瘤特异性末端N-乙酰葡糖胺残基的寡糖序列的方法,所述样品中所述序列的存在是癌症存在的指示。 本发明提供包含多价形式的所述寡糖序列的抗原物质,并且还提供包含所述寡糖序列或与所述寡糖序列结合的物质的诊断试剂,药物组合物和癌症疫苗。 本发明还涉及治疗癌症的方法。

    Influenza virus binding, sialylated oligosaccharide substance and use thereof
    10.
    发明授权
    Influenza virus binding, sialylated oligosaccharide substance and use thereof 失效
    流感病毒结合,唾液酸化寡糖物质及其用途

    公开(公告)号:US07902170B2

    公开(公告)日:2011-03-08

    申请号:US10311713

    申请日:2001-06-20

    摘要: The present invention is directed to human influenza virus binding substance containing at least one oligosaccharide chain, which comprises a terminal NeuNAcα6 linked to: (a) a linear or branched polylactosamine type structure consisting of at least three lactosamine residues, a linear sequence optionally containing one or two α3-linked fucose residues in a non-sialylated lactosamine, a branched structure optionally carrying one or more additional NeuNAcα-residues at a terminal position in a branch, and/or (b) a linear or branched structure with two lactosamine and one lactose residue, a linear structure in addition containing one or two α3-linked fucose residues in a non-sialylated lactosamine or lactose, a branched structure optionally carrying one additional NeuNAcα-residue in a terminal position of the branch, or an analog or derivative of said oligosaccharide chain for use in binding of human influenza virus.

    摘要翻译: 本发明涉及含有至少一个寡糖链的人流感病毒结合物质,其包含与以下连接的末端NeuNAcα6连接的末端NeuNAcα6:(a)由至少三个乳糖胺残基组成的直链或支链多聚乳糖胺型结构,任选地含有一个 或非唾液酸化乳糖胺中的两个α3连接的岩藻糖残基,任选地在支链末端携带一个或多个另外的NeuNAcα残基的支链结构和/或(b)具有两个乳糖胺和一个 乳糖残基,在非唾液酸化乳糖胺或乳糖中另外含有一个或两个α3连接的岩藻糖残基的线性结构,任选地在该分支的末端位置携带一个额外的NeuNAcα-残基的支链结构,或其衍生物 所述寡糖链用于人流感病毒的结合。