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公开(公告)号：US20180318446A1
公开(公告)日：2018-11-08
申请号：US15905576
申请日：2018-02-26
Applicant: ModernaTX, Inc.
Inventor： Stephane Bancel , Jason P. Schrum , Alexander Aristarkhov
CPC classification number: A61K48/005 , A61K45/06 , A61K48/0066 , C07K14/4723 , C12N2320/32
Abstract: Provided are compositions and methods for delivering biological moieties such as modified nucleic acids into cells to kill or reduce the growth of viruses. Such compositions and methods include the use of modified messenger RNAs, and are useful to treat or prevent viral infection, or to improve a subject's heath or wellbeing.
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公开(公告)号：US10064959B2
公开(公告)日：2018-09-04
申请号：US15493829
申请日：2017-04-21
Applicant: ModernaTX, Inc.
Inventor： Jason P. Schrum , Suhaib Siddiqi , Kenechi Ejebe
Abstract: The present disclosure provides modified nucleosides, nucleotides, and nucleic acids, and methods of using thereof.
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公开(公告)号：US09701965B2
公开(公告)日：2017-07-11
申请号：US14535484
申请日：2014-11-07
Applicant: ModernaTX, Inc.
Inventor： Jason P. Schrum , Gregory J. Sieczkiewicz , Kenechi Ejebe , Sayda M. Elbashir
IPC: C12N15/11 , C12N15/13 , C12N15/10 , C12N15/88 , C12N15/113 , C07H19/10 , C12P21/00 , C07H21/02 , C12N5/071 , C07K16/00 , C07K16/28 , G01N33/559
CPC classification number: A61K48/0066 , C07H19/10 , C07H21/02 , C07K16/00 , C07K16/2887 , C07K2317/24 , C12N5/0602 , C12N15/102 , C12N15/11 , C12N15/1136 , C12N15/1138 , C12N15/67 , C12N2310/3341 , C12N2310/335 , C12P21/00 , G01N33/559
Abstract: Provided are compositions and methods for delivering biological moieties such as modified nucleic acids into cells to modulate protein expression. Such compositions and methods include the use of modified messenger RNAs, and are useful for production of proteins.
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公开(公告)号：US10022425B2
公开(公告)日：2018-07-17
申请号：US15266791
申请日：2016-09-15
Applicant: ModernaTX, Inc.
Inventor： Stephane Bancel , Jason P. Schrum , Alexander Aristarkhov
Abstract: Provided are compositions and methods for delivering biological moieties such as modified nucleic acids into cells to kill or reduce the growth of microorganisms. Such compositions and methods include the use of modified messenger RNAs, and are useful to treat or prevent microbial infection, or to improve a subject's heath or wellbeing.
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公开(公告)号：US20180112221A1
公开(公告)日：2018-04-26
申请号：US15611490
申请日：2017-06-01
Applicant: ModernaTX, Inc.
Inventor： Jason P. Schrum , Gregory J. Sieczkiewicz , Kenechi Ejebe , Sayda M. Elbashir
IPC: C12N15/113 , G01N33/559 , C12P21/00 , C12N15/10 , C07H21/02 , C07K16/00 , C12N15/11 , C07H19/10 , C12N5/071 , C07K16/28
CPC classification number: A61K48/0066 , C07H19/10 , C07H21/02 , C07K16/00 , C07K16/2887 , C07K2317/24 , C12N5/0602 , C12N15/102 , C12N15/11 , C12N15/1136 , C12N15/1138 , C12N15/67 , C12N2310/3341 , C12N2310/335 , C12P21/00 , G01N33/559
Abstract: Provided are compositions and methods for delivering biological moieties such as modified nucleic acids into cells to modulate protein expression. Such compositions and methods include the use of modified messenger RNAs, and are useful for production of proteins.
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Patent Agency Ranking
公开(公告)号：US20170348436A1
公开(公告)日：2017-12-07
申请号：US15403517
申请日：2017-01-11
Applicant: ModernaTX, Inc.
Inventor： Stephane Bancel , Tirtha Chakraborty , Antonin de Fougerolles , Sayda M. Elbashir , Matthias John , Atanu Roy , Susan Whoriskey , Kristy M. Wood , Paul Hatala , Jason P. Schrum , Kenechi Ejebe , Jeff Lynn Ellsworth , Justin Guild
IPC: A61K48/00 , A61K9/127 , C12P21/00 , C12P13/04 , C12N15/87 , C12N15/85 , C12N15/52 , C12N15/11 , C12N9/00 , C12N9/88 , C12N9/64 , C12N9/42 , C12N9/24 , C12N9/16 , C12N9/10 , C07K16/00 , C07K14/705 , C07K14/62 , C07K14/56 , C07K14/535 , C07K14/525 , C07K14/515 , C07K14/505 , A61K47/54 , C07K14/47 , C07K14/435 , C07K14/005 , A61K38/48 , A61K38/45 , A61K38/21 , A61K38/19 , A61K38/18 , A61K38/17 , A61K31/7115 , A61K9/51 , A61K9/14 , C07K14/485 , A61K38/00
CPC classification number: A61K48/0066 , A61K9/1271 , A61K9/145 , A61K9/5123 , A61K9/5146 , A61K9/5153 , A61K31/7115 , A61K38/00 , A61K38/17 , A61K38/177 , A61K38/1816 , A61K38/1891 , A61K38/191 , A61K38/193 , A61K38/212 , A61K38/45 , A61K38/4846 , A61K47/543 , A61K48/0033 , A61K48/005 , A61K48/0075 , C07H21/02 , C07K14/005 , C07K14/435 , C07K14/43595 , C07K14/47 , C07K14/4705 , C07K14/4713 , C07K14/4723 , C07K14/4746 , C07K14/475 , C07K14/485 , C07K14/495 , C07K14/505 , C07K14/515 , C07K14/525 , C07K14/535 , C07K14/5418 , C07K14/56 , C07K14/61 , C07K14/62 , C07K14/705 , C07K14/745 , C07K16/00 , C07K16/2863 , C07K16/2887 , C07K16/40 , C12N9/0069 , C12N9/0091 , C12N9/1051 , C12N9/1241 , C12N9/16 , C12N9/2402 , C12N9/2445 , C12N9/6435 , C12N9/6437 , C12N9/644 , C12N9/6443 , C12N9/6451 , C12N9/88 , C12N9/93 , C12N15/11 , C12N15/52 , C12N15/85 , C12N15/87 , C12P13/04 , C12P21/00 , C12P21/005 , C12Y113/12007 , C12Y116/03001 , C12Y207/07012 , C12Y304/21007 , C12Y304/21022 , C12Y304/21027 , C12Y403/02001 , C12Y603/02019 , Y02A50/401 , Y02A50/411 , Y02A50/414 , Y02A50/415 , Y02A50/423 , Y02A50/463 , Y02A50/491
Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
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7.发明授权公开(公告)号：US09814760B2
公开(公告)日：2017-11-14
申请号：US14878400
申请日：2015-10-08
Applicant: ModernaTX, Inc.
Inventor： Stephane Bancel , Tirtha Chakraborty , Antonin de Fougerolles , Sayda M. Elbashir , Matthias John , Atanu Roy , Susan Whoriskey , Kristy M. Wood , Paul Hatala , Jason P. Schrum , Kenechi Ejebe , Jeff Lynn Ellsworth , Justin Guild
IPC: C07H21/02 , C12N15/85 , A61K38/17 , C07K14/47 , C07K14/62 , A61K48/00 , A61K31/7115 , C12N9/88 , A61K9/127 , C12N15/11 , C07K14/705 , C07K14/505 , C07K14/535 , C12N9/64 , C12N9/10 , C12N9/00 , C12N9/42 , C12N15/87 , C12P13/04 , A61K38/45 , C07K14/005 , C12N9/16 , C12N9/24 , C12N15/52 , C07K14/435 , C12P21/00 , C07K14/485 , C07K14/475 , C07K14/495 , C07K14/525 , C07K14/54 , C07K14/56 , C07K14/61 , C07K14/745 , C07K16/28 , C07K16/40 , C12N9/02 , C12N9/12 , C12N9/68 , A61K38/00
CPC classification number: A61K48/0066 , A61K9/1271 , A61K9/145 , A61K9/5123 , A61K9/5146 , A61K9/5153 , A61K31/7115 , A61K38/00 , A61K38/17 , A61K38/177 , A61K38/1816 , A61K38/1891 , A61K38/191 , A61K38/193 , A61K38/212 , A61K38/45 , A61K38/4846 , A61K47/543 , A61K48/0033 , A61K48/005 , A61K48/0075 , C07H21/02 , C07K14/005 , C07K14/435 , C07K14/43595 , C07K14/47 , C07K14/4705 , C07K14/4713 , C07K14/4723 , C07K14/4746 , C07K14/475 , C07K14/485 , C07K14/495 , C07K14/505 , C07K14/515 , C07K14/525 , C07K14/535 , C07K14/5418 , C07K14/56 , C07K14/61 , C07K14/62 , C07K14/705 , C07K14/745 , C07K16/00 , C07K16/2863 , C07K16/2887 , C07K16/40 , C12N9/0069 , C12N9/0091 , C12N9/1051 , C12N9/1241 , C12N9/16 , C12N9/2402 , C12N9/2445 , C12N9/6435 , C12N9/6437 , C12N9/644 , C12N9/6443 , C12N9/6451 , C12N9/88 , C12N9/93 , C12N15/11 , C12N15/52 , C12N15/85 , C12N15/87 , C12P13/04 , C12P21/00 , C12P21/005 , C12Y113/12007 , C12Y116/03001 , C12Y207/07012 , C12Y304/21007 , C12Y304/21022 , C12Y304/21027 , C12Y403/02001 , C12Y603/02019 , Y02A50/401 , Y02A50/411 , Y02A50/414 , Y02A50/415 , Y02A50/423 , Y02A50/463 , Y02A50/491
Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
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8.发明授权公开(公告)号：US10772975B2
公开(公告)日：2020-09-15
申请号：US15790246
申请日：2017-10-23
Applicant: ModernaTX, Inc.
Inventor： Stephane Bancel , Tirtha Chakraborty , Antonin De Fougerolles , Sayda M. Elbashir , Matthias John , Atanu Roy , Susan Whoriskey , Kristy M. Wood , Paul Hatala , Jason P. Schrum , Kenechi Ejebe , Jeff Lynn Ellsworth , Justin Guild
IPC: C07K14/535 , A61K38/17 , A61K48/00 , C12N15/85 , C07K14/47 , C07K14/62 , A61K31/7115 , C12N9/88 , A61K9/127 , C12N15/11 , C07K14/705 , C07K14/505 , C12N9/64 , C12N9/10 , C12N9/00 , C12N9/42 , C12N15/87 , C12P13/04 , A61K38/45 , C07K14/005 , C12N9/16 , C12N9/24 , C12N15/52 , C07K14/435 , C12P21/00 , C07K14/485 , C07H21/02 , C07K14/475 , C07K14/495 , C07K14/525 , C07K14/54 , C07K14/56 , C07K14/61 , C07K14/745 , C07K16/28 , C07K16/40 , C12N9/02 , C12N9/12 , C12N9/68 , A61K47/54 , A61K9/14 , A61K9/51 , A61K38/18 , A61K38/19 , A61K38/21 , A61K38/48 , C07K14/515 , C07K16/00 , A61K31/7088 , A61K47/10 , A61K38/00
Abstract: The invention relates to a pharmaceutical composition including a plurality of lipid nanoparticles having a mean particle size of between 80 nm and 160 nm and containing an mRNA encoding a polypeptide. The lipid nanoparticles include a cationic lipid, a neutral lipid, a cholesterol, and a PEG lipid. The mRNA contains a 5′-cap, 5′-UTR, a 3′-UTR, and a poly-A region with at least 100 nucleotides.
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公开(公告)号：US20180271938A1
公开(公告)日：2018-09-27
申请号：US15981762
申请日：2018-05-16
Applicant: ModernaTX, Inc.
Inventor： Stephane Bancel , Jason P. Schrum , Alexander Aristarkhov
CPC classification number: A61K38/1729 , A61K38/465 , A61K45/06 , A61K48/0075 , C07K14/4723 , C12Y301/27
Abstract: Provided are compositions and methods for delivering biological moieties such as modified nucleic acids into cells to kill or reduce the growth of microorganisms. Such compositions and methods include the use of modified messenger RNAs, and are useful to treat or prevent microbial infection, or to improve a subject's heath or wellbeing.
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公开(公告)号：US09828416B2
公开(公告)日：2017-11-28
申请号：US14750004
申请日：2015-06-25
Applicant: ModernaTX, Inc.
Inventor： Stephane Bancel , Tirtha Chakraborty , Antonin de Fougerolles , Sayda M. Elbashir , Matthias John , Atanu Roy , Susan Whoriskey , Kristy M. Wood , Paul Hatala , Jason P. Schrum , Kenechi Ejebe , Jeff Lynn Ellsworth , Justin Guild
IPC: C12N15/85 , A61K31/7088 , A61K47/48 , C07K14/535 , A61K48/00 , C12N15/88 , A61K9/127 , A61K9/50 , C07K19/00 , A61K38/18 , A61K38/19 , A61K38/48 , C07K14/47 , A61K9/14 , A61K38/17 , A61K47/10 , A61K38/21 , A61K38/36 , A61K38/44 , A61K39/395 , C07K14/475 , C07K14/505 , C07K14/525 , C07K14/56 , C07K14/565 , C07K14/745 , C07K14/75 , C07K16/28 , C07K16/32 , C12N9/02 , C12N9/64 , A61K9/00
CPC classification number: C07K14/535 , A61K9/0019 , A61K9/1271 , A61K9/1272 , A61K9/1277 , A61K9/14 , A61K9/5031 , A61K31/7088 , A61K38/1767 , A61K38/1816 , A61K38/1866 , A61K38/191 , A61K38/193 , A61K38/212 , A61K38/215 , A61K38/36 , A61K38/363 , A61K38/44 , A61K38/4833 , A61K38/4846 , A61K39/3955 , A61K47/10 , A61K47/54 , A61K47/542 , A61K48/00 , A61K48/0033 , A61K48/0066 , A61K48/0075 , C07K14/47 , C07K14/475 , C07K14/505 , C07K14/525 , C07K14/56 , C07K14/565 , C07K14/745 , C07K14/75 , C07K16/2887 , C07K16/32 , C07K19/00 , C12N9/0069 , C12N9/644 , C12N15/85 , C12N15/88 , C12N2840/00 , C12Y113/12007 , C12Y304/21005 , C12Y304/21022
Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
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