公开(公告)号：US06436960B1

公开(公告)日：2002-08-20

申请号：US09601426

申请日：2000-08-01

申请人： You Seung Shin ,  Jong Sung Koh ,  Hyun Il Lee ,  Jin Ho Lee ,  Jong Hyun Kim ,  Hyun Ho Chung ,  Kwi Hwa Kim ,  Tae Hwan Kwak ,  Seong Gu Ro ,  In Ae Ahn ,  Tae Saeng Choi ,  Young Hoon Oh ,  Chung Mi Kim ,  Sun Hwa Lee ,  Hyun Sung Kim

发明人： You Seung Shin ,  Jong Sung Koh ,  Hyun Il Lee ,  Jin Ho Lee ,  Jong Hyun Kim ,  Hyun Ho Chung ,  Kwi Hwa Kim ,  Tae Hwan Kwak ,  Seong Gu Ro ,  In Ae Ahn ,  Tae Saeng Choi ,  Young Hoon Oh ,  Chung Mi Kim ,  Sun Hwa Lee ,  Hyun Sung Kim

IPC分类号： A61K31454

CPC分类号： C07D401/14 ,  C07D417/14

摘要： The present invention relates to a novel piperidine derivative represented by formula (1) which shows an inhibitory activity against farnesyl transferase or pharmaceutically acceptable salts thereof, in which A, E and G are defined in the specification; to a process for preparation of the compound of formula (1); to an intermediate which is used in the preparation of the compound of formula (1); and to a pharmaceutical composition comprising the compound of formula (1) as an active ingredient.

摘要翻译： 本发明涉及式（1）所示的新型哌啶衍生物，其表现出对法呢基转移酶的抑制活性或其药学上可接受的盐，其中A，E和G在本说明书中定义; 涉及制备式（1）化合物的方法; 涉及用于制备式（1）化合物的中间体; 以及包含式（1）化合物作为活性成分的药物组合物。

公开(公告)号：US06268363B1

公开(公告)日：2001-07-31

申请号：US09554646

申请日：2000-05-17

申请人： Hyun Il Lee ,  Jong Sung Koh ,  Jin Ho Lee ,  Won Hee Jung ,  You Seung Shin ,  Hyun Ho Chung ,  Jong Hyun Kim ,  Seong Gu Ro ,  Tae Saeng Choi ,  Shin Wu Jeong ,  Tae Hwan Kwak ,  In Ae Ahn ,  Hyun Sung Kim ,  Sun Hwa Lee ,  Kwi Hwa Kim ,  Jung Kwon Yoo

发明人： Hyun Il Lee ,  Jong Sung Koh ,  Jin Ho Lee ,  Won Hee Jung ,  You Seung Shin ,  Hyun Ho Chung ,  Jong Hyun Kim ,  Seong Gu Ro ,  Tae Saeng Choi ,  Shin Wu Jeong ,  Tae Hwan Kwak ,  In Ae Ahn ,  Hyun Sung Kim ,  Sun Hwa Lee ,  Kwi Hwa Kim ,  Jung Kwon Yoo

IPC分类号： A61K314178

CPC分类号： C07D401/14 ,  C07D403/06 ,  C07D405/14 ,  C07D413/06 ,  C07D417/06 ,  C07D417/14

摘要： The present invention relates to a novel imidazole derivative represented by formula (1) which shows an inhibitory activity against farnesyl transferase or pharmaceutically acceptable salts or isomers thereof, in which A, n1 and Y are defined in the specification; to a process for preparation of the compound of formula (1); to intermediates which are used in the preparation of the compound of formula (1); and to a pharmaceutical composition comprising the compound of formula (1) as an active ingredient.

摘要翻译： 本发明涉及式（1）所示的新型咪唑衍生物，其表现出对法呢基转移酶的抑制活性或其药学上可接受的盐或异构体，其中A，n1和Y在本说明书中定义; 涉及制备式（1）化合物的方法; 用于制备式（1）化合物的中间体; 以及包含式（1）化合物作为活性成分的药物组合物。

公开(公告)号：US06518429B2

公开(公告)日：2003-02-11

申请号：US09813437

申请日：2001-03-20

申请人： Hyun Il Lee ,  Jong Sung Koh ,  Jin Ho Lee ,  Won Hee Jung ,  You Seung Shin ,  Hyun Ho Chung ,  Jong Hyun Kim ,  Seong Gu Ro ,  Tae Saeng Choi ,  Shin Wu Jeong ,  Tae Hwan Kwak ,  In Ae Ahn ,  Hyun Sung Kim ,  Sun Hwa Lee ,  Kwi Hwa Kim ,  Jung Kwon Yoo

发明人： Hyun Il Lee ,  Jong Sung Koh ,  Jin Ho Lee ,  Won Hee Jung ,  You Seung Shin ,  Hyun Ho Chung ,  Jong Hyun Kim ,  Seong Gu Ro ,  Tae Saeng Choi ,  Shin Wu Jeong ,  Tae Hwan Kwak ,  In Ae Ahn ,  Hyun Sung Kim ,  Sun Hwa Lee ,  Kwi Hwa Kim ,  Jung Kwon Yoo

IPC分类号： C07D45302

CPC分类号： C07D401/14 ,  C07D403/06 ,  C07D405/14 ,  C07D413/06 ,  C07D417/06 ,  C07D417/14

摘要： The present invention relates to novel imidazole derivatives which show an inhibitory activity against farnesyl transferase, pharmaceutically acceptable salts or isomers thereof and pharmaceutical compositions comprising such imidazole derivatives. More particularly, the present invention relates to intermediate compounds which are used in the preparation of the imidazole derivatives of the invention. Related processes also are disclosed.

公开(公告)号：US06472526B1

公开(公告)日：2002-10-29

申请号：US10005262

申请日：2001-12-03

申请人： Hyun Il Lee ,  Jong Sung Koh ,  Jin Ho Lee ,  Won Hee Jung ,  You Seung Shin ,  Hyun Ho Chung ,  Jong Hyun Kim ,  Seong Gu Ro ,  Tae Saeng Choi ,  Shin Wu Jeong ,  Tae Hwan Kwak ,  In Ae Ahn ,  Hyun Sung Kim ,  Sun Hwa Lee ,  Kwi Hwa Kim ,  Jung Kwon Yoo

发明人： Hyun Il Lee ,  Jong Sung Koh ,  Jin Ho Lee ,  Won Hee Jung ,  You Seung Shin ,  Hyun Ho Chung ,  Jong Hyun Kim ,  Seong Gu Ro ,  Tae Saeng Choi ,  Shin Wu Jeong ,  Tae Hwan Kwak ,  In Ae Ahn ,  Hyun Sung Kim ,  Sun Hwa Lee ,  Kwi Hwa Kim ,  Jung Kwon Yoo

IPC分类号： C07D40306

CPC分类号： C07D401/14 ,  C07D403/06 ,  C07D405/14 ,  C07D413/06 ,  C07D417/06 ,  C07D417/14

摘要： The present invention relates to a novel imidazole derivative represented by formula (1) which shows an inhibitory activity against farnesyl transferase or pharmaceutically acceptable salts or isomers thereof, in which A, n1 and Y are defined in the specification; to a process for preparation of the compound of formula (1); to intermediates which are used in the preparation of the compound of formula (1): and to a pharmaceutical composition comprising the compound of formula (1) as an active ingredient.

摘要翻译： 本发明涉及式（1）所示的新型咪唑衍生物，其表现出对法呢基转移酶的抑制活性或其药学上可接受的盐或异构体，其中A，n1和Y在本说明书中定义; 涉及制备式（1）化合物的方法; 用于制备式（1）化合物的中间体：和包含式（1）化合物作为活性成分的药物组合物。

公开(公告)号：US06384061B1

公开(公告)日：2002-05-07

申请号：US09463551

申请日：2000-03-30

申请人： Jin Ho Lee ,  Jong Sung Koh ,  Jong Hyun Kim ,  Hyun Il Lee ,  Won Hee Jung ,  Seong Gu Ro ,  You Seong Shin ,  Sang Woong Kim ,  Ki Won Park ,  Tae Hwan Kwak ,  Kyung Duk Moon ,  Hyun Ho Chung

发明人： Jin Ho Lee ,  Jong Sung Koh ,  Jong Hyun Kim ,  Hyun Il Lee ,  Won Hee Jung ,  Seong Gu Ro ,  You Seong Shin ,  Sang Woong Kim ,  Ki Won Park ,  Tae Hwan Kwak ,  Kyung Duk Moon ,  Hyun Ho Chung

IPC分类号： A61K3144

CPC分类号： C07D401/14 ,  C07D233/76 ,  C07D405/14 ,  C07D409/14 ,  C07D417/14

摘要： The present invention relates to novel hydantoin compounds represented by formula (I) which shows an inhibitory activity against farnesyl transferase, and thus can be used as an anti-cancer agent, or pharmaceutically acceptable salts thereof, in which R1, R2, R3 and R4 are as defined in the present application. The present invention also relates to a process for preparation of the compound of formula (I), and to an anti-cancer composition comprising the compound of formula (I) as an active ingredient.

摘要翻译： 本发明涉及式（I）所示的新型乙内酰脲化合物，其表现出对法呢基转移酶的抑制活性，因此可用作抗癌剂或其药学上可接受的盐，其中R1，R2，R3和R4 如本申请中所定义。 本发明还涉及制备式（I）化合物的方法，以及包含式（I）化合物作为活性成分的抗癌组合物。

公开(公告)号：US06500846B1

公开(公告)日：2002-12-31

申请号：US09786227

申请日：2001-03-01

申请人： Chang Yong Hong ,  Tae Sik Park ,  Young Kwan Kim ,  Jin Ho Lee ,  Jong Hyun Kim ,  Dong Myung Kim ,  Ho Sun Son ,  Sang Woong Kim ,  Eunice Eun Kyeong Kim

发明人： Chang Yong Hong ,  Tae Sik Park ,  Young Kwan Kim ,  Jin Ho Lee ,  Jong Hyun Kim ,  Dong Myung Kim ,  Ho Sun Son ,  Sang Woong Kim ,  Eunice Eun Kyeong Kim

IPC分类号： A61K31352

CPC分类号： C07D401/04 ,  C07D311/30 ,  C07D405/12 ,  C07D407/04 ,  C07D409/12 ,  C07D409/14 ,  C07D413/14

摘要： The present invention relates to a novel flavone derivative, pharmaceutically acceptable salt, hydrate, solvate and isomer thereof which is useful as an inhibitor against Cyclin Dependent Kinase (CDK), a process for preparation thereof, and a composition of anti-cancer agent or agent for treating neurodegenerative disease comprising this compound as an active ingredient.

摘要翻译： 本发明涉及可用作抑制细胞周期蛋白依赖性激酶（CDK）的抑制剂的新型黄酮衍生物，其药学上可接受的盐，水合物，溶剂化物和异构体，其制备方法，以及抗癌剂或试剂的组合物 用于治疗包含该化合物作为活性成分的神经变性疾病。

公开(公告)号：US10231291B2

公开(公告)日：2019-03-12

申请号：US13201105

申请日：2009-02-11

申请人： Jong Hyun Kim

发明人： Jong Hyun Kim

IPC分类号： H05B6/80 ,  H05B6/64 ,  A47J27/088

摘要： A heating cooker for a microwave oven in which in a main body through which microwaves are transmitted, an upper portion of a metallic pan is closely coupled, and a heating sheet receiving the microwaves and generating heat and an insulating support are coupled in order onto an undersurface of the pan, the heating cooker including a safety device configured such that a silicone packing is provided in a section of the close coupling between the pan and the main body, and so that if internal pressure of the cooker rises abnormally, the silicone packing is decoupled from the main body so as to reduce the pressure.

公开(公告)号：US08900096B2

公开(公告)日：2014-12-02

申请号：US13547864

申请日：2012-07-12

申请人： Sanghyun Jeong ,  Jong Hyun Kim ,  Youngchul Kim ,  Jang Mi Lee ,  SanLok Song ,  Seungjae Kang ,  Jaeshin Yi ,  Haksung Lee ,  Seung Ki Kong

发明人： Sanghyun Jeong ,  Jong Hyun Kim ,  Youngchul Kim ,  Jang Mi Lee ,  SanLok Song ,  Seungjae Kang ,  Jaeshin Yi ,  Haksung Lee ,  Seung Ki Kong

IPC分类号： B60W10/00

CPC分类号： B60W10/105 ,  B60K6/445 ,  B60W20/50 ,  B60Y2200/92 ,  F16H61/0031 ,  Y02T10/6239

摘要： A system and method for diagnosing and controlling an unusual hydraulic state of an electric variable transmission of a hybrid vehicle achieving multi modes including a first mode and a second mode, the method may include determining whether the first mode is converted into the second mode, determining whether a hydraulic pressure is generated in a clutch which is engaged and the generated hydraulic pressure is higher than a predetermined hydraulic pressure when the first mode is converted into the second mode, and determining that the hybrid vehicle is in an unusual condition if the hydraulic pressure is not generated in the clutch or the generated hydraulic pressure is higher than the predetermined hydraulic pressure.

摘要翻译： 一种用于诊断和控制实现包括第一模式和第二模式的多模式的混合动力车辆的电动变速器的异常液压状态的系统和方法，所述方法可以包括确定第一模式是否被转换为第二模式，确定 在第一模式被转换成第二模式时，在接合的离合器中是否产生液压并且产生的液压高于预定液压，并且如果液压压力确定混合动力车辆处于异常状态 不会在离合器中产生，或者产生的液压高于预定的液压。

公开(公告)号：US08747074B2

公开(公告)日：2014-06-10

申请号：US13177706

申请日：2011-07-07

申请人： Sanghyun Jeong ,  Jong Hyun Kim ,  Seunghyun Yang ,  Sang Lok Song ,  Yeonho Kim ,  Jaeshin Yi ,  Haksung Lee ,  Seung Ki Kong

发明人： Sanghyun Jeong ,  Jong Hyun Kim ,  Seunghyun Yang ,  Sang Lok Song ,  Yeonho Kim ,  Jaeshin Yi ,  Haksung Lee ,  Seung Ki Kong

IPC分类号： F04B17/03 ,  F04B49/06 ,  F04B49/20 ,  F04B49/00 ,  F04B35/04 ,  F04B49/08

CPC分类号： F16H61/0025 ,  B60K6/48 ,  B60K2006/4825 ,  B60W10/02 ,  B60W10/06 ,  B60W10/08 ,  B60W10/30 ,  B60W20/00 ,  B60W30/18018 ,  B60W2510/0291 ,  B60W2510/107 ,  B60W2510/108 ,  B60W2710/1083 ,  B60W2710/305 ,  B60Y2200/92 ,  B60Y2300/192 ,  F04B17/03 ,  F04B35/04 ,  F04B49/002 ,  F04B49/06 ,  F04B49/08 ,  F04B49/20 ,  F16H59/72 ,  F16H61/0021 ,  F16H61/0028 ,  F16H61/0031 ,  F16H2312/20 ,  Y02T10/6221 ,  Y02T10/6252 ,  Y02T10/6286 ,  Y02T10/84 ,  Y10S903/903

摘要： An oil pump control apparatus of a hybrid vehicle is provided that controls an oil pump according to a demand of an output torque and oil temperature. In particular, hydraulic line pressure is controlled by operating an oil pump at maximum power if a starting demand for a hybrid vehicle is detected. Viscosity is calculated as well to correspond to an oil temperature in an engine stop mode and a rotation speed of the oil pump is controlled at a low power. Additionally, viscosity is also calculated according to a variation of a line pressure in a driving mode and the rotation speed of the electric oil pump is controlled in either a low power, a middle power, and a high power state as well.

摘要翻译： 提供一种混合动力车辆的油泵控制装置，其根据输出转矩和油温度的要求来控制油泵。 特别地，如果检测到混合动力车辆的起动需求，则通过以最大功率操作油泵来控制液压管路压力。 还计算粘度以对应于发动机停止模式下的油温，并且将油泵的转速控制在低功率。 此外，还根据驱动模式中的管路压力的变化计算粘度，并且将电动油泵的转速控制在低功率，中功率和高功率状态。

公开(公告)号：US20130045511A1

公开(公告)日：2013-02-21

申请号：US13310536

申请日：2011-12-02

申请人： Hye Won Kim ,  Ji-Hye Lee ,  Soo Youn Hwang ,  Jong Hyun Kim

发明人： Hye Won Kim ,  Ji-Hye Lee ,  Soo Youn Hwang ,  Jong Hyun Kim

IPC分类号： C12P13/08 ,  C12N1/21

CPC分类号： C12R1/15 ,  C12P13/08

摘要： The present invention relates to a microorganism having an enhanced L-valine productivity and a method for producing L-valine using the same. More particularly, the present invention relates to a Corynebacterium glutamicum mutant strain that has resistance to L-valine and derivatives thereof so as to have an enhanced L-valine productivity, and a method for producing L-valine using the same.

摘要翻译： 本发明涉及具有增强的L-缬氨酸生产力的微生物和使用其的L-缬氨酸生产方法。 更具体地，本发明涉及对L-缬氨酸及其衍生物具有抗性的L-缬氨酸生产力提高的谷氨酸棒杆菌突变菌株和使用其的L-缬氨酸生产方法。