公开(公告)号：US20230116918P1

公开(公告)日：2023-04-13

申请号：US17958467

申请日：2022-10-03

申请人： LAZZERI GENETICA S.A.S. di DALLAGO FRANCO & C.

发明人： JOHANNES NEBELMEIR

IPC分类号： A01H6/38

摘要： A new and distinct cultivar of Poinsettia plant named ‘LAZZP01531’, characterized by its upright “V”- shaped and uniformly mounding plant habit; moderately vigorous to vigorous growth habit; freely branching habit and strong stems; dark green-colored leaves; full inflorescences with medium to large deep red-colored flower bracts; and excellent post-production longevity.

公开(公告)号：US09205128B2

公开(公告)日：2015-12-08

申请号：US13637845

申请日：2011-04-01

申请人： Celia Berta Fernandez Ortega ,  Anna Caridys Ramírez Suárez ,  Dionne Casillas Casanova ,  Taimi Emelia Paneque Guerrero ,  Raimundo Ubieta Gómez ,  Marta Dubed Echevarria ,  Leonor Margarita Navea Leyva ,  Lila Rosa Castellanos Serra ,  Carlos Antonio Duarte Cano ,  Viviana Falcón Cama ,  Osvaldo Reyes Acosta

发明人： Celia Berta Fernandez Ortega ,  Anna Caridys Ramírez Suárez ,  Dionne Casillas Casanova ,  Taimi Emelia Paneque Guerrero ,  Raimundo Ubieta Gómez ,  Marta Dubed Echevarria ,  Leonor Margarita Navea Leyva ,  Lila Rosa Castellanos Serra ,  Carlos Antonio Duarte Cano ,  Viviana Falcón Cama ,  Osvaldo Reyes Acosta

IPC分类号： A61K38/10 ,  C12N5/0783 ,  A61K31/713 ,  A61K31/19 ,  A61K38/17 ,  A61K45/06 ,  A61K31/7105 ,  A61K31/5575 ,  C07K14/47 ,  C12N15/113

CPC分类号： A61K38/10 ,  A61K31/19 ,  A61K31/5575 ,  A61K31/7105 ,  A61K31/713 ,  A61K38/1709 ,  A61K38/1748 ,  A61K45/06 ,  C07K14/47 ,  C07K14/4741 ,  C12N5/0636 ,  C12N15/113 ,  C12N15/1131 ,  C12N15/1132 ,  C12N2310/14 ,  C12N2310/531 ,  C12N2320/31

摘要： The present invention describes a method to inhibit replication of the human immunodeficiency virus (HIV) by negatively modulating or altering the cytoskeleton, more precisely the proteins forming the intermediate cytoskeletal filaments, wherein the said proteins are vimentin and/or keratin-10. The replication of the virus is inhibited in human cells by intervening in the structure of these proteins. The present invention is also related to the use of agents, which comprise peptides and/or interfering RNA and/or lipidic compounds, said agents producing a negative modulation or alteration of the cytoskeleton to prevent or to treat the HIV infection. The invention provides means and methods for altering the cytoskeleton/filament structure of cells, as a result of which the infection of human cells by HIV is disturbed and can even be completely inhibited. The cytoskeleton is altered by reducing the amount of vimentin and/or keratin (e.g. by transcriptional control using interfering RNA) or by using peptides that disrupt the cytoskeleton.

摘要翻译： 本发明描述了通过负面调节或改变细胞骨架，更精确地形成中间细胞骨架细丝的蛋白质来抑制人免疫缺陷病毒（HIV）复制的方法，其中所述蛋白质是波形蛋白和/或角蛋白-10。 通过介入这些蛋白质的结构，人类细胞中病毒的复制被抑制。 本发明还涉及包含肽和/或干扰RNA和/或脂质化合物的试剂的用途，所述试剂产生细胞骨架的负调节或改变以预防或治疗HIV感染。 本发明提供用于改变细胞的细胞骨架/细丝结构的方法和方法，其结果是HIV的人细胞感染被干扰并且甚至可以被完全抑制。 通过减少波形蛋白和/或角蛋白的量（例如通过使用干扰RNA的转录控制）或通过使用破坏细胞骨架的肽来改变细胞骨架。

公开(公告)号：US09034338B2

公开(公告)日：2015-05-19

申请号：US12601974

申请日：2008-05-30

申请人： Yamila Carpio Gonzalez ,  Mario Pablo Estrada Garcia

发明人： Yamila Carpio Gonzalez ,  Mario Pablo Estrada Garcia

IPC分类号： A61K39/395 ,  A61K39/00 ,  A61K39/38 ,  C07K1/00 ,  C07K14/00 ,  C07K17/00 ,  C07H21/02 ,  C07H21/04 ,  C07K14/435 ,  A23K1/18 ,  A61K38/00

CPC分类号： A61K39/0003 ,  A23K50/80 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/552 ,  C07K14/43509 ,  C07K2319/00

摘要： The present invention is related with the isolation and cloning of a new gene, the production of the protein encoded by this gene by using recombinant systems, and the use of this antigen in a vaccine formulation as a purified protein and/or naked DNA, to induce an immune response in aquatic organisms against different ectoparasite species, including the known as sea lice, and pathogens associated with these infestations. The vaccine preparations, administered by oral route, immersion bath or injection, demonstrated its efficacy by producing IgM humoral immune response and reducing the number of parasites per fish in the vaccinated fishes.

公开(公告)号：US20140173771A1

公开(公告)日：2014-06-19

申请号：US14124629

申请日：2012-06-08

申请人： Robert Cornelis Schuurink ,  Michael Albertus Haring ,  Eleni Spyropoulou

发明人： Robert Cornelis Schuurink ,  Michael Albertus Haring ,  Eleni Spyropoulou

IPC分类号： C07K14/415 ,  A01H5/12 ,  A01H5/00 ,  C12N15/82 ,  A01H1/02

CPC分类号： C12N15/8243 ,  A01H1/02 ,  A01H1/04 ,  A01H5/00 ,  A01H5/12 ,  C07K14/415 ,  C12N15/8286 ,  C12P5/007 ,  Y02A40/162

摘要： The present invention relates to identification and isolation of zinc finger transcription factor in tomato that specifically expresses in glandular trichomes of Solanum lycopersicum cultivar Moneymaker and binds to the promoters of the genes encoding Terpene Synthase 5 (also known as Monoterpene Synthase 1) and Terpene Synthase 11 (also known as Sesquiterpene Synthase 1). The invention provides the isolated, recombinant or synthetic polynucleotides encoding the polypeptide sequences of SEQ ID NO:2 and variants and fragments thereof. The invention also provides constructs, vectors, host cells and plants genetically modified to contain the polynucleotides of the invention. The methods for producing plants with altered levels of terpenes, including transformed and mutant plants, are also provided.

摘要翻译： 本发明涉及番茄中锌指转录因子的鉴定和分离，其特异性表达在番茄茄子栽培品种Moneymaker的腺体毛中，并结合编码萜烯合酶5（也称为单萜合酶1）和萜烯合酶11的基因的启动子 （也称为倍半萜合酶1）。 本发明提供编码SEQ ID NO：2的多肽序列的分离的，重组的或合成的多核苷酸及其变体和片段。 本发明还提供构建体，载体，宿主细胞和遗传修饰以包含本发明的多核苷酸的植物。 还提供了用于生产具有改变的萜烯含量的植物的方法，包括转化和突变植物。

公开(公告)号：US08741848B2

公开(公告)日：2014-06-03

申请号：US12162505

申请日：2007-01-29

申请人： Vivian Maria Sáez Martinez ,  Rolando Páez Meireles ,  Jorge Amador Berlanga Acosta ,  Blas Yamir Betancourt Rodriguez ,  José Ángel Ramón Hernández

发明人： Vivian Maria Sáez Martinez ,  Rolando Páez Meireles ,  Jorge Amador Berlanga Acosta ,  Blas Yamir Betancourt Rodriguez ,  José Ángel Ramón Hernández

IPC分类号： A61K38/00

CPC分类号： A61K9/1647 ,  A61K9/0021 ,  A61K38/1808

摘要： The present invention relates to a pharmaceutical composition that comprises polymeric microspheres containing epidermal growth factor (EGF) for the application, by the parenteral route, into the lower limbs of diabetic patients with cutaneous chronic ischemic ulcerative wounds. The pharmaceutical composition described herein, in contrast with the state of the art, is useful because reduce the administration frequency during the treatment and allows for the healing of the ulcerative wounds in a shorter time interval with respect to the injection of equivalent quantities of non-encapsulated EGF.

摘要翻译： 本发明涉及一种药物组合物，其包含含有表皮生长因子（EGF）的聚合微球，其通过肠胃外途径施用于具有皮肤慢性缺血性溃疡性创伤的糖尿病患者的下肢。 与现有技术相比，本文所述的药物组合物是有用的，因为在治疗期间减少施用频率并且允许在相对于注射等量的非 - 非甾体抗炎药物的较短时间间隔内愈合溃疡性伤口， 封装的EGF。

公开(公告)号：US20140106987A1

公开(公告)日：2014-04-17

申请号：US14125128

申请日：2012-06-14

申请人： ISTITUTO NAZIONALE GENETICA MOLECOLARE - INGM

发明人： Sergio Abrignani ,  Mauro Bombaci ,  Chiara Zingaretti

IPC分类号： G01N33/68

CPC分类号： G01N33/6893 ,  G01N33/564 ,  G01N2800/085

摘要： The present invention relates to a method for diagnosis or prognosis of liver autoimmune diseases by means of detecting specific biomarkers in biological samples. The invention refers also to a method of monitoring an autoimmune liver disease pathology status after treatment with surgery and/or therapy in a subject with autoimmune liver disease, to kits and microarrays to perform said methods.

摘要翻译： 本发明涉及一种通过检测生物样品中特异性生物标志物来诊断或预后肝脏自身免疫疾病的方法。 本发明还涉及在具有自身免疫性肝病的受试者中用手术和/或治疗治疗后监测自身免疫性肝病病理状态的方法，以及用于实施所述方法的试剂盒和微阵列。

公开(公告)号：US08569470B2

公开(公告)日：2013-10-29

申请号：US12739658

申请日：2008-10-17

申请人： Diógenes Quintana Vázquez ,  Tamara Menendez Medina ,  Anabel Álvarez Acosta ,  Yoelys Cruz Leal ,  Gerardo Enrique Guillen Nieto

发明人： Diógenes Quintana Vázquez ,  Tamara Menendez Medina ,  Anabel Álvarez Acosta ,  Yoelys Cruz Leal ,  Gerardo Enrique Guillen Nieto

IPC分类号： C07H21/04 ,  A61K39/10

CPC分类号： G01N33/56911 ,  A61K39/00 ,  A61K39/099 ,  A61K2039/522 ,  A61K2039/523 ,  A61K2039/53 ,  C07K14/235 ,  Y02A50/466

摘要： The present invention is related with the field of Biomedicine. It comprises the engineering of the Pertactin protein (Prn) and using it as part of bacterial vaccines, and more precisely, as part of acellular vaccines against Bordetella pertusis. The engineered Prn molecules comprise on their structure polimorfisms from different B. pertussis strains, and induce immune responses with protective capacity and opsonophagocytic activity when assayed as vaccines, higher than that generated by other pre-existing vaccines. The engineered Prn variants of the present invention are applicable in human and veterinary medicine.

摘要翻译： 本发明涉及生物医学领域。 它包括Pertactin蛋白（Prn）的工程，并将其用作细菌疫苗的一部分，更确切地说，它是作为针对博德氏菌的无细胞疫苗的一部分。 工程化的Prn分子在其结构上包括来自不同的百日咳杆菌菌株的结构，并且当测定为疫苗时诱导具有保护能力和调理吞噬活性的免疫应答，高于其他预先存在的疫苗产生的疫苗。 本发明的工程化Prn变体可应用于人兽药。

公开(公告)号：US08450559B2

公开(公告)日：2013-05-28

申请号：US12934685

申请日：2009-03-27

申请人： Orlando Borrás Hidalgo ,  Roxana Caridad Portieles Álvarez ,  Merardo Pujol Ferrer ,  Gil Alberto Enriquez Obregón ,  Ernesto Manuel González Ramos ,  Camilo Ayra Pardo ,  Carlos Guillermo Borroto Nordelo

发明人： Orlando Borrás Hidalgo ,  Roxana Caridad Portieles Álvarez ,  Merardo Pujol Ferrer ,  Gil Alberto Enriquez Obregón ,  Ernesto Manuel González Ramos ,  Camilo Ayra Pardo ,  Carlos Guillermo Borroto Nordelo

IPC分类号： A01H5/00 ,  C12N15/09 ,  C12N15/29 ,  C12N15/82

CPC分类号： A01N37/18 ,  C07K14/415 ,  C12N15/8279 ,  C12N15/8282

摘要： The present invention reveals a nucleic acid sequence from Nicotiana megalosiphon encoding for an anti-pathogenic protein. The invention comprises the use of this nucleic acid molecule in transgenic plants of agricultural interest to confer resistance to pathogens. The invention also includes a bioproduct that comprises this anti-pathogenic protein to control plant pathogen agents.

公开(公告)号：US20120021943A1

公开(公告)日：2012-01-26

申请号：US13148829

申请日：2009-02-11

申请人： Purificação Tavares ,  Aida Palmeiro ,  Paula Rendeiro

发明人： Purificação Tavares ,  Aida Palmeiro ,  Paula Rendeiro

IPC分类号： C40B30/04 ,  C40B50/00 ,  C40B40/06 ,  C40B50/02

CPC分类号： C12Q1/6837 ,  C12Q2600/156

摘要： The invention utilizes clinical features of diseases with a genetic background to define logical panels of diseases which have shared signs or symptoms. The invention includes methods for collecting data for use in determining a cause or risk factor for disease and includes micro arrays for use in detecting mutations associated with the diseases set forth in the panel.

摘要翻译： 本发明利用具有遗传背景的疾病的临床特征来定义具有共同体征或症状的疾病的逻辑组。 本发明包括用于收集用于确定疾病的病因或危险因素的数据的方法，并且包括用于检测与该组中阐述的疾病相关的突变的微阵列。

公开(公告)号：US20100196878A1

公开(公告)日：2010-08-05

申请号：US12670666

申请日：2008-07-28

申请人： Carmen Vela Olmo ,  Angel Antonio Venteo Moreno ,  Antonio Jose Sanz Fernández

发明人： Carmen Vela Olmo ,  Angel Antonio Venteo Moreno ,  Antonio Jose Sanz Fernández

IPC分类号： C12Q1/70 ,  G01N33/53 ,  G01N33/566

CPC分类号： G01N33/6854 ,  C12Q1/04 ,  G01N33/536 ,  G01N33/58

摘要： The invention relates to a dual-recognition immunoassay for the detection of antibodies specific to a target antigen in a sample which comprises contacting said target antigen with a sample suspected of containing said antibodies specific to said target antigen under conditions allowing the formation of an antigen-antibody complex; adding a conjugate comprising said target antigen and a marker under conditions allowing the formation of an antigen-antibody-antigen/marker complex; and detecting said antigen-antibody-antigen/marker complex. The immunoassay can be used, among other applications, in the diagnosis of infections caused by pathogenic organisms with high sensitivity and specificity.

摘要翻译： 本发明涉及用于检测样品中靶抗原特异性抗体的双重识别免疫测定法，其包括在允许形成抗原决定簇的条件下使所述靶抗原与怀疑含有所述靶抗原特异性抗体的样品接触， 抗体复合物; 在允许形成抗原 - 抗原 - 抗原/标记复合物的条件下，加入包含所述靶抗原和标记物的缀合物; 并检测所述抗原 - 抗原 - 抗原/标记复合物。 除了其他应用之外，免疫测定可以用于诊断由致病性生物体引起的感染，具有高灵敏度和特异性。