公开(公告)号：US12091384B2

公开(公告)日：2024-09-17

申请号：US17358494

申请日：2021-06-25

申请人： INTEGRATIVE RESEARCH LABORATORIES SWEDEN AB

发明人： Clas Sonesson ,  Maija Buksa ,  Inese Reine

IPC分类号： C07D207/12 ,  C07C57/15

CPC分类号： C07D207/12 ,  C07C57/15 ,  C07B2200/13

摘要： Described is a salt of Formula IIb:

公开(公告)号：US20240270689A1

公开(公告)日：2024-08-15

申请号：US18368754

申请日：2023-09-15

申请人： Carnitech LLC

发明人： Songzhou Hu ,  Zhen Song

IPC分类号： C07D207/12 ,  C07C229/76 ,  C07C233/36 ,  C07C255/63

CPC分类号： C07D207/12 ,  C07C229/76 ,  C07C233/36 ,  C07C255/63

摘要： There is disclosed a process for the production of brivaracetam by converting an intermediate of the formula:




to an intermediate of the formula:




and then to brivaracetam; wherein R1 and R2 are each independently selected from the group consisting of hydrogen, alkali, alkaline earth metal, alkyl, and a mixture thereof.

公开(公告)号：US11970444B2

公开(公告)日：2024-04-30

申请号：US17291736

申请日：2019-11-06

申请人： HARMAN FINOCHEM LIMITED

发明人： Vijay Trimbak Kadam ,  Dhananjay Uddhavrao Ed Aki ,  Ravindra Bhausaheb Pagire ,  Mayur Sanjay Kulkarni ,  Harpreet Singh Minhas ,  Gurpreet Singh Minhas

IPC分类号： C07D207/12 ,  C07C303/32 ,  C07C303/44

CPC分类号： C07D207/12 ,  C07C303/32 ,  C07C303/44

摘要： Disclosed herein is an efficacious process for preparation of highly purified Glycopyrrolate tosylate in high yield. The process is being cost effective, environment friendly and easily scalable to high volume industrial production.

公开(公告)号：US11951093B2

公开(公告)日：2024-04-09

申请号：US17848386

申请日：2022-06-23

申请人： Bodor Laboratories, Inc.

发明人： Nicholas S. Bodor

IPC分类号： A61K31/40 ,  A61K9/00 ,  A61K9/20 ,  A61K9/70 ,  A61K47/38 ,  A61K47/40 ,  A61P1/02 ,  C07D207/10 ,  C07D207/12

CPC分类号： A61K31/40 ,  A61K9/0056 ,  A61K9/006 ,  A61K9/2054 ,  A61K9/7007 ,  A61K47/38 ,  A61K47/40 ,  A61P1/02 ,  C07D207/10 ,  C07D207/12

摘要： Intra-oral formulations comprising soft anticholinergic alkyl esters are useful for treating excessive drooling conditions in subjects, such as humans, suffering from sialorrhea. Preferably, at least one soft anticholinergic ester is provided in an effective amount or concentration in an anhydrous intra-oral formulation that can inhibit excessive drooling resulting from a condition known as sialorrhea.

公开(公告)号：US11926635B2

公开(公告)日：2024-03-12

申请号：US17813382

申请日：2022-07-19

申请人： GEN1E LIFESCIENCES INC.

发明人： Adam Galan ,  Wendy Luo ,  Ritu Lal

IPC分类号： C07D491/107 ,  A61P31/14 ,  C07D207/12 ,  C07D211/42 ,  C07D211/46 ,  C07D239/30 ,  C07D241/08 ,  C07D265/30 ,  C07D267/10 ,  C07D491/048 ,  C07D498/18

CPC分类号： C07D491/107 ,  A61P31/14 ,  C07D207/12 ,  C07D211/42 ,  C07D211/46 ,  C07D239/30 ,  C07D241/08 ,  C07D265/30 ,  C07D267/10 ,  C07D491/048 ,  C07D498/18

摘要： Disclosed herein are p38α mitogen-activated protein kinase inhibitors, pharmaceutical compositions thereof, and therapeutic methods of using the p38α mitogen-activated protein kinase inhibitors.

公开(公告)号：US20240052379A1

公开(公告)日：2024-02-15

申请号：US18346715

申请日：2023-07-03

申请人： Genomatica, Inc.

发明人： Anthony P. Burgard ,  Robin E. Osterhout ,  Stephen J. Van Dien ,  Cara Ann Tracewell ,  Priti Pharkya ,  Stefan Andrae

IPC分类号： C12P7/18 ,  C12N9/04 ,  C12N9/06 ,  C12N9/10 ,  C07D207/12 ,  C08G18/32 ,  C08G63/06 ,  C08G63/12 ,  C08G63/66 ,  C08G69/26 ,  C12N9/88 ,  C12P7/24 ,  C12P19/02

CPC分类号： C12P7/18 ,  C12N9/0006 ,  C12N9/0028 ,  C12N9/1007 ,  C12Y105/0102 ,  C12Y201/01 ,  C12Y101/01244 ,  C12Y101/02007 ,  C07D207/12 ,  C08G18/3206 ,  C08G63/06 ,  C08G63/12 ,  C08G63/66 ,  C08G69/26 ,  C12N9/88 ,  C12P7/24 ,  C12P19/02 ,  C12Y101/01224 ,  C12Y201/0109 ,  C12Y402/01 ,  Y02P20/52

摘要： Provided herein is a non-naturally occurring microbial organism having a methanol metabolic pathway (MMP) that can enhance the availability of reducing equivalents in the presence of methanol. Such reducing equivalents can be used to increase the product yield of organic compounds produced by the microbial organism, such as 1,4-butanediol (BDO). Also provided herein are methods for using such an organism to produce BDO.

公开(公告)号：US20240018113A1

公开(公告)日：2024-01-18

申请号：US18372771

申请日：2023-09-26

申请人： Astellas Pharma, Inc. ,  Mitobridge, Inc.

发明人： Junko Maeda ,  Ikumi Kuriwaki ,  Kai Kitamura ,  Yumi Yamashita ,  Kenichi Kakefuda ,  Akio Kamikawa ,  Kenji Negoro ,  Wataru Hamaguchi ,  Ryushi Seo ,  Jeffrey Ciavarri

IPC分类号： C07D295/16 ,  C07D213/56 ,  C07D231/12 ,  C07D205/04 ,  C07D307/22 ,  C07D207/273 ,  C07D305/08 ,  C07D333/48 ,  C07D405/10 ,  C07D207/16 ,  C07D211/48 ,  C07C237/42 ,  C07C311/46 ,  C07C311/13 ,  C07D207/12 ,  C07D211/62 ,  C07C233/22 ,  C07D295/195 ,  C07C233/69 ,  C07C235/42 ,  C07D309/14 ,  C07D213/75 ,  C07D231/40 ,  C07D403/06 ,  C07C233/81 ,  C07D209/08 ,  C07D295/155 ,  C07D487/10 ,  C07D403/10 ,  C07D401/06 ,  C07D279/12 ,  C07D239/26

CPC分类号： C07D295/16 ,  C07D213/56 ,  C07D231/12 ,  C07D205/04 ,  C07D307/22 ,  C07D207/273 ,  C07D305/08 ,  C07D333/48 ,  C07D405/10 ,  C07D207/16 ,  C07D211/48 ,  C07C237/42 ,  C07C311/46 ,  C07C311/13 ,  C07D207/12 ,  C07D211/62 ,  C07C233/22 ,  C07D295/195 ,  C07C233/69 ,  C07C235/42 ,  C07D309/14 ,  C07D213/75 ,  C07D231/40 ,  C07D403/06 ,  C07C233/81 ,  C07D209/08 ,  C07D295/155 ,  C07D487/10 ,  C07D403/10 ,  C07D401/06 ,  C07D279/12 ,  C07D239/26

摘要： [Problem] A compound which is useful as a STING inhibitor is provided.
[Means for Solution] The present inventors have found aryl alkynamide derivatives having an inhibitory action on STING. The aryl alkynamide derivatives of the present invention have an inhibitory action on STING and can be used as an agent for treating an autoimmune disease, a neurodegenerative disease, a type I interferonopathy and/or other STING-mediated disease.

公开(公告)号：US20230242478A1

公开(公告)日：2023-08-03

申请号：US17610548

申请日：2020-05-07

申请人： BRISTOL-MYERS SQUIBB COMPANY

发明人： Lalgudi S. Harikrishnan ,  Muthoni G. Kamau ,  Brian E. Fink

IPC分类号： C07C317/22 ,  C07D207/12 ,  C07D409/06 ,  C07D407/06 ,  C07D401/06 ,  C07D403/06 ,  C07D417/06

CPC分类号： C07C317/22 ,  C07D207/12 ,  C07D409/06 ,  C07D407/06 ,  C07D401/06 ,  C07D403/06 ,  C07D417/06

摘要： The present invention is directed to compounds of the formula [INSERT CHEMICAL STRUCTURE HERE}] wherein all substituents are defined herein, as well as pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.

公开(公告)号：US11708326B2

公开(公告)日：2023-07-25

申请号：US17106309

申请日：2020-11-30

申请人： CHEMOCENTRYX, INC.

发明人： Christopher Lange ,  Viengkham Malathong ,  Venkat Reddy Mali ,  Jeffrey McMahon ,  Darren J. McMurtrie ,  Sreenivas Punna ,  Howard S. Roth ,  Rajinder Singh ,  Yu Wang ,  Ju Yang ,  Penglie Zhang

IPC分类号： C07D207/12 ,  A61K45/06 ,  C07D401/12 ,  C07D207/267 ,  C07D211/44 ,  C07D403/12 ,  C07D211/38 ,  C07D451/06 ,  C07D205/12 ,  C07F5/02 ,  C07D405/14 ,  C07D401/14 ,  C07D471/10 ,  C07D211/76 ,  A61P37/02 ,  C07D205/04 ,  C07D213/85 ,  C07D295/088 ,  C07D487/10 ,  C07D405/12 ,  A61K31/40 ,  A61K31/4427 ,  A61K31/445 ,  A61K31/454 ,  A61K31/4545 ,  C07D211/40 ,  C07D211/46

CPC分类号： C07D207/12 ,  A61K31/40 ,  A61K31/445 ,  A61K31/4427 ,  A61K31/454 ,  A61K31/4545 ,  A61K45/06 ,  A61P37/02 ,  C07D205/04 ,  C07D205/12 ,  C07D207/267 ,  C07D211/38 ,  C07D211/40 ,  C07D211/44 ,  C07D211/46 ,  C07D211/76 ,  C07D213/85 ,  C07D295/088 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D451/06 ,  C07D471/10 ,  C07D487/10 ,  C07F5/025

摘要： Compounds are provided that are useful as immunomodulators. The compounds have the following Formula (I):




including stereoisomers and pharmaceutically acceptable salts thereof, wherein Z, L, R1a, R1b, R1c, R1d, R2a, R2b, R2c, R3, R4, R5, R6a, R6b, m and n are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

公开(公告)号：US20190194163A1

公开(公告)日：2019-06-27

申请号：US16322278

申请日：2016-08-04

申请人： Sunovion Pharmaceuticals Inc.

发明人： Michele L.R. HEFFERNAN ,  Larry Wendell HARDY ,  Scott P. BROWN ,  Lee W. HERMAN

IPC分类号： C07D401/08 ,  C07D405/06 ,  C07D401/06 ,  C07D401/14 ,  C07D207/12 ,  C07D295/096 ,  C07D295/027 ,  C07D311/22 ,  C07D471/04 ,  C07D235/12 ,  C07D237/14 ,  C07D217/24 ,  C07D295/073 ,  C07D295/108 ,  C07D275/04 ,  C07D311/08 ,  C07D307/83 ,  C07D491/048 ,  C07D277/66 ,  C07D401/12 ,  C07D211/44 ,  C07D211/58 ,  C07D265/30 ,  C07D413/06 ,  C07D241/04 ,  C07D223/08 ,  C07D267/10 ,  C07D243/08 ,  C07D413/08 ,  C07D471/08 ,  C07D487/10 ,  C07D471/10 ,  C07D491/107

CPC分类号： C07D401/08 ,  A61P25/18 ,  A61P25/28 ,  C07D207/12 ,  C07D207/36 ,  C07D211/42 ,  C07D211/44 ,  C07D211/58 ,  C07D213/81 ,  C07D217/24 ,  C07D221/20 ,  C07D223/08 ,  C07D235/12 ,  C07D237/14 ,  C07D241/04 ,  C07D243/08 ,  C07D249/12 ,  C07D265/30 ,  C07D267/10 ,  C07D275/04 ,  C07D277/66 ,  C07D295/027 ,  C07D295/073 ,  C07D295/088 ,  C07D295/096 ,  C07D295/104 ,  C07D295/108 ,  C07D307/83 ,  C07D311/08 ,  C07D311/22 ,  C07D311/58 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/06 ,  C07D405/06 ,  C07D405/12 ,  C07D413/06 ,  C07D413/08 ,  C07D417/04 ,  C07D471/04 ,  C07D471/08 ,  C07D471/10 ,  C07D487/10 ,  C07D491/048 ,  C07D491/107 ,  C07D491/20 ,  C07D513/04

摘要： Compounds of formula I: are disclosed, as are pharmaceutical compositions containing such compounds. Methods of treating neurological or psychiatric disorders in a patient in need are also disclosed. Such disorders include depression, bipolar disorder, pain, schizophrenia, obsessive compulsive disorder, addiction, social disorder, attention deficit hyperactivity disorder, an anxiety disorder, autism, a cognitive impairment, or a neuropsychiatric symptom such as apathy, depression, anxiety, psychosis, aggression, agitation, impulse control disorders, and sleep disorders in neurological disorders such as Alzheimer's and Parkinson's diseases.