公开(公告)号：US12110263B2

公开(公告)日：2024-10-08

申请号：US17740260

申请日：2022-05-09

申请人： CORTEXYME, INC.

发明人： Andrei W. Konradi ,  Robert A. Galemmo, Jr. ,  Stephen S. Dominy ,  Casey C. Lynch ,  Leslie J. Holsinger

IPC分类号： C07C233/62 ,  A61K31/165 ,  A61K31/167 ,  A61K31/41 ,  A61K31/42 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4439 ,  A61K31/505 ,  A61K31/513 ,  A61K31/655 ,  A61K45/06 ,  A61P25/00 ,  A61P31/04 ,  C07B59/00 ,  C07C233/78 ,  C07C235/10 ,  C07C235/50 ,  C07C237/42 ,  C07C245/08 ,  C07C247/16 ,  C07C247/18 ,  C07C317/28 ,  C07C323/40 ,  C07C323/42 ,  C07C381/00 ,  C07D213/65 ,  C07D213/68 ,  C07D213/70 ,  C07D213/81 ,  C07D213/82 ,  C07D239/34 ,  C07D239/36 ,  C07D239/38 ,  C07D257/04 ,  C07D261/12 ,  C07D401/12 ,  C07D413/12 ,  C07F5/02

CPC分类号： C07C233/62 ,  A61K31/165 ,  A61K31/167 ,  A61K31/41 ,  A61K31/42 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4439 ,  A61K31/505 ,  A61K31/513 ,  A61K31/655 ,  A61K45/06 ,  A61P25/00 ,  A61P31/04 ,  C07B59/001 ,  C07C233/78 ,  C07C235/10 ,  C07C235/50 ,  C07C237/42 ,  C07C245/08 ,  C07C247/16 ,  C07C247/18 ,  C07C317/28 ,  C07C323/40 ,  C07C323/42 ,  C07C381/00 ,  C07D213/65 ,  C07D213/68 ,  C07D213/70 ,  C07D213/81 ,  C07D213/82 ,  C07D239/34 ,  C07D239/36 ,  C07D239/38 ,  C07D257/04 ,  C07D261/12 ,  C07D401/12 ,  C07D413/12 ,  C07F5/02 ,  C07C2601/08

摘要： The present invention provides compounds according to Formula I as described herein, and their use for inhibiting the lysine gingipain protease (Kgp) from the bacterium Porphyromonas gingivalis. Also described are gingipain activity probe compounds and methods for assaying gingipain activity are also described, as well as methods for the treatment of disorders associated with P. gingivalis infection, including brain disorders such as Alzheimer's disease.

公开(公告)号：US20240325364A1

公开(公告)日：2024-10-03

申请号：US18578659

申请日：2022-07-08

申请人： Nottingham Trent University

发明人： Mark Duncan Turner ,  Alun Christopher Garner

IPC分类号： A61K31/4439 ,  A61K31/4174 ,  A61K31/42 ,  A61K31/443 ,  A61P3/04

CPC分类号： A61K31/4439 ,  A61K31/4174 ,  A61K31/42 ,  A61K31/443 ,  A61P3/04

摘要： The invention provides a compound of Formula (I) or a tautomer, isomer, prodrug, metal complex, or pharmaceutically acceptable salt thereof for use in the treatment of a metabolic disorder or for inducing weight loss: wherein R1 is: H; a straight or branched alkyl; a straight or branched alkyl substituted with at least one moiety selected from the group comprising: halogen, hydroxy, alkoxy, NH2, mono- or disubstituted amino, thiol, and phosphine; aryl; aralkyl; hydroxy; alkoxy; aryloxy; arylalkoxy; NH2; mono- or disubstituted amino; or halogen; X is: CH or N; L is absent or present, and when present is: an optionally substituted straight or branched C1-C10 alkyl, optionally containing one or more rings, and/or optionally containing one or more double bonds; and Ar is: an optionally substituted 5-membered unsaturated heterocyclic ring.

公开(公告)号：US20240293435A1

公开(公告)日：2024-09-05

申请号：US18588947

申请日：2024-02-27

申请人： William & Mary

发明人： Jason P. McDevitt

IPC分类号： A61K31/675 ,  A61K31/405 ,  A61K31/42

CPC分类号： A61K31/675 ,  A61K31/405 ,  A61K31/42

摘要： Methods and pharmaceutical compositions are described for treating a variety of chronic human afflictions including anxiety disorders, eating disorders, chronic pain, depression, addictive disorders, dementia (e.g., Alzheimer's disease, frontotemporal dementia, Lewy body disorder, and vascular dementia), traumatic brain injury (TBI) and mild cognitive impairment. A sub-hallucinogenic dose of a psychedelic tryptamine, including for example psilacetin and psilocybin, along with a low dose of D-cycloserine are administered to human subjects in order to modify neural pathways to treat the chronic affliction.

公开(公告)号：US20240287005A1

公开(公告)日：2024-08-29

申请号：US18569408

申请日：2022-06-15

申请人： Elanco Tiergesundheit AG ,  Bayer Animal Health GmbH

发明人： Pierre DUCRAY ,  Denise RAGEOT ,  Andreas TURBERG

IPC分类号： C07D261/04 ,  A01N43/80 ,  A01P7/02 ,  A01P7/04 ,  A61K31/42 ,  A61K31/422 ,  A61P33/14 ,  C07D413/12

CPC分类号： C07D261/04 ,  A01N43/80 ,  A01P7/02 ,  A01P7/04 ,  A61K31/42 ,  A61K31/422 ,  A61P33/14 ,  C07D413/12

摘要： The present invention provides compounds of formula (I):




which are useful for long-lasting treatment and control of pests, for example fleas and ticks, in companion animals and livestock, and pharmaceutical compositions and methods of using the same.

公开(公告)号：US20240269121A1

公开(公告)日：2024-08-15

申请号：US18567464

申请日：2022-06-08

申请人： Sol-Gel Technologies Ltd.

发明人： Moshe ARKIN ,  Ofer TOLEDANO ,  Karine NEIMANN ,  Hila HAKAK DJERBI

IPC分类号： A61K31/44 ,  A61K31/05 ,  A61K31/194 ,  A61K31/196 ,  A61K31/202 ,  A61K31/277 ,  A61K31/327 ,  A61K31/4035 ,  A61K31/404 ,  A61K31/4164 ,  A61K31/42 ,  A61K31/421 ,  A61K31/427 ,  A61K31/437 ,  A61K31/4545 ,  A61K31/473 ,  A61K31/519 ,  A61K31/65 ,  A61K31/69 ,  A61K31/7048 ,  A61K45/06

CPC分类号： A61K31/44 ,  A61K31/05 ,  A61K31/194 ,  A61K31/196 ,  A61K31/202 ,  A61K31/277 ,  A61K31/327 ,  A61K31/4035 ,  A61K31/404 ,  A61K31/4164 ,  A61K31/42 ,  A61K31/421 ,  A61K31/427 ,  A61K31/437 ,  A61K31/4545 ,  A61K31/473 ,  A61K31/519 ,  A61K31/65 ,  A61K31/69 ,  A61K31/7048 ,  A61K45/06

摘要： The present invention relates to a method of reducing acne relapse or rosacea relapse rate or severity, by reducing the skin's immunological response, wherein the method comprises administering a topical composition comprising at least one of a PDE4 inhibitor, a JAK inhibitor, an AhR modulator, or any combination thereof.

公开(公告)号：US11998531B1

公开(公告)日：2024-06-04

申请号：US18539688

申请日：2023-12-14

申请人： William Allen Boulanger ,  Zongbo Tong

发明人： William Allen Boulanger ,  Zongbo Tong

IPC分类号： A61K31/42 ,  C07D261/12

CPC分类号： A61K31/42 ,  C07D261/12

摘要： Pharmaceutical intermediates and methods for efficiently preparing muscimol mono-BOC and derivatives thereof in the synthesis of muscimol and congeners and derivatives thereof.

公开(公告)号：US20240148757A1

公开(公告)日：2024-05-09

申请号：US18548678

申请日：2022-03-03

申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM ,  KADMON CORPORATION LLC

发明人： Boyi GAN ,  Kellen OLSZEWSKI ,  Chao MAO

IPC分类号： A61K31/655 ,  A61K31/18 ,  A61K31/277 ,  A61K31/381 ,  A61K31/42 ,  A61K31/437 ,  A61K31/47 ,  A61K31/517 ,  A61P35/00 ,  C12Q1/6851 ,  C12Q1/6886 ,  G01N33/574

CPC分类号： A61K31/655 ,  A61K31/18 ,  A61K31/277 ,  A61K31/381 ,  A61K31/42 ,  A61K31/437 ,  A61K31/47 ,  A61K31/517 ,  A61P35/00 ,  C12Q1/6851 ,  C12Q1/6886 ,  G01N33/57496 ,  C12Q2600/106 ,  C12Q2600/158 ,  G01N2333/90206

摘要： The present disclosure provides methods for treating cancer comprising administering to a subject in need thereof a therapeutically effective amount of a dihydroorotate dehydrogenase (DHODH) inhibitor, wherein the cancer has an altered glutathione peroxidase 4 (GPX4) expression as compared to a control sample. The present disclosure also provides methods of treating a subject with a dihydroorotate dehydrogenase (DHODH) inhibitor where the subject's GPX4 expression is low as compared to a control sample or with a DHODH inhibitor and a ferroptosis inducer where the subject's GPX4 expression is high as compared to a control sample.

公开(公告)号：US11969431B2

公开(公告)日：2024-04-30

申请号：US17139999

申请日：2021-01-01

申请人： Glytech LLC

发明人： Daniel C. Javitt

IPC分类号： A61K31/55 ,  A61K9/00 ,  A61K31/135 ,  A61K31/165 ,  A61K31/4152 ,  A61K31/42 ,  A61K31/4525 ,  A61K31/496 ,  A61K31/554 ,  A61K45/06 ,  A61K47/40 ,  A61P25/00 ,  A61P25/22 ,  A61P25/24

CPC分类号： A61K31/55 ,  A61K9/0019 ,  A61K31/135 ,  A61K31/165 ,  A61K31/4152 ,  A61K31/42 ,  A61K31/4525 ,  A61K31/496 ,  A61K31/554 ,  A61K45/06 ,  A61K47/40 ,  A61P25/00 ,  A61P25/22 ,  A61P25/24 ,  A61K9/0053 ,  A61K2300/00 ,  A61K31/135 ,  A61K2300/00 ,  A61K31/4525 ,  A61K2300/00 ,  A61K31/554 ,  A61K2300/00 ,  A61K31/55 ,  A61K2300/00 ,  A61K31/165 ,  A61K2300/00 ,  A61K31/4152 ,  A61K2300/00

摘要： Provided herein are compositions for reducing symptoms of post-traumatic stress disorder. The compositions include a combination of an N-methyl-D-aspartate (NMDA) receptor antagonist and an anti-depression agent.

公开(公告)号：US20240130982A1

公开(公告)日：2024-04-25

申请号：US18393055

申请日：2023-12-21

申请人： Katholieke Uniersiteit Leuven

发明人： Yicheng NI

IPC分类号： A61K31/09 ,  A61K9/00 ,  A61K31/42 ,  A61K31/661 ,  A61P35/00

CPC分类号： A61K31/09 ,  A61K9/0019 ,  A61K31/42 ,  A61K31/661 ,  A61P35/00 ,  A61K31/122

摘要： The invention relates to vascular disrupting agent (VDA) such as combretastatins for treating avascular or hypo vascular micro-tumors with a diameter below 20 mm.

公开(公告)号：US20240122849A1

公开(公告)日：2024-04-18

申请号：US18530282

申请日：2023-12-06

申请人： Intervet Inc.

发明人： Anne Lehay ,  Annie Flochlay-Sigognault

IPC分类号： A61K9/00 ,  A01N25/02 ,  A01N43/80 ,  A23K20/105 ,  A23K20/132 ,  A23K20/137 ,  A23K50/30 ,  A23K50/75 ,  A61K31/42 ,  A61K47/10 ,  A61K47/14 ,  A61K47/22 ,  A61K47/26

CPC分类号： A61K9/0095 ,  A01N25/02 ,  A01N43/80 ,  A23K20/105 ,  A23K20/132 ,  A23K20/137 ,  A23K50/30 ,  A23K50/75 ,  A61K31/42 ,  A61K47/10 ,  A61K47/14 ,  A61K47/22 ,  A61K47/26

摘要： This invention is directed to a pharmaceutical composition for drinking water administration comprising isoxazoline compounds of formula (I) and a polysorbate surfactant and diethylene glycol monoethyl ether (transcutol); and the use of the composition to treat or prevent parasite infestations of animals.