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公开(公告)号：US12247011B2
公开(公告)日：2025-03-11
申请号：US16635374
申请日：2018-07-31
Applicant: NodThera Limited
Inventor： Mark G. Bock , David Harrison , Alan Paul Watt , Roderick Alan Porter , Nicolas Felix Pierre Boutard , Charles-Henry Robert Yves Fabritius , Grzegorz Witold Topolnicki , Oleksandr Levenets
IPC: C07D231/12 , A61P37/06 , C07C45/68 , C07C201/14 , C07C209/36 , C07C263/10 , C07C271/28 , C07C271/30 , C07D213/55 , C07D231/14 , C07D233/60 , C07D237/08 , C07D239/26 , C07D241/12 , C07D241/24 , C07D249/08 , C07D307/79 , C07D309/12 , C07D409/12 , C07D493/04
Abstract: The present disclosure relates to compounds of Formula (I): and to their pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are useful for inhibiting the maturation of cytokines of the IL-1 family by inhibiting inflammasomes and may be used in the treatment of disorders in which inflammasome activity is implicated, such as autoinflammatory and autoimmune diseases and cancers.
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公开(公告)号：US20230092143A1
公开(公告)日：2023-03-23
申请号：US17814815
申请日：2022-07-25
Applicant: MOEHS IBERICA, S.L.
Inventor： Abdeslam AKHATOU , Alicia DOBARRO RODRÍGUEZ
IPC: C07D401/12 , C07C201/14 , C07D239/34 , C07D239/36
Abstract: A method is for the synthesis of 2,4-dimethylpyrimidin-5-ol, which can be used as an intermediate compound in the synthesis of Lemborexant. The method includes reacting a nitrophenyl compound with N,N-dimethylformamide diethyl acetal.
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公开(公告)号：US11168037B2
公开(公告)日：2021-11-09
申请号：US16757326
申请日：2018-10-17
Inventor： Lidia Vera Giovanna De Luca , Silvia Gaspa , Antonio Valentoni , Gabriele Mulas , Andrea Porcheddu
IPC: C07B39/00 , C07C17/06 , C07C253/30 , C07C201/14 , C07D213/26 , C07D215/12 , C07D217/14 , C07C45/41
Abstract: A process that allows halogenation at the alpha-H position of alkylarenes, optionally further substituted on the aromatic or heteroaromatic ring, is described.
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公开(公告)号：US20200347087A1
公开(公告)日：2020-11-05
申请号：US16724654
申请日：2019-12-23
Applicant: President and Fellows of Harvard College
Inventor： Andrew G. Myers , Ziyang Zhang
IPC: C07H15/12 , C07H17/02 , C07H11/02 , C07H15/18 , C07C201/12 , C07C201/14 , C07H1/00
Abstract: The present invention provides desosamine and mycaminose analogs and nitro sugars and methods for their preparation. The invention also provides methods of cyclizing a compound of Formula (A′) with glyoxal to give a nitro sugar of Formula (B). Methods for the preparation of compound of Formula (D′) are provided comprising cyclization of a nitro alcohol to give a nitro sugar and reduction and alkylation of the nitro sugar to give a desosamine, mycaminose, or an analog thereof.
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公开(公告)号：US10195599B2
公开(公告)日：2019-02-05
申请号：US15911018
申请日：2018-03-02
IPC: C07D301/12 , C07C205/09 , C07C205/00 , B01J31/02 , B01J21/18 , B01J35/00 , B01J35/08 , B01J37/02 , B01J31/08 , B01J31/10 , B01J37/08 , C07C201/14 , C01B32/05
Abstract: Disclosed herein is a simple process for functionalization/grafting of carbon microspheres obtained from bagasse with various active functional groups onto it and use of the same as catalyst for various organic reactions, having very high selectivity and conversion rate.
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Patent Agency Ranking
6.发明申请SYNTHESIS OF FUNCTIONALIZED CARBON MICROSPHERES AND THEIR CATALYST ACTIVITY IN C-O AND C-N BOND FORMATION REACTIONS 审中-公开功能性碳微球的合成及其在C-O和C-N键形成反应中的催化剂活性公开(公告)号：US20160167031A1
公开(公告)日：2016-06-16
申请号：US14901456
申请日：2014-06-25
IPC: B01J31/02 , C07D301/12 , C07C201/14 , B01J37/08
CPC classification number: B01J31/0237 , B01J21/18 , B01J31/0205 , B01J31/0225 , B01J31/08 , B01J31/10 , B01J35/002 , B01J35/08 , B01J37/0209 , B01J37/084 , B01J2231/342 , B01J2231/4205 , B01J2231/72 , C01B32/05 , C07C201/14 , C07D301/12
Abstract: Disclosed herein is a simple process for functionalization/grafting of carbon microspheres obtained from bagasse with various active functional groups onto it and use of the same as catalyst for various organic reactions, having very high selectivity and conversion rate.
Abstract translation: 本文公开了一种简单的方法，用于将从具有各种活性官能团的蔗渣获得的碳微球官能化/接枝到其上，并将其用作各种有机反应的催化剂，具有非常高的选择性和转化率。
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公开(公告)号：US4533776A
公开(公告)日：1985-08-06
申请号：US575649
申请日：1984-02-01
Applicant: Bernd Baasner , Hermann Hagemann , Erich Klauke
Inventor： Bernd Baasner , Hermann Hagemann , Erich Klauke
IPC: C07C67/00 , C07C201/00 , C07C201/14 , C07C205/08 , C07C205/10 , C07C79/12
CPC classification number: C07C205/08 , C07C201/14 , C07C205/10 , C07C2101/14
Abstract: In the preparation of an .alpha.-fluorinated nitroalkane of the formula ##STR1## in which R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are identical or different and individually represent hydrogen, fluorine, chlorine, bromine, alkyl, halogenoalkyl or cycloalkyl, orR.sup.1 and R.sup.3 have the meaning indicated andR.sup.2 and R.sup.4 together represent an alkylene group having 3-6 carbon atoms,by conjugated nitrofluorination of the corresponding olefin of the formula ##STR2## the improvement which comprises employing about 1.1 mols of hydrogen fluoride and 1 to 2 mols of nitric acid per mol of olefin and carrying out the reaction in the presence of an agent which binds water, e.g. chlorosulphonic acid, fluorosulphonic acid, sulphur trioxide, sulphur dioxide, thionyl chloride, thionyl fluoride, sulfuryl chloride or sulfuryl fluoride. The end products, some of which are known, are useful as intermediates in synthesizing herbicides.
Abstract translation: 在制备其中R 1，R 2，R 3和R 4相同或不同并且各自表示氢，氟，氯，溴，烷基，卤代烷基或环烷基的式（Ia）的α-氟化硝基烷烃或R1和R3具有 所表示的含义，R2和R4一起表示具有3-6个碳原子的亚烷基，通过共轭硝基氟化相应的式“烯烃”烯烃，其改进包括使用约1.1摩尔氟化氢和1至2摩尔硝酸 酸/每摩尔烯烃，并在结合水的试剂存在下进行反应，例如 氯磺酸，氟磺酸，三氧化硫，二氧化硫，亚硫酰氯，亚硫酰氟，磺酰氯或硫酰氟。 其中一些已知的最终产物可用作合成除草剂的中间体。
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公开(公告)号：US11891375B2
公开(公告)日：2024-02-06
申请号：US17814815
申请日：2022-07-25
Applicant: MOEHS IBERICA, S.L.
Inventor： Abdeslam Akhatou , Alicia Dobarro Rodríguez
IPC: C07D401/12 , C07C201/14 , C07D239/34 , C07D239/36
CPC classification number: C07D401/12 , C07C201/14 , C07D239/34 , C07D239/36 , C07B2200/13
Abstract: A method is for the synthesis of 2,4-dimethylpyrimidin-5-ol, which can be used as an intermediate compound in the synthesis of Lemborexant. The method includes reacting a nitrophenyl compound with N,N-dimethylformamide diethyl acetal.
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公开(公告)号：US09573881B2
公开(公告)日：2017-02-21
申请号：US14652913
申请日：2013-12-20
Applicant: Nippon Soda Co., Ltd.
Inventor： Hiroki Inoue , Yuzuru Sakata , Shinichi Kobayashi , Yoshikazu Ito , Takashi Kitayama
IPC: C07C209/74 , C07C17/00 , C07C201/14 , C07C209/32 , C07C205/12 , C07C211/52 , C07C17/12
CPC classification number: C07C209/74 , C07C17/00 , C07C17/06 , C07C17/12 , C07C201/08 , C07C201/14 , C07C205/12 , C07C209/32 , C07C211/52 , C07C25/13
Abstract: The present invention provides a halogenated aniline represented by formula (I) (wherein each of X1 and X2 independently represents a chlorine atom, a bromine atom or an iodine atom), a method for producing the halogenated aniline, and other aspects.
Abstract translation: 本发明提供由式（I）表示的卤代苯胺（其中，X 1和X 2各自独立地表示氯原子，溴原子或碘原子），卤代苯胺的制造方法等。
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公开(公告)号：US5565586A
公开(公告)日：1996-10-15
申请号：US396777
申请日：1995-03-01
Applicant: Kimio Hamamura , Chiaki Seki , Masayuki Konishi
Inventor： Kimio Hamamura , Chiaki Seki , Masayuki Konishi
IPC: A61K31/12 , A61K31/122 , A61P3/08 , B01J27/25 , C07B61/00 , C07C201/12 , C07C201/14 , C07C205/37 , C07C50/02
CPC classification number: C07C205/37
Abstract: A process for the industrial preparation of the quinone derivative represented by the following general formula: ##STR1## which is an intermediate for chroman derivatives useful as a blood sugar lowering agent, and novel intermediates, encompasses the following:(1) Oxidation of the corresponding hydroquinone derivative, and(2) Hydrolysis of the corresponding acyl hydroquinone derivative with a Claisen alkali, followed by the oxidation of resulting hydrolyzate.
Abstract translation: 一种用于工业制备由以下通式表示的醌衍生物的方法：作为用作降糖剂的苯并二氢吡喃衍生物的中间体的“IMAGE”和新的中间体包括以下：（1）氧化相应的 氢醌衍生物，和（2）用Claisen碱水解相应的酰基氢醌衍生物，然后氧化得到的水解产物。
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