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公开(公告)号：US12077553B1
公开(公告)日：2024-09-03
申请号：US18388529
申请日：2023-11-09
申请人： Mitotech Ltd
IPC分类号： C07F9/54
CPC分类号： C07F9/5456 , C07B2200/13
摘要： A novel crystalline form of 2,3-dimethyl-1,4-benzoquinone-5-decyl-triphenylphosphonium bromide is provided. The crystalline form was found to have X-ray powder diffraction peaks at 19.25, 21.507, and 23.074 degrees 2 theta, ±0.2 degrees 2 theta. Also provided are industrially feasible methods for manufacture of the crystalline form with high purity.
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公开(公告)号：US11866627B2
公开(公告)日：2024-01-09
申请号：US17192388
申请日：2021-03-04
发明人： Changhee Lee , Dukki Kim , Hyojin Ko , Sehun Kim , Jaehoon Kim , Hyunmi Doh , Yunku Jung , Jaekook Ha
IPC分类号： C09K11/06 , C07C309/30 , C07C53/00 , C07C63/08 , C07F9/54 , C07C43/10 , C07C211/09 , C07C309/04 , H10K85/60 , H10K50/115 , H10K71/00 , H10K71/15
CPC分类号： C09K11/06 , C07C43/10 , C07C53/00 , C07C63/08 , C07C211/09 , C07C309/04 , C07C309/30 , C07F9/5407 , C07F9/5442 , H10K85/60 , C09K2211/10 , C09K2211/1007 , H10K50/115 , H10K71/00 , H10K71/15
摘要： A quantum dot composition includes a quantum dot, and a ligand bonded to a surface of the quantum dot, wherein the ligand includes a head portion bonded to the surface of the quantum dot and containing a polar solvent dissociative functional group, and a tail portion connected to the head portion. A quantum dot composition according to an embodiment is used to form an emission layer of a light emitting element to enhance luminous efficiency of the light emitting element including an emission layer formed through the quantum dot composition.
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公开(公告)号：US20240002409A1
公开(公告)日：2024-01-04
申请号：US16950901
申请日：2020-11-17
IPC分类号： C07F5/02 , C07C211/63 , C07C211/64 , C07C217/08 , C07C219/10 , C07C219/28 , C07C219/30 , C07C271/12 , C07C271/20 , C07C271/24 , C07D213/20 , C07D233/58 , C07D295/037 , C07D413/06 , C07F5/04 , C07F9/54 , G03F7/00 , C07C271/28 , C07D347/00 , C07D233/02 , C07D247/00 , C07D335/02 , C07C271/16 , C07D309/34
CPC分类号： C07F5/027 , C07C2601/14 , C07C211/64 , C07C217/08 , C07C219/10 , C07C219/28 , C07C219/30 , C07C271/12 , C07C271/20 , C07C271/24 , C07D213/20 , C07D233/58 , C07D295/037 , C07D413/06 , C07F5/04 , C07F9/5407 , C07F9/5442 , G03F7/001 , C07C271/28 , C07D347/00 , C07F9/54 , C07D233/02 , C07D247/00 , C07D335/02 , C07C271/16 , C07D309/34 , C07C211/63
摘要： The invention relates to a process for preparing triaryl organo borates proceeding from organoboronic esters in the presence of an n-valent cation 1/n Kn+, comprising the anhydrous workup of the reaction mixture and the use of the triaryl organoborates obtained as co-initiator in photopolymer formulations, holographic media and holograms.
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公开(公告)号：US20230279307A1
公开(公告)日：2023-09-07
申请号：US17919471
申请日：2021-04-07
发明人： Modestino DE FEO , Vanessa PICHON , Thomas SCHUBERT , Boyan ILIEV
IPC分类号： C10M137/12 , C10M169/04 , C07F9/54
CPC分类号： C10M137/12 , C07F9/5407 , C10M169/04 , C10M2203/003 , C10M2223/06 , C10N2030/04
摘要： A phosphonium-based ionic liquid compound including a particular phosphonium cation and a carboxylate anion. A lubricant composition including it, and its use as a detergent and anti-corrosion additive in a lubricant, in particular a marine lubricant.
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公开(公告)号：US20230242558A1
公开(公告)日：2023-08-03
申请号：US18104051
申请日：2023-01-31
IPC分类号： C07F9/54 , C07D405/04 , C07D401/14 , C07D213/56 , C07D213/55
CPC分类号： C07F9/5435 , C07D405/04 , C07D401/14 , C07D213/56 , C07D213/55
摘要： Disclosed herein are compounds related to nicotinate and nicotinamide riboside and methods of making and using said compounds. Also disclosed herein are methods of making nicotinic acid mononucleoside (NAMN).
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公开(公告)号：US11701370B2
公开(公告)日：2023-07-18
申请号：US17090160
申请日：2020-11-05
IPC分类号： A61K31/66 , A61K45/06 , C07F9/54 , C07F9/6568
CPC分类号： A61K31/66 , A61K45/06 , C07F9/54 , C07F9/5442 , C07F9/65688
摘要： The invention provides compounds of Formula (I), or pharmaceutically acceptable salts thereof:
The compounds, compositions, methods and kits of the invention are useful for the treatment of pain, itch, and neurogenic inflammation.-
公开(公告)号：US20230112623A1
公开(公告)日：2023-04-13
申请号：US17961020
申请日：2022-10-06
申请人： JEOL Ltd.
发明人： Seketsu Fukuzawa , Koji Takahashi , Yoshiyuki Itoh , Masaki Takiwaki , Shugo Tsuda , Masayoshi Mochizuki , Taku Yoshiya
IPC分类号： C07F9/54
摘要： Provided is a phosphonium compound represented by Formula (I): in Formula (I), R1, R2, and R3 are independently from each other, an alkyl group or an aryl group, the alkyl group is a substituted or unsubstituted, linear or branched alkyl group having 1 to 20 carbon atoms or a substituted or unsubstituted cyclic alkyl group having 5 to 20 carbon atoms, the aryl group is a substituted or unsubstituted aryl group having 6 to 20 carbon atoms; X is a reactive group having a hydrazide group, a halide group, a pseudohalide group, or a thioester group; and Y− is an anion having a total charge of −1, or Y− is absence.
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公开(公告)号：US20230099421A1
公开(公告)日：2023-03-30
申请号：US17757653
申请日：2020-12-15
IPC分类号： C07D213/04 , C07D405/10 , C07F7/08 , C07F7/10 , C07F9/54 , C07F9/655 , C07F9/58 , C07C22/08 , C07C247/10 , C07C331/24 , C07C203/04 , C07C43/225 , C07C69/635 , C07C323/09 , C07C17/093 , C07C201/02 , C07C41/16 , C07C67/11 , C07C319/14 , C07B59/00 , B01J31/02
摘要： Disclosed herein is a salt of formula I: where R1, X, n, R, R1, Y, m, p, q, Z and o are as defined herein. Also disclosed herein are methods of using said salts in chemical synthesis, such as to prepare compounds isotopically enriched in 18F for use in PET & imaging, as well as methods to make the compounds of formula I.
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公开(公告)号：US20230017373A1
公开(公告)日：2023-01-19
申请号：US17770924
申请日：2020-10-26
摘要： The present invention provides novel mitochondria-targeted Atovaquone compounds (Mito-ATO), a mitochondria-targeted derivative of Atovaquone, and methods of using such compounds. Methods of treating cancer using mito-ATO are also provided. Methods of enhancing an anti-tumor immune response by administering mito-ATO are further provided.
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公开(公告)号：US20220331346A1
公开(公告)日：2022-10-20
申请号：US17307138
申请日：2021-05-04
发明人： Alaric J. DYCKMAN , T.G. Murali Dhar , Hai-Yun Xiao , John L. Gilmore , Michael G. Yang , Zili Xiao , David Marcoux
IPC分类号： A61K31/695 , C07F7/08 , A61K31/135 , C07D215/14 , C07D241/04 , C07C323/29 , C07C251/38 , C07C251/42 , C07C251/44 , C07D209/46 , C07D213/38 , C07C275/26 , C07C217/74 , C07C323/25 , C07C235/46 , C07F9/54 , C07F9/572 , C07F9/09 , C07C215/42 , C07C217/52 , C07C217/58 , C07C219/24 , C07C233/41 , C07C233/65 , C07C251/50 , C07C251/52 , C07C251/54 , C07C271/34 , C07C317/28 , C07C317/32 , C07C321/16 , C07C321/22 , C07C321/28 , C07D213/32 , C07D213/69 , C07D213/70 , C07D215/12 , C07D217/24 , C07D231/12 , C07D231/20 , C07D239/26 , C07D241/12 , C07D277/24 , C07D305/08 , C07D309/06 , C07D309/12 , C07D311/58 , C07D311/76 , C07D319/20 , C07D333/16 , C07F9/117 , C07F9/62 , C07F9/6503 , C07F9/6509 , C07F9/655 , C07F9/6553 , A61K31/137 , A61K31/15 , A61K31/165 , A61K31/166 , A61K31/17 , A61K31/222 , A61K31/24 , A61K31/27 , A61K31/337 , A61K31/351 , A61K31/352 , A61K31/381 , A61K31/415 , A61K31/4174 , A61K31/426 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/47 , A61K31/4965 , A61K31/505 , A61K31/661
摘要： Disclosed are compounds of Formulas (I), (II), (III), (IV), and (V): and/or a salt thereof, wherein R1 is —OH or —OP(O)(OH)2, and X1, X2, X3, R2, R2a, Ra, Rb, and Rc are defined herein. Also disclosed are methods of using such compounds as selective agonists for G protein-coupled receptor S1P1, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.
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