公开(公告)号：US11976117B2

公开(公告)日：2024-05-07

申请号：US16826053

申请日：2020-03-20

Applicant: McMaster University

Inventor： Jonathan Lorne Bramson ,  Christopher W. Helsen ,  Joanne Alicia Hammill ,  Kenneth Anthony Mwawasi

IPC: A61K35/17 ,  C07K14/73 ,  C07K16/28

CPC classification number: C07K16/2803 ,  C07K14/70514 ,  C07K16/2809 ,  C07K2317/622 ,  C07K2319/03

Abstract: A trifunctional molecule is provided, comprising (i) a target-specific ligand, (ii) a ligand that binds a protein associated with a TCR complex, and (iii) a T cell receptor signaling domain polypeptide. Variants of the molecule are provided, including variants that exhibit optimized surface expression, transduction efficiency, and effector functionality. Variations include, for example, different ligands that bind CD3 epsilon (e.g., OKT3, L2K, F6A, UCHT1 and humanized UCHT1), different signaling domains, and different linkers between domains.

公开(公告)号：US20240109870A1

公开(公告)日：2024-04-04

申请号：US18383687

申请日：2023-10-25

Applicant: McMaster University

Inventor： Anthony Rullo ,  Jonathan Bramson ,  Yonghong Wan ,  Benjamin Lake ,  Nickolas Serniuck

IPC: C07D403/12 ,  C07D233/90 ,  C07D493/10

CPC classification number: C07D403/12 ,  C07D233/90 ,  C07D493/10 ,  C07K16/44

Abstract: The present application relates to compounds of Formula I comprising an antibody binding domain (ABD) comprising a hapten that binds to an antibody in a subject, the antibody comprising a hapten binding site, an antibody labelling domain (ALD) comprising a functional group that forms a covalent bond with an amino acid in the antibody that is proximal to the hapten binding site and the formation of the covalent bond results in elimination of the ABD and either a target binding domain (TBD) or a detection moiety domain (DMD), each domain being optionally connected with independently selected linkers. The present application also includes methods and uses of the compounds, for example, for immune recognition of target cells by recruited labelled antibodies.


ABD-(L1)n-ALD-(L2)m-R  I

公开(公告)号：US20240102093A1

公开(公告)日：2024-03-28

申请号：US18478249

申请日：2023-09-29

Applicant: Sanofi-Aventis Deutschland GmbH ,  McMaster University

Inventor： Sibylle HESS ,  Thorsten SADOWSKI ,  Hertzel GERSTEIN ,  Guillaume PARE ,  Gregory STEINBERG

IPC: C12Q1/6876 ,  A61K31/155

CPC classification number: C12Q1/6876 ,  A61K31/155 ,  C12Q2600/106 ,  C12Q2600/158

Abstract: The present invention relates to metformin for use in treating a patient, wherein the patient exhibits an increased level of GDF15 in response to metformin treatment; to methods of identifying a patient who will benefit or who will not benefit from metformin treatment; methods of treating a patient at risk of developing or suffering from a disease or disorder comprising administering therapeutically effective amount of metformin; methods of adapting the dosage of metformin; the usage of GDF15 as biomarker for identifying a patient who will benefit or who will not benefit from metformin treatment, kits for use in identifying a patient who will benefit from metformin treatment and the use of the kits, as well as methods of treating a patient or who will not benefit from metformin treatment.

公开(公告)号：US20240060940A1

公开(公告)日：2024-02-22

申请号：US18452936

申请日：2023-08-21

Applicant: McMaster University

Inventor： Raja Ghosh

IPC: G01N30/56 ,  B01J20/282

CPC classification number: G01N30/56 ,  B01J20/282 ,  G01N2030/562 ,  G01N2030/521

Abstract: A packing assembly for forming a packed-bed for a chromatography device is described herein. The packing assembly includes a bottom plate and a first top plate. The first top plate has a top plate hole centrally positioned therein. The packing assembly also includes a middle plate. The middle plate has a middle plate hole centrally positioned therein. The middle plate hole is aligned with the top plate hole when the packing assembly is in an assembled state. The packing assembly also includes a second top plate. The second top plate has a protrusion extending outwardly. At least a portion of the protrusion has a same size and a same shape as the top plate hole to be received in the top plate hole when the packing assembly is in a packing state. Methods of packing chromatography media in a packing assembly and assembling a chromatography device are also described herein.

公开(公告)号：US11883540B2

公开(公告)日：2024-01-30

申请号：US17320446

申请日：2021-05-14

Applicant: McMaster University

Inventor： Todd Hoare ,  Jonathan Dorogin ,  David Koff ,  Andrew Singh

IPC: A61K9/50 ,  A61K9/00

CPC classification number: A61K9/5031 ,  A61K9/0009 ,  A61K9/501

Abstract: The present application relates to a vehicle whose shell material is modified with at least one additional secondary phase that acts as a cork. In the presence of an energy source (preferably ultrasound), the corks embedded in the shell are either removed from the shell to create permanent pores or perturbed within the shell to create transient pores that can control transport in or out of the vehicle.

公开(公告)号：US20240016841A1

公开(公告)日：2024-01-18

申请号：US18251992

申请日：2021-11-05

Applicant: Triumvira Immunologics USA, Inc. ,  McMaster University

Inventor： Jonathan Lorne Bramson ,  SeungMi Yoo ,  Sarah Asbury ,  Allyson Moore ,  Ling Wang ,  Brian Philip

IPC: A61K35/17 ,  A61K31/675 ,  C07K16/28 ,  C07K16/32 ,  A61K39/00 ,  A61K38/20 ,  A61P35/00

CPC classification number: A61K35/17 ,  A61K31/675 ,  C07K16/2803 ,  C07K16/32 ,  C07K16/2878 ,  A61K39/4611 ,  A61K39/464406 ,  A61K39/464412 ,  A61K38/2013 ,  A61P35/00 ,  A61K2239/13 ,  A61K2239/21

Abstract: γδ T cells comprising a molecule comprising (i) a target-specific antigen-binding domain, (ii) an antigen-binding domain that binds a protein associated with a TCR complex, and (iii) a T cell receptor signaling domain polypeptide are provided.

公开(公告)号：US11827624B2

公开(公告)日：2023-11-28

申请号：US17249332

申请日：2021-02-26

Applicant: McMaster University

Inventor： Anthony Rullo ,  Benjamin Lake ,  Nickolas Semiuck

IPC: C07D403/12 ,  C07D233/90 ,  C07D493/10 ,  C07K16/44

CPC classification number: C07D403/12 ,  C07D233/90 ,  C07D493/10 ,  C07K16/44

Abstract: The present application relates to compounds of Formula I comprising an antibody binding domain (ABD) comprising a hapten that binds to an antibody in a subject, the antibody comprising a hapten binding site, an antibody labelling domain (ALD) comprising a functional group that forms a covalent bond with an amino acid in the antibody that is proximal to the hapten binding site and the formation of the covalent bond results in elimination of the ABD and either a target binding domain (TBD) or a detection moiety domain (DMD), each domain being optionally connected with independently selected linkers. The present application also includes methods and uses of the compounds, for example, for immune recognition of target cells by recruited labelled antibodies.

公开(公告)号：US20230349893A1

公开(公告)日：2023-11-02

申请号：US18027587

申请日：2021-09-22

Applicant: McMaster University

Inventor： Tohid Didar ,  Amid Shakeri ,  Hanie Yousefi

IPC: G01N33/543

CPC classification number: G01N33/54353

Abstract: This application relates to a method for fabricating a biofunctionalized surface on a substrate, wherein the substrate comprises hydroxyl groups on the surface to be biofunctionalized, the method comprising: covalently attaching organosilane groups to less than all of the hydroxyl groups on the surface of the substrate; covalently attaching one or more biospecies to the surface of the substrate; and applying a lubricant to the substrate, wherein the biospecies comprises a biorecognition element that detects a target analyte in a sample. A biofunctionalized surface made therefrom and use thereof, such as for biosensing applications, are also disclosed.

公开(公告)号：US11795127B2

公开(公告)日：2023-10-24

申请号：US17964347

申请日：2022-10-12

Applicant: McMaster University

Inventor： Jakob Magolan ,  Nicholas Jentsch ,  Xiong Zhang ,  Mathew Piotrowski ,  Patrick Darveau ,  Meghan Fragis ,  Jarrod Johnson ,  Nicole Ritchie ,  Arnav Kaul

IPC: C07C37/14 ,  C07J7/00 ,  B01J21/04 ,  C07D209/08 ,  C07C41/26 ,  C07D307/80 ,  C07C201/12 ,  C07J1/00 ,  C07D311/30 ,  C07D311/32 ,  C07C253/30

CPC classification number: C07C37/14 ,  B01J21/04 ,  C07C41/26 ,  C07C201/12 ,  C07C253/30 ,  C07D209/08 ,  C07D307/80 ,  C07D311/30 ,  C07D311/32 ,  C07J1/0059 ,  C07J7/0005

Abstract: The present application describes process for preparing an ortho-allylated hydroxy aryl compounds such as compounds of Formula (I) by reacting an allylic alcohol with a hydroxy aryl compound in the presence of aluminum compound selected from alumina and aluminum alkoxides and in a non-protic solvent wherein at least one carbon atom ortho to the hydroxy group in the hydroxy aryl compound is unsubstituted. The present application also includes compounds of Formula (I).

公开(公告)号：US20230295635A1

公开(公告)日：2023-09-21

申请号：US17966575

申请日：2022-10-14

Applicant: McMaster University

Inventor： John D. Brennan ,  Monsur Ali ,  Michael Wolfe ,  Dawn White ,  Manali Mukherjee ,  Parameswaran Nair ,  Alfredo Capretta

IPC: C12N15/115 ,  C12Q1/28

CPC classification number: C12N15/115 ,  C12Q1/28 ,  C12N2310/16

Abstract: This disclosure relates to DNA aptamers that bind eosinophil peroxidase, including uses thereof, such as in eosinophil peroxidase detection assays. Also provided is a method for detecting the presence of eosinophil peroxidase in a sample, using the DNA aptamers that bind eosinophil peroxidase. Further provided is a kit for detecting the presence of eosinophil peroxidase in a sample, using the DNA aptamers that bind eosinophil peroxidase.