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公开(公告)号：US11933686B2
公开(公告)日：2024-03-19
申请号：US17852557
申请日：2022-06-29
Applicant: Repligen Corporation
Inventor： Travis R. Ward
CPC classification number: G01L19/14 , G01L19/0007 , G01L19/0618 , F16K17/04
Abstract: A pressure gauge and/or relief valve which may be used in a single-use fluid system, such as a sterilizable fluid system. The pressure gauge and/or pressure relief valve may be configured to measure and to relieve fluid within a fluid-containing structure, the pressure gauge relief valve including a housing having a first end, a second end, and an inner surface defining a passage between the first end and the second end, a movable element movable within the passage, wherein the housing first end is configured to be coupled with a fluid-containing structure, the housing second end is spaced from the housing first end; and the movable element is movable with respect to the housing to indicate pressure therein and to allow fluid to pass between the movable element and the inner surface of the passage at a selected pressure.
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92.发明公开公开(公告)号：US20230400405A1
公开(公告)日：2023-12-14
申请号：US18198523
申请日：2023-05-17
Applicant: Repligen Corporation
Inventor： Matthew Muller , Richard Hall, III , Yusheng Zhang , Peter Halatin
CPC classification number: G01N21/255 , G01J3/10 , G01N21/3103 , G01J3/42
Abstract: A compact light source for coupling to a movable optic probe may include a light emitting diode (LED), to generate a probe signal at a first bandwidth, an optic coupler, disposed adjacent to the LED, and arranged to couple the probe signal into the movable probe, and a narrow bandpass filter disposed to receive the probe signal at the first bandwidth, and to output the probe signal into the movable probe at a second bandwidth, less than the first bandwidth.
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93.发明公开公开(公告)号：US20230383241A1
公开(公告)日：2023-11-30
申请号：US18200112
申请日：2023-05-22
Applicant: Repligen Corporation
Inventor： Charles Hill , Joey Tse , Mario Sinani , Earl Pineda
IPC: C12M1/00
Abstract: A bleed recovery system for use in a bioreactor system is disclosed. The bleed recovery system being configured to recover product of interest from the bleed material of the bioreactor system. In one embodiment, the bioreactor system includes a bleed recovery system for removing cell cultures from the bioreactor. The bleed recovery system includes a bleed pump coupled to the bioreactor so that cell bleed material can be removed from the bioreactor, a bleed vessel for receiving the cell bleed material, a cell retention device coupled to the bleed vessel, a harvest pump coupled to the cell retention device to deposit the product of interest into a second harvest tank, and a bleed pump connected to the bleed vessel to deposit the spent bleed material into a waste tank. Thus arranged, some or all of the product of interest can be separated from the spent medium.
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公开(公告)号：US11754191B2
公开(公告)日：2023-09-12
申请号：US17835166
申请日：2022-06-08
Applicant: Repligen Corporation
Inventor： Michael C. Gagne , Dean C. Richards , Steven V. Cates
CPC classification number: F16K7/04 , F16K27/0236 , F16L57/00 , F16L57/02 , F16L2201/20
Abstract: Fluid management systems for handling pressurized fluid connect various subsystems or subunits without the need to use reinforced tubing. The system utilizes one or more segments of unreinforced conduit that are encapsulated at various points along a length of the segment with one or more rigid encapsulating members. The unreinforced conduit may be made a disposable element while the rigid encapsulating members may be re-used. In one aspect, the encapsulating member may include a two-part valve body that surrounds and encapsulates a portion of the unreinforced conduit. In another aspect, the encapsulating member may include a two-part jacket that surrounds and encapsulates a portion of the unreinforced conduit. The two-part valve bodies and two-part jackets may be joined at various points within the system as part of the overall flow system.
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公开(公告)号：US20230256392A1
公开(公告)日：2023-08-17
申请号：US18166520
申请日：2023-02-09
Applicant: Repligen Corporation
Inventor： Mark Perreault , Paul Lowell
CPC classification number: B01D61/18 , B01D61/146 , B01D63/0822 , B01D69/10
Abstract: A self-contained filtration assembly with a self-contained filtration cassette therein. The cassette may be formed from one or more layers membranes and spacers (spacers, screens, or combinations thereof) all having the same general shape. The cassette may have a feed inlet path and a retentate outlet path extending through the layers of the cassette within the perimeter of the cassette, and a permeate outlet path between the cassette exterior and the interior of the cassette housing. The housing may have a generally circular or elliptical cross-section. A clamping assembly may hold together the components of the housing, and may be elongated in a direction along the flow path of the feedstream through the cassette. Various port-defining zones defined in the layers of the cassette may be sealed in a manner facilitating assembly of the cassette as well as isolation of the flow paths therein.
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Patent Agency Ranking
公开(公告)号：US11719348B2
公开(公告)日：2023-08-08
申请号：US17869009
申请日：2022-07-20
Applicant: Repligen Corporation
Inventor： Michael C. Gagne , Steven V. Cates
IPC: F16K7/04 , F16K7/07 , F16K27/00 , F16K7/00 , F16K31/06 , F16K7/06 , F16K11/02 , F16K11/10 , F16K3/30
CPC classification number: F16K7/04 , F16K3/30 , F16K7/00 , F16K7/045 , F16K7/06 , F16K7/07 , F16K11/027 , F16K11/10 , F16K27/003 , F16K31/0655 , F16K7/066 , Y10T137/60 , Y10T137/87153 , Y10T137/87684 , Y10T137/87708 , Y10T137/87885 , Y10T137/87925
Abstract: An encapsulated valve system includes a first housing portion having a first facing surface, the first facing surface comprising a plurality of branch pathways formed as a recess within the first facing surface. The valve system further includes a second housing portion having a second facing surface, the second facing surface comprising a plurality of branch pathways formed as a recess within the second facing surface. A disposable conduit is configured to be interposed between the first and second housing portions and disposed within the recess of the first facing surface and the recess of the second facing surface. The disposable conduit is thus sandwiched between the first and second facing surfaces. A plurality of pinch valve actuators are mounted on one or both of the first housing portion and the second housing portion, the plurality of pinch valve actuators configured to pinch the disposable conduit at selective branch pathways.
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公开(公告)号：US20230191671A1
公开(公告)日：2023-06-22
申请号：US18084655
申请日：2022-12-20
Applicant: Repligen Corporation
Inventor： Stephen Murphy , Christopher Bullock
CPC classification number: B29C45/14467 , B29C45/2612 , B29C45/2669 , B29L2031/24
Abstract: A tubing system with a coupler join positioned between and joining tubing segments. The coupler join is formed to reduce dead legs and hold up volumes within, and/or to reduce materials used to form, and/or to simplify the manufacturing process of the tubing system. The coupler join may be sized, shaped, configured, and/or dimensioned to join tubing segments, such as pre-formed tubing segments, in a streamlined configuration, such as to substantially correspond with the outer and inner diameters of the tubing segments. The tubing system and coupler join may be formed with a mold configured to form a coupler join securely coupling spaced apart ends of tubing segments to be joined together in a configuration which reduces dead legs and hold up volumes within the resulting tubing system.
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公开(公告)号：US11673083B2
公开(公告)日：2023-06-13
申请号：US17721846
申请日：2022-04-15
Applicant: Repligen Corporation
Inventor： Rudolf Pavlik , Ralf Kuriyel
CPC classification number: B01D35/26 , B01D29/11 , B01D29/66 , B01D29/902 , B01D29/908 , B01D65/02 , B01D69/08 , C12M29/16 , C12M41/44 , B01D2201/165 , B01D2321/04 , B01D2321/12
Abstract: A fluid filtration system includes a fluid storage vessel such as a bioreactor, a filter housing including a filter element disposed therein, a pump coupled between the fluid storage vessel and the filter housing, and a flow diverter disposed between the pump and the filter housing. The pump is configured to move fluid from the fluid storage vessel through the filter element, and the flow diverter is configured for selectively directing fluid received from the pump to the first or second end of the filter housing. In a first mode of operation, the flow diverter directs flow through the filter housing in a first direction, while in a second mode of operation, the flow diverter directs flow through the filter housing in a second direction opposite the first direction.
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公开(公告)号：US11667672B2
公开(公告)日：2023-06-06
申请号：US17331963
申请日：2021-05-27
Applicant: REPLIGEN CORPORATION
Inventor： Michael Bransby
CPC classification number: C07K1/36 , B01D15/3809 , B01D61/146 , B01D63/02 , B01D69/08 , B01D2311/06 , B01D2311/2626 , B01D2315/10 , B01D2315/14 , B01D2317/022 , B01D2317/025 , B01D2311/06 , B01D2311/2626
Abstract: The present disclosure pertains to filtration methods comprising: passing a first fluid that comprises cells, cell debris and targeted product produced by the cells through a first filter thereby separating the first fluid into a first retentate comprising cells and a first permeate comprising targeted product and cell debris; combining resin beads having affinity for targeted product with the first permeate to form a second fluid containing resin beads with bound target product and cell debris; passing the second fluid through a second filter thereby separating the second fluid into a second retentate comprising resin beads with bound target product and a second permeate comprising cell debris; combining an elution buffer with the second retentate to form a third fluid that comprises a mixture of resin beads and unbound targeted product; and passing the third fluid through a third filter thereby separating resin beads from targeted product.
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公开(公告)号：US11643628B2
公开(公告)日：2023-05-09
申请号：US17218563
申请日：2021-03-31
Applicant: REPLIGEN CORPORATION
Inventor： Michael Bransby , Derek Carroll
CPC classification number: C12M29/16 , B01D61/18 , B01D69/081 , B01D71/26 , B01D71/48 , C12M29/10 , C12M33/10 , B01D2315/10 , B01D2325/02
Abstract: The present disclosure relates to hollow fiber tangential flow filters, including hollow fiber tangential flow depth filters, for various applications, including bioprocessing and pharmaceutical applications, systems employing such filters, and methods of filtration using the same.
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