公开(公告)号：US07476555B2

公开(公告)日：2009-01-13

申请号：US11599473

申请日：2006-11-15

申请人： Wen Tsay ,  Bao-Iai Hwang ,  David Y Chang ,  Ling Huang

发明人： Wen Tsay ,  Bao-Iai Hwang ,  David Y Chang ,  Ling Huang

IPC分类号： G01R31/26 ,  H01L21/66

CPC分类号： H01L23/3114 ,  H01L22/20 ,  H01L24/13 ,  H01L2224/05001 ,  H01L2224/05026 ,  H01L2224/0557 ,  H01L2224/05571 ,  H01L2224/05573 ,  H01L2924/00014 ,  H01L2924/014 ,  H01L2924/09701 ,  H01L2924/14 ,  H01L2924/00 ,  H01L2224/05599

摘要： A method of chip manufacturing, comprises of a design stage; a simulation stage; a foundry stage; a testing/packaging stage; a cutting stage; and a final coating stage. The present invention provides a method of chip testing comprises of disposing a substrate layer on a wafer having a plurality of chips; exposing a plurality of pads on the chips of the wafer; forming bumps on the pads of the chips of the wafer; performing tests from the bumps on the chips of the wafer. Alternatively, the present invention provides a method of chip testing comprises of disposing a substrate layer on a wafer having a plurality of chips; connecting a plurality of pads on the chips of the wafer to a plurality of corresponding pads on the substrate layer; planting bumps on the pads on the opposite side of the substrate layer; performing tests from the bumps on the substrate layer.

摘要翻译： 一种芯片制造方法，包括设计阶段; 仿真阶段; 铸造阶段 测试/包装阶段; 切割阶段 和最后的涂装阶段。 本发明提供了一种芯片测试方法，包括在具有多个芯片的晶片上设置衬底层; 在晶片的芯片上暴露多个焊盘; 在晶片的芯片的焊盘上形成凸块; 从晶片的芯片上的凸块进行测试。 或者，本发明提供一种芯片测试方法，包括：在具有多个芯片的晶片上设置衬底层; 将所述晶片的芯片上的多个焊盘连接到所述衬底层上的多个相应焊盘; 在衬底层的相对侧的衬垫上种植凸起; 从衬底层上的凸起进行测试。

公开(公告)号：US20080131435A1

公开(公告)日：2008-06-05

申请号：US12022772

申请日：2008-01-30

申请人： Jeffrey Stavenhagen ,  Sujata Vijh ,  Christopher Rankin ,  Sergey Gorlatov ,  Ling Huang

发明人： Jeffrey Stavenhagen ,  Sujata Vijh ,  Christopher Rankin ,  Sergey Gorlatov ,  Ling Huang

IPC分类号： A61K39/395 ,  C07K16/00 ,  C12N15/00 ,  C07H21/04 ,  C12N5/00 ,  C12P21/04

CPC分类号： C07K14/70535 ,  C07K14/36 ,  C07K14/405 ,  C07K16/005 ,  C07K16/283 ,  C07K16/2887 ,  C07K16/32 ,  C07K16/44 ,  C07K2317/24 ,  C07K2317/52 ,  C07K2317/71 ,  C07K2317/72 ,  C07K2317/732 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/70 ,  G01N33/6857 ,  G01N2333/70535

摘要： The present invention relates to molecules, particularly polypeptides, more particularly immunoglobulins (e.g., antibodies), comprising a variant Fc region, wherein said variant Fc region comprises at least one amino acid modification relative to a wild-type Fc region, which variant Fc region binds FcγRIIIA and/or FcγRIIA with a greater affinity, relative to a comparable molecule comprising the wild-type Fc region. The molecules of the invention are particularly useful in preventing, treating, or ameliorating one or more symptoms associated with a disease, disorder, or infection. The molecules of the invention are particularly useful for the treatment or prevention of a disease or disorder where an enhanced efficacy of effector cell function (e.g., ADCC) mediated by FcγR is desired, e.g., cancer, infectious disease, and in enhancing the therapeutic efficacy of therapeutic antibodies the effect of which is mediated by ADCC.

摘要翻译： 本发明涉及包括变体Fc区的分子，特别是多肽，更特别是免疫球蛋白（例如，抗体），其中所述变体Fc区相对于野生型Fc区包含至少一个氨基酸修饰，所述变体Fc区 相对于包含野生型Fc区的可比较分子，以更大的亲和力结合FcγRIIIA和/或FcγRIIA。 本发明的分子特别可用于预防，治疗或改善与疾病，病症或感染相关的一种或多种症状。 本发明的分子特别可用于治疗或预防需要通过FcγAMR介导的效应细胞功能增强的功效（例如ADCC）的疾病或病症，例如癌症，感染性疾病和增强治疗功效 的治疗性抗体，其作用由ADCC介导。

公开(公告)号：US07355008B2

公开(公告)日：2008-04-08

申请号：US10754922

申请日：2004-01-09

申请人： Jeffrey Stavenhagen ,  Sujata Vijh ,  Christopher Rankin ,  Sergey Gorlatov ,  Ling Huang

发明人： Jeffrey Stavenhagen ,  Sujata Vijh ,  Christopher Rankin ,  Sergey Gorlatov ,  Ling Huang

IPC分类号： C07K16/00 ,  C12P21/08 ,  C07K1/00

CPC分类号： C07K14/70535 ,  C07K14/36 ,  C07K14/405 ,  C07K16/005 ,  C07K16/283 ,  C07K16/2887 ,  C07K16/32 ,  C07K16/44 ,  C07K2317/24 ,  C07K2317/52 ,  C07K2317/71 ,  C07K2317/72 ,  C07K2317/732 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/70 ,  G01N33/6857 ,  G01N2333/70535

摘要： The present invention relates to molecules, particularly polypeptides, more particularly immunoglobulins (e.g., antibodies), comprising a variant Fc region, wherein said variant Fc region comprises at least one amino acid modification relative to a wild-type Fc region, which variant Fc region binds FcγRIIA and/or FcγRIIA with a greater affinity, relative to a comparable molecule comprising the wild-type Fc region. The molecules of the invention are particularly useful in preventing, treating, or ameliorating one or more symptoms associated with a disease, disorder, or infection. The molecules of the invention are particularly useful for the treatment or prevention of a disease or disorder where an enhanced efficacy of effector cell function (e.g., ADCC) mediated by FcγR is desired, e.g., cancer, infectious disease, and in enhancing the therapeutic efficacy of therapeutic antibodies the effect of which is mediated by ADCC.

摘要翻译： 本发明涉及包括变体Fc区的分子，特别是多肽，更特别是免疫球蛋白（例如，抗体），其中所述变体Fc区相对于野生型Fc区包含至少一个氨基酸修饰，所述变体Fc区 相对于包含野生型Fc区的可比分子，以更高的亲和力结合FcγRIIA和/或FcγRIIA。 本发明的分子特别可用于预防，治疗或改善与疾病，病症或感染相关的一种或多种症状。 本发明的分子特别可用于治疗或预防需要通过FcγAMR介导的效应细胞功能增强的功效（例如ADCC）的疾病或病症，例如癌症，感染性疾病和增强治疗功效 的治疗性抗体，其作用由ADCC介导。

公开(公告)号：US20070244303A1

公开(公告)日：2007-10-18

申请号：US11757939

申请日：2007-06-04

申请人： Leslie Johnson ,  Ling Huang ,  Hua Li ,  Nadine Tuaillon

发明人： Leslie Johnson ,  Ling Huang ,  Hua Li ,  Nadine Tuaillon

IPC分类号： C07K16/00

CPC分类号： C07K16/283 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/41 ,  C07K2317/732

摘要： CD16A binding proteins useful for the reduction of a deleterious immune response are described. In one aspect, humanized anti-cd16A antibodies, optionally lacking effector function, are used for the treatment of immune disorders such as idiopathic thrombocytopenic purpura and autoimmune hemolytic anemia.

摘要翻译： 描述了可用于减少有害免疫反应的CD16A结合蛋白。 一方面，任选缺乏效应子功能的人源化抗-CD16A抗体用于治疗免疫疾病，例如特发性血小板减少性紫癜和自身免疫性溶血性贫血。

公开(公告)号：US20070198996A1

公开(公告)日：2007-08-23

申请号：US11448821

申请日：2006-06-08

申请人： Gary Chiu ,  Vincent Yang ,  David Y. Chang ,  Ling Huang ,  Wen Tsay

发明人： Gary Chiu ,  Vincent Yang ,  David Y. Chang ,  Ling Huang ,  Wen Tsay

IPC分类号： G06F9/46

CPC分类号： G06F9/4411

摘要： A driver installation free system including a peripheral storing a device driver, a host, an operation system, an application interface and a middleware is provided. When the peripheral device is coupled with the host, the middleware utilizes the bus driver to read a configuration of the peripheral device, the driver function information and the driver parameter structure from the peripheral device, and generates relationships between the standard command and the device driver command as well as between the standard parameter structure and the driver parameter structure.

摘要翻译： 提供了一种驱动程序安装免费系统，包括存储设备驱动程序，主机，操作系统，应用程序接口和中间件的外围设备。 当外围设备与主机耦合时，中间件利用总线驱动器从外围设备读取外围设备的配置，驱动程序功能信息和驱动程序参数结构，并产生标准命令和设备驱动程序之间的关系 命令以及标准参数结构和驱动程序参数结构之间。

公开(公告)号：US20070077429A1

公开(公告)日：2007-04-05

申请号：US11171894

申请日：2005-06-30

申请人： Chad Mirkin ,  Lidong Qin ,  Sungho Park ,  Ling Huang ,  Sung-Wook Chung

发明人： Chad Mirkin ,  Lidong Qin ,  Sungho Park ,  Ling Huang ,  Sung-Wook Chung

IPC分类号： B32B1/00 ,  B05D1/36 ,  B05D3/10

CPC分类号： H01C17/06513 ,  B82Y5/00 ,  B82Y10/00 ,  B82Y20/00 ,  G01N33/531 ,  H01L29/0665 ,  H01L29/0673 ,  H01L29/068 ,  H01L29/861 ,  Y10S977/762 ,  Y10S977/81 ,  Y10S977/849 ,  Y10S977/856 ,  Y10S977/857 ,  Y10T428/2938 ,  Y10T428/2982

摘要： Multicomponent nanorods having segments with differing electronic and/or chemical properties are disclosed. The nanorods can be tailored with high precision to create controlled gaps within the nanorods or to produce diodes or resistors, based upon the identities of the components-making up the segments of the nanorods. Macrostructural composites of these nanorods also are disclosed.

摘要翻译： 公开了具有不同电子和/或化学性质的多组分纳米棒。 纳米棒可以以高精度进行定制，以在纳米棒内产生受控间隙，或者基于构成纳米棒段的部件的身份产生二极管或电阻器。 还公开了这些纳米棒的宏观结构复合材料。

公开(公告)号：US07112439B2

公开(公告)日：2006-09-26

申请号：US10753309

申请日：2004-01-08

申请人： Leslie Sydnor Johnson ,  Ling Huang

发明人： Leslie Sydnor Johnson ,  Ling Huang

IPC分类号： C12N5/16 ,  C12N15/85 ,  C12N1/21

CPC分类号： C07K16/00 ,  A01K2267/01 ,  C07K16/283 ,  C07K2317/10 ,  C07K2317/24 ,  C07K2317/51 ,  C07K2317/52 ,  C07K2317/55 ,  C07K2317/622 ,  C07K2319/30 ,  C12N7/00 ,  C12N15/8509 ,  C12N2795/14043

摘要： The present invention provides a dual expression vector, and methods for its use, for the expression and secretion of a full-length polypeptide of interest in eukaryotic cells, and a soluble domain or fragment of the polypeptide in bacteria. When expressed in bacteria, transcription from a bacterial promoter within a first intron and termination at the stop codon in a second intron results in expression of a fragment of the polypeptide, e.g., a Fab fragment, whereas in mammalian cells, splicing removes the bacterial regulatory sequences located in the two introns and generates the mammalian signal sequence, allowing expression of the full-length polypeptide, e.g., IgG heavy or light chain polypeptide. The dual expression vector system of the invention can be used to select and screen for new monoclonal antibodies, as well as to optimize monoclonal antibodies for binding to antigenic molecules of interest.

摘要翻译： 本发明提供双重表达载体及其用于在真核细胞中表达和分泌全长多肽的方法，以及细菌中多肽的可溶性结构域或片段。 当在细菌中表达时，来自第一内含子内的细菌启动子的转录和终止密码子在第二内含子中终止导致多肽片段的表达，例如Fab片段，而在哺乳动物细胞中，剪接除去细菌调节 位于两个内含子中的序列并产生哺乳动物信号序列，允许表达全长多肽，例如IgG重链或轻链多肽。 本发明的双表达载体系统可用于选择和筛选新的单克隆抗体，以及优化用于结合感兴趣的抗原分子的单克隆抗体。