利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

124 条记录 (耗时 0.029 秒)

    Nucleic acid encoding bovine extracellular rage binding protein (en-rage)
    91.
    发明授权
    Nucleic acid encoding bovine extracellular rage binding protein (en-rage) 失效
    编码牛细胞外rage结合蛋白的核酸（en-rage）

    公开(公告)号：US06555340B1

    公开(公告)日：2003-04-29

    申请号：US09263312

    申请日：1999-03-05

    申请人： Ann Marie Schmidt ,  David Stern

    发明人： Ann Marie Schmidt ,  David Stern

    IPC分类号： C12P2106

    CPC分类号： A61K38/1703 ,  A01K2217/05 ,  C07K14/70503

    摘要： The present invention provides for an isolated human EN-RAGE peptide. The present invention also provides for a method for determining whether a compound is capable of inhibiting the interaction of an EN-RAGE peptide with a RAGE peptide. The present invention also provides for a method for inhibiting inflammation in a subject which comprises administering to the subject a compound capable of interfering with the interaction between EN-RAGE peptide and receptor for advanced glycation endproduct (RAGE) in the subject thereby inhibiting inflammation in the subject.

    摘要翻译： 本发明提供了分离的人类EN-RAGE肽。 本发明还提供了一种用于确定化合物是否能够抑制EN-RAGE肽与RAGE肽的相互作用的方法。 本发明还提供了一种抑制受试者的炎症的方法，其包括向受试者施用能够干扰受试者的EN-RAGE肽和受体之间相互作用的晚期糖基化终产物（RAGE）的相互作用，从而抑制受试者的炎症 学科。

    Methods involving direct write optical lithography
    92.
    发明授权
    Methods involving direct write optical lithography 失效
    包括直写光刻技术的组成和方法

    公开(公告)号：US06480324B2

    公开(公告)日：2002-11-12

    申请号：US09880058

    申请日：2001-06-14

    申请人： Calvin F. Quate ,  David Stern

    发明人： Calvin F. Quate ,  David Stern

    IPC分类号： G02B2608

    CPC分类号： G03F7/70291 ,  B01J19/0046 ,  B01J2219/00353 ,  B01J2219/00439 ,  B01J2219/00527 ,  B01J2219/00529 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00608 ,  B01J2219/00612 ,  B01J2219/00617 ,  B01J2219/00626 ,  B01J2219/00637 ,  B01J2219/00659 ,  B01J2219/00689 ,  B01J2219/00711 ,  B01J2219/00722 ,  B01J2219/00725 ,  B82Y30/00 ,  C40B40/06 ,  C40B60/14 ,  G03F7/70283 ,  G03F7/704

    摘要： An improved optical photolithography system and method provides predetermined light patterns generated by a direct write system without the use of photomasks. The Direct Write System provides predetermined light patterns projected on the surface of a substrate (e.g., a wafer) by using a computer controlled component for dynamically generating the predetermined light pattern, e.g., a spatial light modulator. Image patterns are stored in a computer and through electronic control of the spatial light modulator directly illuminate the wafer to define a portion of the polymer array, rather than being defined by a pattern on a photomask. Thus, in the Direct Write System each pixel is illuminated with an optical beam of suitable intensity and the imaging (printing) of an individual feature is determined by computer control of the spatial light modulator at each photolithographic step without the use of a photomask. The Direct Write System including a spatial light modulator is particularly useful in the synthesis of DNA arrays and provides an efficient element for polymer array synthesis by using spatial light modulators to generate a predetermined light pattern that defines the image patterns of a polymer array to be deprotected.

    摘要翻译： 改进的光学光刻系统和方法提供由直接写入系统产生的预定光图案，而不使用光掩模。 直接写入系统通过使用用于动态生成预定光图案的计算机控制部件（例如空间光调制器）来提供投影在基板（例如，晶片）的表面上的预定光图案。 图像图案存储在计算机中，并且通过空间光调制器的电子控制直接照亮晶片以限定聚合物阵列的一部分，而不是由光掩模上的图案限定。 因此，在直写系统中，每个像素用适当强度的光束照射，并且通过在每个光刻步骤的计算机控制空间光调制器而不使用光掩模来确定单个特征的成像（打印）。 包括空间光调制器在内的直接写入系统在DNA阵列的合成中特别有用，并且通过使用空间光调制器产生限定要去保护的聚合物阵列的图像图案的预定光图案，为聚合物阵列合成提供有效元素 。

    Endotoxin-induced thrombosis factor which induces procoagulant activity in endothelial cells
    94.
    发明授权
    Endotoxin-induced thrombosis factor which induces procoagulant activity in endothelial cells 失效
    在内皮细胞中诱导程序性活化的内毒素诱导的血栓形成因子

    公开(公告)号：US5227368A

    公开(公告)日：1993-07-13

    申请号：US486311

    申请日：1990-02-28

    申请人： Herwig Gerlach ,  David Stern

    发明人： Herwig Gerlach ,  David Stern

    IPC分类号： A61K38/00 ,  C07K14/52 ,  C07K16/24 ,  C12N15/19

    CPC分类号： C07K16/24 ,  C07K14/52 ,  A61K38/00

    摘要： This invention provides a purified endotoxin-induced thrombosis factor, preferably an endotoxin-induced thrombosis factor characterized by an apparent molecular weight between about 50,000 and 65,000 daltons, more specifically about 55,000 daltons, on reduced and nonreduced SDS-polyacrylamide gels, by maximal recovery on elution from such gels at 52,000 to 58,000 daltons, by the ability to migrate as a single band on such gels, by the ability to precipitate in ammonium sulfate at saturations from 40% to 70%, by the ability to precipitate in polyethylene glycol at concentrations above 15%, by high hydrophobicity, by the ability to bind weakly to a hydroxylapatite column and to a lentil lectin column, by the ability to bind tightly to a hydrophobic interaction resin and smear off with ethylene glycol, and by the ability to bind tightly to a reverse-phase column and elute more effectively with isopropranol than with acetonitrile, by the ability to bind to an anion exchange resin over a pH range from 5 to 10, by the inability to bind to a cation exchange resin, by resistance to acid denaturation up to 30 minutes, resistance to polymyxin, sensitivity to heating at 95.degree. C. for 30 minutes, and sensitivity to trypsin exposure for 24 hours. Another characteristic of a purified endotoxin-induced thrombosis factor that it maximally induces tissue factor after six to eight hours, and continues to induce tissue factor for up to sixty hours. This invention also provides purified nucleic acid molecules, antibodies, an inhibitor, an antagonist, pharmaceutical compositions, methods of treatment, and methods of preparation all directed to endotoxin-induced thrombosis factor.

    摘要翻译： 本发明提供纯化的内毒素诱导的血栓形成因子，优选内毒素诱导的血栓形成因子，其特征在于在还原和非还原的SDS-聚丙烯酰胺凝胶上的表观分子量在约50,000和65,000道尔顿之间，更具体地约55,000道尔顿，通过 通过在这种凝胶上作为单条带迁移的能力，通过在40％至70％的饱和度下在硫酸铵中沉淀的能力，通过在聚乙二醇中沉淀的能力，从这种凝胶中洗脱52,000至58,000道尔顿 15％以上，疏水性高，通过与羟基磷灰石柱和扁豆凝集素柱弱结合的能力，通过与疏水相互作用树脂紧密结合并用乙二醇去除的能力，以及紧密结合的能力 到反相柱，并且用异丙醇比乙腈更有效地洗脱，通过在pH下结合阴离子交换树脂的能力 通过不能与阳离子交换树脂结合，通过耐酸性变性达30分钟，耐多粘菌素，对95℃加热30分钟的敏感性和对胰蛋白酶暴露的灵敏度为24，范围为5至10 小时。 纯化的内毒素诱导的血栓形成因子的另一个特征是其在6至8小时后最大程度地诱导组织因子，并继续诱导组织因子长达六十小时。 本发明还提供纯化的核酸分子，抗体，抑制剂，拮抗剂，药物组合物，治疗方法以及针对内毒素诱导的血栓形成因子的全部制备方法。

    Aerosol dispensed latex paint and package containing the same
    95.
    发明授权
    Aerosol dispensed latex paint and package containing the same 失效
    AEROSOL分配的LATEX涂料和包含它的包装

    公开(公告)号：US4066596A

    公开(公告)日：1978-01-03

    申请号：US541850

    申请日：1975-01-17

    申请人： David Stern

    发明人： David Stern

    IPC分类号： B05B1/34 ,  B05B11/00 ,  B05B15/02 ,  B65D83/14 ,  B65D83/16 ,  C09D5/02 ,  C08J3/20 ,  C09D9/04

    CPC分类号： B65D83/20 ,  B05B1/3436 ,  B05B15/02 ,  B05B15/0208 ,  B65D83/345 ,  B65D83/40 ,  B65D83/62 ,  C09D5/021 ,  Y10S524/903

    摘要： The invention involves a pressurized package containing an aqueous latex paint which is discharged from a collapsible piston within the pressurized container by the action of a propellant under pressure, and wherein the stream of paint discharging upon opening of the valve of the container is broken up by a mechanical breaker before being discharged through the nozzle in the form of a fine spray or mist devoid of propellant. Means are provided in the form of a cap for the nozzle for reducing or substantially eliminating the space about the nozzle after use of portions of the contents of the package to prevent drying out of any paint adhering to the nozzle and thereby clogging the nozzle. The paint employed is an aqueous acrylic latex emulsion paint in which the pigment content ranges from 2% to 15%.

    INFORMATION PROPAGATION PROBABILITY FOR A SOCIAL NETWORK
    98.
    发明申请
    INFORMATION PROPAGATION PROBABILITY FOR A SOCIAL NETWORK 有权
    社会网络的信息传播概率

    公开(公告)号：US20120158630A1

    公开(公告)日：2012-06-21

    申请号：US12971191

    申请日：2010-12-17

    申请人： Tauhid Rashed Zaman ,  Jurgen Anne Francois Marie Van Gael ,  David Stern ,  Ralf Herbrich ,  Gilad Lotan

    发明人： Tauhid Rashed Zaman ,  Jurgen Anne Francois Marie Van Gael ,  David Stern ,  Ralf Herbrich ,  Gilad Lotan

    IPC分类号： G06N3/00 ,  G06F15/173

    CPC分类号： G06N5/04 ,  G06N99/005 ,  G06Q30/02 ,  H04L43/08 ,  H04L51/32

    摘要： One or more techniques and/or systems are disclosed for predicting propagation of a message on a social network. A predictive model is trained to determine a probability of propagation of information on the social network using both positive and negative information propagation feedback, which may be collected while monitoring the social network over a desired period of time for information propagation. A particular message can be input to the predictive model, which can determine a probability of propagation of the message on the social network, such as how many connections may receive at least a portion of the message and/or a likelihood of at least a portion of the message reaching respective connections in the social network.

    摘要翻译： 公开了一种或多种技术和/或系统来预测消息在社交网络上的传播。 训练一个预测模型，以确定使用正和负信息传播反馈在社交网络上传播信息的概率，可以在信息传播的期望时间段内监视社交网络时收集信息。 可以将特定消息输入到预测模型，预测模型可以确定消息在社交网络上的传播概率，例如多少连接可以接收消息的至少一部分和/或至少一部分的可能性 的消息到达社交网络中的各个连接。

    HUMAN-ASSISTED TRAINING OF AUTOMATED CLASSIFIERS
    99.
    发明申请
    HUMAN-ASSISTED TRAINING OF AUTOMATED CLASSIFIERS 有权
    人工辅助自动分类培训

    公开(公告)号：US20120158620A1

    公开(公告)日：2012-06-21

    申请号：US12970158

    申请日：2010-12-16

    申请人： Ulrich Paquet ,  David Stern ,  Jurgen Anne Francois Mari Van Gael ,  Ralf Herbrich

    发明人： Ulrich Paquet ,  David Stern ,  Jurgen Anne Francois Mari Van Gael ,  Ralf Herbrich

    IPC分类号： G06F15/18

    CPC分类号： G06N99/005 ,  G06N3/08

    摘要： Many computing scenarios involve the classification of content items within one or more categories. The content item set may be too large for humans to classify, but an automated classifier (e.g., an artificial neural network) may not be able to classify all content items with acceptable accuracy. Instead, the automated classifier may calculate a classification confidence while classifying respective content items. Content items having a low classification confidence may be sent to a human classifier, and may be added, along with the categories identified by the human classifier, to a training set. The automated classifier may then be retrained using the training set, thereby incrementally improving the classification confidence of the automated classifier while conserving the involvement of human classifiers. Additionally, human classifiers may be rewarded for classifying the content items, and the costs of such rewards may be considered while selecting content items for the training set.

    摘要翻译： 许多计算场景包括对一个或多个类别内的内容项进行分类。 内容项集合可能太大以致人类不能进行分类，但是自动分类器（例如，人造神经网络）可能不能够以可接受的准确度对所有内容项进行分类。 相反，自动分类器可以在分类各个内容项目时计算分类置信度。 具有低分类置信度的内容项目可以被发送到人类分类器，并且可以与人类分类器识别的类别一起被添加到训练集合中。 然后可以使用训练集再次训练自动分类器，从而逐渐改进自动分类器的分类置信度，同时节省人类分类器的参与。 此外，可以奖励人类分类器对内容项进行分类，并且可以在选择训练集的内容项时考虑这种奖励的成本。

    Extracellular novel RAGE binding protein ( EN-RAGE) and uses thereof
    100.
    发明申请
    Extracellular novel RAGE binding protein ( EN-RAGE) and uses thereof 审中-公开
    细胞外新型RAGE结合蛋白（EN-RAGE）及其用途

    公开(公告)号：US20090228997A1

    公开(公告)日：2009-09-10

    申请号：US11807884

    申请日：2007-05-29

    申请人： Ann Marie Schmidt ,  David Stern

    发明人： Ann Marie Schmidt ,  David Stern

    IPC分类号： A01K67/027 ,  C07K16/18 ,  C07K14/00 ,  C07H21/04 ,  C07H21/02

    CPC分类号： C07K14/70503 ,  A01K2217/05 ,  A61K38/00

    摘要： The present invention provides for an isolated human EN-RAGE peptide. The present invention also provides for a method for determining whether a compound is capable of inhibiting the interaction of an EN-RAGE peptide with a RAGE peptide, which comprises: (a) admixing: (i) a RAGE peptide or an sRAGE peptide or a fragment of either thereof, (ii) an EN-RAGE peptide or a fragment thereof, and (iii) the compound; (b) measuring the level of interaction between the peptide of step (a) (i) and the peptide of step (a) (ii), and (c) comparing the amount of interaction measured in step (b) with the amount measured between the petpide of step (a)(i) and the peptide of step (a) (ii) in the absence of the compound, thereby determining whether the compound is capable of inhibiting the interaction of the EN-RAGE peptide with the RAGE peptide, wherein a reduction in the amount of interaction in the presence of the compound indicates that the compound is capable of inhibiting the interaction. The present invention also provides for a method for inhibiting inflammation in a subject which comprises administering to the subject a compound capable of interfering with the interaction between EN-RAGE peptide and receptor for advanced glycation endproduct (RAGE) in the subject thereby inhibiting inflammation in the subject.

    摘要翻译： 本发明提供了分离的人类EN-RAGE肽。 本发明还提供了一种用于确定化合物是否能够抑制EN-RAGE肽与RAGE肽的相互作用的方法，其包括：（a）混合：（i）RAGE肽或sRAGE肽或 片段，（ii）EN-RAGE肽或其片段，和（iii）化合物; （b）测量步骤（a）（i）的肽与步骤（a）（ii）的肽之间的相互作用水平，和（c）将步骤（b）中测量的相互作用量与测量的量进行比较 在不存在化合物的情况下，步骤（a）（i）的petpide和步骤（a）（ii）的肽之间，从而确定化合物是否能够抑制EN-RAGE肽与RAGE肽的相互作用 其中在化合物存在下相互作用量的减少表明该化合物能够抑制相互作用。 本发明还提供了一种抑制受试者的炎症的方法，其包括向受试者施用能够干扰受试者的EN-RAGE肽和受体之间相互作用的晚期糖基化终产物（RAGE）的相互作用，从而抑制受试者的炎症 学科。