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    Metalloprotease highly expressed in the testis, MMP-29
    91.
    发明授权
    Metalloprotease highly expressed in the testis, MMP-29 有权
    金属蛋白酶在睾丸中高度表达，MMP-29

    公开(公告)号：US07285633B2

    公开(公告)日：2007-10-23

    申请号：US11313356

    申请日：2005-12-21

    申请人： Shujian Wu ,  Jian Chen ,  John N. Feder ,  Liana Lee ,  Stanley R. Krystek

    发明人： Shujian Wu ,  Jian Chen ,  John N. Feder ,  Liana Lee ,  Stanley R. Krystek

    IPC分类号： A61K38/17

    CPC分类号： C12N9/6489

    摘要： The present invention provides novel polynucleotides encoding MMP-29 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel MMP-29 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    摘要翻译： 本发明提供了编码MMP-29多肽的新型多核苷酸，其片段和同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型MMP-29多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

    Systems for variable programming of non-volatile memory
    93.
    发明授权
    Systems for variable programming of non-volatile memory 有权
    用于非易失性存储器可变编程的系统

    公开(公告)号：US07259987B2

    公开(公告)日：2007-08-21

    申请号：US11316141

    申请日：2005-12-21

    申请人： Jian Chen ,  Chi-Ming Wang

    发明人： Jian Chen ,  Chi-Ming Wang

    IPC分类号： G11C11/34

    CPC分类号： G11C16/3459 ,  G11C11/5628 ,  G11C11/5642 ,  G11C16/0483 ,  G11C16/3418 ,  G11C16/3427 ,  G11C16/3454 ,  G11C2211/5621

    摘要： Systems and methods in accordance with various embodiments can provide for reduced program disturb in non-volatile semiconductor memory. In one embodiment, select memory cells such as those connected to a last word line of a NAND string are programmed using one or more program verify levels or voltages that are different than a corresponding level used to program other cells or word lines. One exemplary embodiment includes using a lower threshold voltage verify level for select physical states when programming the last word line to be programmed for a string during a program operation. Another embodiment includes applying a lower program voltage to program memory cells of the last word line to select physical states. Additional read levels are established for reading the states programmed using lower verify levels in some exemplary implementations. A second program voltage step size that is larger than a nominal step size is used in one embodiment when programming select memory cells or word lines, such as the last word line to be programmed for a NAND string.

    摘要翻译： 根据各种实施例的系统和方法可以提供非易失性半导体存储器中减少的程序干扰。 在一个实施例中，使用与编程其他单元或字线的相应级别不同的一个或多个程序验证电平或电压对连接到NAND串的最后字线的选择存储器单元进行编程。 一个示例性实施例包括在编程在程序操作期间编程用于字符串的最后一个字线时，使用较低的阈值电压验证电平来选择物理状态。 另一个实施例包括将较低编程电压施加到最后字线的编程存储单元以选择物理状态。 在一些示例性实施方式中，建立读取使用较低验证电平编程的状态的附加读取电平。 在一个实施例中，当编程选择存储器单元或字线（诸如要为NAND串编程的最后字线）时，使用大于标称步长的第二编程电压步长。

    Polynucleotide encoding a novel acyl coenzyme A, monoacylglycerol acyltransferase-3 (MGAT3), and uses thereof
    94.
    发明授权
    Polynucleotide encoding a novel acyl coenzyme A, monoacylglycerol acyltransferase-3 (MGAT3), and uses thereof 有权
    编码新型酰基辅酶A，单酰基甘油酰基转移酶-3（MGAT3）的多核苷酸及其用途

    公开(公告)号：US07259002B2

    公开(公告)日：2007-08-21

    申请号：US10761905

    申请日：2004-01-21

    申请人： John N. Feder ,  Thomas C. Nelson ,  Jian Chen ,  Rupalie Meegalla ,  Michael Ramaker ,  Dong Cheng

    发明人： John N. Feder ,  Thomas C. Nelson ,  Jian Chen ,  Rupalie Meegalla ,  Michael Ramaker ,  Dong Cheng

    IPC分类号： C12N9/10 ,  C12N1/20 ,  C12N15/00 ,  C07H21/04

    CPC分类号： C12N9/1029

    摘要： The present invention provides novel polynucleotides encoding MGAT3 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing MGAT3 polypeptides, fragments, and homologues thereof. The invention further relates to diagnostic and therapeutic methods for applying these novel MGAT3 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, such as obesity. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    摘要翻译： 本发明提供了编码MGAT3多肽的新型多核苷酸，其片段及其同源物。 还提供载体，宿主细胞，抗体，以及用于产生MGAT3多肽，其片段及其同源物的重组和合成方法。 本发明还涉及将这些新型MGAT3多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症如肥胖症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

    Polynucleotide encoding a novel human serpin secreted from lymphoid cells, LSI-01
    95.
    发明授权
    Polynucleotide encoding a novel human serpin secreted from lymphoid cells, LSI-01 有权
    编码从淋巴细胞分泌的新型人丝氨酸蛋白酶的多核苷酸，LSI-01

    公开(公告)号：US07256267B2

    公开(公告)日：2007-08-14

    申请号：US11329900

    申请日：2006-01-11

    申请人： Jian Chen ,  Thomas Nelson ,  Donna A Bassolino ,  Daniel L. Cheney

    发明人： Jian Chen ,  Thomas Nelson ,  Donna A Bassolino ,  Daniel L. Cheney

    IPC分类号： C07K14/81 ,  C07K19/00 ,  C12N15/15 ,  C12N15/62 ,  C12N15/79

    CPC分类号： C07K14/8121 ,  A61K38/00 ,  C07K2299/00

    摘要： The present invention provides novel polynucleotides encoding LSI-01 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel LSI-01 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    摘要翻译： 本发明提供了编码LSI-01多肽的新型多核苷酸，其片段和同系物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型LSI-01多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

    Polynucleotide encoding a novel TRP channel family member, TRP-PLIK2, and splice variants thereof
    97.
    发明申请
    Polynucleotide encoding a novel TRP channel family member, TRP-PLIK2, and splice variants thereof 有权
    编码新型TRP通道家族成员的多核苷酸，TRP-PLIK2及其剪接变体

    公开(公告)号：US20070172880A1

    公开(公告)日：2007-07-26

    申请号：US11726234

    申请日：2007-03-21

    申请人： Ning Lee ,  Jian Chen ,  John Feder ,  Shujian Wu ,  Han Chang ,  Liana Lee ,  Michael Blanar ,  David Bol

    发明人： Ning Lee ,  Jian Chen ,  John Feder ,  Shujian Wu ,  Han Chang ,  Liana Lee ,  Michael Blanar ,  David Bol

    IPC分类号： C12Q1/68 ,  G01N33/53 ,  A61K38/17 ,  C07K14/705 ,  C07K16/28 ,  C07H21/04 ,  C12P21/06

    CPC分类号： C07K14/705

    摘要： The present invention provides novel polynucleotides encoding TRP-PLIK2 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding variants and splice variants of TRP-PLIK2 polypeptides, TRP-PLIK2b, TRP-PLIK2c, and TRP-PLIK2d, respectively. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel TRP-PLIK2, TRP-PLIK2b, TRP-PLIK2c, and TRP-PLIK2d polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    摘要翻译： 本发明提供了编码TRP-PLIK2多肽的新型多核苷酸，其片段和同源物。 本发明还提供分别编码TRP-PLIK2多肽，TRP-PLIK2b，TRP-PLIK2c和TRP-PLIK2d的变体和剪接变体的多核苷酸。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型TRP-PLIK2，TRP-PLIK2b，TRP-PLIK2c和TRP-PLIK2d多肽应用于诊断，治疗和/或预防与这些相关的各种疾病和/或病症的诊断和治疗方法 多肽。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

    READ OPERATION FOR NON-VOLATILE STORAGE THAT INCLUDES COMPENSATION FOR COUPLING
    99.
    发明申请
    READ OPERATION FOR NON-VOLATILE STORAGE THAT INCLUDES COMPENSATION FOR COUPLING 有权

    公开(公告)号：US20070109850A1

    公开(公告)日：2007-05-17

    申请号：US11616757

    申请日：2006-12-27

    申请人： Yan Li ,  Jian Chen

    发明人： Yan Li ,  Jian Chen

    IPC分类号： G11C16/04

    CPC分类号： G11C16/26 ,  G11C11/5642 ,  G11C16/3418 ,  G11C16/3422

    摘要： Shifts in the apparent charge stored on a floating gate (or other charge storing element) of a non-volatile memory cell can occur because of the coupling of an electric field based on the charge stored in adjacent floating gates (or other adjacent charge storing elements). The problem occurs most pronouncedly between sets of adjacent memory cells that have been programmed at different times. To compensate for this coupling, the read process for a given memory cell will take into account the programmed state of an adjacent memory cell.

    COMPENSATING FOR COUPLING DURING READ OPERATIONS OF NON-VOLATILE MEMORY
    100.
    发明申请
    COMPENSATING FOR COUPLING DURING READ OPERATIONS OF NON-VOLATILE MEMORY 有权

    公开(公告)号：US20070109849A1

    公开(公告)日：2007-05-17

    申请号：US11616741

    申请日：2006-12-27

    申请人： Jian Chen

    发明人： Jian Chen

    IPC分类号： G11C16/04

    CPC分类号： G11C16/3418 ,  G11C11/5642 ,  G11C16/3422 ,  G11C2211/5634 ,  G11C2211/5648

    摘要： Shifts in the apparent charge stored on a floating gate (or other charge storing element) of a non-volatile memory cell can occur because of the coupling of an electric field based on the charge stored in adjacent floating gates (or other adjacent charge storing elements). The problem occurs most pronouncedly between sets of adjacent memory cells that have been programmed at different times. To compensate for this coupling, the read process for a given memory cell will take into account the programmed state of an adjacent memory cell.