公开(公告)号：US20120192628A1

公开(公告)日：2012-08-02

申请号：US13394759

申请日：2010-07-09

申请人： Wei Liu ,  Andrew P. Phelan ,  Zhong-Qi Jin ,  Ying-An Zhan ,  Shuang Yu ,  Fu-Qiang Huang ,  Li Wang ,  Yin-Fei Wu ,  Jian Zou

发明人： Wei Liu ,  Andrew P. Phelan ,  Zhong-Qi Jin ,  Ying-An Zhan ,  Shuang Yu ,  Fu-Qiang Huang ,  Li Wang ,  Yin-Fei Wu ,  Jian Zou

IPC分类号： G01N1/10

CPC分类号： B01L3/502 ,  B01L2200/025 ,  B01L2200/0689 ,  B01L2200/141 ,  B01L2300/027 ,  B01L2300/047 ,  B01L2300/048 ,  B01L2300/0609 ,  B01L2300/0627 ,  B01L2300/0681 ,  B01L2300/0825 ,  B01L2300/087 ,  B01L2300/165 ,  B01L2400/0478 ,  G01N1/10 ,  G01N33/493

摘要： A device and a method for analyzing an analyte in a liquid sample are provided. The device comprises a detecting chamber included in a detection device for containing a detecting element; a liquid sample transferring chamber; and a film with small pores disposed between the detecting chamber and liquid sample transferring chamber. When the detection device is inserted into a liquid sample collecting chamber, the liquid sample in the collecting chamber enters the liquid sample transferring chamber but can not enter the detecting chamber via the film with small pores. When a piston is inserted into the liquid sample transferring chamber, the piston forces a part of liquid sample in the liquid sample transferring chamber to enter the detecting chamber via the film with small pores. Using the device and the method can determine an analyte in a sample quantitatively and can complete the detection in one step.

摘要翻译： 提供了用于分析液体样品中的分析物的装置和方法。 该装置包括检测室，包括在用于容纳检测元件的检测装置中; 液体样品转移室; 以及设置在检测室和液体样品转移室之间的具有小孔的膜。 当检测装置插入到液体样品收集室中时，收集室中的液体样品进入液体样品传送室，但是不能通过具有小孔的膜进入检测室。 当活塞插入到液体样品传送室中时，活塞迫使液体样品传送室中的一部分液体样品通过具有小孔的膜进入检测室。 使用该装置和方法可以定量地确定样品中的分析物，并且可以在一个步骤中完成检测。

公开(公告)号：US08231872B2

公开(公告)日：2012-07-31

申请号：US12732371

申请日：2010-03-26

申请人： Randolph J. Noelle ,  Li Wang

发明人： Randolph J. Noelle ,  Li Wang

IPC分类号： A61K39/395

CPC分类号： C07K16/2827 ,  A61K38/00 ,  A61K2039/505 ,  C07K14/70596 ,  C07K2319/00 ,  C07K2319/30 ,  G01N33/505 ,  Y02A50/412 ,  Y02A50/423

摘要： The present invention relates to novel regulatory T cell proteins. One protein, designated PD-L3, resembles members of the PD-L1 family, and co-stimulates αCD3 proliferation of T cells in vitro. A second, TNF-like, protein has also been identified as being upregulated upon αCD3/αGITR stimulation. This protein has been designated Treg-sTNF. Proteins, antibodies, activated T cells and methods for using the same are disclosed.In particular methods of using these proteins and compounds, preferably antibodies, which bind or modulate (agonize or antagonize) the activity of these proteins, as immune modulators and for the treatment of cancer, autoimmune disease, allergy, infection and inflammatory conditions, e.g. multiple sclerosis is disclosed.

摘要翻译： 本发明涉及新型调节性T细胞蛋白。 称为PD-L3的一种蛋白质类似于PD-L1家族的成员，并且在体外共同刺激T细胞的αCD3增殖。 第二种TNF样蛋白也被鉴定为在αCD3/αGITR刺激下上调。 该蛋白质已被命名为Treg-sTNF。 公开了蛋白质，抗体，活化的T细胞和使用它们的方法。 特别是使用这些蛋白质和化合物（优选抗体）的方法，其结合或调节（激动或拮抗）这些蛋白质的活性，作为免疫调节剂和用于治疗癌症，自身免疫疾病，变态反应，感染和炎性病症，例如， 公开了多发性硬化。

公开(公告)号：US20120188060A1

公开(公告)日：2012-07-26

申请号：US13258859

申请日：2009-12-28

申请人： Jiang Du ,  Li Wang ,  Jian Zhang

发明人： Jiang Du ,  Li Wang ,  Jian Zhang

IPC分类号： G06K7/01

CPC分类号： G06K7/10039

摘要： The present invention discloses a method and system for tallying tags in a radio frequency identification system. The method comprises: upon receiving a tallying command sent by the reader, the tags reflecting a first response message used for decoding and checking (S402); upon receiving the first response message, the reader sending a decoded random number (RN) if it decodes the first response message correctly; upon receiving the decoded RN, the tags reflecting a second response message containing tag ID information after confirming that the RN is consistent with their own RN (S405); and upon receiving the second response message, the reader confirming that the tallying is completed if the tag ID information contained in the second response message is correct (S407).

摘要翻译： 本发明公开了一种用于在射频识别系统中标记标签的方法和系统。 该方法包括：在接收到读取器发送的计数命令时，该标签反映用于解码和检查的第一响应消息（S402）; 在接收到第一响应消息时，读取​​器如果正确地解码第一响应消息，则发送解码随机数（RN）; 在接收到解码的RN之后，标签在确认RN与其自己的RN一致之后反映包含标签ID信息的第二响应消息（S405）; 并且在接收到第二响应消息时，如果包含在第二响应消息中的标签ID信息正确，则读取器确认已经完成了计数（S407）。

公开(公告)号：US08163907B2

公开(公告)日：2012-04-24

申请号：US12863593

申请日：2009-01-05

申请人： Guo-hua Chen ,  Li Wang

发明人： Guo-hua Chen ,  Li Wang

IPC分类号： C07D401/12 ,  C07D213/80

CPC分类号： C07D211/90

摘要： A dihydropyridine (DHP) calcium antagonist compound and its preparation method and medical use are related to preparation methods of compounds of general formulas (I) and (II) as shown below and their pharmaceutical salts and applications for treating cardiovascular diseases, and R1 represents a substituted or unsubstituted heterocyclic, aromatic ring or aralkyl group, and the substituent may be C1-C4 alkyl, C1-C4 alkoxyl, halogen, cyano, trifluoromethyl, trifluoromethoxyl, methylthio, nitro, amino or hydroxyl group; R2 represents a C1-C8 alkyl group; R3 and R4 are the same or different, and each represents a hydrogen, halogen, cyano, trifluoromethyl, trifluoromethoxyl, methylthio, nitro or amino group or a C1-C4 alkyl, C1-C4 alkoxyl, C1-C4 alkenyl, or C1-C4 alkinyl group; R5 and R6 are the same or different, and each represents a C1-C4 alkyl group; X represents O, S or a single bond; m=0-6, n=1-6, and m and n are the same or different.

摘要翻译： 二氢吡啶（DHP）钙拮抗剂化合物及其制备方法和医疗用途与下列通式（I）和（II）化合物的制备方法及其药物盐和治疗心血管疾病的应用有关，R1代表 取代或未取代的杂环，芳环或芳烷基，取代基可以是C 1 -C 4烷基，C 1 -C 4烷氧基，卤素，氰基，三氟甲基，三氟甲氧基，甲硫基，硝基，氨基或羟基。 R2表示C1-C8烷基; R 3和R 4相同或不同，各自表示氢，卤素，氰基，三氟甲基，三氟甲氧基，甲硫基，硝基或氨基或C 1 -C 4烷基，C 1 -C 4烷氧基，C 1 -C 4烯基或C 1 -C 4 炔基; R5和R6相同或不同，各自表示C1-C4烷基; X表示O，S或单键; m = 0-6，n = 1-6，m和n相同或不同。

公开(公告)号：US20120080642A1

公开(公告)日：2012-04-05

申请号：US13254228

申请日：2010-02-16

申请人： Jianguo Ren ,  Xiangming He ,  Li Wang ,  Runbao Yan ,  Weihua Pu ,  Jianjun Li ,  Jian Gao

发明人： Jianguo Ren ,  Xiangming He ,  Li Wang ,  Runbao Yan ,  Weihua Pu ,  Jianjun Li ,  Jian Gao

IPC分类号： H01M4/04 ,  H01M4/38 ,  B82B3/00

CPC分类号： H01M4/38 ,  H01M4/42 ,  H01M4/46 ,  H01M4/583 ,  H01M4/587 ,  H01M4/625 ,  H01M2004/027

摘要： The present invention relates to a process for preparing an alloy composite negative electrode material having a spherical carbon matrix structure for lithium ion batteries by spray-drying carbothermal reduction. The invention covers a process for preparing a negative electrode material for a lithium ion battery with a general formula A-M/Carbon, wherein A is a metal selected from the group consisting of Si, Sn, Sb, Ge and Al; and wherein M is different from A and is at least one element selected from the group consisting of B, Cr, Nb, Cu, Zr, Ag, Ni, Zn, Fe, Co, Mn, Sb, Zn, Ca, Mg, V, Ti, In, Al, Ge; and comprising the steps of: —providing a solution comprising an organic polymer and either chemically reducible nanometric A- and M-precursor compounds, or nanometric Si and a chemically reducible M-precursor compound, when said metal A is Si; —spray-drying said solution whereby a A- and M-precursor bearing polymer powder is obtained, and—calcining said powder in a neutral atmosphere at a temperature between 500 and 1000° C. for 3 to 10 hours whereby, in this carbothermal reduction, a carbon matrix is obtained bearing homogeneously distributed A-M alloy particles.

摘要翻译： 本发明涉及通过喷雾干燥碳热还原制备具有锂离子电池的球形碳基质结构的合金复合负极材料的方法。 本发明涉及一种制备具有通式A-M /碳的锂离子电池用负极材料的方法，其中A为选自Si，Sn，Sb，Ge和Al的金属; 其中M与A不同，为选自B，Cr，Nb，Cu，Zr，Ag，Ni，Zn，Fe，Co，Mn，Sb，Zn，Ca，Mg，V中的至少一种元素 ，Ti，In，Al，Ge; 并且包括以下步骤：当所述金属A为Si时，提供包含有机聚合物和化学还原性纳米A和M前体化合物或纳米Si和化学还原性M前体化合物的溶液; 喷雾干燥所述溶液，由此获得具有A和M前体的聚合物粉末，并且在中性气氛中在500-1000℃的温度下煅烧所述粉末3至10小时，由此在该碳热还原 得到带有均匀分布的AM合金颗粒的碳基体。

公开(公告)号：US08143305B2

公开(公告)日：2012-03-27

申请号：US12675897

申请日：2008-08-27

申请人： Gopinadhan N. Anilkumar ,  Frank Bennett ,  Tin-Yau Chan ,  Kevin X. Chen ,  Mousumi Sannigrahi ,  Francisco Velazquez ,  Srikanth Venkatraman ,  Qingbei Zeng ,  Jose S. Duca ,  Charles A. Lesburg ,  Joseph A. Kozlowski ,  F. George Njoroge ,  Stuart B. Rosenblum ,  Neng-Yang Shih ,  Stephen J. Gavalas ,  Yueheng Jiang ,  Patrick A. Pinto ,  Haiyan Pu ,  Oleg B. Selyutin ,  Bancha Vibulbhan ,  Li Wang ,  Wanli Wu ,  Weiying Yang ,  Yuhua Huang ,  Hsueh-Cheng Huang ,  Robert Palermo ,  Boris Feld

发明人： Gopinadhan N. Anilkumar ,  Frank Bennett ,  Tin-Yau Chan ,  Kevin X. Chen ,  Mousumi Sannigrahi ,  Francisco Velazquez ,  Srikanth Venkatraman ,  Qingbei Zeng ,  Jose S. Duca ,  Charles A. Lesburg ,  Joseph A. Kozlowski ,  F. George Njoroge ,  Stuart B. Rosenblum ,  Neng-Yang Shih ,  Stephen J. Gavalas ,  Yueheng Jiang ,  Patrick A. Pinto ,  Haiyan Pu ,  Oleg B. Selyutin ,  Bancha Vibulbhan ,  Li Wang ,  Wanli Wu ,  Weiying Yang ,  Yuhua Huang ,  Hsueh-Cheng Huang ,  Robert Palermo ,  Boris Feld

IPC分类号： A01N43/38 ,  A61K31/40 ,  C07D209/04

CPC分类号： C07D417/14 ,  C07D209/42 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14

摘要： The present invention relates to 2,3-Substituted Indole Derivatives, compositions comprising at least one 2,3-Substituted Indole Derivative, and methods of using the 2,3-Substituted Indole Derivatives for treating or preventing a viral infection or a virus-related disorder in a patient.

摘要翻译： 本发明涉及2,3-取代的吲哚衍生物，包含至少一种2,3-取代的吲哚衍生物的组合物和使用2,3-取代的吲哚衍生物用于治疗或预防病毒感染或病毒相关的方法 病人无序。

公开(公告)号：US20120051305A1

公开(公告)日：2012-03-01

申请号：US13259587

申请日：2009-10-19

申请人： Junhu Wang ,  Wenhuan Wang ,  Bo Sun ,  Yanfeng Guan ,  Li Wang

发明人： Junhu Wang ,  Wenhuan Wang ,  Bo Sun ,  Yanfeng Guan ,  Li Wang

IPC分类号： H04W74/04 ,  H04W72/04

CPC分类号： H04L1/1887 ,  H04L1/1812 ,  H04L1/1896 ,  H04L5/0021

摘要： The present invention discloses a method for retransmitting hybrid automatic based on persistent scheduling. The method includes: a base station sending retransmission attribute information of a persistent scheduling service to a terminal by a control signaling. An HARQ mechanism under a persistent scheduling mode is perfected by defining a retransmission region of the persistent scheduling service, and retransmission data packets are centralized to be transmitted in the retransmission region at a synchronization time, which, compared with the prior art, saves the overhead of resource indication information indicating each retransmission packet.

摘要翻译： 本发明公开了一种基于持续调度重传混合自动的方法。 该方法包括：基站通过控制信令向终端发送持续调度业务的重传属性信息。 通过定义持续调度业务的重传区域来完善持续调度模式下的HARQ机制，并且将重发数据分组集中在同步时间的重传区域中进行发送，与现有技术相比，节省了开销 指示每个重发分组的资源指示信息。

公开(公告)号：US20120037883A1

公开(公告)日：2012-02-16

申请号：US13059388

申请日：2008-08-19

申请人： Fengyi Jiang ,  Li Wang ,  Junlin Liu ,  Yingwen Tang

发明人： Fengyi Jiang ,  Li Wang ,  Junlin Liu ,  Yingwen Tang

IPC分类号： H01L33/04

CPC分类号： H01L25/0753 ,  H01L27/156 ,  H01L33/0079 ,  H01L33/508 ,  H01L2924/0002 ,  H01L2924/00

摘要： A light-emitting device includes a conductive substrate (320), a multilayer semiconductor structure situated above the conductive substrate including a n-type doped semiconductor layer (308), a p-type doped semiconductor layer (312) situated above the n-type doped semiconductor layer (308), and a MQW active layer (310) situated between the p-type and n-type doped semiconductor layer (308,312). The multilayer semiconductor structure is divided by grooves (300) to form a plurality of independent light-emitting mesas (304,306). At least one light-emitting mesa (304,306) comprises a color conversion layer (324,326).

摘要翻译： 发光器件包括导电衬底（320），位于导电衬底上方的包括n型掺杂半导体层（308）的多层半导体结构，位于n型掺杂半导体层之上的p型掺杂半导体层（312） 掺杂半导体层（308）和位于p型和n型掺杂半导体层（308,312）之间的MQW有源层（310）。 多层半导体结构被凹槽（300）划分以形成多个独立的发光台面（304,306）。 至少一个发光台面（304,306）包括颜色转换层（324,326）。

公开(公告)号：US20110301491A1

公开(公告)日：2011-12-08

申请号：US13177912

申请日：2011-07-07

申请人： Robert W. Stadler ,  Li Wang

发明人： Robert W. Stadler ,  Li Wang

IPC分类号： A61B5/053

CPC分类号： A61B5/0538 ,  A61B5/0537 ,  A61B5/4875 ,  A61B5/686 ,  A61B5/7275 ,  A61N1/362 ,  A61N1/3627 ,  A61N1/36521 ,  G06F12/0862 ,  G06F12/0877

摘要： A method and apparatus for detection of changes in impedance a patient that includes generating measured impedances, generating an adaptive baseline trend of the measured impedances corresponding to a first time period, generating a short term trend of the measured impedances corresponding to a second time period less than the first time period, determining changes in relative position of the short term trend and the baseline trend, the determined changes in relative position corresponding to determining intersecting of the baseline trend by the short term trend, determining differences between the baseline trend and calculated period average impedances, and accumulating, in response to determining no intersecting of the baseline trend by the short term trend, the determined differences between the baseline trend and the calculated period average impedances.

摘要翻译： 一种用于检测患者阻抗变化的方法和装置，包括产生测量的阻抗，产生对应于第一时间段的所测量的阻抗的自适应基线趋势，产生对应于第二时间段的所测量的阻抗的短期趋势 确定短期趋势相对位置的变化和基准趋势，确定相对位置的变化对应于基线趋势与短期趋势的相交，确定基线趋势与计算周期之间的差异 平均阻力和累积，以确定基准趋势与短期趋势的相交，确定基线趋势与计算的周期平均阻抗之间的差异。

公开(公告)号：US08044416B2

公开(公告)日：2011-10-25

申请号：US12093549

申请日：2008-03-25

申请人： Li Wang ,  Fengyi Jiang ,  Yingwen Tang ,  Junlin Liu

发明人： Li Wang ,  Fengyi Jiang ,  Yingwen Tang ,  Junlin Liu

IPC分类号： H01L33/30

CPC分类号： H01L33/0079 ,  H01L33/08 ,  H01L33/20 ,  H01L33/44

摘要： One embodiment of the present invention provides a method for fabricating a high-power light-emitting diode (LED). The method includes etching grooves on a growth substrate, thereby forming mesas on the growth substrate. The method further includes fabricating indium gallium aluminum nitride (InGaAlN)-based LED multilayer structures on the mesas on the growth substrate, wherein a respective mesa supports a separate LED structure. In addition, the method includes bonding the multilayer structures to a conductive substrate. The method also includes removing the growth substrate. Furthermore, the method includes depositing a passivation layer and an electrode layer above the InGaAlN multilayer structures, wherein the passivation layer covers the sidewalls and bottom of the grooves. Moreover, the method includes creating conductive paths which couple a predetermined number of adjacent individual LEDs, thereby allowing the LEDs to share a common power supply and be powered simultaneously to form a high-power LED array.

摘要翻译： 本发明的一个实施例提供一种制造大功率发光二极管（LED）的方法。 该方法包括在生长衬底上蚀刻凹槽，从而在生长衬底上形成台面。 该方法还包括在生长衬底上的台面上制造基于铟镓铝（InGaAlN）的LED多层结构，其中相应的台面支撑单独的LED结构。 此外，该方法包括将多层结构粘合到导电基底上。 该方法还包括去除生长底物。 此外，该方法包括在InGaAlN多层结构上沉积钝化层和电极层，其中钝化层覆盖槽的侧壁和底部。 此外，该方法包括产生耦合预定数量的相邻独立LED的导电路径，从而允许LED共享公共电源并且被同时供电以形成大功率LED阵列。