公开(公告)号：US20080077074A1

公开(公告)日：2008-03-27

申请号：US11504444

申请日：2006-08-15

申请人： Richard Keenan ,  Richard A. King ,  James R. Braig

发明人： Richard Keenan ,  Richard A. King ,  James R. Braig

IPC分类号： A61N1/30

CPC分类号： G01N21/274 ,  A61B5/14532 ,  A61B5/14557 ,  A61B5/15003 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150389 ,  A61B5/150503 ,  A61B5/150755 ,  A61B5/150854 ,  A61B5/153 ,  A61B5/157 ,  A61B5/4839 ,  A61B2560/0223 ,  A61M5/14212 ,  G01N21/35 ,  G01N2021/3133

摘要： A method of analyzing bodily fluids from a patient at the point of care for the patient is provided. The method comprises establishing fluid communication between an analyte detection system and a bodily fluid in the patient. A portion of the bodily fluid is drawn from the patient. The analyte detection system analyzes the bodily fluid to measure a concentration of an analyte. A test is performed on the analyte detection system according to a predetermined schedule to determine if the analyte detection system is properly calibrated. To perform the test a sample of a quality control solution is drawn into the analyte detection system and measured. The test results are compared to a reference range for the quality control solutions. If the measurements are within the reference range, the analyte detection system is permitted to resume analyzing the bodily fluids of the patient.

摘要翻译： 提供了在患者护理点分析来自患者的体液的方法。 该方法包括在患者体内建立分析物检测系统和体液之间的流体连通。 体液的一部分从患者身上抽出。 分析物检测系统分析体液以测量分析物的浓度。 根据预定时间表对分析物检测系统进行测试，以确定分析物检测系统是否被适当校准。 为了进行测试，质量控制解决方案的样品被绘制到分析物检测系统中并进行测量。 将测试结果与质量控制解决方案的参考范围进行比较。 如果测量值在参考范围内，则允许分析物检测系统重新分析患者的体液。

公开(公告)号：US20080077073A1

公开(公告)日：2008-03-27

申请号：US11504327

申请日：2006-08-15

申请人： Richard Keenan ,  Richard A. King ,  Heather T. Wisor ,  James R. Braig

发明人： Richard Keenan ,  Richard A. King ,  Heather T. Wisor ,  James R. Braig

IPC分类号： A61N1/30

CPC分类号： G01N21/274 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/14557 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150389 ,  A61B5/150503 ,  A61B5/150755 ,  A61B5/150854 ,  A61B5/153 ,  A61B5/157 ,  A61B5/7475 ,  A61M5/142 ,  A61M5/172 ,  A61M5/1723 ,  A61M2005/1726 ,  A61M2205/18 ,  A61M2205/505 ,  A61M2205/60 ,  G01N21/35 ,  G01N2021/3133 ,  G06F19/3468

摘要： An embodiment of an analyte detection system includes a fluid transport network having a patient end configured to provide fluid communication with a body fluid in a patient and a body fluid analyzer accessible via the fluid transport network. The body fluid analyzer is configured to measure a level of an analyte of interest in the body fluid. A pump unit is coupled to the fluid transport network. The pump unit has a sample input mode and an infusion mode. In the sample input mode, the pump unit is operable to transport a sample of the body fluid from the patient end and toward the body fluid analyzer. In the infusion mode, the pump unit is operable to transport an infusion fluid toward and out the patient end. The analyte detection system also includes a user interface for communication with the body fluid analyzer. The user interface includes an input element configured to accept user input corresponding to a patient health event. In some embodiments, the patient health event includes a patient health action or information relevant to clinical interpretation of data pertaining to measured analyte levels.

摘要翻译： 分析物检测系统的实施例包括流体输送网络，其具有被配置为提供与患者体液的流体连通的患者端以及可经由流体输送网络访问的体液分析器。 体液分析器被配置为测量体液中感兴趣的分析物的水平。 泵单元联接到流体输送网络。 泵单元具有样品输入模式和输液模式。 在样品输入模式中，泵单元可操作以将体液样品从患者端输送到体液分析器。 在输注模式中，泵单元可操作以将输液朝向和离开患者端传送。 分析物检测系统还包括用于与体液分析仪通信的用户界面。 用户界面包括被配置为接受对应于患者健康事件的用户输入的输入元件。 在一些实施方案中，患者健康事件包括与测量的分析物水平有关的数据的临床解释相关的患者健康作用或信息。

公开(公告)号：US06645142B2

公开(公告)日：2003-11-11

申请号：US09728743

申请日：2000-12-01

申请人： James R. Braig ,  Gary E. Hewett ,  Michael A. Munrow ,  Julian M. Cortella ,  Kamrava Azizi ,  Daniel S. Goldberger

发明人： James R. Braig ,  Gary E. Hewett ,  Michael A. Munrow ,  Julian M. Cortella ,  Kamrava Azizi ,  Daniel S. Goldberger

IPC分类号： A61B500

CPC分类号： G06F19/3418 ,  A61B5/0002 ,  A61B5/14532 ,  G06F19/00 ,  G16H40/40 ,  Y10S128/903 ,  Y10S128/904

摘要： A glucose monitoring instrument having network-based communication features which provide a link between patient and practitioner. The glucose monitoring instrument comprises circuitry for communicating data with one or more destination sites on the network which are configured to transmit and receive information to and from the instrument. Instrument measurements are transmitted over the link in addition to information and guidance, to provide increased accuracy, improved program compliance, and patient guidance from a supervisory authority or medical practitioner. In addition, a set of calibration features encourage calibration compliance.

公开(公告)号：US6091504A

公开(公告)日：2000-07-18

申请号：US82662

申请日：1998-05-21

申请人： Stephen D. Walker ,  Robert A. Nichols ,  William A. Curnan ,  Sophat Svai ,  James R. Braig ,  Daniel S. Goldberger

发明人： Stephen D. Walker ,  Robert A. Nichols ,  William A. Curnan ,  Sophat Svai ,  James R. Braig ,  Daniel S. Goldberger

IPC分类号： G01N21/39 ,  G01N21/00

CPC分类号： G01N21/39

摘要： A system and method for determining the concentration of an analyte such as oxygen in an unknown gas sample. A Vertical Cavity Surface Emitting Laser (VCSEL) is used as a variable wavelength light source which is "swept" through a wavelength range by varying the drive signal applied thereto. Quantitative spectroscopic analysis of the unknown gas sample is performed without the requirement of feedback circuitry for tuning the light source to the characteristic frequency of an analyte. Instead, the VCSEL is repeatedly "swept" through a range of frequencies determined by the drive signal, and the absorption is measured by the detector. The absorption lines do not always occur at the same place but instead move along around during the sweep based on the temperature and baseline current. The absorption at a particular wavelength may be determined by overlaying the drive signal and its timing information over the detected absorption signal.

摘要翻译： 用于确定未知气体样品中分析物如氧的浓度的系统和方法。 垂直腔面发射激光器（VCSEL）被用作通过改变施加到其上的驱动信号通过波长范围“扫过”的可变波长光源。 进行未知气体样品的定量光谱分析，而不需要用于将光源调谐到分析物的特征频率的反馈电路。 相反，VCSEL在由驱动信号确定的频率范围内被重复扫描，并且由检测器测量吸收。 吸收线并不总是发生在相同的位置，而是基于温度和基线电流在扫描过程中沿着周围移动。 可以通过将驱动信号及其定时信息覆盖在检测到的吸收信号上来确定特定波长处的吸收。

公开(公告)号：US6049081A

公开(公告)日：2000-04-11

申请号：US093951

申请日：1998-06-08

申请人： Bernhard B. Sterling ,  James R. Braig ,  Daniel S. Goldberger ,  Charles E. Kramer ,  Arthur M. Shulenberger ,  Rick Trebino ,  Richard A. King

发明人： Bernhard B. Sterling ,  James R. Braig ,  Daniel S. Goldberger ,  Charles E. Kramer ,  Arthur M. Shulenberger ,  Rick Trebino ,  Richard A. King

IPC分类号： G01N21/35 ,  G01N21/71

CPC分类号： A61B5/14532 ,  A61B5/01 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/1491 ,  G01N21/71 ,  A61B5/14539 ,  G01N21/35

摘要： Spectrometric methodology for non-invasively obtaining optical spectra from heterogeneous material for the identification and quantification of constituent compounds. There is provided a transient or steady state subsurface thermal gradient spectroscopic methodology for obtaining in vivo optical spectra relating to the concentration of n analytes at depths to around 330 microns in human tissue, and for determining that concentration from the spectra. The methodology is employable on a wide variety of spectrometric devices, and enables: a real time determination of both surface and reference intensities; a fast, efficient calibration of the spectrometric device; and results in the provision of an analytical parameter which avoids the measurement of the optical path length to enable the extremely accurate calculation of a ratio of concentrations of n analytes in the system under analysis.

摘要翻译： 用于非侵入性地从异质材料获得光谱用于鉴定和定量组成化合物的光谱测定方法。 提供了一种瞬态或稳态地下热梯度光谱方法，用于获得与人体组织深度至330微米处的n种分析物的浓度有关的体内光谱，并用于确定来自光谱的浓度。 该方法可用于各种光谱测量装置，并且能够：实时确定表面和参考强度; 快速，高效地校准光谱仪; 并且导致提供了避免测量光程长度的分析参数，以使得能够非常精确地计算分析系统中的n种分析物的浓度比。

公开(公告)号：US6025597A

公开(公告)日：2000-02-15

申请号：US957309

申请日：1997-10-23

申请人： Bernhard B. Sterling ,  James R. Braig ,  Daniel S. Goldberger ,  Charles E. Kramer ,  Arthur M. Shulenberger ,  Rick Trebino ,  Richard King ,  Rogelio O. Herrera

发明人： Bernhard B. Sterling ,  James R. Braig ,  Daniel S. Goldberger ,  Charles E. Kramer ,  Arthur M. Shulenberger ,  Rick Trebino ,  Richard King ,  Rogelio O. Herrera

IPC分类号： A61B5/00 ,  G01J3/42 ,  G01N21/35 ,  G01N21/71 ,  G01N25/72

CPC分类号： A61B5/1455 ,  A61B5/14532 ,  G01J3/42 ,  G01N21/71 ,  G01N25/72 ,  G01N21/35

摘要： A noninvasive infrared spectrometer which includes an infrared detector system for measuring the intensity, wavelength, and time varying nature of infrared energy emanating from deep layers within a body. Before detection, the energy emanating from deep within the body passes through layers of that body in the presence of a natural or induced thermal gradient. The measured infrared energy is processed into an absorption spectra and then into a concentration of at least one constituent of the body which concentration may be strongly dependent on the depth into the body. In one embodiment the temperature gradient is induced by chilling the surface of the body to provide a clearer indication of the infrared absorption levels of the deeper constituents. Other embodiments describe the sequential or simultaneous heating and cooling of the heterogenous body to induce and capture the transient infrared absorption spectral information.

摘要翻译： 一种非侵入式红外光谱仪，其包括用于测量从体内深层发出的红外能量的强度，波长和时变特性的红外检测器系统。 在检测之前，从身体深处发出的能量在自然或诱导的热梯度存在下通过该身体的各层。 测量的红外能量被加工成吸收光谱，然后被加工成至少一种身体成分的浓度，其浓度可能强烈地依赖于进入体内的深度。 在一个实施方案中，通过冷却身体的表面来诱导温度梯度，以提供更深层次成分的红外吸收水平的更清楚的指示。 其他实施方案描述了异源体的顺序或同时加热和冷却以诱导和捕获瞬时红外吸收光谱信息。

公开(公告)号：US5877500A

公开(公告)日：1999-03-02

申请号：US816088

申请日：1997-03-13

申请人： James R. Braig ,  Arthur M. Shulenberger

发明人： James R. Braig ,  Arthur M. Shulenberger

IPC分类号： G01J1/02 ,  G01J1/04 ,  G01J5/04 ,  G01J5/08 ,  G01J5/02

CPC分类号： G01J5/061 ,  G01J5/04 ,  G01J5/045 ,  G01J5/06 ,  G01J5/08 ,  G01J5/0815 ,  G01J5/0862 ,  G01J5/0881 ,  G01J5/0893 ,  G01J5/0205

摘要： The present invention comprises a system and method for detecting multiple wavelength bands of infrared radiation. The present invention incorporates an optical concentrator or "optical funnel" to increase the energy density on the detection elements and discrete filters mounted in the funnels and a mounting structure for individual detector elements. An apparatus in accordance with the present invention is an advance over conventional infrared detector assemblies in several areas. The apparatus in accordance with the present invention provides a unified means for mounting detectors, optical concentrators and infrared filters. It also provides an efficient means for electrical connection to the detector elements. The present invention provides a mounting structure for the detectors bonding them directly to the body of the optical funnel and passing light into them from the "backside" of the detector elements. The present invention prevents cross talk by mounting the detector elements at the focused end of individual optical concentrators.

摘要翻译： 本发明包括用于检测红外辐射的多个波长带的系统和方法。 本发明包括光集中器或“光漏斗”，以增加安装在漏斗中的检测元件和分立滤光片上的能量密度和用于各个检测器元件的安装结构。 根据本发明的装置是在几个领域中超过常规红外探测器组件的进步。 根据本发明的装置提供了用于安装检测器，光集中器和红外滤光器的统一装置。 它还提供了用于与检测器元件电连接的有效手段。 本发明提供了一种用于检测器的安装结构，它们将它们直接连接到光漏斗的主体并将光从检测器元件的“背面”传送到它们中。 本发明通过将检测器元件安装在各个聚光器的聚焦端处来防止串扰。

公开(公告)号：US5247185A

公开(公告)日：1993-09-21

申请号：US782990

申请日：1991-10-28

申请人： Roger O. Herrera ,  James R. Braig ,  Daniel S. Goldberger

发明人： Roger O. Herrera ,  James R. Braig ,  Daniel S. Goldberger

IPC分类号： G01J5/02 ,  G01J3/10 ,  G01J5/00 ,  G01N21/01 ,  G01N21/35 ,  G05D23/24 ,  H05B3/46

CPC分类号： G05D23/24 ,  G01J3/108 ,  H05B3/46 ,  G01N21/3504 ,  G01N2201/069

摘要： An infrared source which provides a miniature, highly stable and efficient source of infrared energy for use with infrared detectors and the like. The infrared source of the invention incorporates a platinum resistance temperature detector (RTD) which is integrated with the heater element to provide a means of electronic servo control of the heater temperature. The heater element and the RTD are tightly coupled thermally to provide accurate, continuous tracking and control of the heater temperature. The infrared source design provides excellent infrared energy output with less than one watt input power to the heater.

摘要翻译： 提供用于红外探测器等的微型，高度稳定和高效的红外能量源的红外源。 本发明的红外光源包括与加热器元件集成的铂电阻温度检测器（RTD），以提供加热器温度的电子伺服控制装置。 加热器元件和RTD紧密耦合，以提供对加热器温度的精确，连续的跟踪和控制。 红外源设计为加热器提供了不到一瓦特输入功率的出色的红外能量输出。

公开(公告)号：US5159936A

公开(公告)日：1992-11-03

申请号：US570205

申请日：1990-08-17

申请人： Mark Yelderman ,  Daniel S. Goldberger ,  James R. Braig

发明人： Mark Yelderman ,  Daniel S. Goldberger ,  James R. Braig

IPC分类号： A61B5/01 ,  A61B20060101 ,  A61B1/227 ,  A61B5/00 ,  G01J20060101 ,  G01J5/04 ,  G01J5/06 ,  G01J5/10 ,  G01J5/12 ,  G01J5/14 ,  G01K11/00 ,  G01K13/00

CPC分类号： G01J5/04 ,  A61B1/227 ,  G01J5/02 ,  G01J5/028 ,  G01J5/08 ,  G01J5/0812 ,  G01J5/0862 ,  G01J2005/066 ,  G01J2005/068 ,  G01J5/045 ,  G01J5/049 ,  G01J5/14

摘要： A noncontact infrared tympanic thermometer which does not require environmental stabilization or waveguide temperature control because it utilizes an optically stabilized infrared detector for detecting the infrared energy emitted by the tympanic membrane. The optical stabilization renders the instrument insensitive to ambient temperature effects and allows it to read true tympanic membrane temperatures unaffected by the temperature of the side walls of the detector package. This selectivity is accomplished by locating a neutral density filter over half of the optical aperture of the detector package such that the neutral density filter "shadows" only one of two thermopile channels for detecting the infrared energy emitted by the tympanic membrane. The two thermopile channels are connected in series opposition such that any optical signal equally present in both channels will yield a zero net output. Since the infrared energy emitted by the walls of the detector package reach each detector equally, the effects of these emissions on the temperature measurement are eliminated. The neutral density filter prevents the energy from the tympanic membrane from falling equally on the two thermopile detectors and similarly cancelling. Instead, the resulting differential signal may be processed along with the ambient temperature signal to determine the temperature of the tympanic membrane. The infrared detector of the invention may also be incorporated into an otoscope.

摘要翻译： 一种非接触红外鼓膜温度计，其不需要环境稳定或波导温度控制，因为它使用光学稳定的红外检测器来检测由鼓膜发射的红外能量。 光学稳定化使仪器对环境温度的影响不敏感，并允许其读取不受检测器封装侧壁温度影响的真实鼓膜温度。 这种选择性是通过将中性密度滤光片定位在检测器封装的光学孔径的一半上来实现的，使得中性密度滤光器仅“阴影”两个热电堆通道中的一个，用于检测由鼓膜发射的红外能量。 两个热电堆通道串联连接，使得两个通道中同样存在的任何光信号将产生零净输出。 由于检测器组件的壁发射的红外能量均匀地到达每个检测器，所以消除了这些排放对温度测量的影响。 中性密度过滤器防止鼓膜的能量均匀地下降到两个热电堆检测器上并且类似地消除。 相反，所得到的差分信号可以与环境温度信号一起被处理以确定鼓膜的温度。 本发明的红外检测器也可以结合到耳镜中。

公开(公告)号：US5081998A

公开(公告)日：1992-01-21

申请号：US522177

申请日：1990-05-11

申请人： Mark Yelderman ,  Daniel S. Goldberger ,  James R. Braig

发明人： Mark Yelderman ,  Daniel S. Goldberger ,  James R. Braig

IPC分类号： A61B5/083 ,  G01J1/24 ,  G01J5/12 ,  G01N21/31 ,  G01N21/35

CPC分类号： A61B5/083 ,  G01N21/3504 ,  G01J1/24 ,  G01J5/12 ,  G01N2021/3166 ,  G01N2201/126

摘要： Improved infrared detectors for use in device such as capnographs are provided. A preferred embodiment of an infrared detector of the invention is comprised of paired thermopiles, connect in opposed relation to each other, which are preceded by an analytical or reference filter for passing a desired wavelength and a neutral density filter in the optical path of one of the thermopiles in the pair. The difference between the outputs can be used to eliminate the effects of background thermal noise, thereby improving performance of the detector. Preferably, a reference channel and an analytical channel are provided so that the respective differences between the detectors in each pair can be used to further cancel the effects of background thermal noise.

摘要翻译： 提供了改进的红外探测器，用于诸如盖帽仪等设备。 本发明的红外检测器的一个优选实施例由成对的热电堆组成，它们彼此相对地连接，其前面是用于使所需波长传递的分析或参考滤波器，以及在 这对热电堆。 输出之间的差异可以用于消除背景热噪声的影响，从而提高检测器的性能。 优选地，提供参考通道和分析通道，使得可以使用每对中的检测器之间的相应差异来进一步抵消背景热噪声的影响。