公开(公告)号：US07638639B2

公开(公告)日：2009-12-29

申请号：US12011935

申请日：2008-01-30

申请人： Mathai Mammen ,  Adam Hughes ,  Yu-hua Ji ,  Li Li ,  Weijiang Zhang

发明人： Mathai Mammen ,  Adam Hughes ,  Yu-hua Ji ,  Li Li ,  Weijiang Zhang

IPC分类号： C07D207/04 ,  C07D211/06

CPC分类号： C07D207/08 ,  A61K31/40 ,  C07D207/09 ,  C07D207/16 ,  C07D211/34

摘要： This invention is directed to compounds of formula I: wherein R1-R5 and a-e are as defined in the specification; or pharmaceutically-acceptable salt or solvate or stereoisomer thereof. The invention also directed to pharmaceutical compositions containing such compounds; processes and intermediates useful for preparing such compounds; and methods for treating disease conditions mediated by muscarinic receptors using such compounds.

公开(公告)号：US20090269569A1

公开(公告)日：2009-10-29

申请号：US12497791

申请日：2009-07-06

申请人： Janos Fucsko ,  John A. Smythe, III ,  Li Li ,  Grady S. Waldo

发明人： Janos Fucsko ,  John A. Smythe, III ,  Li Li ,  Grady S. Waldo

IPC分类号： B32B27/00 ,  C08G77/00 ,  B32B15/08

CPC分类号： H01L21/02164 ,  H01L21/02222 ,  H01L21/02236 ,  H01L21/02282 ,  H01L21/02343 ,  H01L21/3125 ,  H01L21/316 ,  H01L21/76205 ,  H01L21/76801 ,  H01L21/76802 ,  H01L21/76826 ,  H01L21/76828 ,  H01L21/76829 ,  H01L21/76831 ,  H01L21/76832

摘要： Semiconductor devices, structures and systems that utilize a polysilazane-based silicon oxide layer or fill, and methods of making the oxide layer are disclosed. In one embodiment, a polysilazane solution is deposited on a substrate and processed with ozone in a wet oxidation at low temperature to chemically modify the polysilazane material to a silicon oxide layer.

摘要翻译： 公开了利用聚硅氮烷基氧化硅层或填充物的半导体器件，结构和系统以及制造氧化物层的方法。 在一个实施方案中，将聚硅氮烷溶液沉积在基底上，并在低温下经湿氧化处理臭氧，以将聚硅氮烷材料化学改性为氧化硅层。

公开(公告)号：US07591959B2

公开(公告)日：2009-09-22

申请号：US11325591

申请日：2006-01-04

申请人： Li Li ,  Don L. Yates

发明人： Li Li ,  Don L. Yates

IPC分类号： C23F1/00

CPC分类号： C03C15/00 ,  C03C17/22 ,  C03C2218/32 ,  C03C2218/33 ,  H01L21/31111 ,  H01L21/32 ,  H01L21/76202

摘要： An etchant for removing materials with a plurality of selectivities exhibits a first etch selectivity at a first temperature and a second etch selectivity at a second temperature. The etchant may include phosphoric acid, fluoboric acid, or sulfuric acid. The materials that the etchant is configured to remove may include dielectric materials, such as silicon nitride and silicon oxide. The first temperature may be about 175° C. and the second temperature may be about 155° C.

摘要翻译： 用于去除具有多个选择性的材料的蚀刻剂在第一温度下表现出第一蚀刻选择性，在第二温度下表现出第二蚀刻选择性。 蚀刻剂可以包括磷酸，氟硼酸或硫酸。 蚀刻剂被配置为去除的材料可以包括介电材料，例如氮化硅和氧化硅。 第一温度可以是约175℃，第二温度可以是约155℃。

公开(公告)号：US07589426B2

公开(公告)日：2009-09-15

申请号：US11516243

申请日：2006-09-06

申请人： Tongbi Jiang ,  Li Li ,  William M. Hiatt

发明人： Tongbi Jiang ,  Li Li ,  William M. Hiatt

IPC分类号： H01L23/52 ,  H01L23/48 ,  H01L23/40 ,  H01L23/485 ,  H01L23/498

CPC分类号： H01L21/486 ,  H01L21/4803 ,  H01L21/4846 ,  H01L21/4853 ,  H01L21/4857 ,  H01L21/561 ,  H01L21/6835 ,  H01L23/3114 ,  H01L23/49816 ,  H01L24/10 ,  H01L24/13 ,  H01L24/16 ,  H01L24/81 ,  H01L24/97 ,  H01L2221/68345 ,  H01L2224/0554 ,  H01L2224/05568 ,  H01L2224/05573 ,  H01L2224/13 ,  H01L2224/13099 ,  H01L2224/16225 ,  H01L2224/32225 ,  H01L2224/73204 ,  H01L2224/81005 ,  H01L2224/81801 ,  H01L2224/83005 ,  H01L2224/83102 ,  H01L2224/92125 ,  H01L2224/97 ,  H01L2924/00014 ,  H01L2924/01005 ,  H01L2924/01006 ,  H01L2924/01013 ,  H01L2924/01029 ,  H01L2924/01033 ,  H01L2924/01072 ,  H01L2924/01074 ,  H01L2924/01079 ,  H01L2924/01087 ,  H01L2924/014 ,  H01L2924/14 ,  H01L2924/15174 ,  H01L2924/15311 ,  H01L2924/181 ,  H05K3/0032 ,  H05K3/0052 ,  H05K3/0058 ,  H05K3/4644 ,  H05K3/4682 ,  H05K2203/016 ,  H05K2203/0384 ,  H01L2224/81 ,  H01L2924/00012 ,  H01L2224/83 ,  H01L2924/00 ,  H01L2224/05599 ,  H01L2224/0555 ,  H01L2224/0556

摘要： Methods for creating redistribution layers for only selected dice, such as known good dice, to form relatively thin semiconductor component assemblies and packages, and the assemblies and packages created by the methods, are disclosed. A sacrificial layer is deposited on a support substrate. An etch stop layer having a lower etch is deposited on the sacrificial layer. Redistribution lines in a dielectric material are formed on the support substrate on the etch stop layer. Semiconductor dice, either singulated or at the wafer level, are connected to the redistribution lines. The assembly may be scribed to allow the sacrificial layer to be etched to enable removal of the semiconductor dice and associated redistribution layer from the support substrate. The etch stop layer is removed to allow access to the redistribution lines for conductive bumping.

摘要翻译： 公开了用于仅为所选择的骰子创建再分布层（例如已知的骰子）以形成相对薄的半导体元件组件和封装以及由该方法产生的组件和包的方法。 牺牲层沉积在支撑衬底上。 具有较低蚀刻的蚀刻停止层沉积在牺牲层上。 介电材料中的再分布线形成在蚀刻停止层上的支撑衬底上。 单片化或晶圆级的半导体管芯连接到再分配线。 可以对组件进行划线以允许蚀刻牺牲层，以便能够从支撑衬底去除半导体晶片和相关联的再分配层。 去除蚀刻停止层以允许进入用于导电凸起的再分配线。

公开(公告)号：US20090171175A1

公开(公告)日：2009-07-02

申请号：US12343733

申请日：2008-12-24

申请人： Li Li ,  Scott Amundson ,  Corydon A. Hinton

发明人： Li Li ,  Scott Amundson ,  Corydon A. Hinton

IPC分类号： A61B5/1455

CPC分类号： A61B5/14551 ,  A61B2560/029

摘要： According to various embodiments, methods and systems are provided for configuring a medical device connected to a network based on an identification. In one embodiment, a method is provided that includes receiving an identification, retrieving configuration parameters from a network based at least in part upon the identification, and selecting one or more configuration parameters based at least in part upon the identification. In various embodiments, a system is provided that includes a medical device configured to communicate over a network, wherein the medical device may receive information from the network and the monitor is configured to select one or more configuration parameters based at least in part upon the information received from the network.

摘要翻译： 根据各种实施例，提供了用于基于识别来配置连接到网络的医疗设备的方法和系统。 在一个实施例中，提供了一种方法，其包括接收标识，至少部分地基于所述标识从网络检索配置参数，以及至少部分地基于所述标识来选择一个或多个配置参数。 在各种实施例中，提供了一种系统，其包括被配置为通过网络通信的医疗设备，其中所述医疗设备可以从网络接收信息，并且所述监视器被配置为至少部分地基于所述信息来选择一个或多个配置参数 从网络接收。

公开(公告)号：US20090171170A1

公开(公告)日：2009-07-02

申请号：US12343792

申请日：2008-12-24

申请人： Li Li ,  Scott Amundson ,  Corydon A. Hinton

发明人： Li Li ,  Scott Amundson ,  Corydon A. Hinton

IPC分类号： A61B5/00

CPC分类号： A61B5/00 ,  A61B5/0002 ,  A61B5/14551 ,  A61B5/746 ,  A61B2562/085

摘要： In an embodiment, a system is provided that includes a sensor configured to monitor a physiological parameter of the patient. The sensor is further configured to communicate with a portable electronic device configured to communicate over a wireless network. A method of operation of a sensor is provided that includes receiving data from a sensor configured to sense a physiological parameter and determining the physiological parameter from the data. A method of operation of a portable electronic device is also provided.

摘要翻译： 在一个实施例中，提供了一种系统，其包括被配置为监测患者的生理参数的传感器。 传感器还被配置为与被配置为通过无线网络进行通信的便携式电子设备进行通信。 提供了一种传感器的操作方法，其包括从配置成感测生理参数并根据数据确定生理参数的传感器接收数据。 还提供了一种便携式电子设备的操作方法。

公开(公告)号：US07549876B2

公开(公告)日：2009-06-23

申请号：US12229349

申请日：2008-08-21

申请人： Qi-Jun Zhao ,  Li Li ,  Hua Yin

发明人： Qi-Jun Zhao ,  Li Li ,  Hua Yin

IPC分类号： H01R13/62

CPC分类号： G06K13/08 ,  G06K7/0021

摘要： An electrical card connector (100) for insertion of an electrical card (200) comprises an insulative housing (1), a plurality of terminals (2) coupled to the insulative housing and a first shell (4). The insulative housing comprises a base portion (11), an arm portion (12) extending from a lateral side of the base portion, and a receiving space (13) formed between the base portion and the arm portion to receive the electrical card. The terminals are coupled to the base portion and extend into the receiving space for electrical connection to the electrical card. The first shell (4) is integrally molded with the insulative housing (1) and covers the insulative housing.

摘要翻译： 用于插入电卡（20​​0）的电子卡连接器（100）包括绝缘壳体（1），耦合到绝缘壳体的多个端子（2）和第一壳体（4）。 绝缘壳体包括基部（11），从基部的侧面延伸的臂部（12）和形成在基部和臂部之间以容纳电卡的容纳空间（13）。 端子耦合到基部并延伸到接收空间中以电连接到电卡。 第一壳体（4）与绝缘壳体（1）整体模制并覆盖绝缘壳体。

公开(公告)号：US20090156419A1

公开(公告)日：2009-06-18

申请号：US12162286

申请日：2007-02-06

申请人： Huafang Gao ,  Ze Li ,  Dong Wang ,  Yanhua Liu ,  Xiang Liu ,  Yangzhou Jiang ,  Li Li ,  Chuanzan Zhao ,  Gengxin Lan ,  Tao Guo ,  Bin Cai ,  Jing Cheng

发明人： Huafang Gao ,  Ze Li ,  Dong Wang ,  Yanhua Liu ,  Xiang Liu ,  Yangzhou Jiang ,  Li Li ,  Chuanzan Zhao ,  Gengxin Lan ,  Tao Guo ,  Bin Cai ,  Jing Cheng

IPC分类号： C40B30/04

CPC分类号： C12Q1/6881 ,  C12Q1/6832 ,  C12Q2600/156 ,  C12Q2535/131 ,  C12Q2527/107

摘要： The present invention provides an improved nucleic acid hybridization process employing a modified oligonucleotide probe comprising naturally occurring nucleotide bases. At least one nucleotide in the modified oligonucleotide is artificially mismatched relative to the control nucleic acid in addition to any mismatches arising from a variant nucleic acid target containing a sequence variation. The artificial mismatch and the sequence variation positions are separated from one another on the oligonucleotide by six to nine nucleotide positions.

摘要翻译： 本发明提供使用包含天然存在的核苷酸碱基的修饰的寡核苷酸探针的改进的核酸杂交方法。 除了由含有序列变异的变体核酸靶产生的任何错配之外，修饰寡核苷酸中至少一个核苷酸相对于对照核酸人为错配。 将人工错配和序列变异位置在寡核苷酸上彼此分开6至9个核苷酸位置。

公开(公告)号：US20090142317A1

公开(公告)日：2009-06-04

申请号：US12325464

申请日：2008-12-01

申请人： Tinghua Cao ,  Li Li

发明人： Tinghua Cao ,  Li Li

IPC分类号： A61K35/12

CPC分类号： A61K39/001 ,  A61K38/14 ,  A61K2039/5158

摘要： Disclosed in this specification is a process for producing ex vivo expanded CD4+CD25+ regulatory T cells. The process includes the steps of extracting a sample that includes peripheral blood mononuclear cells from a human donor. The extracted cells include a certain number of cells which are CD4+CD25+ regulatory T cells. The relative population of the CD4+CD25+ regulatory T cells is enhanced such that the Treg cells constitute the majority of the cells in the sample. Thereafter, the population of the enriched Treg cells, that may include third-party derived Treg cells, is expanded to produce a clinically meaningful population of cells for use in the treatment of GVHD.

摘要翻译： 在本说明书中公开的是制备离体扩增的CD4 + CD25 +调节性T细胞的方法。 该方法包括从人供体中提取包含外周血单核细胞的样品的步骤。 提取的细胞包括一定数量的CD4 + CD25 +调节性T细胞的细胞。 增加CD4 + CD25 +调节性T细胞的相对群体，使得Treg细胞构成样品中的大部分细胞。 此后，扩增可能包括第三方衍生的Treg细胞的富集的Treg细胞的群体，以产生用于治疗GVHD的临床有意义的细胞群。

公开(公告)号：US20090118598A1

公开(公告)日：2009-05-07

申请号：US12348742

申请日：2009-01-05

申请人： Carine Hoarau ,  Li Li

发明人： Carine Hoarau ,  Li Li

IPC分类号： A61B5/1455 ,  A61B5/00 ,  A61B5/11

CPC分类号： A61B5/6826 ,  A61B5/14552 ,  A61B5/6838

摘要： A sensor may be adapted to provide output to indicate when the sensor experiences abnormal forces or pressure. The forces may be outside forces, or the forces may be generated by patient motion. A sensor system as provided may also be adapted to correct for such forces when calculating measurements related to a physiological characteristic.

摘要翻译： 传感器可以适于提供输出以指示传感器何时经历异常的力或压力。 力可能是外力，或者力可以由患者运动产生。 所提供的传感器系统还可以适于在计算与生理特征相关的测量时校正这种力。