-
公开(公告)号：US11771807B2
公开(公告)日：2023-10-03
申请号：US16515946
申请日：2019-07-18
发明人： Sashank Reddy , Russell Martin , Xiaowei Li , Calvin Chang , Kevin Colbert , Hai-Quan Mao
IPC分类号： A61L27/58 , A61L27/54 , A61L27/20 , A61L27/18 , A61L27/44 , A61L27/38 , A61L27/52 , A61M5/19 , A61L27/48 , A61L27/56 , B82Y5/00 , B82Y30/00 , B82Y40/00
CPC分类号： A61L27/58 , A61L27/18 , A61L27/20 , A61L27/3808 , A61L27/3834 , A61L27/3895 , A61L27/44 , A61L27/48 , A61L27/52 , A61L27/54 , A61L27/56 , A61M5/19 , A61L2300/412 , A61L2300/414 , A61L2300/602 , A61L2300/604 , A61L2300/622 , A61L2400/06 , A61L2400/12 , A61L2430/34 , A61M2202/08 , A61M2202/09 , B82Y5/00 , B82Y30/00 , B82Y40/00
摘要： A soft tissue device can incorporate a composite material comprising a gel and at least one nanostructure disposed within the gel. A soft tissue device can further incorporate biologically active materials such as cells, tissues. A method for healing a soft tissue defect while promoting soft tissue regeneration can include applying a soft tissue device to a soft tissue defect, wherein the composite material includes a gel and a nanostructure disposed within the gel. A method for manufacturing a soft tissue device for use in healing soft tissue defects can include providing a gel, disposing nanofibers within the gel, and a biologically active material.
-
公开(公告)号：US11771703B2
公开(公告)日：2023-10-03
申请号：US16495098
申请日：2018-03-16
发明人： Harry C. Dietz , Joseph Shin
IPC分类号： A61K31/551 , A61K38/55
CPC分类号： A61K31/551 , A61K38/55
摘要： The instant disclosure provides methods and compositions for the diagnosis, treatment and prevention of a TGFβ2-associated disease, disorder and/or condition, including, e.g., Scleroderma, other fibrotic disease, grade 4 glioblastoma (GBM) and/or Primary Open-Angle Glaucoma (POAG). The disclosure further provides pharmaceutical compositions and kits for the diagnosis, treatment and prevention of TGFβ2-associated diseases, disorders and/or conditions.
-
93.发明授权公开(公告)号：US11766488B2
公开(公告)日：2023-09-26
申请号：US16315458
申请日：2017-07-05
发明人： Vinod Jaskula-Ranga , Donald Zack , Derek Welsbie
CPC分类号： A61K48/005 , A61K9/0014 , A61K9/0019 , C12N15/86 , C12N2310/20 , C12N2330/51 , C12N2710/10344 , C12N2750/14143
摘要： The presently disclosed subject matter provides compositions and methods comprising improvements of a CRISPR system (e.g. CRISPR associated (Cas) 9 (CRISPR-Cas9, non-Cas9 CRISPR systems). Such compositions may comprise modifications to the H1 promoter region, addition of 5′UTR modifications, different orthologous sequences of the H1 promoter, novel compact bidirectional promoter sequences with both pol II and pol III activity, addition of Kozak consensus sequences, termination sequences, addition of conditional pol II/pol III bidirectional promoter expression, addition of a donor template sequence for correcting mutations, or combinations thereof. Other aspects of the invention relate to modifications to Cas9 through post-transcriptional cell-cycle regulation fusions, engineered partial target sites such that the nuclease can bind without DNA cleavage, auto-regulation sites, and N-terminal modifications to modulate half-life.
-
公开(公告)号：US11766478B2
公开(公告)日：2023-09-26
申请号：US17006224
申请日：2020-08-28
发明人： Tzyy-Choou Wu , Chien-Fu Hung
CPC分类号： A61K39/39 , A61K9/0019 , A61K33/243 , A61K38/1709 , A61K39/0011 , A61K47/643 , A61K47/646 , C07K14/4721 , A61K2039/54 , A61K2039/545 , A61K2039/55516 , C07K2319/40 , C07K2319/50
摘要： Described herein are methods comprising administering to a mammalian subject an effective amount of an annexin chimeric fusion protein, wherein the annexin chimeric fusion protein comprises at least one immunogenic antigen, thereby enhancing the antigen specific immune response relative to administration of the immunogenic antigen alone. Methods and kits for treating or preventing recurrence of hyper proliferating diseases, e.g., cancer, are described. A method may comprise priming a mammal by administering to the mammal an effective amount of a chemotherapeutic agent and boosting the mammal by administering to the mammal an effective amount of an annexin chimeric fusion.
-
公开(公告)号：US11759466B2
公开(公告)日：2023-09-19
申请号：US16977309
申请日：2019-03-01
发明人： Norman Haughey , Barbara Slusher , Camilo Rojas
IPC分类号： A61K31/51 , A61P31/18 , A61K31/519 , A61K31/4178 , A61K31/5025
CPC分类号： A61K31/519 , A61K31/4178 , A61K31/5025 , A61P31/18
摘要： Methods for treating a Human Immunodeficiency Virus (HIV) infection comprising administering to a subject in need of treatment thereof an effective amount of a small molecule nSMase2 inhibitor.
-
公开(公告)号：US11758100B2
公开(公告)日：2023-09-12
申请号：US17753074
申请日：2020-09-09
发明人： Mehran Armand , Shuya Liu , Wei-Lun Huang , Austin Shin
IPC分类号： G06T7/80 , H04N9/31 , G06V10/143 , G06V20/64
CPC分类号： H04N9/3185 , G06T7/85 , G06V10/143 , H04N9/3194 , G06T2207/10012 , G06T2207/30204 , G06V20/64
摘要： A device may provide, to a camera and a projector of a portable projection mapping device, first instructions for calibrating the camera and the projector, and may receive, based on the first instructions, calibration parameters for the camera and the projector. The device may calculate a stereo calibration between the camera and the projector based on the calibration parameters, and may provide, to the camera, second instructions for recognizing a reference instrument associated with the portable projection mapping device. The device may receive, based on the second instructions, binocular images, and may determine additional parameters based on the binocular images. The device may determine recognition parameters for recognizing the reference instrument, based on the binocular images and the additional parameters. The device may process the recognition parameters and the stereo calibration, with an optical tracking model, to generate and provide overlay visualization data to the portable projection mapping device.
-
公开(公告)号：US20230282818A1
公开(公告)日：2023-09-07
申请号：US18140671
申请日：2023-04-28
IPC分类号： H01M4/485 , C01G33/00 , H01M4/66 , H01M10/0525 , H01M10/0565
CPC分类号： H01M4/485 , C01G33/006 , H01M4/663 , H01M10/0525 , H01M10/0565 , C01P2006/40 , H01M2004/027
摘要： Processes for preparing a niobate material are provided, in which the processes include the following steps: (i) providing a niobium-containing source; (ii) providing a transitional metal source (TMS), a post-transitional metal source (PTMS), or both; (iii) dissolving (a) the niobium-containing source, and (b) the TMS, the PTMS, or both in an aqueous medium to form an intermediate solution; (iv) forming an intermediate paste by admixing an inert support material with the intermediate solution; (v) optionally coating the intermediate paste on a support substrate; and (vi) removing the inert support material by subjecting the intermediate paste to a calcination process and providing a transition-metal-niobate (TMN) and/or a post-transition-metal-niobate (PTMN). Anodes including a TMN and/or PTMN are also provided.
-
公开(公告)号：US20230278222A1
公开(公告)日：2023-09-07
申请号：US18019039
申请日：2021-08-02
发明人： Russell H. Taylor , Axel Kriege , Peter Kazanides , Balazs Vagvolgyi , Anton Deguet , Mikhail Khrenov
CPC分类号： B25J9/1689 , B25J13/06 , B25J9/1697
摘要： A robotic system for remote operation of human-controllable equipment includes a remotely operable robotic subsystem configured to be at least one of mounted on or arranged adjacent to the human-controllable equipment to be controlled, and a remote controller that is configured to be operated by a human. The remote controller emulates a control representation of the human-controllable equipment such that a human can provide commands using the control representation. The remotely operable robotic subsystem is configured to receive commands from the remote controller to thereby operate the human-controllable equipment.
-
公开(公告)号：US20230276877A1
公开(公告)日：2023-09-07
申请号：US18091499
申请日：2022-12-30
发明人： Michael H. Jin , Evan D. Jacque , Jarod C. Gagnon , Nathan J. Fairbanks , Drew P. Seker , Kenneth Bontje , Mark Bollong
IPC分类号： A41D19/015 , A41D13/012 , A41D19/00 , A41D31/06
CPC分类号： A41D19/01529 , A41D13/012 , A41D19/0006 , A41D31/065 , B32B2307/7265
摘要： A diving glove includes quilted material defining a plurality of pockets. Each of the pockets is filled with aerogel beads. The glove may be worn underneath a waterproof layer in a dry diving suit. The glove includes multiple seams dividing the pockets. The seams are located to maintain a distribution of beads across the glove that effectively insulates the wearer's hand and prevents the beads from impeding the wearer's manual dexterity. The glove includes a web portion extending across a back side of the fingers. The web portion can be used to create an enclosed space for insulating the wearer's fingers.
-
公开(公告)号：US11745165B2
公开(公告)日：2023-09-05
申请号：US16639763
申请日：2018-08-17
发明人： Honggang Cui , Yi Li , Lye Lin Lock , XuanKuo Xu , Zhengjian Li
CPC分类号： B01J20/24 , B01D15/3809 , B01J20/28023 , B01J20/3425 , B01J20/3475 , C07K1/22 , C07K7/08 , C07K14/31 , C07K16/065
摘要： The present invention provide novel immunofiber compositions for protein or peptide purification and simple and cost-efficient methods and systems using these compositions. In some embodiments, the immunofibers comprise a customized Z-33 peptide derived from Staphylococcus aureus Protein A which is used to construct immuno-amphiphile molecules that assemble into immunofibers in aqueous solution with bioactive epitopes on the surface and have peptide or protein binding ability.
-
-
-
-
-
-
-
-
-
搜索结果
5561 条记录 (耗时 0.063 秒)
