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公开(公告)号：US11902407B2
公开(公告)日：2024-02-13
申请号：US18064540
申请日：2022-12-12
发明人： Muriel Medard , Derya Malak , Alejandro Cohen
IPC分类号： H04L69/324 , H04L1/00 , H04L1/1867 , H04W28/02 , H04L47/38 , H04L1/12 , H04W40/12 , H04L45/00 , H04L45/24
CPC分类号： H04L69/324 , H04L1/0001 , H04L1/004 , H04L1/0041 , H04L1/0045 , H04L1/0076 , H04L1/12 , H04L1/1867 , H04L45/24 , H04L45/70 , H04L47/38 , H04W28/0231 , H04W28/0257 , H04W40/12
摘要： Techniques are disclosed for an adaptive and causal random linear network coding (AC-RLNC) with forward error correction (FEC) for a communication channel with delayed feedback. An example methodology implementing the techniques includes transmitting one or more coded packets in a communication channel, determining a channel behavior of the channel, and adaptively adjusting a transmission of a subsequent coded packet in the first channel based on the determined channel behavior. The communication channel may be a point-to-point communication channel between a sender and a receiver. The channel behavior may be determined based on feedback acknowledgements provided by the receiver. The subsequent coded packet may be a random linear combination of one or more information packets.
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公开(公告)号：US11898142B2
公开(公告)日：2024-02-13
申请号：US16645571
申请日：2018-09-07
申请人： THE BROAD INSTITUTE, INC. , MASSACHUSETTS INSTITUTE OF TECHNOLOGY , PRESIDENT AND FELLOWS OF HARVARD COLLEGE
发明人： Feng Zhang , Jonathan Gootenberg , Omar Abudayyeh
IPC分类号： C12N15/113 , C12N9/22 , G01N33/53 , B01L3/00
CPC分类号： C12N15/113 , B01L3/5085 , C12N9/22 , G01N33/5308 , B01L2300/123 , B01L2300/126 , C12N2310/20 , C12N2800/80
摘要： The embodiments disclosed herein utilized RNA targeting effectors to provide a robust CRISPR-based diagnostic with attomolar sensitivity. Embodiments disclosed herein can detect both DNA and RNA with comparable levels of sensitivity and can differentiate targets from non-targets based on single base pair differences. Moreover, the embodiments disclosed herein can be prepared in freeze-dried format for convenient distribution and point-of-care (POC) applications. Such embodiments are useful in multiple scenarios in human health including, for example, viral detection, bacterial strain typing, sensitive genotyping, and detection of disease-associated cell free DNA.
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公开(公告)号：US20240043934A1
公开(公告)日：2024-02-08
申请号：US18021625
申请日：2021-08-22
申请人： The Broad Institute, Inc. , Massachusetts Institute of Technology , The General Hospital Corporation
发明人： Aviv Regev , William Hwang , Karthik Jagadeesh , Jimmy Guo , Tyler Jacks , Hannah Hoffman
IPC分类号： C12Q1/6886
CPC分类号： C12Q1/6886 , C12Q2600/112 , G01N2800/7028
摘要： Described herein are pancreatic ductal adenocarcinoma (PDAC) signatures and methods of detecting the same in a sample from heterogeneity-score a subject. Also described herein, are methods of methods of diagnosing, prognosing, and/or treating PDAC in a subject that can include detecting one or more of the PDAC signatures.
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公开(公告)号：US20240043828A1
公开(公告)日：2024-02-08
申请号：US18030324
申请日：2021-10-05
发明人： Feng Zhang , Alim Ladha
IPC分类号： C12N15/10 , C12N9/22 , C12N15/11 , C12N9/12 , C07K14/195
CPC分类号： C12N15/102 , C12N9/22 , C12N15/11 , C12N9/1252 , C12Y207/07007 , C07K14/195 , C12N2310/20
摘要： Described in several embodiments herein are compositions, systems, and methods for targeted gene modification, targeted insertion, perturbation of gene transcripts, and nucleic acid editing. Described in several embodiments are nucleic acid targeting systems that include components of CRISPR systems, VirD polypeptide(s), and DNA polymerase(s).
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公开(公告)号：US20240043369A1
公开(公告)日：2024-02-08
申请号：US18343417
申请日：2023-06-28
发明人： Stephen L. Craig , Jeremiah A. Johnson , Shu Wang , Michael Rubinstein , Abraham Herzog-Arbeitman
IPC分类号： C07C69/757 , C08F36/20 , C07C69/753
CPC分类号： C07C69/757 , C08F36/20 , C07C69/753
摘要： Disclosed herein are cyclobutane-based crosslinking compounds that, when incorporated into acrylate-based polymeric materials, can produce toughened acrylate polymer networks. Also disclosed herein are polymers comprising the crosslinkers, methods of preparing toughened polymer networks using the crosslinkers, and methods of using the polymer networks.
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公开(公告)号：US11892668B2
公开(公告)日：2024-02-06
申请号：US17473255
申请日：2021-09-13
发明人： Mathias Kolle , Benjamin Miller
摘要： The present disclosure describes photonic materials that reversibly change color in response to the material being stretched or otherwise mechanically deformed.
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公开(公告)号：US11890377B2
公开(公告)日：2024-02-06
申请号：US17162656
申请日：2021-01-29
发明人： Michael Heartlein , Daniel Anderson , Yizhou Dong , Frank DeRosa
CPC分类号： A61K9/1272 , A61K38/177 , A61K38/1709 , A61K38/4846 , A61K38/53 , A61K48/005 , A61K48/0033 , A61K48/00
摘要： The present invention provides, among other things, methods of delivering mRNA in vivo, including administering to a subject in need of delivery a composition comprising an mRNA encoding a protein, encapsulated within a liposome such that the administering of the composition results in the expression of the protein encoded by the mRNA in vivo, wherein the liposome comprises a cationic lipid of formula I-c:
or a pharmaceutically acceptable salt thereof.-
公开(公告)号：US11885684B2
公开(公告)日：2024-01-30
申请号：US17243157
申请日：2021-04-28
发明人： Juejun Hu , Derek Kita , Jerome Michon
CPC分类号： G01J3/4406 , G01J3/0205 , G01J3/0218 , G01J3/10 , G01N21/65
摘要： A method of performing Raman spectroscopy can include guiding a Raman pump beam with an optical fiber, where the Raman pump beam inducing fluorescence in the optical fiber. The beam and the fluorescence are coupled to a photonic integrated circuit (PIC) via the fiber. The beam is used to excite a sample in optical communication with the PIC via evanescent coupling and induces Raman scattering in the sample. The Raman scattering is collected via the PIC, and the Raman pump beam as well as the fluorescence is filtered out from the Raman scattering via the PIC.
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公开(公告)号：US11884566B2
公开(公告)日：2024-01-30
申请号：US17011981
申请日：2020-09-03
IPC分类号： C02F3/34 , C02F3/32 , E21C41/22 , C07K14/825 , C12N1/06 , C12N1/16 , C12N9/02 , C12N9/10 , C12N9/88 , E21C41/32 , C22B3/18 , C02F101/20 , C02F103/10
CPC分类号： C02F3/342 , C02F3/322 , C02F3/347 , C07K14/825 , C12N1/063 , C12N1/16 , C12N9/0008 , C12N9/1029 , C12N9/1085 , C12N9/88 , E21C41/22 , E21C41/32 , C02F2101/20 , C02F2101/203 , C02F2103/10 , C07K2319/03 , C12Y102/01011 , C12Y203/01031 , C12Y205/01047 , C12Y404/01008 , C22B3/18 , Y02P10/20
摘要： Metal bioremediation and metal mining strategies can include compositions and methods.
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公开(公告)号：US20240026382A1
公开(公告)日：2024-01-25
申请号：US18470189
申请日：2023-09-19
发明人： Feng Zhang , Soumya Kannan , Han Altae-Tran
CPC分类号： C12N15/90 , C12N9/22 , C12N15/102 , C12N9/78 , C12Y305/04005 , C12Y305/04004 , C12Y207/07049
摘要： Described herein are systems, methods, and compositions capable of targeting nucleic acids. Describe in certain exemplary embodiments herein are a class of small Cas proteins (Type II-D Cas proteins) and systems thereof. Also described in certain exemplary embodiments herein are methods of modifying target sequences using the class of small Cas proteins (Type II-D Cas proteins) and systems thereof described herein.
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