SUGAR CHAIN ADDED GLP-1 PEPTIDE
    94.
    发明申请
    SUGAR CHAIN ADDED GLP-1 PEPTIDE 有权
    糖链添加GLP-1肽

    公开(公告)号:US20090111739A1

    公开(公告)日:2009-04-30

    申请号:US12140866

    申请日:2008-06-17

    IPC分类号: A61K38/16 C07K14/00

    CPC分类号: C07K14/605 A61K38/00

    摘要: The present invention relates to an oligosaccharide chain added GLP-1 peptide that has higher stability in blood than that of GLP-1 and, preferably, exhibits higher activity of controlling blood-sugar levels than that of GLP-1. The present invention relates to an oligosaccharide chain added GLP-1 peptide having GLP-1 activity, wherein at least one amino acid is substituted with an oligosaccharide chain added amino acid, in: (a) GLP-1; (b) a peptide having the amino acid sequence of GLP-1 with deletion, substitution or addition of one or several amino acids; or (c) a GLP-1 analog.

    摘要翻译: 本发明涉及一种与GLP-1相比血液中稳定性更高的糖链附加GLP-1肽,优选表现出比GLP-1更高的控制血糖水平的活性。 本发明涉及:(a)GLP-1;具有GLP-1活性的附加了糖链的GLP-1肽,其中至少一个氨基酸被添加了糖链的氨基酸取代。 (b)具有缺失,取代或添加一个或几个氨基酸的具有GLP-1氨基酸序列的肽; 或(c)GLP-1类似物。

    Process for production of living radical polymers and polymers
    98.
    发明授权
    Process for production of living radical polymers and polymers 有权
    生产活性自由基聚合物和聚合物的方法

    公开(公告)号:US07291690B2

    公开(公告)日:2007-11-06

    申请号:US10523611

    申请日:2003-08-08

    IPC分类号: C08F22/00 C08G65/12 C08G59/17

    CPC分类号: C08F4/00 C08F293/005

    摘要: A process for producing a living radical polymer characterized in that a vinyl monomer is polymerized with use of a living radical polymerization initiator represented by the formula (1) and a compound represented by the formula (2), and the living radical polymer obtained by the process wherein R1 is C1-C8 alkyl, aryl, substituted aryl or an aromatic heterocyclic group, R2 and R3 are each a hydrogen atom or C1-C8 alkyl, and R4 is aryl, substituted aryl, an aromatic heterocyclic group, acyl, oxycarbonyl or cyano (R1Te)2  (2) wherein R1 is the same as above.

    摘要翻译: 一种活性自由基聚合物的制造方法,其特征在于,使用由式(1)表示的活性自由基聚合引发剂和式(2)表示的化合物,使乙烯基单体聚合而得到的活性自由基聚合物 其中R 1是C 1 -C 8烷基,芳基,取代的芳基或芳族杂环基,R 2, SUP&gt;和R 3 3各自为氢原子或C 1 -C 8烷基,R 4为 芳基,取代的芳基,芳族杂环基,酰基,氧羰基或氰基<?在线公式描述=“在线公式”末端=“铅”→(R 1) (2)<?in-line-formula description =“In-line Formulas”end =“tail”?>其中R 1与上述相同。

    Process for producing sugar chain asparagine derivative
    99.
    发明授权
    Process for producing sugar chain asparagine derivative 有权
    制备糖链天冬酰胺衍生物的方法

    公开(公告)号:US07135566B2

    公开(公告)日:2006-11-14

    申请号:US10481246

    申请日:2002-06-19

    IPC分类号: C07H1/06 C07H5/06

    摘要: The present invention provides a process for preparing a sugar chain asparagine derivative. According to the process, various isolated sugar chain asparagine derivatives useful in the field of the development of pharmaceuticals and the like can be conveniently obtained in a large amount as compared to that of the prior art. The present invention also provides a process for preparing a sugar chain asparagine and a process for preparing a sugar chain via a step for preparing a sugar chain asparagine derivative. The present invention further provides a novel sugar chain asparagine derivative, a sugar chain asparagine and a sugar chain.

    摘要翻译: 本发明提供了制备糖链天冬酰胺衍生物的方法。 根据该方法,与现有技术相比,可以方便地获得与药物开发领域有用的各种分离的糖链天冬酰胺衍生物。 本发明还提供了制备糖链天冬酰胺的方法和通过制备糖链天冬酰胺衍生物的步骤制备糖链的方法。 本发明还提供了一种新型的糖链天冬酰胺衍生物,糖链天冬酰胺和糖链。